DNA damage by cadmium and arsenic salts assessed by the single cell gel electrophoresis assay

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 498, Issue 1-2, 2001, Pages 47-55

  Mourón, Silvana Andrea ^a   Golijow, Carlos Daniel ^a   Dulout, Fernando Noel ^a  

^a FACULTAD DE CIENCIAS VETERINARIAS   (Argentina)

Author keywords

Arsenic; Cadmium; Comet assay

Indexed keywords

ARSENITE SODIUM; CACODYLIC ACID; CADMIUM CHLORIDE; CADMIUM SULFATE;

ARTICLE; CARCINOGENICITY; CELLULAR DISTRIBUTION; COMET ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA CROSS LINKING; DNA DAMAGE; DNA STRAND BREAKAGE; EXCISION REPAIR; EXPOSURE; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; INHIBITION KINETICS; MIGRATION; PRIORITY JOURNAL;

ARSENIC; ARSENITES; CACODYLIC ACID; CADMIUM CHLORIDE; CADMIUM COMPOUNDS; CELL LINE; COMET ASSAY; DNA; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; HUMANS; SODIUM COMPOUNDS; SULFATES;

EID: 0035889585     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(01)00266-2     Document Type: Article

References (46)

1. Toxicological principles of metal carcinogenesis with special emphasis on cadmium
2. Toxicology of cadmium
3. Cadmium carcinogenicity and genotoxicity
4. Cadmium carcinogenesis in review
5. Evaluation of the direct genotoxic potential of cadmium in four different rodent cell lines
6. Induction and repair inhibition of oxidative DNA damage by nickel(II) and cadmium(II) in mammalian cells
7. Cadmium, gene regulation, and cellular signaling in mammalian cells
8. Disturbance of DNA damage recognition after UV-irradiation by nickel(II) and cadmium(II) in mammalian cells
9. Carcinogenicity of metal compounds: Possible role of DNA repair inhibition
10. Possible role of caspase-3 inhibition in cadmium-induced blockage of apoptosis
11. Metals and disorders of cell accumulation: Modulation of apoptosis and cell proliferation
12. Arsenic: Health effects, mechanisms of action and research issues
13. The enigma of arsenic carcinogenesis: Role of metabolism
14. Possible carcinogenic potential of dimethylarsinic acid as assessed in rat in vivo models: A review
15. Urinary bladder carcinogenicity of dimethylarsinic acid in male F344 rats
16. Mutagenicity of arsenic in mammalian cells: Role of reactive oxygen species
17. Involvement of reactive oxygen species and caspase - Activation in arsenite-induced apoptosis
18. Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression
19. Interaction of arsenic(III) with nucleotide excision repair in UV-irradiated human fibroblasts
20. Aneugenic effect of sodium arsenite on human lymphocytes in vitro: An individual susceptibility effect detected
21. Chromosomal aberrations in peripheral blood lymphocytes from native Andean women and children from northwestern Argentina exposed to arsenic in drinking water
22. Disruption of microtubule assembly and spindle formation as a mechanism for the induction of aneuploid cells by sodium arsenite and vanadium pentoxide
23. Variation in arsenic-induced sister chromatid exchange in human lymphocytes and lymphoblastoid cell lines
24. Association between the clastogenic effect in peripheral lymphocytes and human exposure to arsenic through drinking water
25. Differential susceptibility to carcinogen-induced amplification of SV40 and dhfr sequences in SV40-transformed human keratinocytes
26. Sodium arsenite induces chromosome endoreduplication and inhibits protein phosphatase activity in human fibroblasts
27. Arsenic(III), but not antimony, induces DNA-protein cross-links
28. A simple technique for quantitation of low levels of DNA damage in individual cells
29. The comet assay: A comprehensive review
30. Single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testing
31. Detection of DNA-cross-linking agents with the alkaline comet assay
32. Detection of cross-links with the comet assay in relationship to genotoxicity and citotoxicity
33. The comet assay: A new method to examine heterogeneity associated with solid tumors
34. Aneugenic effects of some metal compounds assessed by chromosome counting in MRC-5 human cells
35. Alteraciones cromosómicas y metabolismo de arsénico en poblaciones humanas expuestas en forma crónica en Argentina
36. Comparative investigations of the genotoxic effects of metals in the single cell gel (SCG) assay and the sister chromatid exchange (SCE) test
37. Effect of arsenic and cadmium on the persistence of mutagen-induced DNA lesions in human cells
38. The single cell gel/comet assay: A microgel electrophoretic technique for the detection of DNA damage and repair in individual cells
39. Cadmium induces apoptosis in a human T cell line
40. Cadmium-induced apoptosis in mouse liver
41. Cadmium-induced apoptosis in the urogenital organs of the male rat and its suppression by chelation
42. Use of the anaphase-telophase test to detect aneugenic compounds: Effects of propionaldehyde and cadmium chloride
43. Contribution to the validation of the anaphase-telophase test: Aneugenic and clastogenic effects of cadmium sulfate, potassium dichromate and nickel chloride in Chinese hamster ovary cells