Development of the structural basis for antimicrobial and hemolytic activities of peptides based on gramicidin S and design of novel analogs using NMR spectroscopy

Journal of Biological Chemistry

Volumn 275, Issue 19, 2000, Pages 14287-14294

  McInnes, Campbell ^a,b   Kondejewski, Leslie H ^a   Hodges, Robert S ^a   Sykes, Brian D ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b CYCLACEL LTD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; DRUG ANALOG; GRAMICIDIN DERIVATIVE; GRAMICIDIN S; SOLVENT; TRIFLUOROETHANOL; WATER;

ANTIMICROBIAL ACTIVITY; ARTICLE; DIASTEREOISOMER; DRUG DESIGN; HEMOLYSIS; HYDROPHOBICITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANTI-INFECTIVE AGENTS; DRUG DESIGN; GRAMICIDIN; HEMOLYSIS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; TRIFLUOROETHANOL;

EID: 0034640414     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.19.14287     Document Type: Article

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