Therapeutic targets from a Drosophila model of Alzheimer's disease

Current Opinion in Pharmacology

Volumn 4, Issue 5, 2004, Pages 513-516

  Crowther, Damian C ^a   Kinghorn, Kerri J ^a   Page, Richard ^a   Lomas, David A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; DIZOCILPINE;

ALZHEIMER DISEASE; ANIMAL MODEL; ARTICLE; DROSOPHILA MELANOGASTER; DRUG DESIGN; DRUG TARGETING; GENETIC SCREENING; LIFESPAN; MEMORY; MOTOR PERFORMANCE; NERVE DEGENERATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMELLING; TRANSGENIC ORGANISM; ANIMAL; BIOSYNTHESIS; DISEASE MODEL; DRUG ANTAGONISM; GENETICS; PATHOLOGY; REVIEW; TRANSGENIC ANIMAL;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; ANIMALS, GENETICALLY MODIFIED; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER;

EID: 16644363664     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2004.07.001     Document Type: Review

References (31)

1. D.W. Dickson The pathogenesis of senile plaques J Neuropathol Exp Neurol 56 1997 321-339
2. D.J. Selkoe Alzheimer's disease: Genes, proteins, and therapy Physiol Rev 81 2001 741-766
3. C. Nilsberth A. Westlind-Danielsson C.B. Eckman M.M. Condron K. Axelman C. Forsell C. Stenh J. Luthman D.B. Teplow S.G. Younkin et al. The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation Nat Neurosci 4 2001 887-893
4. K. Murakami K. Irie A. Morimoto H. Ohigashi M. Shindo M. Nagao T. Shimizu T. Shirasawa Synthesis, aggregation, neurotoxicity, and secondary structure of various A beta 1-42 mutants of familial Alzheimer's disease at positions 21-23 Biochem Biophys Res Commun 294 2002 5-10
5. K.N. Dahlgren A.M. Manelli W.B. Stine Jr. L.K. Baker G.A. Krafft M.J. LaDu Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability J Biol Chem 277 2002 32046-32053
6. M.T. Lai E. Chen M.C. Crouthamel J. DiMuzio-Mower M. Xu Q. Huang E. Price R.B. Register X.P. Shi D.B. Donoviel et al. Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities J Biol Chem 278 2003 22475-22481
7. D.C. Crowther Familial conformational diseases and dementias Hum Mutat 20 2002 1-14
8. G.K. Wilcock M.M. Esiri Plaques, tangles and dementia. A quantitative study J Neurol Sci 56 1982 343-356
9. H. Braak E. Braak Morphological criteria for the recognition of Alzheimer's disease and the distribution pattern of cortical changes related to this disorder Neurobiol Aging 15 1994 355-356
10. J. Naslund V. Haroutunian R. Mohs K.L. Davis P. Davies P. Greengard J.D. Buxbaum Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline JAMA 283 2000 1571-1577
11. M.P. Lambert A.K. Barlow B.A. Chromy C. Edwards R. Freed M. Liosatos T.E. Morgan I. Rozovsky B. Trommer K.L. Viola et al. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins Proc Natl Acad Sci U S A 95 1998 6448-6453
12. D.M. Walsh I. Klyubin J.V. Fadeeva W.K. Cullen R. Anwyl M.S. Wolfe M.J. Rowan D.J. Selkoe Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo Nature 416 2002 535-539
13. R. Kayed E. Head J.L. Thompson T.M. McIntire S.C. Milton C.W. Cotman C.G. Glabe Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis Science 300 2003 486-489
14. M. Goedert M.G. Spillantini Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease Biochim Biophys Acta 1502 2000 110-121
15. S. Oddo A. Caccamo J.D. Shepherd M.P. Murphy T.E. Golde R. Kayed R. Metherate M.P. Mattson Y. Akbari F.M. LaFerla Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction Neuron 39 2003 409-421
16. M.A. Westerman D. Cooper-Blacketer A. Mariash L. Kotilinek T. Kawarabayashi L.H. Younkin G.A. Carlson S.G. Younkin K.H. Ashe The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease J Neurosci 22 2002 1858-1867
17. S. Davis S. Laroche What can rodent models tell us about cognitive decline in Alzheimer's disease? Mol Neurobiol 27 2003 249-276
18. L. Luo T. Tully K. White Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene Neuron 9 1992 595-605
19. A. Fossgreen B. Brückner C. Czech C.L. Masters K. Beyreuther R. Paro Transgenic Drosophila expressing human amyloid precursor protein show γ-secretase activity and blistered wing phenotype Proc Natl Acad Sci U S A 95 1998 13703-13708
20. R. Vassar B.D. Bennett S. Babu-Khan S. Kahn E.A. Mendiaz P. Denis D.B. Teplow S. Ross P. Amarante R. Loeloff et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE Science 286 1999 735-741
21. R. Yan M.J. Bienkowski M.E. Shuck H. Miao M.C. Tory A.M. Pauley J.R. Brashier N.C. Stratman W.R. Mathews A.E. Buhl et al. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity Nature 402 1999 533-537
22. S. Sinha J.P. Anderson R. Barbour G.S. Basi R. Caccavello D. Davis M. Doan H.F. Dovey N. Frigon J. Hong et al. Purification and cloning of amyloid precursor protein beta-secretase from human brain Nature 402 1999 537-540
23. I. Greeve D. Kretzschmar J.A. Tschape A. Beyn C. Brellinger M. Schweizer R.M. Nitsch R. Reifegerste Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila J Neurosci 24 2004 3899-3906
24. K. Iijima H.P. Liu A.S. Chiang S.A. Hearn M. Konsolaki Y. Zhong Dissecting the pathological effects of human A{beta}40 and A{beta}42 in Drosophila: A potential model for Alzheimer's disease Proc Natl Acad Sci U S A 101 2004 6623-6628
25. Crowther DC, Kinghorn KJ, Duthie FAI, Gubb D, Lomas DA: Inhibitors of Aβ aggregation rescue a Drosophila model of Alzheimer's disease. In Proceedings of the 45th Annual Drosophila research Conference; 2004; Washington DC, USA. The Genetics Society of America; 2004:95.
26. C.W. Wittmann M.F. Wszolek J.M. Shulman P.M. Salvaterra J. Lewis M. Hutton M.B. Feany Tauopathy in Drosophila: Neurodegeneration without neurofibrillary tangles Science 293 2001 711-714
27. G.R. Jackson M. Wiedau-Pazos T.K. Sang N. Wagle C.A. Brown S. Massachi D.H. Geschwind Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila Neuron 34 2002 509-519
28. J.M. Shulman M.B. Feany Genetic modifiers of tauopathy in Drosophila Genetics 165 2003 1233-1242
29. P. Kazemi-Esfarjani S. Benzer Genetic suppression of polyglutamine toxicity in Drosophila Science 287 2000 1837-1840
30. P.K. Auluck H.Y. Chan J.Q. Trojanowski V.M. Lee N.M. Bonini Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease Science 295 2002 865-868
31. B. Reisberg R. Doody A. Stoffler F. Schmitt S. Ferris H.J. Mobius Memantine in moderate-to-severe Alzheimer's disease N Engl J Med 348 2003 1333-1341