Reduced glucocorticoid sensitivity of monocyte interleukin-6 release in male employees with high plasma levels of tumor necrosis factor-α

Life Sciences

Volumn 75, Issue 1, 2004, Pages 1-10

  Wirtz, Petra H ^a   Von Känel, Roland ^b   Kunz Ebrecht, Sabine ^c   Ehlert, Ulrike ^a   Fischer, Joachim E ^b  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b ETH ZURICH   (Switzerland)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Cardiovascular disease; Cytokines; Glucocorticoid sensitivity; Inflammation; Monocytes

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CARDIOVASCULAR RISK; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE RELEASE; EMPLOYEE; HUMAN; INCUBATION TIME; MALE; MONOCYTE; PROTEIN BLOOD LEVEL;

ADULT; ARTERIOSCLEROSIS; DEXAMETHASONE; GLUCOCORTICOIDS; HUMANS; LIPOPOLYSACCHARIDES; MALE; MONOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 16544376237     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2003.11.024     Document Type: Article

References (32)

1. Adcock I.M., Caramori G. Cross-talk between pro-inflammatory transcription factors and glucocorticoids. Immunol. Cell Biol. 79:2001;376-384.
2. Barnes P.J., Karin M. Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 336:1997;1066-1071.
3. Breuninger L.M., Dempsey W.L., Uhl J., Murasko D.M. Hydrocortisone regulation of interleukin-6 protein production by a purified population of human peripheral blood monocytes. Clin. Immunol. Immunopathol. 69:1993;205-214.
4. Chrousos G.P. The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N. Engl. J. Med. 332:1995;1351-1362.
5. De Groote D., Gevaert Y., Lopez M., Gathy R., Fauchet F., Dehart I., Jadoul M., Radoux D., Franchimont P. Novel method for the measurement of cytokine production by a one-stage procedure. J. Immunol. Methods. 163:1993;259-267.
6. De Groote D., Zangerle P.F., Gevaert Y., Fassotte M.F., Beguin Y., Noizat-Pirenne F., Pirenne J., Gathy R., Lopez M., Dehart I.et al. Direct stimulation of cytokines (IL-1 beta, TNF-alpha, IL-6, IL-2, IFN- gamma and GM-CSF) in whole blood: I. Comparison with isolated PBMC stimulation. Cytokine. 4:1992;239-248.
7. DeRijk R., Michelson D., Karp B., Petrides J., Galliven E., Deuster P., Paciotti G., Gold P.W., Sternberg E.M. Exercise and circadian rhythm-induced variations in plasma cortisol differentially regulate interleukin-1 beta (IL-1 beta), IL-6, and tumor necrosis factor-alpha (TNF alpha) production in humans: high sensitivity of TNF alpha and resistance of IL-6. J. Clin. Endocrinol. Metab. 82:1997;2182-2191.
8. DeRijk R.H., Petrides J., Deuster P., Gold P.W., Sternberg E.M. Changes in corticosteroid sensitivity of peripheral blood lymphocytes after strenous exercise in humans. Journal of Clinical Endocrinology and Metabolism. 81:1996;228-235.
9. Elenkov I.J., Wilder R.L., Bakalov V.K., Link A.A., Dimitrov M.A., Fisher S., Crane M., Kanik K.S., Chrousos G.P. IL-12, TNF-alpha, and hormonal changes during late pregnancy and early postpartum: implications for autoimmune disease activity during these times. J. Clin. Endocrinol. Metab. 86:2001;4933-4938.
10. Elkind M.S., Cheng J., Boden-Albala B., Rundek T., Thomas J., Chen H., Rabbani L.E., Sacco R.L. Tumor necrosis factor receptor levels are associated with carotid atherosclerosis. Stroke. 33:2002;31-37.
11. Franchimont D., Martens H., Hagelstein M.T., Louis E., Dewe W., Chrousos G.P., Belaiche J., Geenen V. Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor. J. Clin. Endocrinol. Metab. 84:1999;2834-2839.
12. Heinrich P.C., Castell J.V., Andus T. Interleukin-6 and the acute phase response. Biochem. J. 265:1990;621-636.
13. Jonsson D., Rosengren A., Dotevall A., Lappas G., Wilhelmsen L. Job control, job demands and social support at work in relation to cardiovascular risk factors in MONICA 1995, Goteborg. J. Cardiovasc. Risk. 6:1999;379-385.
14. Koukkunen H., Penttila K., Kemppainen A., Halinen M., Penttila I., Rantanen T., Pyorala K. C-reactive protein, fibrinogen, interleukin-6 and tumour necrosis factor-alpha in the prognostic classification of unstable angina pectoris. Ann. Med. 33:2001;37-47.
15. Michael Y.L., Colditz G.A., Coakley E., Kawachi I. Health behaviors, social networks, and healthy aging: cross-sectional evidence from the Nurses' Health Study. Qual. Life Res. 8:1999;711-722.
16. Mikuniya T., Nagai S., Tsutsumi T., Morita K., Mio T., Satake N., Izumi T. Proinflammatory or regulatory cytokines released from BALF macrophages of healthy smokers. Respiration. 66:1999;419-426.
17. Pickup J.C., Chusney G.D., Thomas S.M., Burt D. Plasma interleukin-6, tumour necrosis factor alpha and blood cytokine production in type 2 diabetes. Life Sci. 67:2000;291-300.
18. Plutzky J. Inflammatory pathways in atherosclerosis and acute coronary syndromes. Am. J. Cardiol. 88:2001;10K-15K.
19. Ridker P.M., Rifai N., Stampfer M.J., Hennekens C.H. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation. 101:2000;1767-1772.
20. Ridker P.M., Rifai N., Pfeffer M., Sacks F., Lepage S., Braunwald E. Elevation of tumor necrosis factor-alpha and increased risk of recurrent coronary events after myocardial infarction. Circulation. 101:2000;2149-2153.
21. Rohde L.E., Arroyo L.H., Rifai N., Creager M.A., Libby P., Ridker P.M., Lee R.T. Plasma concentrations of interleukin-6 and abdominal aortic diameter among subjects without aortic dilatation. Arterioscler. Thromb. Vasc. Biol. 19:1999;1695-1699.
22. Rohleder N., Schommer N.C., Hellhammer D.H., Engel R., Kirschbaum C. Sex differences in glucocorticoid sensitivity of proinflammatory cytokine production after psychosocial stress. Psychosom. Med. 63:2001;966-972.
23. Ross R. Atherosclerosis-an inflammatory disease. N. Engl. J. Med. 340:1999;115-126.
24. Sapolsky R.M., Romero L.M., Munck A.U. How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr. Rev. 21:2000;55-89.
25. Schafer C., Schips I., Landig J., Bode J.C., Bode C. Tumor-necrosis- factor and interleukin-6 response of peripheral blood monocytes to low concentrations of lipopolysaccharide in patients with alcoholic liver disease. Z. Gastroenterol. 33:1995;503-508.
26. Schnorpfeil P., Noll A., Wirtz P., Schulze R., Ehlert U., Frey K., Fischer J.E. Assessment of exhaustion and related risk factors in employees in the manufacturing industry - a cross-sectional study. Int. Arch. Occup. Environ. Health. 75:2002;535-540.
27. Seeman T.E., Singer B.H., Rowe J.W., Horwitz R.I., McEwen B.S. Price of adaptation-allostatic load and its health consequences. MacArthur studies of successful aging. Arch. Intern. Med. 157:1997;2259-2268.
28. Vaddi K., Nicolini F.A., Mehta P., Mehta J.L. Increased secretion of tumor necrosis factor-alpha and interferon-gamma by mononuclear leukocytes in patients with ischemic heart disease. Relevance in superoxide anion generation. Circulation. 90:1994;694-699.
29. Webster J.C., Oakley R.H., Jewell C.M., Cidlowski J.A. Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative beta isoform: a mechanism for the generation of glucocorticoid resistance. Proc. Natl. Acad. Sci. U. S. A. 98:2001;6865-6870.
30. Wick G., Hu Y., Schwarz S., Kroemer G. Immunoendocrine communication via the hypothalamo-pituitary-adrenal axis in autoimmune diseases. Endocr. Rev. 14:1993;539-563.
31. Wright S.D., Ramos R.A., Tobias P.S., Ulevitch R.J., Mathison J.C. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science. 249:1990;1431-1433.
32. Yudkin J.S., Kumari M., Humphries S.E., Mohamed-Ali V. Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis. 148:2000;209-214.