Analysis of telomerase activity and telomere length in bone and soft tissue tumors

Oncology Reports

Volumn 11, Issue 6, 2004, Pages 1307-1311

  Terasaki, Tadashi ^a   Kyo, Satoru ^a   Takakura, Masahiro ^a   Maida, Yoshiko ^a   Tsuchiya, Hiroyuki ^a   Tomita, Katsuro ^a   Inoue, Masaki ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Bone and soft tissue; Sarcoma; Telomerase; Telomere

Indexed keywords

DNA BINDING PROTEIN; MESSENGER RNA; TELOMERASE;

ARTICLE; BONE TUMOR; CANCER STAGING; CHEMISTRY; COMPARATIVE STUDY; ENZYMOLOGY; GENETICS; HUMAN; MESENCHYMOMA; MESODERM; METABOLISM; METASTASIS; OSTEOSARCOMA; PATHOLOGY; SARCOMA; SURVIVAL RATE; TELOMERE; TUMOR RECURRENCE;

BONE NEOPLASMS; DNA-BINDING PROTEINS; HUMANS; MESENCHYMOMA; MESODERM; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; OSTEOSARCOMA; RNA, MESSENGER; SARCOMA; SURVIVAL RATE; TELOMERASE; TELOMERE;

EID: 16544374778     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.11.6.1307     Document Type: Article

References (41)

1. Harley CB, Futcher AB, Greider CW: Telomeres shorten during ageing of human fibroblasts. Nature 345: 458-460, 1990.
2. Watson JD: Origin of concatameric T4 DNA. Nature 239: 197-201, 1972.
3. Vaziri H, West MD, Allsopp RC, et al: ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly (ADP-ribose) polymerase. EMBO J 16: 6018-6033, 1997. (Pubitemid 27427297)
4. Allsopp RC, Vaziri H, Patterson C, et al: Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci USA 89: 10114-10118, 1992.
5. Greider CW and Blackburn EH: A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 337: 331-337, 1989.
6. Yu GL, Bradley JD, Attardi LD and Blackburn EH: In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs. Nature 344: 126-132, 1990.
7. Kim NW, Piatyszek MA, Prowse KR, et al: Specific association of human telomerase activity with immortal cells and cancer. Science 266: 2011-2015, 1994.
8. Counter CM, Hirte HW, Bacchetti S and Harley CB: Telomerase activity in human ovarian carcinoma. Proc Natl Acad Sci USA 91: 2900-2904, 1994. (Pubitemid 24130141)
9. Kyo S, Kanaya T, Ishikawa H, Ueno H and Inoue M: Telomerase activity in gynecological tumors. Clin Cancer Res 2: 2023-2028, 1996. (Pubitemid 27006635)
10. Kyo S, Kunimi K, Uchibayashi T, Namiki M and Inoue M: Telomerase activity in human urothelial tumors. Am J Clin Pathol 107: 555-560, 1997. (Pubitemid 27183988)
11. Feng J, Funk WD, Wang SS, et al: The RNA component of human telomerase. Science 269: 1236-1241, 1995.
12. Harrington L, McPhail T, Mar V, et al: A mammalian telomerase-associated protein. Science 275: 973-977, 1997. (Pubitemid 27087712)
13. Liu Y, Snow BE, Hande MP, et al: Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo. Mol Cell Biol 20: 8178-8184, 2000.
14. Meyerson M, Counter CM, Eaton EN, et al: hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 90: 785-795, 1997. (Pubitemid 27357969)
15. Nakamura TM, Morin GB, Chapman KB, et al: Telomerase catalytic subunit homologs from fission yeast and human. Science 277: 955-959, 1997. (Pubitemid 27366681)
16. Kanaya T, Kyo S, Takakura M, et al: hTERT is a critical determinant of telomerase activity in renal-cell carcinoma. Int J Cancer 78: 539-543, 1998. (Pubitemid 28507174)
17. Kyo S, Kanaya T, Takakura M, et al: Expression of human telomerase subunits in ovarian malignant, borderline and benign tumors. Int J Cancer 80: 804-809, 1999. (Pubitemid 29108852)
18. Takakura M, Kyo S, Kanaya T, Tanaka M and Inoue M: Expression of human telomerase subunits and correlation with telomerase activity in cervical cancer. Cancer Res 58: 1558-1561, 1998. (Pubitemid 28193624)
19. Ito H, Kyo S, Kanaya T, et al: Expression of human telomerase subunits and correlation with telomerase activity in urothelial cancer. Clin Cancer Res 7: 1603-1608, 1998. (Pubitemid 28304720)
20. Bodnar AG, Ouellette M, Frolkis M, et al: Extension of life-span by introduction of telomerase into normal human cells. Science 279: 349-352, 1998. (Pubitemid 28063364)
21. Weinrich SL, Pruzan R, Ma L, et al: Reconstitution of human telomerase with template RNA component hTERC and the catalytic protein subunit hTERT. Nat Genet 17: 498-502, 1997. (Pubitemid 27518407)
22. Nakayama J, Tahara H, Tahara E, et al: Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. Nat Genet 18: 65-68, 1998. (Pubitemid 28027882)
23. Shay JW and Bacchetti S: A survey of telomerase activity in human cancer. Eur J Cancer 5: 787-791, 1997.
24. Dessain SK, Yu H, Reddel RR, Beijersbergen RL and Weinberg RA: Methylation of the human telomerase gene CpG island. Cancer Res 60: 537-541, 2000. (Pubitemid 30094546)
25. Devereux TR, Horikawa I, Anna CH, et al: DNA methylation analysis of the promoter region of the human telomerase reverse transcriptase (hTERT) gene. Cancer Res 59: 6087-6090, 1999. (Pubitemid 30035625)
26. Takakura M, Kyo S, Sowa Y, et al: Telomerase activation by histone deacetylase inhibitor in normal cells. Nucleic Acids Res 29: 3006-3011, 2001. (Pubitemid 32685226)
27. Cong YS and Bacchetti S: Histone deacetylation is involved in the transcriptional repression of hTERT in normal human cells. J Biol Chem 275: 35665-35668, 2000.
28. Hiyama E, Yokoyama T, Tatsumoto N, et al: Telomerase activity in gastric cancer. Cancer Res 55: 3258-3262, 1995.
29. Clark GM, Osborne CK, Levitt D, Wu F and Kim NW: Telomerase activity and survival of patients with node-positive breast cancer. J Natl Cancer Inst 89: 1874-1881, 1997. (Pubitemid 28009823)
30. Aogi K, Woodman A, Urquidi V, et al: Telomerase activity in soft-tissue and bone sarcomas. Clin Cancer Res 12: 4776-4781, 2000. (Pubitemid 32110419)
31. Schneider-Stock R, Epplen JT and Walter H: Telomeric lengths and telomerase activity in liposarcomas. Mol Carcinog 24: 144-151, 1999. (Pubitemid 29115917)
32. Bovee JV, van Den Broek LJ, Cleton-Jansen AM and Hogendoorn PC: Chondrosarcoma is not characterized by detectable telomerase activity. J Pathol 193: 354-360, 2001. (Pubitemid 32229868)
33. Yan P, Coindre JM, Benhattar J, Bosman FT and Guillou L: Telomerase activity and human telomerase reverse transcriptase mRNA expression in soft tissue tumors: correlation with grade, histology, and proliferative activity. Cancer Res 59: 3166-3170, 1999. (Pubitemid 29316017)
34. Schneider-Stock R, Rys J, Jaeger V, et al: Prognostic significance of telomerase activity in soft tissue sarcomas. Int J Oncol 15: 775-780, 1999.
35. Tomoda R, Sato M, Tsumiki H, et al: Telomerase activity and human telomerase reverse transcriptase mRNA expression are correlated with clinical aggressiveness in soft tissue tumors. Cancer 95: 1127-1133, 2002. (Pubitemid 34925366)
36. Yoo J and Robinson RA: Expression of telomerase activity and telomerase RNA in human soft tissue sarcomas. Arch Pathol Lab Med 24: 393-397, 2000. (Pubitemid 30152141)
37. Chong L, van Steensel B, Broccoli D, et al: A human telomeric protein. Science 270: 1663-1667, 1995. (Pubitemid 26002442)
38. Broccoli D, Smogorzewska A, Chong L and De Lange T: Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat Genet 17: 231-235, 1997.
39. Bryan TM, Englezou A, Dalla-Pozza L, Dunham MA and Reddel RR: Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nat Med 3: 1271-1274, 1997. (Pubitemid 27508830)
40. Dunham MA, Neumann AA, Fasching CL and Reddel RR: Telomere maintenance by recombination in human cells. Nat Genet 26: 447-450, 2000.
41. Ulner GA, Huang HY, Otero J, Zhao Z, Ben-Porat L, Satagopan JM, Gorlick R, Meyers P, Healey JH, Huvos AG, Hoffman AR and Ladanyi M: Absence of a telomere maintenance mechanism as a favorable prognostic factor in patients with osteosarcoma. Cancer Res 63: 1759-1763, 2003. (Pubitemid 36469314)