Corticotropin releasing hormone neurons in the paraventricular nucleus are direct targets for neuropeptide Y neurons in the arcuate nucleus: An anterograde tracing study

Brain Research

Volumn 854, Issue 1-2, 2000, Pages 122-129

  Li, Chien ^a   Chen, Peilin ^a   Smith, M Susan ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Arcuate nucleus; Corticotropin releasing hormone; Median eminence; Neuropeptide Y; NPY Y1 receptor; Paraventricular nucleus

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; LEUKOAGGLUTININ; NEUROPEPTIDE Y; RECEPTOR SUBTYPE;

ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; CONFOCAL MICROSCOPY; FEMALE; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE TEST; IONTOPHORESIS; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; THALAMUS MIDLINE NUCLEUS;

ANIMALS; ARCUATE NUCLEUS; CORTICOTROPIN-RELEASING HORMONE; FEMALE; MEDIAN EMINENCE; NEURONS; NEUROPEPTIDE Y; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PHYTOHEMAGGLUTININS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROPEPTIDE Y;

EID: 0033958941     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)02324-0     Document Type: Article

References (35)

1. Aramakis V.B., Stanley B.G., Ashe J.H. Neuropeptide Y receptor agonists: multiple effects on spontaneous activity in the paraventricular hypothalamus. Peptides. 17:1996;1349-1357.
2. Brady L.S., Smith M.A., Gold P.W., Herkenham M. Altered expression of hypothalamic neuropeptide mRNAs in food-restricted and food-deprived rats. Neuroendocrinology. 52:1990;441-447.
3. Ciofi P., Crowley W.R., Pillez A., Schmued L.L., Tramus G., Mazzuca M. Plasticity in expression of immunoreactivity for neuropeptide Y, enkephalins and neurotensin in the hypothalamic tubero-infundibular dopaminergic system during lactation in mice. J. Neuroendocrinol. 5:1993;599-602.
4. Ciofi P., Fallon J.H., Croix D., Polak J.M., Tramu G. Expression of neuropeptide Y precursor-immunoreactivity in the hypothalamic dopaminergic tubero-infundibular system during lactation in rodents. Endocrinology. 128:1991;823-834.
5. Criscione L., Rigollier P., Batzl-Hartmann C., Rueger H., Stricker-Krongrad A., Wyss P., Brunner L., Whitebread S., Yamaguchi Y., Gerald C., Heurich R.O., Walker M.W., Chiesi M., Schilling W., Hofbauer K.G., Levens N. Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y5 receptor. J. Clin. Invest. 102:1998;2136-2145.
6. M.E. De Quidt, H. Kiyama, P.C. Emson, Pancreatic polypeptide, neuropeptide Y and peptide YY in central neurons, in: A. Björklund, T. Hökfelt, M.J. Kuhar (Eds.), Handbook of Chemical Neuroanatomy, Vol. 9: Neuropeptide in the CNS, Part II, Elsevier, Amsterdam, 1990, pp. 287-358.
7. Fischer D., Patchev V.K., Hellback S., Hassan A.H., Almeida O.F. Lactation as a model for naturally reversible hypercorticalism plasticity in the mechanisms governing hypothalamo-pituitary-adrenocortical activity in rats. J. Clin. Invest. 96:1995;1208-1215.
8. Gerald C., Walker M.W., Criscione L., Gustavson E.L., Batzi-Hartmann C., Smith K.E., Vaysse P.J.J., Durkin M.M., Laz T.M., Linemeyer D.L., Schaffhauser A.P., Whitebread S., Hofbauer K.G., Taber R.L., Branchek T.A., Weinshank R.L. A receptor subtype involved in neuropeptide Y-induced food intake. Nature. 382:1996;168-171.
9. Gerfen C.R., Sawchenko P.E. An anterograde neuroanatomical tracing method that shows detailed morphology of neurons, their axons and terminals: immunohistochemical localization of an axonally transported plant lectin, Phaseolus vulgaris leucoagglutinin (PHA-L). Brain Res. 290:1984;219-238.
10. Gustafson E.L., Smith K.E., Durkin M.M., Walker M.W., Gerald C., Weinshank R., Branchek T.A. Distribution of the neuropeptide Y Y2 receptor mRNA in rat central nervous system. Mol. Brain Res. 46:1997;223-235.
11. Heinrichs S.C., Menzaghi F., Koob G.F. Neuropeptide Y-induced feeding and its control. Vitam. Horm. 54:1998;51-67.
12. Hwang B.H., Guntz J.M. Downregulation of corticotropin-releasing factor mRNA, but not vasopressin mRNA, in the paraventricular hypothalamic nucleus of rats following nutritional stress. Brain Res. Bull. 43:1997;509-514.
13. Kalra S.P., Crowley W.R. Neuropeptide Y: a novel neuroendocrine peptide in the control of pituitary hormone secretion, and its relation to luteinizing hormone. Front. Neuroendocrinol. 13:1992;1-46.
14. Kalra S.P., Kalra P.S. Nutritional infertility: the role of the interconnected hypothalamic neuropeptide Y-galanin-opioid network. Front. Neuroendocrinol. 17:1996;371-401.
15. Kask A., Rago L., Harro J. Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y1-selective antagonist BIBP3226. Br. J. Pharmacol. 124:1998;1507-1515.
16. Kiss A., Jezova D., Aguilera G. Activity of the hypothalamic pituitary adrenal axis and sympathoadrenal system during food and water deprivation in the rat. Brain Res. 663:1994;84-92.
17. Larsen P.J., Kristensen P. Distribution of neuropeptide Y receptor expression in the rat suprachiasmatic nucleus. Mol. Brain Res. 60:1998;69-76.
18. C. Li, P. Chen, M.A. Smith, Morphological evidence for direct interaction between arcuate nucleus neuropeptide Y (NPY) neurons and gonadotropin releasing hormone (GnRH) neurons and the possible involvement of NPY Y1 receptors. Endocrinology, in press, 1999.
19. Li C., Chen P., Smith M.S. The acute suckling stimulus induces expression of Neuropeptide Y (NPY) in cells in the dorsomedial hypothalamus and Increase NPY expression in the arcuate nucleus. Endocrinology. 139:1998;1645-1652.
20. Li C., Chen P., Smith M.S. Neuropeptide Y (NPY) neurons in the arcuate nucleus (ARH) and dorsomedial nucleus (DMH), areas activated during lactation, project to the paraventricular nucleus of the hypothalamus (PVH). Reg. Pept. 75-76:1998;93-100.
21. Liposits Z., Sievers L., Paull W.K. Neuropeptide-Y and ACTH-immunoreactivity innervation of corticotropin releasing factor (CRF)-synthesizing neurons in the hypothalamus of the rat. An immunocytochemical analysis at the light and electron microscopic levels. Histochemistry. 88:1988;227-234.
22. Pape J.-R., Tramu G. Suckling-induced changes in neuropeptide Y and proopiomelanocortin gene expression in the arcuate nucleus of the rat: evaluation of a putative intervention of prolactin. Neuroendocrinology. 63:1996;540-549.
23. G. Paxinos, C. Waston, The Rat Brain in Stereotaxic Coordinates, 4th edn., Academic Press, New York, 1986.
24. Parker R.M., Herzog H. Regional distribution of Y-receptor subtype mRNAs in rat brain. Eur. J. Neurosci. 11:1999;1431-1448.
25. Sahu A., Kalra S.P., Crowley W.R., Kalra P.S. Evidence that NPY-containing neurons in the brainstem project into selected hypothalamic nuclei: implication in feeding behavior. Brain Res. 457:1988;376-378.
26. Sawchenko P.E., Swanson L.W., Grzanna R., Howe P.R., Bloom S.R., Polak J.M. Colocalization of neuropeptide Y immunoreactivity in brainstem catecholaminergic neurons that project to the paraventricular nucleus of the hypothalamus. J. Comp. Neurol. 241:1985;138-153.
27. Sawchenko P.E. Evidence for differential regulation of corticotropin-releasing factor and vasopressin immunoreactivities in parvocellular neurosecretory and autonomic-related projections of the paraventricular nucleus. Brain Res. 437:1987;253-263.
28. Sawchenko P.E., Imaki T., Potter K., Kovács J., Vale W. The functional neuroanatomy of corticotropin-releasing factor. Ciba Found. Symp. 172:1993;5-29.
29. Schaffhauser A.O., Stricker-Krongrad A., Brunner L., Cumin F., Gerald C., Whitebread S., Criscione L., Hofbauer K.G. Inhibition of food intake by neuropeptide Y Y5 receptor antisense oligodeoxynucleotides. Diabetes. 46:1997;1792-1798.
30. Smith M.S. Lactation alters neuropeptide-Y and proopiomelanocortin gene expression in the arcuate nucleus of the rat. Endocrinology. 133:1993;1258-1265.
31. Stanley B.G., Magdalin W., Seirafi A., Nguyen M.M., Leibowitz S.F. Evidence for neuropeptide Y mediation of eating produced by food deprivation and for a variant of the Y1 receptor mediating this peptide's effect. Peptides. 13:1992;581-587.
32. Suda T., Tozawa F., Iwai I., Sato Y., Sumitomo T., Nakano Y., Yamada M., Demura H. Neuropeptide Y increases the corticotropin-releasing factor messenger ribonucleic acid level in the rat hypothalamus. Mol. Brain Res. 18:1993;311-315.
33. Tomaszuk A., Simpson C., Williams G. Neuropeptide Y, the hypothalamus and the regulation of energy homeostasis. Horm. Res. 46:1996;53-58.
34. Wahlestedt C., Skagerberg G., Ekman R., Heilig M., Sundler F., Hakanson R. Neuropeptide Y (NPY) in the area of the hypothalamic paraventricular nucleus activates the pituitary-adrenocortical axis in the rat. Brain Res. 417:1987;33-38.
35. 5 NPY receptors Brain Res. 778:1997;242-250.