Resistance to UV-Induced Apoptosis in Human Keratinocytes during Accelerated Senescence Is Associated with Functional Inactivation of p53

Journal of Cellular Physiology

Volumn 198, Issue 1, 2004, Pages 100-109

  Chaturvedi, V ^a   Qin, J Z ^a   Stennett, L ^a   Choubey, D ^a   Nickoloff, B J ^a,b  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^b LOYOLA UNIVERSITY HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; LYSINE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN P53; TRICHOSTATIN A;

ACETYLATION; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DEACETYLATION; FIBROBLAST; GROWTH DISORDER; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MODIFICATION; RADIOSENSITIVITY; SENESCENCE; ULTRAVIOLET RADIATION;

ACETYLATION; APOPTOSIS; CELL AGING; CELL DIVISION; CELLS, CULTURED; EPIDERMIS; FIBROBLASTS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; INTERFERON TYPE II; KERATINOCYTES; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

EID: 1642555946     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.10392     Document Type: Article

References (54)

1. Appella E, Anderson CW. 2001. Post-translational modifications and activation of p53 by genotoxic stresses. Eur J Biochem 268:2764-2772.
2. Atadja P, Wong H, Garkavstev I, Veillette C, Riabowol K. 1995. Increased activity of p53 in senescing fibroblasts. Proc Natl Acad Sci USA 92:8348-8352.
3. Brash DE. 1996. Cellular proofreading. Nat Med 2:525.
4. Brash DE, Ziegler A, Jonason AS, Simon JA, Kunala S, Leffell DJ. 1996. Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion. J Invest Dermatol Symp Proc 1:136-142.
5. Brezden CB, Rauth AM. 1996. Differential cell death in immortalized and non-immortalized cells at confluency. Oncogene 12:201-206.
6. Brooks CL, Gu W. 2003. Ubiquitination, phosphorylation, and acetylation: The molecular basis for p53 regulation. Curr Opin Cell Biol 15:164-171.
7. Burren R, Scaletta C, Frenk E, Panizzon RG, Applegate LA. 1998. Sunlight and carcinogenesis: Exposure of p53 and pyridine dimers in human skin following UVA I, UVA I + II, and solar stimulating radiation. Intl J Cancer 76:201-206.
8. Campisi J. 2000. Cancer, aging, and cellular senescence. In Vivo 14:183-188.
9. Campisi J. 2001. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol 11:S27-S31.
10. Chao C, Saito S, Kang J, Anderson CW, Appella E, Xu Y. 2000. p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage. EMBO J 19:4967-4975.
11. Chaturvedi V, Qin J-Z, Denning MF, Choubey D, Nickoloff BJ. 1999. Apoptosis in proliferating, senescent, and immortalized keratinocytes. J Biol Chem 274:23358-23367.
12. Chernov MV, Bean LJ, Lerner N, Stark GR. 2001. Regulation of ubiquitination and degradation of p53 in unstressed cells through c-terminal phosphorylation. J Biol Chem 276:31819-31824.
13. Cleaver JE. 1968. Defective repair replication of DNA in xeroderma pigmentosum. Nature 218:652-656.
14. Ferbeyre G, de Stanchina E, Querido E, Baptiste N, Prives C, Lowe SW. 2000. Pml is induced by oncogenic ras and promotes premature senescence. Genes Dev 14:2015-2027.
15. Ferbeyre G, de Stanchina E, Lin AW, Querido E, McCurrach ME, Hannon GJ, Lowe SW. 2002. Oncogenic ras and p53 cooperate to induce cellular senescence. Mol Cell Biol 22:3497-3508.
16. Gniadecki R, Hansen M, Wulf HC. 1997. Two pathways for identification of apoptosis by ultraviolet radiation in cultured human keratinocytes. J Invest Dermatol 109:163-169.
17. Gu W, Roeder RG. 1997. Activation of p53 sequence-specific DNA binding by acetylation of the p53 c-terminal domain. Cell 90:595-606.
18. Hall PA, McKee PH, Menage HP, Dover R, Lane DP. 1993. High levels of p53 protein in UV-irradiated normal human skin. Oncogene 8:203-207.
19. Harvat BL, Jetten AM. 2001. Decreased growth inhibitory responses of squamous carcinoma cells to interferon-gamma involve failure to recruit cki proteins into cdk2 complexes. J Invest Dermatol 117:1274-1281.
20. Hudson JD, Shoaibi MA, Maestro R, Carnero A, Hannon GJ, Beach DH. 1999. A proinflammatory cytokine inhibits p53 tumor suppressor activity. J Exp Med 190:1375-1382.
21. Jonason AS, Kunala S, Price GJ, Restifo RJ, Spinelli HM, Persing JA, Leffell DJ, Tarone RE, Brash DE. 1996. Frequent clones of p53-mutated keratinocytes in normal human skin. Proc Natl Acad Sci USA 93:14025-14029.
22. Kraemer KH. 1997. Sunlight and skin cancer: Another link revealed. Proc Natl Acad Sci USA 94:11-14.
23. Kubilus J, Christopher C, Pat N, Holly S, Klausner M. 1996. Response of the epiderm skin model to topically applied irritants and allergens. In Vitro Toxicol 9:157-166.
24. Lane DP. 1992. Cancer. p53, guardian of the genome. Nature 358:15-16.
25. Levine AJ. 1997. p53, the cellular gatekeeper for growth and division. Cell 88:323-331.
26. Li G, Mitchell DL, Ho VC, Reed JC, Tron VA. 1996. Decreased DNA repair but normal apoptosis in ultraviolet irradiated skin of p53 transgenic mice. Am J Pathol 148:1113-1123.
27. Li G, Tron VA, Ho VC. 1998. Induction of squamous cell carcinoma in p53-deficient mice after ultraviolet irradiation. J Invest Dermatol 110:72-75.
28. Liu L, Scolnick DM, Trievel RC, Zhang HB, Marmorstein R, Halazonetis TD, Berger SL. 1999. p53 sites acetylated in vitro by pcaf and p300 are acetylated in vivo in response to DNA damage. Mol Cell Biol 19:1202-1209.
29. Liu Y, Colosimo AL, Yang XJ, Liao D. 2000. Adenovirus elb 55-kilodalton oncoprotein inhibits p53 acetylation by pcaf. Mol Cell Biol 20:5540-5553.
30. Lotem J, Sachs L. 1999. Cytokines as suppressors of apoptosis. Apoptosis 4:187-196.
31. Meek DW. 1998. Multisite phosphorylation and the integration of stress signals at p53. Cell Signal 10:159-166.
32. Miller DL, Weinstock MA. 1994. Nonmelanoma skin cancer in the United States: Incidence. J Am Acad Dermatol 30:774-778.
33. Nakazawa H, English D, Randell PL, Nakazawa K, Martel N, Armstrong BK, Yamasaki H. 1994. UV and skin cancer: Specific p53 gene mutation in normal skin as a biologically relevant exposure measurement. Proc Natl Acad Sci USA 91:360-364.
34. Norris DA. 1995. Differential control of cell death in the skin. Arch Dermatol 131:945-948.
35. Pena JC, Rudin CM, Thompson CB. 1998. A bcl-xl transgene promotes malignant conversion of chemically initiated skin papillomas. Cancer Res 58:2111-2116.
36. Ponten F, Lindman H, Bostrom A, Berne B, Bergh J. 2001. Induction of p53 expression in skin by radiotherapy and UV radiation: A randomized study. J Natl Cancer Inst 93:128-133.
37. Prives C, Manley JL. 2001. Why is p53 acetylated? Cell 107:815-818.
38. Qin JZ, Chaturvedi V, Denning MF, Choubey D, Diaz MO, Nickoloff BJ. 1999. Role of NF-kB in the apoptotic resistant phenotype of keratinocytes. J Biol Chem 274:37957-37964.
39. Qin JZ, Chaturvedi V, Denning MF, Bacon P, Panella J, Choubey D, Nickoloff BJ. 2002. Regulation of apoptosis by p53 in UV-irradiated human epidermis, psoriatic plaques, and senescent keratinocytes. Oncogene 21:2991-3002.
40. Rees JL. 1995. p53 and the origins of skin cancer. J Invest Dermatol 107:883-884.
41. Rodriguez-Villanueva J, Greenhalgh D, Wang XJ, Bundman D, Cho S, Delehedde M, Roop D, McDonnell TJ. 1998. Human keratin-1. Bcl-2 transgenic mice aberrantly express keratin 6, exhibit reduced sensitivity to keratinocyte cell death induction, and are susceptible to skin tumor formation. Oncogene 16:853-863.
42. Sakaguchi K, Herrera JE, Saito S, Miki T, Bustin M, Vassilev A, Anderson CW, Appella E. 1998. DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev 12:2831-2841.
43. Seluanov A, Gorbunova V, Falcovitz A, Sigal A, Milyavsky M, Zurer I, Shohat G, Goldfinger N, Rotter V. 2001. Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53. Mol Cell Biol 21:1552-1564.
44. Sharpless AE, DePinho RA. 2002. p53: Good cop/bad cop. Cell 110:9-12.
45. Teraki Y, Shiohara T. 1999. Apoptosis and the skin. Eur J Dermatol 9:413-425.
46. Tyner SD, Venkatachalam S, Choi J, Jones S, Ghebranious N, Igelmann H, Lu X, Soron G, Cooper B, Brayton C, Hee Park S, Thompson T, Karsenty G, Bradley A, Donehower LA. 2002. p53 mutant mice that display early ageing-associated phenotypes. Nature 415:45-53.
47. Vousden KH. 2000. p53: Death star. Cell 103:691-694.
48. Vousden KH, Woude GF. 2000. The ins and outs of p53. Nat Cell Biol 2:E178-E180.
49. Webley K, Bond JA, Jones CJ, Blaydes JP, Craig A, Hupp T, Wynford-Thomas D. 2000. Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage. Mol Cell Biol 20:2803-2808.
50. Wehrli P, Viard I, Bullani R, Tschopp J, French LE. 2000. Death receptors in cutaneous biology and disease. J Invest Dermatol 115:141-148.
51. Wolf P, Cox P, Yarosh DB, Kripke ML. 1995. Sunscreens and t4n5 liposomes differ in their ability to protect against ultraviolet-induced sunburn cell formation, alterations of dendritic epidermal cells, and local suppression of contact hypersensitivity. J Invest Dermatol 104:287-292.
52. Yin Y, Luciani MG, Fahraeus R. 2002. p53 stability and activity is regulated by mdm2-mediated induction of alternative p53 translation products. Nat Cell Biol 4:462-467.
53. Zhu J, Zhang S, Jiang J, Chen X. 2000. Definition of the p53 functional domains necessary for inducing apoptosis. J Biol Chem 275:39927-39934.
54. Ziegler A, Jonason AS, Leffell DJ, Simon JA, Sharma HW, Kimmelman J, Remington L, Jacks T, Brash DE. 1994. Sunburn and p53 in the onset of skin cancer. Nature 372:773-776.