CDK4 expression and activity are required for cytokine responsiveness in T cells

Journal of Immunology

Volumn 165, Issue 12, 2000, Pages 6693-6702

  Modiano, J F ^a   Mayor, J ^a   Ball, C ^a   Fuentes, M K ^a   Linthicum, D S ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 4; CYTOKINE; HERBIMYCIN A; INTERLEUKIN 2; PROTEIN P16; PROTEIN P21; STAUROSPORINE;

ARTICLE; CELL CYCLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 0034672003     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.12.6693     Document Type: Article

References (60)

1. Positive versus negative signaling by lymphocyte antigen receptors
2. Regulation of synthesis and activity of the PLSTIRE-protein (cylin-dependent kinase 6 (cdk6)) a major cyclin D-associated cdk4 homologue in normal human T lymphocytes
3. Differential requirements for interleukin-2 distinguish the expression and activity of the cyclin-dependent kinases Cdk4 and Cdk2 in human T cells
4. Sustained activation of the raf-MEK-ERK pathway elicits cytokine unresponsiveness in T cells
5. The retinoblastoma protein and cell cycle control
6. RB protein as a cellular 'corral' for growth-promoting proteins
7. Modulation of retinoblastoma protein activity during the cell cycle
8. 1/S cyclin-dependent kinases
9. Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation
10. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes
11. Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes
12. Protein kinase C regulates both production and secretion of interleukin 2
13. Quantitative and qualitative signals determine T-cell cycle entry and progression
14. Post-transcriptional regulation of T cell IL-2 production by human pooled immunoglobulin
15. Distinct roles for cyclin-dependent kinases in cell cycle control
16. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
17. p21 is a universal inhibitor of cyclin kinases
18. Symmetry of the activation of cyclin-dependent kinases in mitogen and growth factor-stimulated T lymphocytes
19. Differential regulation of the synthesis and activity of the major cyclin-dependent kinases, p34cdc2, p33cdk2, and p34cdk4, during cell cycle entry and progression in normal human T lymphocytes
20. Cyclin dependent kinase regulation
21. 0 T cells
22. Modulation of the p27(Kip1) cyclin-dependent kinase inhibitor expression during IL-4-mediated human B cell activation
23. Signal transduction by interleukin 2 in human T cells activation of tyrosine and ribosomal S6 kinases and cell-cycle regulatory genes
24. 1 phase of the cell cycle in response to antigen receptor signaling
25. Regulation of the catalytic subunit (p34PSK-J3/cdk4) for the major D-type cyclin in mature B lymphocytes
26. Growth factor regulation of cyclin D1 mRNA expression through protein synthesis-dependent and -independent mechanisms
27. Regulation of androgen-dependent prostatic cancer cell growth androgen regulation of CDK2, CDK4, and CKI p16 genes
28. 1-S phase progression is accompanied by increased cyclin D1 expression and decreased cyclin-dependent kinase inhibitor association with cyclin E-Cdk2
29. 1 correlates with loss of D-cyclin/cdk4 expression and altered cell size control
30. Suppression of cyclin-dependent kinase 4 during induced differentiation of erythroleukemia cells
31. Cell cycle start from quiescence controlled by tyrosine phosphorylation of Cdk4
32. 1 arrest reduced by ionizing radiation
33. Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase
34. Inactivation of the cyclin D-dependent kinase in the rat fibroblast cell line, 3Y1, induced by contact inhibition
35. Assembly of cyclin D-dependent kinase and titration of p27(Kip1) regulated by mitogen-activated protein kinase kinase (Mek1)
36. 1 phase in rodent fibroblasts
37. 1 phase in primary human T lymphocytes
38. Calmodulin regulates the expression of cdks, cyclins and replicative enzymes during proliferative activation of human T lymphocytes
39. Inhibition of IL 2-driven proliferation of murine T lymphocyte clones by supraoptimal levels of immobilized anti-T cell receptor monoclonal antibody
40. Anti-CD3 antibody induces unresponsiveness to IL-2 in Th1 clones but not in Th2 clones
41. Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin
42. Accessory molecule and costimulation requirements for CD4 T cell response
43. Signals and signs for lymphocyte responses
44. Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones
45. Variations in Jun and Fos protein expression and AP-1 activity in cycling, resting and stimulated fibroblasts
46. Increased expression of cyclin D1 and the Rb tumor suppressor gene in c-K-ras transformed rat enterocytes
47. 1 progression in NIH 3T3 cells
48. Transforming p21(ras) mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions
49. Regulation of the cell cycle machinery by oncogenic ras
50. Cyclin-dependent kinase-2 (Cdk2) forms an inactive complex with cyclin D1 since Cdk2 associated with cyclin D1 is not phosphorylated by Cdk7-cyclin-H
51. Role of the INK4a locus in tumor suppression and cell mortality
52. Role of CDK4 and p16INK4A in interleukin-6-mediated growth of multiple myeloma
53. Loss of the cyclin-dependent kinase 4-inhibitor (p16, MTS1) gene is frequent in and highly specific to lymphoid tumors in primary human hematopoietic malignancies
54. Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia
55. Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
56. A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice
57. Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1)
58. Frequent deletion of p16INK4a/MTS1 and p15INK4b/MTS2 in pediatric acute lymphoblastic leukemia
59. Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16INK4a and p19ARF, is a candidate for the plasmacytoma susceptibility locus, Pctrl
60. + cells of older lupus mice