The Crystal Structure of Fibroblast Growth Factor (FGF) 19 Reveals Novel Features of the FGF Family and Offers a Structural Basis for Its Unusual Receptor Affinity

Biochemistry

Volumn 43, Issue 3, 2004, Pages 629-640

  Harmer, Nicholas J ^a   Pellegrini, Luca ^a   Chirgadze, Dima ^a   Fernandez Recio, Juan ^a   Blundell, Tom L ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CHEMICAL BONDS; CONFORMATIONS; CRYSTAL STRUCTURE; PROTEINS;

CELL PROLIFERATION; FIBROBLAST GROWTH FACTORS (FGF);

BIOCHEMISTRY;

FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 19; FIBROBLAST GROWTH FACTOR 4; FIBROBLAST GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 4; HEPARIN; PROTEOGLYCAN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; COMPLEX FORMATION; CRYSTAL STRUCTURE; DISULFIDE BOND; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN STRUCTURE; RECEPTOR AFFINITY;

AMINO ACID SEQUENCE; COMPUTATIONAL BIOLOGY; CRYSTALLOGRAPHY, X-RAY; FIBROBLAST GROWTH FACTORS; HEPARIN; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 4; RECEPTORS, FIBROBLAST GROWTH FACTOR; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

VERTEBRATA;

EID: 1642494893     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035320k     Document Type: Article

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