Sequence analyses and comparative modeling of fly and worm fibroblast growth factor receptors indicate that the determinants for FGF and heparin binding are retained in evolution

FEBS Letters

Volumn 501, Issue 1, 2001, Pages 51-58

  Nagendra, H G ^a   Harrington, Adrian E ^a   Harmer, Nicholas J ^a   Pellegrini, Luca ^a   Blundell, Tom L ^a   Burke, David F ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Apert syndrome; Caenorhabditis elegans; Drosophila melanogaster; Fibroblast growth factor receptor; Heparin binding

Indexed keywords

ARGININE; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 2; HEPARIN; PROLINE; LIGAND;

AMINO ACID SEQUENCE; ARTICLE; CAENORHABDITIS ELEGANS; COMPLEX FORMATION; CRYSTAL STRUCTURE; DROSOPHILA MELANOGASTER; LIGAND BINDING; MOLECULAR EVOLUTION; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN QUATERNARY STRUCTURE; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE; RECEPTOR BINDING; SEQUENCE HOMOLOGY; SPECIES COMPOSITION; WILD TYPE; ACROCEPHALOSYNDACTYLY; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; ELECTRICITY; GENETICS; HUMAN; METABOLISM; NUCLEOTIDE SEQUENCE; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ACROCEPHALOSYNDACTYLIA; ANIMALS; BINDING SITES; CAENORHABDITIS ELEGANS; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DROSOPHILA MELANOGASTER; ELECTROSTATICS; EVOLUTION, MOLECULAR; FIBROBLAST GROWTH FACTORS; HEPARIN; HUMANS; LIGANDS; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION; RECEPTORS, FIBROBLAST GROWTH FACTOR; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, PROTEIN;

EID: 0035854648     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/S0014-5793(01)02603-5     Document Type: Article

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