Conformationally constrained analogues of diacylglycerol (DAG). 15.1 The indispensable role of the sn-1 and sn-2 carbonyls in the binding of dag- lactones to protein kinase C (PK-C)

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 23, 1998, Pages 3403-3408

  Benzaria, Samira ^a   Bienfait, Bruno ^a   Nacro, Kassoum ^a   Wang, Shaomeng ^a   Lewin, Nancy E ^a   Beheshti, Maryam ^a   Blumberg, Peter M ^a   Marquez, Victor E ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONYL DERIVATIVE; DIACYLGLYCEROL DERIVATIVE; LACTONE; PROTEIN KINASE C;

ARTICLE; CELL PROLIFERATION; ENTROPY; ENZYME CONFORMATION; HYDROGEN BOND; LIGAND BINDING; MOLECULAR MODEL; PROTEIN BINDING; SECOND MESSENGER;

EID: 0032402377     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00614-3     Document Type: Article

References (17)

1. 1. Previous reference in the sequence: Marquez, V. E.; Sharma, R.; Wang, S.; Lewin, N.; Blumberg, P.M.; Kim, I-S.; Lee, J. Bioorg. Med. Chem. Lett. 1998, 8, 1757.
2. 2. Nishizuka, Y. Science 1986, 233, 305.
3. 3. Berridge, M. Annu. Rev. Biochem. 1987, 56, 159.
4. 4. Ono, Y.; Fujii, T.; Igarashi, K.; Kuno, T.; Tanaka, C.; Kikkawa, U.; Nishizuka, Y. Proc. Natl. Acad. Sci. U.S.A. 1989, 86, 4868.
5. 5. Blumberg, P. M. Cancer Res. 1988, 48, 1.
6. 6. Hug, H.; Sarre, T. F. Biochem. J. 1993, 291, 329.
7. 7. Sharma, R; Lee, J.; Wang, S.; Milne, G. W. A.; Lewin, N. E.; Blumberg, P. M.; Marquez, V. E. J. Med. Chem. 1996, 39, 19.
8. 8. Lee, J.; Wang, S.; Milne, G. W. A.; Sharma, R.; Lewin, N. E.; Blumberg, P. M; Marquez, V. E. J. Med. Chem. 1996, 39, 29.
9. 9. Lee, J.; Sharma, R.; Wang, S; Milne, G. W. A.; Lewin, N. E.; Szallasi, Z.; Blumberg, P. M.; George, C.; Marquez, V. E. J. Med. Chem. 1996, 39, 36.
10. 10. Wang, S.; Milne, G. W. A.; Nicklaus, M. C.; Marquez, V. E.; Lee, J.; Blumberg, P. M. J. Med. Chem. 1994, 37, 1326.
11. 11. Zhang, G. G.; Kazanietz, M. G.; Blumberg, P. M.; Hurley, J. H. Cell 1995, 81, 917.
12. 12. Morris, G. M.; Goodsell, D. S.; Huey, R.; Olson, A. J. J. Comput.-Aided Mol. Des. 1996, 10, 293-304. [URL of AutoDock: http://www.scripps.edu/pub/olson-web/doc/autodoc/index.html]
13. 13. Humphrey, W.; Dalke, A.; Schulten, K. J. Mol. Graphics 1996, 14.1, 33. [URL of VMD: http://www.ks.uiuc.edu/Research/vmd/].
14. 4: C, 71.70, H, 10.94. Found: C, 71.39; H, 10.77.
15. 4: C, 71.70, H, 10.94. Found: C, 71.82; H, 10.92.
16. 4: C, 71.70, H, 10.94. Found: C, 71.61; H, 10.84).
17. 17. Krauter, G.; Von der Lieth, C.-W.; Schmidt, R.; Hecker, E. Eur. J. Biochem. 1996, 242, 417.