Structure/activity relationships of polyfunctional diterpenes of the tigliane type. A pharmacophore model for protein-kinase-C activators based on structure/activity studies and molecular modeling of the tumor promoters 12-O-tetradecanoylphorbol 13-acetate and 3-O-tetradecanoylingenol

European Journal of Biochemistry

Volumn 242, Issue 2, 1996, Pages 417-427

  Krauter, Goetz ^a   Von Der Lieth, Claus W ^a   Schmidt, Rainer ^a   Hecker, Erich ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Ingenol ester; Initiation promotion; Phorbol ester; Protein kinase C; Structure activity relationship

Indexed keywords

DITERPENE; ISOENZYME; PHORBOL ESTER; PROTEIN KINASE C; TIGLIANE DERIVATIVE; TUMOR PROMOTER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPUTER ANALYSIS; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; HYDROPHOBICITY; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SKIN IRRITATION; STRUCTURE ACTIVITY RELATION; THEORY; TOPICAL DRUG ADMINISTRATION; TUMOR PROMOTION;

ANIMALIA;

EID: 0029835426     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1996.0417r.x     Document Type: Article

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