Rusty notions of cell injury

Journal of Hepatology

Volumn 40, Issue 4, 2004, Pages 696-698

  Lemasters, John J ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYTOCHROME C; FERRIC ION; FERROUS ION; IRON;

APOPTOSIS; CELL DAMAGE; CELL DEATH; CELL ULTRASTRUCTURE; CONFOCAL MICROSCOPY; EDITORIAL; ENZYME RELEASE; FLUORESCENCE ANALYSIS; HEMOCHROMATOSIS; HUMAN; INTRACELLULAR SPACE; IRON OVERLOAD; IRON TRANSPORT; LIVER CELL; LIVER INJURY; LIVER LYSOSOME; LIVER TOXICITY; MEMBRANE PERMEABILITY; MITOCHONDRION; MOLECULAR PROBE; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; CELLS, CULTURED; HEPATOCYTES; IRON; MITOCHONDRIA, LIVER; PERMEABILITY; RATS; REACTIVE OXYGEN SPECIES;

EID: 1642412428     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2004.02.015     Document Type: Editorial

References (32)

1. Rauen U., Petrat F., Sustmann R., de Groot H. Iron-induced mitochondrial permeability transition in cultured hepatocytes. J Hepatol. 40:2004;607-615.
2. Kerkweg U., Li T., de Groot H., Rauen U. Cold-induced apoptosis of rat liver cells in University of Wisconsin solution: the central role of chelatable iron. Hepatology. 35:2002;560-567.
3. Swanson C.A. Iron intake and regulation: implications for iron deficiency and iron overload. Alcohol. 30:2003;99-102.
4. Nieminen A.-L., Dawson T.L., Gores G.J., Kawanishi T., Herman B., Lemasters J.J. Protection by acidotic pH and fructose against lethal injury to rat hepatocytes from mitochondrial inhibition, ionophores and oxidant chemicals. Biochem Biophys Res Commun. 167:1990;600-606.
5. Imberti R., Nieminen A.L., Herman B., Lemasters J.J. Mitochondrial and glycolytic dysfunction in lethal injury to hepatocytes by t-butylhydroperoxide: protection by fructose, cyclosporin A and trifluoperazine. J Pharmacol Exp Ther. 265:1993;392-400.
6. Nieminen A.L., Saylor A.K., Herman B., Lemasters J.J. ATP depletion rather than mitochondrial depolarization mediates hepatocyte killing after metabolic inhibition. Am J Physiol. 267:1994;C67-C74.
7. Marsh D.C., Vreugdenhil P.K., Mack V.E., Belzer F.O., Southard J.H. Glycine protects hepatocytes from injury caused by anoxia, cold ischemia and mitochondrial inhibitors, but not injury caused by calcium ionophores or oxidative stress. Hepatology. 17:1993;91-98.
8. Lemasters J.J.V. Necrapoptosis and the mitochondrial permeability transition: shared pathways to necrosis and apoptosis. Am J Physiol. 276:1999;G1-G6.
9. Bernardi P. Mitochondrial transport of cations: channels, exchangers, and permeability transition. Physiol Rev. 79:1999;1127-1155.
10. Qian T., Herman B., Lemasters J.J. The mitochondrial permeability transition mediates both necrotic and apoptotic death of hepatocytes exposed to Br-A23187. Toxicol Appl Pharmacol. 154:1999;117-125.
11. Kim J.S., Qian T., Lemasters J.J. Mitochondrial permeability transition in the switch from necrotic to apoptotic cell death in ischemic rat hepatocytes. Gastroenterology. 124:2003;494-503.
12. Kehrer J.P. The Haber-Weiss reaction and mechanisms of toxicity. Toxicology. 149:2000;43-50.
13. Day B.J., Fridovich I., Crapo J.D. Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury. Arch Biochem Biophys. 347:1997;256-262.
14. Flatmark T., Romslo I. Energy-dependent accumulation of iron by isolated rat liver mitochondria. Requirement of reducing equivalents and evidence for a unidirectional flux of Fe(II) across the inner membrane. J Biol Chem. 250:1975;6433-6438.
15. Chen Y.Y., Ho K.P., Xia Q., Qian Z.M. Hydrogen peroxide enhances iron-induced injury in isolated heart and ventricular cardiomyocyte in rats. Mol Cell Biochem. 231:2002;61-68.
16. Petrat F., de Groot H., Rauen U. Subcellular distribution of chelatable iron: a laser scanning microscopic study in isolated hepatocytes and liver endothelial cells. Biochem J. 356:2001;61-69.
17. Petrat F., de Groot H., Sustmann R., Rauen U. The chelatable iron pool in living cells: a methodically defined quantity. Biol Chem. 383:2002;489-502.
18. Zahrebelski G., Nieminen A.L., al Ghoul K., Qian T., Herman B., Lemasters J.J. Progression of subcellular changes during chemical hypoxia to cultured rat hepatocytes: a laser scanning confocal microscopic study. Hepatology. 21:1995;1361-1372.
19. Nieminen A.L., Saylor A.K., Tesfai S.A., Herman B., Lemasters J.J. Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide. Biochem J. 307:1995;99-106.
20. She H., Xiong S., Lin M., Zandi E., Giulivi C., Tsukamoto H. Iron activates NF-kappaB in Kupffer cells. Am J Physiol Gastrointest Liver Physiol. 283:2002;G719-G726.
21. Tsukamoto H. Iron regulation of hepatic macrophage TNFalpha expression. Free Radic Biol Med. 32:2002;309-313.
22. Xiong S., She H., Takeuchi H., Han B., Engelhardt J.F., Barton C.H., et al. Signaling role of intracellular iron in NF-kappaB activation. J Biol Chem. 278:2003;17646-17654.
23. Wang G.L., Semenza G.L. Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction. Blood. 82:1993;3610-3615.
24. Wenger R.H. Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression. FASEB J. 16:2002;1151-1162.
25. Ponka P., Lok C.N. The transferrin receptor: role in health and disease. Int J Biochem Cell Biol. 31:1999;1111-1137.
26. Tabuchi M., Yoshimori T., Yamaguchi K., Yoshida T., Kishi F. Human NRAMP2/DMT1, which mediates iron transport across endosomal membranes, is localized to late endosomes and lysosomes in HEp-2 cells. J Biol Chem. 275:2000;22220-22228.
27. Wildenthal K., Decker R.S. The role of lysosomes in the heart. Adv Myocardiol. 2:1980;349-358.
28. Ollinger K., Brunk U.T. Cellular injury induced by oxidative stress is mediated through lysosomal damage. Free Radic Biol Med. 19:1995;565-574.
29. Brunk U.T., Neuzil J., Eaton J.W. Lysosomal involvement in apoptosis. Redox Rep. 6:2001;91-97.
30. Persson H.L., Yu Z., Tirosh O., Eaton J.W., Brunk U.T. Prevention of oxidant-induced cell death by lysosomotropic iron chelators. Free Radic Biol Med. 34:2003;1295-1305.
31. Yu Z., Persson H.L., Eaton J.W., Brunk U.T. Intralysosomal iron: a major determinant of oxidant-induced cell death. Free Radic Biol Med. 34:2003;1243-1252.
32. Lichtman S.N., Wang J., Lemasters J.J. Lipopolysaccharide-stimulated TNF-alpha release from cultured rat Kupffer cells: sequence of intracellular signaling pathways. J Leukoc Biol. 64:1998;368-372.