Iron regulation of hepatic macrophage TNFα expression

Free Radical Biology and Medicine

Volumn 32, Issue 4, 2002, Pages 309-313

  Tsukamoto, Hidekazu ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

Author keywords

Alcoholic liver disease; Free radicals; Iron chelator; Kupffer cells; NF B; Redox regulation

Indexed keywords

DEFERIPRONE; FREE RADICAL; HEME DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IRON; IRON CHELATE; LIPOPOLYSACCHARIDE; OXYGENASE; TUMOR NECROSIS FACTOR ALPHA;

ALCOHOL LIVER DISEASE; CELL ACTIVATION; CELL CULTURE; CHRONIC LIVER DISEASE; CYTOKINE PRODUCTION; DISEASE MODEL; ELECTRON SPIN RESONANCE; ERYTHROPHAGOCYTOSIS; IRON METABOLISM; IRON STORAGE; LIPOPHILICITY; LIVER; MACROPHAGE; MOLECULAR WEIGHT; NONHUMAN; OXIDATION REDUCTION REACTION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; ANIMAL; BIOLOGICAL MODEL; HUMAN; LIVER DISEASE; METABOLISM;

ANIMALIA;

ANIMALS; ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICALS; HUMANS; IRON; LIVER; LIVER DISEASES; MACROPHAGES; MODELS, BIOLOGICAL; NF-KAPPA B; OXIDATION-REDUCTION; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037082349     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00772-9     Document Type: Article

References (51)

1. Increased tumor necrosis factor production by monocytes in alcoholic hepatitis
2. Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5′-regulatory region. Induction by cytokines and phorbol ester
3. Role of endotoxin in the hepatic microvascular inflammatory response to ethanol
4. Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity
5. Cytokine regulation of hepatic stellate cells in liver fibrosis
6. Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice
7. ICAM-1 is involved in the mechanism of alcohol-induced liver injury: Studies with knockout mice
8. Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat
9. Interleukin-10
10. Interleukin-10 controls neutrophilic infiltration, hepatocyte proliferation, and liver fibrosis induced by carbon tetrachloride in mice
11. Hepatoprotective role of interleukin 10 in galactosamine/lipopolysaccharide mouse liver injury
12. Interleukin 10 promoter region polymorphisms and susceptibility to advanced alcoholic liver disease
13. Iron in infection, immunity, inflammation and neoplasia
14. Decreased concentrations of tumor necrosis factor-alpha in supernatants of monocytes from homozygotes for hereditary hemochromatosis
15. Functional defects in phagocytic cells from patients with iron overload
16. Impaired phagocytic activity of neutrophils in patients receiving haemodialysis: The critical role of iron overload
17. Iron overload alters innate and T helper cell responses to Candida albicans in mice
18. Depression of macrophage respiratory burst capacity and arachidonic acid release after Fc receptor-mediated phagocytosis
19. Macrophage dysfunction following the phagocytosis of IgG-coated erythrocytes: Production of lipid peroxidation products
20. Effect of Kupffer cell phagocytosis of erythrocytes and erythrocyte ghosts on susceptibility to endotoxemia and bacteremia
21. Iron metabolism in the erythrophagocytosing Kupffer cell
22. Iron augments macrophage-mediated killing of Brucella abortus alone and in conjunction with interferon-gamma
23. The role of iron in the cytotoxicity of tumor necrosis factor
24. Iron induces lipid peroxidation in cultured macrophages, increases their ability to oxidatively modify LDL, and affects their secretory properties
25. Reactive oxygen species facilitate the in vitro and in vivo lipopolysaccharide-induced release of tumor necrosis factor
26. The role of alcoholism in hepatic iron storage disease
27. The oral iron chelator, 1,2-dimethyl-3-hydroxypyrid-4-one reduces hepatic-free iron, lipid peroxidation and fat accumulation in chronically ethanol-fed rats
28. Role of iron in NF-kappa B activation and cytokine gene expression by rat hepatic macrophages
29. Experimental liver cirrhosis induced by alcohol and iron
30. Role of inflammation in liver fibrogenesis
31. Alcohol mediates increases in hepatic and serum nonheme iron stores in a rat model for alcohol-induced liver injury
32. Iron primes hepatic macrophages for NF-kappaB activation in alcoholic liver injury
33. Iron in human atheroma and LDL oxidation by macrophages following erythrophagocytosis
34. Erythrocyte insufflation-induced protection against oxygen toxicity: Role of cytokines
35. Iron dependent NF-kB activation by hepatic macrophages
36. EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages
37. IFN-gamma-activated macrophages: Detection by electron paramagnetic resonance of complexes between L-arginine-derived nitric oxide and non-heme iron proteins
38. Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible
39. Biosynthesis of nitric oxide activates iron regulatory factor in macrophages
40. Iron depletion: Possible cause of tumor cell cytotoxicity induced by activated macrophages
41. Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells
42. Co-stimulatory effect of nitric oxide on endothelial NF-kappaB implies a physiological self-amplifying mechanism
43. Nitric oxide attenuates vascular smooth muscle cell activation by interferon-gamma. The role of constitutive NF-kappa B activity
44. Role of hydroxyl radical in silica-induced NF-kappa B activation in macrophages
45. The role of hydroxyl radical as a messenger in the activation of nuclear transcription factor NF-kappaB
46. On the role of hydroxyl radical and the effect of tetrandrine on nuclear factor-kappaB activation by phorbol 12-myristate 13-acetate
47. Cooperativity between oxidants and tumor necrosis factor in the activation of nuclear factor (NF)-kappaB: Requirement of Ras/mitogen- activated protein kinases in the activation of NF-kappaB by oxidants
48. Molecular mechanisms and therapeutic strategies related to nitric oxide
49. Pathways for the regulation of macrophage iron metabolism by the anti- inflammatory cytokines IL-4 and IL-13
50. Induction of ferritin synthesis by oxidative stress. Transcriptional and post-transcriptional regulation by expansion of the "free" iron pool
51. Induction of ferritin synthesis in ischemic-reperfused rat liver: Analysis of the molecular mechanisms