Activation-threshold tuning in an affinity modal for the T-cell repertoire

Proceedings of the Royal Society B: Biological Sciences

Volumn 271, Issue 1539, 2004, Pages 609-616

  Scherer, Almut ^a,b   Noest, André ^a   De Boer, Rob J ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b ETH ZURICH   (Switzerland)

Author keywords

Activation threshold tuning; Computer simulation models; Mathematical models; T cell repertoire; Tolerance induction

Indexed keywords

ANTIGEN; PEPTIDE;

CYTOLOGY; PEPTIDE;

ARTICLE; CELLULAR IMMUNITY; COMPUTER MODEL; COMPUTER SIMULATION; CROSS REACTION; IMMUNOLOGICAL TOLERANCE; IMMUNOREACTIVITY; LYMPHOCYTE CLONE; MATHEMATICAL MODEL; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; THYMUS;

EID: 1642407596     PISSN: 09628452     EISSN: 14712970     Source Type: Journal    
DOI: 10.1098/rspb.2003.2653     Document Type: Article

References (47)

1. Anderton, S. M. & Wraith, D. C. 2002 Selection and fine-tuning of the autoimmune T-cell repertoire. Nature Rev. Immunol. 2, 487-498.
2. Anderton, S. M., Radu, C. G., Lowrey, P. A., Ward, E. S. & Wraith, D. C. 2001 Negative selection during the peripheral immune response to antigen. J. Exp. Med. 193, 1-11.
3. Arstila, T. P., Casrouge, A., Baron, V., Even, J., Kanellopoulos, J. & Kourilsky, P. 2000 Diversity of human αβ T cell receptors. Science 288, 1135.
4. Ashton-Rickardt, P. G. & Tonegawa, S. 1994 A differentialavidity model for T-cell selection. Immunol. Today 15, 362-366.
5. Blattman, J. N., Antia, R., Sourdive, D. J., Wang, X., Kaech, S. M., Murali-Krishna, K., Altman, J. D. & Ahmed, R. 2002 Estimating the precursor frequency of naive antigen-specific CD8 T cells. J. Exp. Med. 195, 657-664.
6. Borghans, J. A. & De Boer, R. J. 2002 Memorizing innate instructions requires a sufficiently specific adaptive immune system. Int. Immunol. 14, 525-532.
7. Borghans, J. A., Noest, A. J. & De Boer, R. J. 1999 How specific should immunological memory be? J. Immunol. 163, 569-575.
8. Borrow, P. (and 10 others) 1997 Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus. Nature Med. 3, 205-211.
9. Bouneaud, C., Kourilsky, P. & Bousso, P. 2000 Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion. Immunity 13, 829-840.
10. Busch, D. H. & Pamer, E. G. 1999 T cell affinity maturation be selective expansion during infection. J. Exp. Med. 189, 701-710.
11. Busch, D. H., Fillip, I. & Pamer, E. G. 1998 Evolution of a complex T cell receptor repertoire during primary and recall bacterial infection. J. Exp. Med. 188, 61-70.
12. Chidgey, A. & Boyd, R. 1997 Agonist peptide modulates T cell selection thresholds through qualitative and quantitative shifts in CD8 co-receptor expression. Int. Immunol. 9, 1527-1536.
13. Chidgey, A. P. & Boyd, R. L. 1998 Positive selection of low responsive, potentially autoreactive T cells induced by high avidity, non-deleting interactions. Int. Immunol. 10, 999-1008.
14. Davey, G. M., Schober, S. L., Endrizzi, B. T., Dutcher, A. K., Jameson, S. C. & Hogquist, K. A. 1998 Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells. J. Exp. Med. 188, 1867-1874.
15. De Boer, R. J. & Perelson, A. S. 1991 Size and connectivity as emergent properties of a developing immune network. J. Theor. Biol. 149, 381-424.
16. De Boer, R. J. & Perelson, A. S. 1993 How diverse should the immune system be? Proc. R. Soc. Lond. B 252, 171-175.
17. Detours, V. & Perelson, A. S. 1999 Explaining high alloreactivity as a quantitative consequence of affinity-driven thymocyte selection. Proc. Natl Acad. Sci USA 96, 5153-5158.
18. Detours, V. & Perelson, A. S. 2000 The paradox of alloreactivity and self MHC restriction: quantitative analysis and statistics. Proc. Natl Acad. Sci. USA 97, 8479-8483.
19. Detours, V., Sulzer, B. & Perelson, A. S. 1996 Size and connectivity of the idiotypic network are independent of the discreteness of the affinity distribution. J. Theor. Biol. 183, 409-416.
20. Detours, V., Mehr, R. & Perelson, A. S. 1999 A quantitative theory of affinity-driven T cell repertoire selection. J. Theor. Biol. 200, 389-403.
21. Detours, V., Mehr, R. & Perelson, A. S. 2000 Deriving quantitative constrains on T cell selection from data on the mature T cell repertoire. J. Immunol. 164, 121-128.
22. Douek, D. C., Betts, M. R., Brenchley, J. M., Hill, B. J., Ambrozak, D. R., Nagai, K. L., Karandikar, N. J., Casazza, J. P. & Koup, R. A. 2002 A novel approach to the analysis of specificity, clonality, and frequency of HIV-specific T cell responses reveals a potential mechanism for control of viral escape. J. Immunol. 168, 3099-3104.
23. Dubois, P. M., Pihlgren, M., Tomkowiak, M., Van Mechelen, M. & Marvel, J. 1998 Tolerant CD8 T cells induced by multiple injections of peptide antigen show impaired TCR signaling and altered proliferative responses in vitro and in vivo. J. Immunol. 161, 5260-5267.
24. Du Pasquier, L., Robert, J., Courtet, M. & Mussmann, R. 2003 B-cell development in the amphibian Xenopus. Immunol. Rev. 175, 2021-2213.
25. Ernst, B., Lee, D. S., Chang, J. M., Sprent, J. & Surh, C. D. 1999 The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery. Immunity 11, 173-181.
26. +) T cell response in vivo. J. Exp. Med. 192, 1719-1730.
27. Grossman, Z. & Paul, W. E. 1992 Adaptive cellular interactions in the immune system: the tunable activation threshold and the significance of subthreshold responses. Proc. Natl Acad. Sci. USA 89, 10365-10369.
28. Grossman, A. & Paul, W. E. 2000 Self-tolerance: context dependent tuning of T cell antigen recognition. Semin. Immunol. 12, 197-203.
29. Grossman, Z. & Singer, A. 1996 Tuning of activation thresholds explains flexibility in the selection and development of T cells in the thymus. Proc. Natl Acad. Sci. USA 93, 14 747-14 752.
30. Hunt, D. F., Henderson, R. A., Shabanowitz, J., Sakaguchi, K., Michel, H., Sevilir, N., Cox, A. L., Appella, E. & Engelhard, V. H. 1992 Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry. Science 255, 1261-1263.
31. Huseby, E. S., Crawford, F., White, J., Kappler, J. & Marrack, P. 2003 Negative selection imparts peptide specificity to the mature T cell repertoire. Proc. Natl Acad. Sci. USA 100, 11 565-11 570.
32. Kedl, R. M., Schaefer, B. C., Kappler, J. W. & Marrack, P. 2002 T cells down-modulate peptide-MHC complexes on APCs in vivo. Nature Immunol. 3, 27-32.
33. Kesmir, C., Borghans, J. A. M. & De Boer, R. J. 2000 Diversity of human αβ T cell receptors. Science 288, 1135a.
34. Langman, R. E. & Cohn, M. 1987 The E-T (elephant-tadpole) paradox necessitates the concept of a unit of B-cell function: the protection. Mol. Immunol. 24, 675-697.
35. Lapedes, A. & Farber, R. 2001 The geometry of shape space: application to influenza. J. Theor. Biol. 212, 57-69.
36. Lucas, B., Stefanova, I., Yasutomo, K., Dautigny, N. & Germain, R. N. 1999 Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlines formation of a useful T cell repertoire. Immunity 10, 367-376.
37. Nicholson, L. B., Anderson, A. C. & Kuchroo, V. K. 2000 Tuning T cell activation threshold and effector function with cross-reactive peptide ligands. Int. Immunol. 12, 205-213.
38. Noest, A. J. 2000 Designing lymphocyte functional structure for optimal signal detection: voila, T cells. J. Theor. Biol. 207, 195-216.
39. Perelson, A. S. & Oster, G. F. 1979 Theoretical studies of clonal selection: minimal antibody repertoire size and reliability of self-non-self discrimination. J. Theor. Biol. 81, 645-670.
40. Segel, L. A. & Perelson, A. S. 1987 Computations in shape space..... In Theoretical Immunology Workshop Santa Fé, SFI studies in the sciences of complexity (ed. A. S. Perelson), pp. 321-336. Reading, MA: Addison-Wesley.
41. +) T cells without selection of higher affinity TCR. Nature Immunol. 2, 711-717.
42. Smith, D. J., Forrest, S., Hightower, R. R. & Perelson, A. S. 1997 Deriving shape space parameters from immunological data. J. Theor. Biol. 189, 141-150.
43. Smith, D. J., Forrest, S., Ackley, D. H. & Perelson, A. S. 1999 Variable efficacy of repeated annual influenza vaccination. Proc. Natl Acad. Sci. USA 96, 14 001-14 006.
44. Smith, K., Seddon, B., Purbhoo, M. A., Zamoyska, R., Fisher, A. G. & Merkenschlager, M. 2001 Sensory adaptation in naïve peripheral CD4 T cells. J. Exp. Med. 194, 1253-1261.
45. Van Den Berg, H. A., Rand, D. A. & Burroughs, N. J. 2001 A reliable and safe T cell repertoire based on low-affinity T cell receptors. J. Theor. Biol. 209, 465-486.
46. Van Meerwijk, J. P., Marguerat, S., Lees, R. K., Germain, R. N., Fowlkes, B. J. & MacDonald, H. R. 1997 Quantitative impact of thymic clonal deletion on the T cell repertoire. J. Exp. Med. 185, 377-383.
47. Wong, P., Barton, G. M., Forbush, K. A. & Rudensky, A. Y. 2001 Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands. J. Exp. Med. 193, 1179-1187.