Positive selection of low responsive, potentially autoreactive T cells induced by high avidity, non-deleting interactions

International Immunology

Volumn 10, Issue 7, 1998, Pages 999-1008

  Chidgey, Ann P ^a   Boyd, Richard L ^a  

^a MONASH UNIVERSITY MEDICAL SCHOOL   (Australia)

Author keywords

Agonist peptide; Antagonist peptide; CD8 ; Peptide variants; Positive selection

Indexed keywords

CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CELL SELECTION; CELL SUSPENSION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ACETYLTRANSFERASES; ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; COCULTURE TECHNIQUES; DIMERIZATION; DOWN-REGULATION; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PHENOTYPE; PROTEINS; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0031812259     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/10.7.999     Document Type: Article

References (40)

1. Pawlowski, T. J., Singleton, M. D., Loh, D. Y., Berg, R. and Staerz, U. D. 1996. Permissive recognition during positive selection. Eur. J. Immunol. 26:851.
2. Hogquist, K. A., Tomlinson, A. J., Kieper, W. C., McGargill, M. A., Hart, M. C., Naylor, S. and Jameson, S. C. 1997. Identification of a naturally occurring ligand for thymic positive selection. Immunity 6:389.
3. Evavold, B. D., Sloan-Lancaster, J., Wilson, K. J., Rothbard, J. B. and Allen, P. M. 1995. Specific T cell recognition of minimally homologous peptides: evidence for multiple endogenous ligands. Immunity 2:655.
4. Tallquist, M. D., Yun, T. J. and Pease, L. R. 1996. A single T cell receptor recognizes structurally distinct MHC/peptide complexes with high specificity. J. Exp. Med. 184:1017.
5. Chidgey, A. P. and Boyd, R. L. 1997. Agonist peptide modulates T cell selection thresholds through qualitative and quantitative shifts in CD8 co-receptor expression. Int. Immunol. 9:1527.
6. Kersh, G. J. and Allen, P. M. 1996. Essential flexibility in the T-cell recognition of antigen. Nature 222:495.
7. Evavold, B. D., Sloan-Lancaster, J. and Allen, P. 1993. Tickling the TCR: selective T cell functions stimulated by altered peptide ligands. Immunol. Today 14:602.
8. Sloan-Lancaster, J. and Allen, P. M. 1996. Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology. Annu. Rev. Immunol. 14:1.
9. Sloan-Lancaster, J., Steinberg, T. H. and Allen, P. M. 1996. Selective activation of the calcium signalling pathway by altered peptide ligands. J. Exp. Med. 184:1525.
10. La Face, D. M., Couture, C., Anderson, K., Shih, G., Alexander, J., Sette, A., Mustelin, T., Altman, A. and Grey, H. M. 1997. Differential T cell signaling induced by antagonist peptide-MHC complexes and the associated phenotypic responses. J. Immunol. 158:2057.
11. Lyons, D. S., Lieberman, S. A., Hampl, J., Boniface, J. J., Chien, Y., Berg, L. J. and Davis, M. M. 1996. A TCR binds to antagonist ligands with lower affinities and faster dissociation rates that to agonists. Immunity 5:53.
12. Alam, S. M., Travers, P. J., Wung, J. L., Nasholds, W., Redpath, S., Jameson, S. C. and Gascoigne, N. R. J. 1996. T-cell receptor affinity and thymocyte positive selection. Nature 381:616.
13. Hogquist, K. A., Jameson, S. C., Heath, W. R., Howard, J. L., Bevan, M. J. and Carbone, F. R. 1994. T cell receptor antagonist peptides induce positive selection. Cell 76:17.
14. + thymocytes by T-cell receptor peptide antagonists. Proc. Natl Acad. Sci. USA 91:4057.
15. Spain, L. M., Jorgensen, J. L., Davis, M. M. and Berg, L. J. 1994. A peptide antigen antagonist prevents the differentiation of T cell receptor transgenic thymocytes. J. Immunol. 152:1709.
16. Williams, O., Tanaka, Y., Bix, M., Murdjeva, M., Littman, D. R. and Kioussis. D. 1996. Inhibition of thymocyte negative selection by T cell receptor antagonist peptides. Eur. J. Immunol. 26:532.
17. + T lymphocytes. Eur. J. Immunol. 23:2834.
18. -/- mice. J. Immunol. 155:3727.
19. Goldrath, A. W., Hogquist, K. A. and Bevan, M. J. 1997. CD8 lineage commitment in the absence of CD8. Immunity 6:633
20. Sebzda, E., Choi, M., Fung-Leung, W. P., Mak, T. W. and Ohashi, P. S. 1997. Peptide-induced positive selection of TCR transgenic thymocytes in a co-receptor-independent manner. Immunity 6:643.
21. Crooks, M. E. C. and Littman, D. R. 1994. Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 β chain. Immunity 1:277.
22. Fung Leung, W. P., Wallace, V. A., Gray, D., Sha, W. C., Pircher, H., Teh, H. S., Loh, D. Y. and Mak, T. W. 1993. CD8 is needed for positive selection but differentially required for negative selection of T cells during thymic ontogeny. Eur. J. Immunol. 23:212.
23. Itano, A., Cado, D., Chan, F. K. M. and Robey, E. 1994. A role for the cytoplasmic tail of the β chain of CD8 in thymic selection. Immunity. 1:287.
24. + T cells in CD8 beta gene-targeted mice. J. Exp. Med. 180:959.
25. Renard, V., Romero, P., Vivier, E., Malissen, B. and Luescher, I. F. 1996. CD8b increases CD8 co-receptor function and participation in TCR-ligand binding. J. Exp. Med. 184:2439
26. Garcia, K. C., Scott, C. A., Brunmark, A., Carbone, F. R., Peterson, P. A., Wilson, I. A. and Teyton, L. 1996. CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes. Nature 384:577.
27. Luescher, I. F., Vivier, E., Layer, A., Mahiou, J., Godeau, F., Malissen, B. and Romero, P. 1995. CD8 modulation of T-cell antigen receptor-ligand interactions on living cytotoxic T lymphocytes. Nature 373:353.
28. Pircher, H., Burki, K., Lang, R., Hengartner, H. and Zinkernagel. R. M. 1989. Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature 342:559.
29. Sebzda, E., Kundig, T. M., Thomson, C. T., Aoki, K., Mak, S.-Y., Mayer, J. P., Zamborelli, T., Nathenson, S. G. and Ohashi, P. S. 1996. Mature T cell reactivity altered by peptide agonist that induces positive selection. J. Exp. Med. 183:1093.
30. Bachmann, M. F., Oxenius, A., Speiser, D. E., Mariathasan, S., Hengartner, H., Zinkernagel, R. and Ohashi, P. S. 1997. Peptide-induced T cell receptor down-regulation on naive T cells predicts agonist/partial agonist properties and strictly correlates with T cell activation. Eur. J. Immunol. 27:2195.
31. Bachmann, M. F., Ohteki, T., McKall-Faienza, K., Zakarian, A., Kagi, D., Speiser, D. E. and Ohashi, P. S. 1997. Altered peptide ligands trigger perforin-rather than fas-dependent cell lysis. J. Immunol. 159:4165.
32. Chomczynski, P. and Sacchi, N. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156.
33. Nakauchi, H., Shinkai, Y. and Okumura, K. 1987. Molecular cloning of Lyt-3, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology to immunoglobulin and T cell receptor variable and joining regions. Proc. Natl Acad. Sci. USA 84:4210.
34. Chidgey, A., Pircher, H., MacDonald, H. R. and Boyd, R. 1997. An adult stromal cell suspension model for in vitro positive selection. Dev. Immunol., in press.
35. Sebzda, E., Wallace, V. A., Mayer, J., Yeung, R. S. M., Mak, T. W. and Ohashi, P. S. 1994. Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science 263:1615.
36. Williams, O., Tanaka, Y., Tarazona, R. and Kioussis, D. 1997. The agonist-antagonist balance in positive selection. Immunol. Today 18:121.
37. + T cell. Immunity 3:79.
38. Girao, C., Hu, Q., Sun, J. and Ashton-Rickardt, P. G. 1997. Limits to the differential avidity model of T cell selection in the thymus. J. Immunol. 159:4205.
39. 1 mice. Clin. Immunol. Immunopathol. 76:297.
40. bm12 mice. J. Immunol 150:4702.