Kinetics of Factor Xa Inhibition by Recombinant Tick Anticoagulant Peptide: Both Active Site and Exosite Interactions Are Required for a Slow- and Tight-Binding Inhibition Mechanism

Biochemistry

Volumn 43, Issue 12, 2004, Pages 3368-3375

  Rezaie, Alireza R ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; DISSOCIATION; ENZYME INHIBITION; POLYPEPTIDES; QUADRATIC PROGRAMMING; RATE CONSTANTS;

DISSOCIATION CONSTANT; QUADRATIC EQUATION;

BIOCHEMISTRY;

BLOOD CLOTTING FACTOR 10A; PROTEINASE; RECOMBINANT TICK ANTICOAGULANT PEPTIDE; SODIUM ION;

ARTICLE; ASSAY; BINDING AFFINITY; DISSOCIATION CONSTANT; ENZYME ACTIVE SITE; EQUILIBRIUM CONSTANT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

1-CARBOXYGLUTAMIC ACID; ANTICOAGULANTS; ARGININE; BINDING SITES; BINDING, COMPETITIVE; CELL LINE; FACTOR XA; HUMANS; KINETICS; MUTAGENESIS, SITE-DIRECTED; ORNITHODOROS; PEPTIDES; PHENYLALANINE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SERINE PROTEINASE INHIBITORS; TYROSINE;

ACARI;

EID: 1642341747     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi036177y     Document Type: Article

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