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Volumn 10, Issue 1 SPEC. ISS., 2004, Pages 39-55

Evaluating the relationship between variance in enzyme expression and toxicant concentration in health risk assessment

Author keywords

Biotransformation; Clearance; Enzyme variance; Pharmacokinetics; Risk assessment; Uncertainty factors; Xenobiotics

Indexed keywords

ANIMALIA;

EID: 1642336265     PISSN: 10807039     EISSN: None     Source Type: Journal    
DOI: 10.1080/10807030490280945     Document Type: Conference Paper
Times cited : (7)

References (25)
  • 1
    • 0027535473 scopus 로고
    • Pharmacokinetic modeling of trichloroethylene and trichloroacetic acid in humans
    • Allen BC and Fisher JW. 1993. Pharmacokinetic modeling of trichloroethylene and trichloroacetic acid in humans. Risk Anal 13:71-86
    • (1993) Risk Anal , vol.13 , pp. 71-86
    • Allen, B.C.1    Fisher, J.W.2
  • 2
    • 0036445603 scopus 로고    scopus 로고
    • Naphthalene-induced respiratory tract toxicity: Metabolic mechanisms of toxicity
    • Buckpitt A, Boland B, Isbell M, et al. 2002. Naphthalene-induced respiratory tract toxicity: Metabolic mechanisms of toxicity. Drug Metab Rev 34:791-820
    • (2002) Drug Metab Rev , vol.34 , pp. 791-820
    • Buckpitt, A.1    Boland, B.2    Isbell, M.3
  • 3
    • 23044531656 scopus 로고    scopus 로고
    • Trichloroethylene: Using new information to improve the cancer characterization
    • Cogliano VJ, Scott CS, Caldwell JC, et al. 2001. Trichloroethylene: Using new information to improve the cancer characterization. Hum Ecol Risk Assess 7:755-66
    • (2001) Hum Ecol Risk Assess , vol.7 , pp. 755-766
    • Cogliano, V.J.1    Scott, C.S.2    Caldwell, J.C.3
  • 4
    • 0037290646 scopus 로고    scopus 로고
    • Human variability in CYP3A4 metabolism and CYP3A4-related uncertainty factors for risk assessment
    • Dorne JLCM, Walton K, and Renwick AG. 2003. Human variability in CYP3A4 metabolism and CYP3A4-related uncertainty factors for risk assessment. Food Chem Toxicol 41:201-24
    • (2003) Food Chem Toxicol , vol.41 , pp. 201-224
    • Dorne, J.L.C.M.1    Walton, K.2    Renwick, A.G.3
  • 5
    • 0033074472 scopus 로고    scopus 로고
    • Effects of disease on expression and regulation of CYPs
    • Farrell G. 1999. Effects of disease on expression and regulation of CYPs. Mol Aspects Med 20:55-70
    • (1999) Mol Aspects Med , vol.20 , pp. 55-70
    • Farrell, G.1
  • 6
    • 0032055241 scopus 로고    scopus 로고
    • Effects of chemical inducers on human microsomal epoxide hydrolase in primary hepatocyte cultures
    • Hassett C, Laurenzana EM, Sidhu JS, et al. 1998. Effects of chemical inducers on human microsomal epoxide hydrolase in primary hepatocyte cultures. Biochem Pharmacol 55:1059-69
    • (1998) Biochem Pharmacol , vol.55 , pp. 1059-1069
    • Hassett, C.1    Laurenzana, E.M.2    Sidhu, J.S.3
  • 8
    • 0026716863 scopus 로고
    • Sex-specific cytochrome P-450 as a cause of sex- and species-related differences in drug toxicity
    • Kato R and Yamazoe Y. 1992. Sex-specific cytochrome P-450 as a cause of sex- and species-related differences in drug toxicity. Toxicol Lett 64/65:661-7
    • (1992) Toxicol Lett , vol.64-65 , pp. 661-667
    • Kato, R.1    Yamazoe, Y.2
  • 9
    • 0030670353 scopus 로고    scopus 로고
    • Extrapolation of in vitro enzyme induction data to humans in vivo
    • Kedderis GL. 1997. Extrapolation of in vitro enzyme induction data to humans in vivo. Chem Biol Interact 107:109-21
    • (1997) Chem Biol Interact , vol.107 , pp. 109-121
    • Kedderis, G.L.1
  • 10
    • 0036792160 scopus 로고    scopus 로고
    • Brassica, biotransformation and cancer risk: Genetic polymorphisms alter the preventive effects of cruciferous vegetables
    • Lampe JW and Peterson S. 2002. Brassica, biotransformation and cancer risk: Genetic polymorphisms alter the preventive effects of cruciferous vegetables. J Nutr 132:2991-4
    • (2002) J Nutr , vol.132 , pp. 2991-2994
    • Lampe, J.W.1    Peterson, S.2
  • 12
    • 0037041195 scopus 로고    scopus 로고
    • Incorporating human interindividual biotransformation variance in health risk assessment
    • Lipscomb JC and Kedderis GL. 2002. Incorporating human interindividual biotransformation variance in health risk assessment. Sci Tot Environ 288:13-21
    • (2002) Sci Tot Environ , vol.288 , pp. 13-21
    • Lipscomb, J.C.1    Kedderis, G.L.2
  • 13
    • 0031062286 scopus 로고    scopus 로고
    • Cytochrome P450-dependent metabolism of trichloroethylene: Interindividual differences in humans
    • Lipscomb JC, Garrett CM, and Snawder JE. 1997. Cytochrome P450-dependent metabolism of trichloroethylene: Interindividual differences in humans. Toxicol Appl Pharmacol 142: 311-8
    • (1997) Toxicol Appl Pharmacol , vol.142 , pp. 311-318
    • Lipscomb, J.C.1    Garrett, C.M.2    Snawder, J.E.3
  • 14
    • 0032191413 scopus 로고    scopus 로고
    • In vitro to in vivo extrapolation for trichloroethylene metabolism in humans
    • Lipscomb JC, Fisher JW, Confer PD, et al. 1998a. In vitro to in vivo extrapolation for trichloroethylene metabolism in humans. Toxicol Appl Pharmacol 152:376-87
    • (1998) Toxicol Appl Pharmacol , vol.152 , pp. 376-387
    • Lipscomb, J.C.1    Fisher, J.W.2    Confer, P.D.3
  • 15
    • 2642709830 scopus 로고    scopus 로고
    • Use of kinetic and mechanistic data in species extrapolation of bioactivation: Cytochrome P-450 dependent trichloroethylene metabolism at occupationally relevant concentrations
    • Lipscomb JC, Garrett CM, and Snawder JE. 1998b. Use of kinetic and mechanistic data in species extrapolation of bioactivation: Cytochrome P-450 dependent trichloroethylene metabolism at occupationally relevant concentrations. J Occup Health 40:110-7
    • (1998) J Occup Health , vol.40 , pp. 110-117
    • Lipscomb, J.C.1    Garrett, C.M.2    Snawder, J.E.3
  • 16
    • 0037282743 scopus 로고    scopus 로고
    • Variance of microsomal protein and cytochrome P450 2E1 and 3A forms in adult human liver
    • Lipscomb JC, Teuschler LK, Swartout JC, et al. 2003a. Variance of microsomal protein and cytochrome P450 2E1 and 3A forms in adult human liver. Toxicol Mech Methods 13:45-51
    • (2003) Toxicol Mech Methods , vol.13 , pp. 45-51
    • Lipscomb, J.C.1    Teuschler, L.K.2    Swartout, J.C.3
  • 17
    • 0345791469 scopus 로고    scopus 로고
    • The impact of cytochrome P450 2E1-dependent metabolic variance on a risk relevant pharmacokinetic outcome in humans
    • Lipscomb JC, Teuschler LK, Swartout J, et al. 2003b. The impact of cytochrome P450 2E1-dependent metabolic variance on a risk relevant pharmacokinetic outcome in humans. Risk Analysis 23:1221-38
    • (2003) Risk Analysis , vol.23 , pp. 1221-1238
    • Lipscomb, J.C.1    Teuschler, L.K.2    Swartout, J.3
  • 18
    • 0025055648 scopus 로고
    • Enzyme induction in the cytochrome P-450 system
    • Okey AB. 1990. Enzyme induction in the cytochrome P-450 system. Pharmacol Ther 45:241-98
    • (1990) Pharmacol Ther , vol.45 , pp. 241-298
    • Okey, A.B.1
  • 19
    • 0031715333 scopus 로고    scopus 로고
    • The effect of high-dose endotoxin on CYP3A2 expression in the rat
    • Roe AL, Warren G, Hou G, et al. 1998. The effect of high-dose endotoxin on CYP3A2 expression in the rat. Pharmacol Res 15:1603-8
    • (1998) Pharmacol Res , vol.15 , pp. 1603-1608
    • Roe, A.L.1    Warren, G.2    Hou, G.3
  • 20
    • 0344272946 scopus 로고    scopus 로고
    • Characterization of cytochrome P450 and glutathione S-transferase activity and expression in male and female ob/ob mice
    • Roe AL, Howard G, Blouin R, et al. 1999. Characterization of cytochrome P450 and glutathione S-transferase activity and expression in male and female ob/ob mice. Int J Obes Relat Metab Disord 23:48-53
    • (1999) Int J Obes Relat Metab Disord , vol.23 , pp. 48-53
    • Roe, A.L.1    Howard, G.2    Blouin, R.3
  • 21
    • 0033946779 scopus 로고    scopus 로고
    • Trichloroethylene Health Risks - State of the science
    • Scott CS and Cogliano VJ. 2000. Trichloroethylene Health Risks - State of the science. Environ Health Perspect 108(Suppl 2):159-60
    • (2000) Environ Health Perspect , vol.108 , Issue.2 SUPPL. , pp. 159-160
    • Scott, C.S.1    Cogliano, V.J.2
  • 22
    • 0033743267 scopus 로고    scopus 로고
    • Interindividual Variance of Cytochrome P450 Forms in Human Hepatic Microsomes: Correlation of Individual Forms with Xenobiotic Metabolism and Implications in Risk Assessment
    • Snawder JE and Lipscomb JC. 2000. Interindividual Variance of Cytochrome P450 Forms in Human Hepatic Microsomes: Correlation of Individual Forms with Xenobiotic Metabolism and Implications in Risk Assessment. Regul Toxicol Pharmacol 32:200-9
    • (2000) Regul Toxicol Pharmacol , vol.32 , pp. 200-209
    • Snawder, J.E.1    Lipscomb, J.C.2
  • 24
    • 0031051848 scopus 로고    scopus 로고
    • Human stomach alcohol and aldehyde dehydrogenases: Comparison of expression pattern and activities in alimentary tract
    • Yin S-J, Liao C-S, Wu C-W, et al. 1997. Human stomach alcohol and aldehyde dehydrogenases: Comparison of expression pattern and activities in alimentary tract. Gastroenterol 112:766-75
    • (1997) Gastroenterol , vol.112 , pp. 766-775
    • Yin, S.-J.1    Liao, C.-S.2    Wu, C.-W.3
  • 25
    • 0033625701 scopus 로고    scopus 로고
    • The effects of the ALDH2*1/2, CYP2E1 C1/C2 and C/D genotypes on blood ethanol elimination
    • Yoshihara E, Ameno K, Nakamura K, et al. 2000. The effects of the ALDH2*1/2, CYP2E1 C1/C2 and C/D genotypes on blood ethanol elimination. Drug Chem Toxicol 23:371-9
    • (2000) Drug Chem Toxicol , vol.23 , pp. 371-379
    • Yoshihara, E.1    Ameno, K.2    Nakamura, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.