Effects of chemical inducers on human microsomal epoxide hydrolase in primary hepatocyte cultures

Biochemical Pharmacology

Volumn 55, Issue 7, 1998, Pages 1059-1069

  Hassett, Christopher ^a   Laurenzana, Elizabeth M ^a   Sidhu, Jaspreet S ^a   Omiecinski, Curtis J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Cell culture; Human; Microsomal epoxide hydrolase; Primary hepatocytes

Indexed keywords

AROCLOR 1254; BETA NAPHTHOFLAVONE; BUTYLATED HYDROXYANISOLE; CIPROFIBRATE; CYTOCHROME P450; DEXAMETHASONE; ENZYME INDUCING AGENT; EPOXIDE HYDROLASE; MESSENGER RNA; PHENOBARBITAL; POLYCYCLIC AROMATIC HYDROCARBON;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; LIVER CELL CULTURE; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL;

ADULT; AGED; CELL LINE; CELLS, CULTURED; CHILD, PRESCHOOL; CYTOCHROME P-450 CYP1A2; DENSITOMETRY; ELECTRON TRANSPORT COMPLEX IV; ENZYME INDUCTION; EPOXIDE HYDROLASES; FEMALE; HUMANS; INFANT; LIVER; MALE; MICROSOMES, LIVER; MIDDLE AGED; PROTEIN BIOSYNTHESIS; RNA;

EID: 0032055241     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00679-5     Document Type: Article

References (53)

1. Gonzalez F.J. The molecular biology of cytochrome P450s. Pharmacol Rev. 40:1989;243-288.
2. Paine A.J. Heterogeneity of cytochrome P450 and its toxicological significance. Hum Exp Toxicol. 14:1995;1-7.
3. Guengerich F.P. Characterization of human microsomal cytochrome P-450 enzymes. Annu Rev Pharmacol Toxicol. 29:1989;241-264.
4. Boobis A.R., Sesardic D., Murray B.P., Edwards R.J., Singleton A.M., Rich K.J., Murray S., de la Torre R., Segura J., Pelkonen O., Pasanen M., Kobauashi S., Zhi-Guang T., Davies D.S. Species variation in the response of the cytochrome P-450-dependent monooxygenase system to inducers and inhibitors. Xenobiotica. 20:1990;1139-1161.
5. Meyer U.A. Molecular genetics and the future of pharmacogenetics. Pharmacol Ther. 46:1990;349-355.
6. Daly A.K., Cholerton S., Gregory W., Idle J.R. Metabolic polymorphisms. Pharmacol Ther. 57:1993;129-160.
7. Langouet S., Morel F., Meyer D.J., Fardel O., Corcos L., Ketterer B., Guillouzo A. A comparison of the effect of inducers on the expression of glutathione-S-transferases in the liver of the intact rat and in hepatocytes in primary culture. Hepatology. 23:1996;881-887.
8. Schuetz E.G., Li D., Omiecinski C.J., Muller E.U., Kleinman H.K., Elswick B., Guzelian P.S. Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix. J Cell Physiol. 134:1988;309-323.
9. Sidhu J.S., Farin F.M., Omiecinski C.J. Influence of extracellular matrix overlay on phenobarbital-mediated induction of CYP2B1, 2B2, and 3A1 genes in primary adult rat hepatocyte cultures. Arch Biochem Biophys. 301:1993;103-113.
10. Sidhu J.S., Farin F.M., Kavanagh T.J., Omiecinski C.J. Effect of tissue-culture substratum and extracellular matrix overlay on liver-selective and xenobiotic inducible gene expression in primary rat hepatocytes. In Vitro Toxicol. 7:1994;225-242.
11. Sidhu J.S., Omiecinski C.J. Modulation of xenobiotic-inducible cytochrome P450 gene expression by dexamethasone in primary rat hepatocytes. Pharmacogenetics. 5:1995;24-36.
12. Schuetz E.G., Schuetz J.D., Thompson M.T., Fisher R.A., Madariage J.R., Strom S.C. Phenotypic variability in induction of P-glycoprotein mRNA by aromatic hydrocarbons in primary human hepatocytes. Mol Carcinog. 12:1995;61-65.
13. Schuetz E.G., Schuetz J.D., Strom S.C., Thompson M.T., Fisher R.A., Molowa D.T., Li D., Guzelian P.S. Regulation of human liver cytochromes P-450 in family 3A in primary and continuous culture of human hepatocytes. Hepatology. 18:1993;1254-1262.
14. 1 metabolism in human hepatocytes in primary culture. Cancer Res. 55:1995;5574-5579.
15. Donato M.T., Castell J.V., Gómez-Lechón M.J. Effect of model inducers on cytochrome P450 activities of human hepatocytes in primary culture. Drug Metab Dispos. 23:1995;553-558.
16. Beetham J.K., Grant D., Arand M., Garbarino J., Kiyosue T., Pinot F., Oesch F., Belknap W.R., Shinozaki K., Hammock B.D. Gene evolution of epoxide hydrolases and recommended nomenclature. DNA Cell Biol. 14:1995;61-71.
17. Hassett C., Turnblom S.M., DeAngeles A., Omiecinski C.J. Rabbit microsomal epoxide hydrolase Isolation and characterization of the xenobiotic metabolizing enzyme cDNA . Arch Biochem Biophys. 271:1989;380-389.
18. Porter T.D., Beck T.W., Kasper C.B. Complementary DNA and amino acid sequence of rat liver microsomal, xenobiotic epoxide hydrolase. Arch Biochem Biophys. 248:1986;121-129.
19. Skoda R.C., Demierre A., McBride O.W., Gonzalez F.J., Meyer U.A. Human microsomal xenobiotic epoxide hydrolase. Complementary DNA sequence, complementary DNA-directed expression in COS-1 cells, and chromosomal localization. J Biol Chem. 263:1988;1549-1554.
20. (+)-dependent bile acid transport by hepatocytes is mediated by a protein similar to microsomal epoxide hydrolase. Am J Physiol. 264:1993;G528-G534.
21. von Dippe P., Amoui M., Stellwagen R.H., Levy D. The functional expression of sodium-dependent bile acid transport in Madin-Darby canine kidney cells transfected with the cDNA for microsomal epoxide hydrolase. J Biol Chem. 271:1996;18176-18180.
22. Alves C., von Dippe P., Amoui M., Levy D. Bile acid transport into hepatocyte smooth endoplasmic reticulum vesicles is mediated by microsomal epoxide hydrolase, a membrane protein exhibiting two distinct topological orientations. J Biol Chem. 268:1993;20148-20155.
23. Honscha W., Platte H.D., Oesch F., Friedberg T. Relationship between the microsomal epoxide hydrolase and the hepatocellular transport of bile acids and xenobiotics. Biochem J. 311:1995;975-979.
24. Martz F., Failinger C. III, Blake D.A. Phenytoin teratogenesis Correlation between embryopathic effect and covalent binding of putative arene oxide metabolite in gestational tissue . J Pharmacol Exp Ther. 203:1977;231-239.
25. Buehler B.A., Delimont D., van Waes M., Finnell R.H. Prenatal prediction of risk of the fetal hydantoin syndrome. N Engl J Med. 322:1990;1567-1572.
26. Friedberg T., Becker R., Oesch F., Glatt H. Studies on the importance of microsomal epoxide hydrolase in the detoxification of arene oxides using the heterologous expression of the enzyme in mammalian cells. Carcinogenesis. 15:1994;171-175.
27. Gautier J.C., Urban P., Beaune P., Pompon D. Simulation of human benzo[a]pyrene metabolism deduced from the analysis of individual kinetic steps in recombinant yeast. Chem Res Toxicol. 9:1996;418-425.
28. Shou M., Gonzalez F.J., Gelboin H.V. Stereoselective epoxidation and hydration at the K-region of polycyclic aromatic hydrocarbons by cDNA-expressed cytochromes P450 1A1, 1A2, and epoxide hydrolase. Biochemistry. 35:1996;15807-15813.
29. Hassett C., Aicher L., Sidhu J.S., Omiecinski C.J. Human microsomal epoxide hydrolase Genetic polymorphism and functional expression in vitro of amino acid variants . Hum Mol Genet. 3:1994;421-428.
30. Gaedigk A., Spielberg S.P., Grant D.M. Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions. Pharmacogenetics. 4:1994;142-153.
31. 1. Proc Natl Acad Sci USA. 92:1995;2384-2387.
32. Lancaster J.M., Brownlee H.A., Bell D.A., Futreal P.A., Marks J.R., Berchuck A., Wiseman R.W., Taylor J.A. Microsomal epoxide hydrolase polymorphism as a risk factor for ovarian cancer. Mol Carcinog. 17:1996;160-162.
33. Hassett C., Robinson K.B., Beck N.B., Omiecinski C.J. The human microsomal epoxide hydrolase gene (EPHX1) Complete nucleotide sequence and structural characterization. Genomics. 23:1994;433-442.
34. Hassett C., Lin J., Carty C.L., Laurenzana E.M., Omiecinski C.J. Human hepatic microsomal epoxide hydrolase Comparative analysis of polymorphic expression. Arch Biochem Biophys. 337:1997;275-283.
35. Farin F.M., Omiecinski C.J. Regiospecific expression of cytochrome P-450s and microsomal epoxide hydrolase in human brain tissue. J Toxicol Environ Health. 40:1993;317-335.
36. Omiecinski C.J., Aicher L., Holubkov R., Checkoway H. Human peripheral lymphocytes as indicators of microsomal epoxide hydrolase activity in liver and lung. Pharmacogenetics. 3:1993;150-158.
37. Omiecinski C.J., Aicher L., Swenson L. Developmental expression of human microsomal epoxide hydrolase. J Pharmacol Exp Ther. 269:1994;417-423.
38. Seglen P.O. Preparation of isolated rat liver cells. Methods Cell Biol. 13:1976;29-83.
39. Sidhu J.S., Omiecinski C.J. Forskolin-mediated induction of CYP3A1 mRNA expression in primary rat hepatocytes is independent of elevated intracellular cyclic AMP. J Pharmacol Exp Ther. 276:1996;238-245.
40. Kostrubsky V.E., Strom S.C., Wood S.G., Wrighton S.A., Sinclair P.R., Sinclair J.F. Ethanol and isopentanol increase CYP3A and CYP2E in primary cultures of human hepatocytes. Arch Biochem Biophys. 322:1995;516-520.
41. Ledley F.D., Adams R.M., Soriano H.E., Darlington G., Finegold M., Lanford R., Carey D., Lewis D., Baley P.A., Rothenberg S., Kay M., Brandt M., Moen R., Anderson W.F., Whitington P., Pokorny W., Woo S.L.C. Development of a clinical protocol for hepatic gene transfer Lessons learned in preclinical studies . Pediatr Res. 33:(4 Pt 1):1993;313-320.
42. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162:1987;156-159.
43. Farin F.M., Pohlman T.H., Omiecinski C.J. Expression of cytochrome P450s and microsomal epoxide hydrolase in primary cultures of human umbilical vein endothelial cells. Toxicol Appl Pharmacol. 124:1994;1-9.
44. Kocarek T.A., Schuetz E.G., Strom S.C., Fisher R.A., Guzelian P.S. Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes. Drug Metab Dispos. 23:1995;415-421.
45. Zangar R.C., Woodcroft K.J., Kocarek T.A., Novak R.F. Xenobiotic-enhanced expression of cytochrome P450 2E1 and 2B1/2B2 in primary cultured rat hepatocytes. Drug Metab Dispos. 23:1995;681-687.
46. Daujat M., Peryt B., Lesca P., Fourtanier G., Domergue J., Maurel P. Omeprazole, an inducer of human CYP1A1 and 1A2, is not a ligand for the Ah receptor. Biochem Biophys Res Commun. 188:1992;820-825.
47. Diaz D., Fabre I., Daujat M., Saint Aubert B., Bories P., Michel H., Maurel P. Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450. Gastroenterology. 99:1990;737-747.
48. Morel F., Fardel O., Meyer D.J., Langouet S., Gilmore K.S., Meunier B., Tu C-PD, Kensler T.W., Ketterer B., Guillouzo A. Preferential increase of glutathione S-transferase class α transcripts in cultured human hepatocytes by phenobarbital, 3-methylcholanthrene, and dithiolethiones. Cancer Res. 53:1993;231-234.
49. Schrenk D., Stuven T., Gohl G., Viebahn R., Bock K.W. Induction of CYP1A and glutathione S-transferase activities by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in human hepatocyte cultures. Carcinogenesis. 16:1995;943-946.
50. Hammock B.D., Ota K. Differential induction of cytosolic epoxide hydrolase, microsomal epoxide hydrolase, and glutathione S-transferase activities. Toxicol Appl Pharmacol. 71:1983;254-265.
51. Meijer J., DePierre J.W. Hepatic levels of cytosolic, microsomal and 'mitochondrial' epoxide hydrolases and other drug-metabolizing enzymes after treatment of mice with various xenobiotics and endogenous compounds. Chem Biol Interact. 62:1987;249-269.
52. Kim S.G. Transcriptional regulation of rat microsomal epoxide hydrolase gene by imidazole antimycotic agents. Mol Pharmacol. 42:1992;273-279.
53. Madden S.L., Galella E.A., Riley D., Bertelsen A.H., Beaudry G.A. Induction of cell growth regulatory genes by p53. Cancer Res. 56:1996;5384-5390.