Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice

Circulation Research

Volumn 91, Issue 10, 2002, Pages 938-944

  Didion, Sean P ^a   Ryan, Michael J ^a   Didion, Lisa A ^a   Fegan, Pamela E ^a   Sigmund, Curt D ^a   Faraci, Frank M ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Carotid artery; Cerebral arterioles; Genetically altered mice; Nitric oxide; Superoxide dismutase 1

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ACETYLCHOLINE; COPPER ZINC SUPEROXIDE DISMUTASE; LUCIGENIN; NITRIC OXIDE; PAPAVERINE; PHENYLEPHRINE; POTASSIUM CHLORIDE; SEROTONIN; SUPEROXIDE; SUPEROXIDE DISMUTASE;

ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; CAROTID ARTERY; CHEMOLUMINESCENCE; CONFOCAL MICROSCOPY; COPPER ZINC SUPEROXIDE DISMUTASE DEFICIENCY; ENZYME ACTIVITY; ENZYME DEFICIENCY; MOUSE; NONHUMAN; PRIORITY JOURNAL; VASCULAR DISEASE; VASODILATATION;

ANIMALS; ARTERIOLES; BLOOD PRESSURE; BRAIN; CAROTID ARTERIES; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; HOMOZYGOTE; MICE; MICE, MUTANT STRAINS; SUPEROXIDE DISMUTASE; SUPEROXIDES; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VASODILATION; VASODILATOR AGENTS;

EID: 0037112407     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000043280.65241.04     Document Type: Article

References (53)

1. Beckman JS, Koppenol WH. Nitric oxide, superoxide and peroxynitrite: The good, the bad, and the ugly. Am J Physiol. 1996;271:C1424-C1437.
2. Wei EP, Kontos HA, Christman CW, DeWitt DS, Povlishock JT. Superoxide generation and reversal of acetylcholine-induced cerebral arteriolar dilatation after acute hypertension. Circ Res. 1985;57:781-787.
3. Didion SP, Ryan MJ, Baumbach GL, Sigmund CD, Faraci FM. Superoxide contributes to vascular dysfunction in mice that express human renin and human angiotensinogen. Am J Physiol Heart Circ Physiol. 2002;283:H1569-H1576.
4. Didion SP, Hathaway CA, Faraci FM. Superoxide levels and function of cerebral blood vessels after inhibition of CuZn-SOD. Am J Physiol Heart Circ Physiol. 2001;281:H1697-H1703.
5. Iadecola C, Zhang F, Niwa K, Eckman C, Turner SK, Fischer E, Younkin S, Borchelt DR, Hsiao KK, Carlson GA. SODI rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein. Nat Neurosci. 1999;2:157-161.
6. Kinoshita H, Milstien S, Wambi C, Katusic ZS. Inhibition of tetrahydrobiopterin biosynthesis impairs endothelium-dependent relaxations in canine basilar artery. Am J Physiol. 1997;273:H718-H724.
7. Mayhan WG. Superoxide dismutase partially restores impaired dilatation of the basilar artery during diabetes mellitus. Brain Res. 1997;760:204-209.
8. Ignarro LJ, Byrns RE, Buga GM, Wood KS, Chaudhuri G. Pharmacological evidence that endothelium-derived relaxing factor is nitric oxide: Use of pyrogallol and superoxide dismutase to study endothelium-dependent and nitric oxide-elicited vascular smooth muscle relaxation. J Pharmacol Exp Ther. 1988;244:181-189.
9. Dowell FJ, Hamilton CA, McMurray J, Reid JL. Effects of a xanthine oxidase/hypoxanthine free radical and reactive oxygen species generating system on endothelial function in New Zealand white rabbit aortic rings. J Cardiovasc Pharmacol. 1993;22:792-797.
10. Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress. Circ Res. 2000;87:840-844.
11. Stralin P, Karlsson K, Johansson BO, Marklund SL. The interstitium of the human arterial wall contains very large amounts of extracellular superoxide dismutase. Arterioscler Thromb Vasc Biol. 1995;15:2032-2036.
12. Fukai T, Siegfried MR, Ushio-Fukai M, Cheng Y, Kojda G, Harrison DG. Regulation of the vascular extracellular superoxide dismutase by nitric oxide and exercise training. J Clin Invest. 2000;105:1631-1639.
13. Fukai T, Siegfried MR, Ushio-Fukai M, Griendling KK, Harrison DG. Modulation of extracellular superoxide dismutase expression by angiotensin II and hypertension. Circ. Res. 1999;85:23-28.
14. Fukai T, Galis ZS, Meng XP, Parthasarathy S, Harrison DG. Vascular expression of extracellular superoxide dismutase in atherosclerosis. J Clin Invest. 1998;101:2101-2111.
15. Mugge A, Elwell JH, Peterson TE, Harrison DG. Release of intact endothelium derived relaxing factor depends on endothelial superoxide dismutase activity. Am J Physiol Cell Physiol. 1991;260:C219-C225.
16. Oury TD, Day BJ, Crapo JD. Extracellular superoxide dismutase: A regulator of nitric oxide bioavailability. Lab Invest. 1996;75:617-636.
17. Matzuk MM, Dionne L, Guo Q, Kumar TR, Lebovitz RM. Ovarian function in superoxide dismutase 1 and 2 knockout mice. Endocrinology. 1998;139:4008-4011.
18. -/- mouse hearts. Circulation. 2002;105:981-986.
19. Kondo T, Reaume AG, Huang T-T, Carlson E, Murakami K, Chen SF, Hoffman EK, Scott RW, Epstein CJ, Chan PH. Reduction of CuZn-superoxide dismutase activity exacerbates neuronal cell injury and edema formation after transient focal cerebral ischemia. J Neurosci. 1997;17:4180-4189.
20. Kawase M, Murakami K, Fujimura M, Morita-Fujimura Y, Gasche Y, Kondo T, Scott RW, Chan PH. Exacerbation of delayed cell injury after transient global ischemia in mutant mice with CuZn superoxide dismutase deficiency. Stroke. 1999;30:1962-1968.
21. The Jackson Laboratory Web site. Available at: http://www.jax.org. Accessed October 14, 2002.
22. Spitz DR, Oberley LW. An assay for superoxide dismutase activity in mammalian tissue homogenates. Anal Biochem. 1989;179:8-18.
23. Fang X, Weintraub NL, Rios CD, Chappell DA, Zwacka RM, Engelhardt JF, Oberley LW, Yan T, Heistad DD, Spector AA. Overexpression of human superoxide dismutase inhibits oxidation of low-density lipoprotein by endothelial cells. Circ Res. 1998;82:1289-1297.
24. Nakane H, Chu Y, Faraci FM, Oberley LW, Heistad DD. Gene transfer of extracellular superoxide dismutase increases superoxide dismutase activity in cerebral spinal fluid. Stroke. 2001;32:184-189.
25. Didion SP, Faraci FM. Effects of NADH and NADPH on superoxide levels and cerebral vascular tone. Am J Physiol Heart Circ Physiol. 2002;282:H688-H695.
26. Lund DD, Faraci FM, Miller FJ Jr, Heistad DD. Gene transfer of endothelial nitric oxide synthase improves relaxation of carotid arteries from diabetic rabbits. Circulation. 2000;101:1027-1033.
27. Nakane H, Miller FJ Jr, Faraci FM, Toyoda K, Heistad DD. Gene transfer of endothelial nitric oxide synthase reduces angiotensin II-induced endothelial dysfunction. Hypertension. 2000;35:595-601.
28. Miller FJ Jr, Gutterman DD, Rios CD, Heistad DD, Davidson BL. Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis. Circ Res. 1998;82;1298-1305.
29. Bonthu S, Heistad DD, Chappell DA, Lamping KG, Faraci FM Atherosclerosis, vascular remodeling, and impairment of endothelium-dependent relaxation in genetically altered hyperlipidemic mice. Arterioscler Thromb Vasc Biol. 1997;17:2333-2340.
30. Lamping KG, Faraci FM. Role of sex differences and effects of endothelial NO synthase deficiency in responses of carotid arteries to serotonin. Arterioscler Thromb Vasc Biol. 2001;21:523-528.
31. Faraci FM, Sigmund CD, Shesely EG, Maeda N, Heistad DD. Responses of carotid artery in mice deficient in expression of the gene for endothelial NO synthase. Am J Physiol. 1998;274:H564-H570.
32. Didion SP, Carmines PK, Ikenaga H, Mayhan WG. Enhanced constrictor responses of skeletal muscle arterioles during myocardial infarction. Am J Physiol. 1997;273:H1502-H1508.
33. G-nitro-L-arginine methylester (L-NAME) on functional and biochemical α1-adrenoceptor-mediated responses in rat blood vessels. Br J Pharmacol. 1996;117:757-763.
34. Lerman A, Sandok EK, Hilebrand FL Jr, Burnett JC Jr. Inhibition of endothelium-derived relaxing factor enhances endothelin-mediated vasoconstriction. Circulation. 1992;85:1894-1898.
35. Zhang J, Van Meel JC, Pfaffendorf M, Zhang J, Van Zweiten PA. Endothelium-dependent, nitric oxide-mediated inhibition of angiotensin II-induced contractions in rabbit aorta. Eur J Pharmacol. 1994;262:247-253.
36. Sobey CG, Faraci FM. Effects of a novel inhibitor of guanylyl cyclase on dilator responses of mouse cerebral arterioles. Stroke. 1997;28:837-842.
37. Yamada M, Lamping KG, Duttaroy A, Zhang W, Cui Y, Bymaster FP, McKinzie DL, Felder CC, Deng C-X, Faraci FM, Wess J. Cholinergic dilation of cerebral blood vessels is abolished in M5 muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci USA. 2001;98:14096-14101.
38. Ryan MJ, Didion SP, Davis DR, Faraci FM, Sigmund CD. Endothelial dysfunction and blood pressure variability in selected inbred mouse strains. Arterioscler Thromb Vasc Biol. 2002;22:42-48.
39. Didion SP, Heistad DD, Faraci FM. Mechanisms that produce nitric oxide-mediated relaxation of cerebral arteries during atherosclerosis. Stroke. 2001;32:761-766.
40. Huang, T-T, Yasunami M, Carlson EJ, Gillespie AM, Reaume AG, Hoffman EK, Chan PH, Scott RW, Epstein CJ. Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997;344:424-432.
41. Reaume AG, Elliott JL, Hoffman EK, Kowall NW, Ferrante RJ, Siwek DF, Wilcox HM, Flood DG, Beal MF, Brown RH Jr, Scott RW, Snider WD. Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury. Nature Genetics. 1996;13:43-47.
42. Ho YS, Gargano M, Cao J, Bronson RT, Heimler I, Hutz RJ. Reduced fertility in female mice lacking copper-zinc superoxide dismutase. J Biol Chem. 1998;273:7765-7769.
43. Pagano PJ, Tornheim K, Cohen RA. Superoxide production by rabbit thoracic aorta: Effect of endothelium-derived nitric oxide. Am J Physiol. 1993;265:H707-H712.
44. Wambi-Kiesse CO, Katusic ZS. Inhibition of copper/zinc superoxide dismutase impairs NO-mediated endothelium-dependent relaxation. Am J Physiol. 1999;276:H1043-H1048.
45. Sobey CG, Faraci FM. Subarachnoid haemorrhage: What happens to the cerebral arteries? Clin Exp Pharmacol Physiol. 1998;25:867-876.
46. Kontos HA. Oxygen radicals in cerebral ischemia: The 2001 Willis lecture. Stroke. 2001;32:2712-2716.
47. Droge W. Free radicals in the physiological control of cell function. Physiol Rev. 2002;82:47-95.
48. Nakazono K, Watanabe N, Matsuno K, Sasaki J, Sato T, Inoue M. Does superoxide underlie the pathogenesis of hypertension? Proc Natl Acad Sci USA. 1991;88:10045-10048.
49. Shesely EG, Maeda N, Kim HS, Desai KM, Krege JH, Laubach VE, Sherman PA, Sessa WC, Smithies O. Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proc Natl Acad Sci USA. 1996;93:13176-13181.
50. Wang HD, Johns DG, Xu S, Cohen RA. Role of superoxide anion in regulating pressor and vascular hypertrophic response to angiotensin II. Am J Physiol Heart Circ. Physiol. 2002;282:H1697-H1702.
51. Kobayashi T, Kamata K. Relationship among cholesterol, superoxide anion and endothelium-dependent relaxation in diabetic rats. Eur J Pharmacol. 1999;367:213-222.
52. Kamata K, Kobayashi T. Changes in superoxide dismutase mRNA expression by streptozotocin-induce diabetes. Br J Pharmacol. 1996;199:583-589.
53. Forgione MA, Weiss N, Heydrick S, Cap A, Klings ES, Bierl C, Eberhardt RT, Farber HW, Loscalzo J. Cellular glutathione peroxidase deficiency and endothelial dysfunction. Am J Physiol Heart Circ Physiol. 2002;282:H1255-H1261.