O6-3-[131I]iodobenzylguanine: Improved Synthesis and Further Evaluation of a Potential Agent for Imaging of Alkylguanine-DNA Alkyltransferase

Bioconjugate Chemistry

Volumn 15, Issue 2, 2004, Pages 402-408

  Vaidyanathan, Ganesan ^a   Affleck, Donna J ^a   Norman, Joseph ^a   Welsh, Phil ^a   Liu, Wenge ^a   Johnson, Stewart P ^a   Friedman, Henry S ^a   Zalutsky, Michael R ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CELLS; DNA; MAMMALS;

ALKYLTRANSFERASE; BENZYL RINGS; DNA REPAIR PROTEINS; GUANINE; IN-VITRO; MEDULLOBLASTOMA; NON-INVASIVE IMAGING; RADIOCHEMICAL YIELD; SINGLE-STEP; TWO-STEP APPROACH;

TUMORS;

6 O (3 IODOBENZYL)GUANINE I 131; 6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; 6 O BENZYLGUANINE; IODINE 131; UNCLASSIFIED DRUG; DRUG DERIVATIVE; GUANINE; IODOBENZENE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; O (6) METHYLGUANINE; O-(6)-METHYLGUANINE; RADIOACTIVE IODINE;

ANIMAL CELL; ARTICLE; CELL DENSITY; CELL FUNCTION; CONTROLLED STUDY; DNA REPAIR; HUMAN; HUMAN CELL; LUNG; MEDULLOBLASTOMA; NONHUMAN; RADIOCHEMISTRY; RHABDOMYOSARCOMA; STOMACH; SYNTHESIS; THYROID GLAND; XENOGRAFT; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; COMPARATIVE STUDY; DRUG SCREENING; METABOLISM; METHODOLOGY; MOUSE; NUDE MOUSE; PROTEIN BINDING; TUMOR CELL LINE;

ANIMALIA; ILEX COOKII;

ANIMALS; CELL LINE, TUMOR; DRUG EVALUATION, PRECLINICAL; GUANINE; HUMANS; IODINE RADIOISOTOPES; IODOBENZENES; MICE; MICE, INBRED BALB C; MICE, NUDE; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PROTEIN BINDING; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 1642280340     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc0341977     Document Type: Article

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