Ultrasonographic contrast media: Has the time come in obstetrics and gynecology?

Journal of Ultrasound in Medicine

Volumn 24, Issue 4, 2005, Pages 517-531

  Abramowicz, Jacques S ^a,b  

^a RUSH MEDICAL COLLEGE   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Gynecology; Nanomolecular imaging; Obstetrics; Ovarian cancer; Ultrasonographic contrast medium

Indexed keywords

BIOLOGICAL ORGANS; DATA REDUCTION; GYNECOLOGY; MEDICAL IMAGING; SEARCH ENGINES; SIGNAL PROCESSING; TUMORS;

CLINICAL APPLICATIONS; MICROBUBBLES; ULTRASONOGRAPHY;

ULTRASONICS;

ALBUNEX; CONTRAST MEDIUM; FS 069; PERFLUTREN; SHU 508; SONOVUE;

BREAST; CANCER DIAGNOSIS; CARDIOLOGY; CONTRAST ENHANCEMENT; DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; DOPPLER ECHOGRAPHY; ECHOGRAPHY; EMULSION; FEMALE; GYNECOLOGY; HUMAN; IMAGE ENHANCEMENT; INTERNET; LIVER; MEDICAL TECHNOLOGY; MEDLINE; MICROBUBBLE; MOLECULE; NANOMOLECULE; OBSTETRICS; OVARY CANCER; PERFUSION; PHARMACOKINETICS; PROSTATE; REVIEW; SAFETY; SIGNAL PROCESSING; UTERINE TUBE; UTERUS;

EID: 16344391801     PISSN: 02784297     EISSN: None     Source Type: Journal    
DOI: 10.7863/jum.2005.24.4.517     Document Type: Review

References (151)

1. Kuo HC, Chang FM, Wu CH, Yao BL, Liu CH. The primary application of three-dimensional ultrasonography in obstetrics. Am J Obstet Gynecol 1992; 166:880-886.
2. Merz E, Bahlman F, Weber G. Volume scanning in the evaluation of fetal malformations: a new dimension in prenatal diagnosis. Ultrasound Obstet Gynecol 1995; 5:222-227.
3. Nelson TR, Downey DB, Pretorius DH, Fenster A. Three-Dimensional Ultrasound. Philadelphia, PA: Lippincott Williams & Wilkins; 1999.
4. Lee WR. Ultrasound imaging in three and four dimensions. Semin Ultrasound CT MR 2001; 22:85-105.
5. Xu HX, Zhang QP, Lu MD, Xiao XT. Comparison of two-dimensional and three-dimensional sonography in evaluating fetal malformations. J Clin Ultrasound 2002; 30:515-525.
6. Blomley MJK, Cooke JC, Unger EC, Monaghan MJ, Cosgrove DA. Microbbuble contrast agents: a new era in ultrasound. BMJ 2001; 322:1222-1225.
7. Mattrey RF, Steinbach GC. Ultrasound contrast agents: state of the art. Invest Radiol 1991; 26:S5-S11.
8. Dawson P, Cosgrove DO, Grainger RG (eds). Textbook of Contrast Media. Oxford, England: Isis Medical Media; 1999.
9. Goldberg BB, Liu JB, Forsberg F. Ultrasound contrast agents: a review. Ultrasound Med Biol 1994; 20:319-333.
10. Mulvagh SL, DeMaria AN, Feinstein SB, et al. Contrast echocardiography: current and future applications. J Am Soc Echocardiogr 2000; 13:331-342.
11. Ferrara KW, Merritt C RB, Burns PN, Foster S, Mattrey RF, Wickline SA. Evaluation of tumor angiogenesis with US: imaging, Doppler and contrast agents. Acad Radiol 2001; 7:824-839.
12. Salata OV. Applications of nanoparticles in biology and medicine. J Nanobiotechnology 2004; 2:3-13.
13. Abramowicz JS. Ultrasound contrast media and their use in obstetrics and gynecology. Ultrasound Med Biol 1997; 23:1287-1298.
14. Gramiak R, Shah PM. Echocardiogram of the aortic root. Invest Radiol 1968; 3:356-366.
15. Ziskin MC, Bonakdarpour A, Weinstein DP, Lynch PR. Contrast agents for diagnostic ultrasound. Invest Radiol 1972; 7:500-505.
16. Bruce M, Averkiou M, Tiemann K, Lohmaier S, Powers J, Beach K. Vascular flow and perfusion imaging with ultrasound contrast agents. Ultrasound Med Biol 2004; 30:735-743.
17. Schutt EG, Klein DH, Mattrey RM, Riess JG. Injectable microbubbles as contrast agents for diagnostic ultrasound imaging: the key role of perfluorochemicals. Angew Chem Int Ed Engl 2003; 42:3218-3235.
18. Burns PN. Harmonic imaging with ultrasound contrast agents. Clin Radiol 1996; 51(suppl 1):50-55.
19. Girard MS, Mattrey RF, Baker KG, Peterson T, Deiranieh LH, Steinbach GC. Comparison of standard and second harmonic B-mode sonography in the detection of renal infarction with sonographic contrast in a rabbit model. J Ultrasound Med 2000; 19:185-192.
20. Forsberg F, Liu JB, Chiou HJ, Rawool NM, Parker L, Goldberg BB. Comparison of fundamental wide-band harmonic imaging of liver tumors. Ultrasonics 2000; 38:110-113.
21. Burns PN, Wilson SR, Simpson DH. Pulse inversion imaging of liver blood flow: improved method for characterizing focal masses with microbubble contrast. Invest Radiol 2000; 35:58-71.
22. Shubik P. Vascularization of tumors: a review. J Cancer Res Clin Oncol 1982; 103:211-216.
23. Derchi LE, Martinoli C, Pretolesi F, Crespi G, Buccicardi D. Quantitative analysis of contrast enhancement. Eur Radiol 1999; 9:S372-S376.
24. Ramnarine KV, Leen E, Oppo K, Angerson WJ, McArdle CS. Contrast-enhanced Doppler perfusion index: clinical and experimental evaluation. J Ultrasound Med 2002; 21:1121-1129.
25. Dayton PA, Ferrara KW. Targeted imaging using ultrasound. J Magn Reson Imaging 2002; 16:362-377.
26. Lindner JR, Song J, Xu F, et al. Noninvasive ultrasound imaging of inflammation using microbubbles targeted to activated leukocytes. Circulation 2000; 102:2745-2750.
27. Lindner JR, Song J, Christiansen J, Klibanov AL, Xu F, Ley K. Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin. Circulation 2001; 104:2107-2112.
28. Unger EC, McCreery TP, Sweitzer RH, Shen D, Wu G. In vitro studies of a new thrombus-specific ultrasound contrast agent. Am J Cardiol 1998; 81:58G-61G.
29. Cwajg J, Xie F, O'Leary E, Kricsfeld D, Dittrich H, Porter TR. Detection of angiographically significant coronary artery disease with accelerated intermittent imaging after intravenous administration of ultrasound contrast material. Am Heart J 2000; 139:675-683.
30. Harvey C, Blomley M. Imaging investigation of liver haemodynamics in patients at risk for hepatic metastatic disease. Br J Radiol 2005; 78:103-104.
31. Forsberg F, Goldberg BB, Liu JB, Merton DA, Rawool NM, Shi WT. Tissue-specific US contrast agent for evaluation of hepatic and splenic parenchyma. Radiology 1999; 210:125-132.
32. Basilico R, Blomley MJ, Cosgrove DO, et al. The first phase I study of a novel ultrasound contrast agent (BR14): assessment of safety and efficacy in liver and kidneys. Acad Radiol 2002; 9(suppl 2):S380-S381.
33. Harvey CJ, Blomley MJ, Eckersley RJ, Heckemann RA, Butler-Barnes J, Cosgrove DO. Pulse-inversion mode imaging of liver specific microbubbles: improved detection of subcentimeter metastases. Lancet 2000; 355:807-808.
34. Halpern EJ, Rosenberg M, Gomella LG. Prostate cancer: contrast-enhanced ultrasound for detection. Radiology 2001; 219:219-225.
35. D'Arrigo J, Simon RH, Ho SY. Lipid-coated uniform microbubble for earlier sonographic detection of brain tumors. J Neuroimaging 1991; 1:134-139.
36. Schaer GN, Koechli OR, Schuessler B, Haller U. Improvements of perineal sonographic bladder neck imaging with ultrasound contrast medium. Obstet Gynecol 1995; 86:950-954.
37. Goldstein SR. Saline infusion sonohysterography. Clin Obstet Gynecol 1996; 39:248-258.
38. Moghimi SM, Hunter CA, Murray JC. Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol Rev 2001; 53:283-318.
39. Demos S, Alkan-Onyuksel H, Kane B, et al. In vivo targeting of acoustically reflective liposomes for intravascular and transvascular ultrasonic enhancement. J Am Coll Cardiol 1999; 33:867-875.
40. Alkan-Onyuksel H, Demos SM, Lanza GM, et al. Development of inherently echogenic liposomes as an ultrasonic contrast agent. J Pharm Sci 1996; 85:486-490.
41. Demos SM, Onyuksel H, Gilbert J, et al. In vitro targeting of antibody-conjugated echogenic liposomes for site-specific ultrasonic image enhancement. J Pharm Sci 1997; 86:167-171.
42. Lindner JR. Molecular imaging with contrast ultrasound and targeted microbubbles. J Nucl Cardiol 2004; 11:215-221.
43. Wickline SA, Lanza GM. Nanotechnology for molecular imaging and targeted therapy. Circulation 2003; 107:1092-1095.
44. Lanza GM, Wickline SA. Targeted ultrasonic contrast agents for molecular imaging and therapy. Prog Cardiovasc Dis 2001; 44:13-31.
45. Lanza GM, Wallace KD, Fisher SE, et al. High frequency ultrasonic detection of thrombi with a targeted contrast system. Ultrasound Med Biol 1997; 23:863-870.
46. Lindner JR. Detection of inflamed plaques with contrast ultrasound. Am J Cardiol 2002; 90:326-356.
47. Folkman J, Watson K, Ingber D. Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 1989; 339:58-61.
48. McDonald DM, Baluk P. Significance of blood vessel leakiness in cancer. Cancer Res 2002; 62:5381-5385.
49. Hashizume H, Baluk P, Morikawa S, et al. Openings between defective endothelial cells explain tumor vessel leakiness. Am J Pathol 2000; 156:1363-1380.
50. Hobbs SK, Monsky WL, Yuan F, et al. Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proc Natl Acad Sci USA 1998; 95:4607-4612.
51. Leong-Poi H, Christiansen J, Klibanov AL, Kaul S, Lindner JR. Non-invasive assessment of neoangiogenesis by ultrasound and microbubbles targeted to av integrins. Circulation 2003; 107:455-460.
52. Ellegala DB, Leong-Poi H, Carpenter JE, et al. Imaging tumor angiogenesis with contrast ultrasound and microbubbles targeted to avb3. Circulation 2003; 108:336-341.
53. Forsberg F, Dicker AP, Thakur ML, et al. Comparing contrast-enhanced ultrasound to immunohistochemical markers of angiogenesis in a human melanoma xenograft model: preliminary results. Ultrasound Med Biol 2002; 28:445-451.
54. Unger EC, McCreery TP, Sweitzer RH, Caldwell V, Wu Y. Acoustically active lipospheres containing paclitaxel: a new therapeutic ultrasound contrast agent. Invest Radiol 1998; 33:886-892.
55. Miller MW. Gene transfection and drug delivery. Ultrasound Med Biol 2000; 26(suppl 1):S59-S62.
56. Unger EC, McCreery TP, Sweitzer RH. Ultrasound enhanced gene expression of liposomal transfection. Invest Radiol 1997; 32:723-727.
57. Price RJ, Kaul S. Contrast ultrasound targeted drug and gene delivery: an update on a new therapeutic modality. J Cardiovasc Pharmacol 2002; 7:171-180.
58. Christiansen J, French BA, Klibanov AL, Kaul S, Lindner JR. Targeted tissue transfection with ultrasound destruction of plasmid-bearing cationic microbubbles. Ultrasound Med Biol 2003; 29:1759-1767.
59. Miller DL, Quddus J. Sonoporation of monolayer cells by diagnostic ultrasound activation of contrast-agent gas bodies. Ultrasound Med Biol 2000; 26:661-667.
60. Price RJ, Skyba DM, Kaul S, Skalak TC. Delivery of colloidal particles and red blood cells to tissue through microvessel ruptures created by targeted microbubble destruction with ultrasound. Circulation 1998; 98:1264-1267.
61. Lundgren CE, Bergoe GW, Tyssebotn I. The theory and application of intravascular microbubbles as an ultra-effective means of transporting oxygen and other gases. Undersea Hyperb Med 2004; 31:105-106.
62. Porter T, Xie F. Ultrasound, microbubbles and thrombolysis. Prog Cardiovasc Dis 2001; 44:101-110.
63. Nanda NC. Echocontrast enhancers: how safe are they? In: Nanda NC, Schlief R (eds). Advances in Echo Imaging Using Contrast Enhancement. Vol 2. Dordrecht, the Netherlands: Kluwer Academic Publishers; 1993:97-100.
64. Feinstein SB, Cheirif J, Ten Cate FJ, et al. Safety and efficacy of a new transpulmonary ultrasound contrast agent: initial multicenter clinical results. J Am Coll Cardiol 1990; 16:316-324.
65. Mattrey RF, Strich G, Shelton RE, et al. Perfluorochemicals as US contrast agents for tumor imaging and hepatosplenomegaly: preliminary clinical results. Radiology 1987; 163:339-343.
66. Mattrey RF. Perfluorocytylbromide: a new contrast agent for CT, sonography and MR imaging. AJR Am J Roentgenol 1989; 152:247-252.
67. Stride E, Saffari N. The potential for thermal damage posed by microbubble ultrasound contrast agents. Ultrasonics 2004; 42:907-913.
68. ter Haar GR. Ultrasonic contrast agents: safety consideration reviewed. Eur J Radiol 2002; 41:217-221.
69. Miller MW, Miller DL, Brayman AA. A review of in vitro bioeffects of inertial ultrasound cavitation from a mechanistic perspective. Ultrasound Med Biol 1996; 22:1131-1154.
70. Guzman HR, Nguyen DX, Khan S, Prausnitz M. Ultrasound-mediated disruption of cell membranes, II: heterogenous effects on cells. J Acoustic Soc Am 2001; 110:597-606.
71. Miller DL, Gies RA. Enhancement of ultrasonically induced hemolysis by perfluorocarbon-based compared to air-based echo-contrast agents. Ultrasound Med Biol 1998; 24:285-292.
72. Miller MW, Everbach EC, Cox C, Knapp RR, Brayman AA, Sherman TA. A comparison of the hemolytic potential of Optison and Albunex in whole human blood in vitro: acoustic pressure, ultrasound frequency, donor and passive cavitation detection considerations. Ultrasound Med Biol 2001; 27:709-721.
73. Miller MW, Brayman AA, Sherman TA, Abramowicz JS, Cox C. Comparative sensitivity of human fetal and adult erythrocytes to hemolysis by pulsed 1 MHz ultrasound. Ultrasound Med Biol 2001; 27:419-425.
74. Miller MW, Battaglia LF. The relevance of cell size on ultrasound-induced hemolysis in mouse and human blood in-vitro. Ultrasound Med Biol 2003; 29:1479-1485.
75. Abramowicz JS, Miller MW, Battaglia LF, Mazza S. Comparative hemolytic effectiveness of 1 MHz ultrasound on human and rabbit blood in vitro. Ultrasound Med Biol 2003; 29:867-873.
76. Tarantal AF, Canfield DR. Ultrasound-induced lung hemorrhage in the monkey. Ultrasound Med Biol 1994; 20:65-72.
77. Dalecky D, Raemen CH, Child SZ, Carstensen EL. Intestinal hemorrhage from exposure to pulsed ultrasound. Ultrasound Med Biol 1995; 21:1067-1072.
78. Wible JH Jr, Galen KP, Wojdyla JK, Hughes MS, Klibanov AL, Brandenburger GH. Microbubbles induce renal hemorrhage when exposed to diagnostic ultrasound in anesthetized rats. Ultrasound Med Biol 2002; 28:1535-1546.
79. Greenleaf WJ, Bolander, Sarkar G, Goldring MB, Greenleaf JF. Artificial cavitation nuclei significantly enhance acoustically induced cell transfection. Ultrasound Med Biol 1998; 24:587-595.
80. Miller P, Nanda NC. Contrast echocardiography: new agents. Ultrasound Med Biol 2004; 30:425-434.
81. Porter TR, Xie F. Clinical experience in the detection of coronary artery disease with myocardial contrast echocardiography. Echocardiography 2002; 19:399-407.
82. Feinstein SB. The powerful microbubble: from bench to bedside, from intravascular indicator to therapeutic delivery system, and beyond. Am J Physiol 2004; 287:H450-H457.
83. Meltzer RS, Serruys PW, Hugenholtz PG, Roelandt J. Intravenous carbon dioxide as an echocardiographic contrast agent. J Clin Ultrasound 1982; 9:127-131.
84. Blomley MJ, Albrecht T, Cosgrove D, et al. Stimulated acoustic emission to image a late liver- and spleen-specific phase of Levovist in normal volunteers and patients with and without liver disease. Ultrasound Med Biol 1999; 25:1341-1352.
85. Eyding J, Wilkening W, Postert T. Brain perfusion and ultrasonic imaging techniques. Eur J Ultrasound 2002; 16:91-104.
86. Nielsen MB, Bang N. Contrast enhanced ultrasound in liver imaging. Eur J Radiol 2004; 51(suppl):S3-S8.
87. Bryant TH, Blomley MJ, Albrecht T, et al. Improved characterization of liver lesions with liver-phase uptake of liver-specific microbubbles: prospective multicenter study. Radiology 2004; 232:799-809.
88. Kedar RP, Cosgrove DO, McCready VR, Bamber JC, Carter ER. Microbubble contrast agent for color Doppler US: effect on breast masses. Radiology 1996; 198:679-686.
89. Baz E, Madjar H, Reuss C, Vetter M, Hackeloer B, Holz K. The role of enhanced Doppler ultrasound in differentiation of benign vs malignant scar lesion after breast surgery for malignancy. Ultrasound Obstet Gynecol 2000; 15:377-382.
90. Aarnink RG, Beelage HP, de la Rosete JJ, Debruyne FM, Wijkstra H. Contrast angiosonography: a technology to improve Doppler ultrasound examinations of the prostate. Eur Urol 1999; 35:9-20.
91. Frauscher F, Klauser A, Halpern EJ, Horninger W, Bartsch G. Detection of prostate cancer with a microbubble ultrasound contrast agent. Lancet 2001; 357:1849-1850.
92. Cosgrove DO. Ultrasound contrast agents. In: Dawson P, Cosgrove DO, Grainger RG (eds). Textbook of Contrast Media. Oxford, England: ISIS Medical Media; 1999:451-587.
93. Goldberg BB, Raichlen JS, Forsberg F (eds). Ultrasound Contrast Agents. 2nd ed. London, England: Martin Dunitz; 2001.
94. Correas GM, Bridal L, Lesavre A, Mejean A, Claudon M, Helenon O. Ultrasound contrast agents: properties, principles of action, tolerance, and artifacts. Eur Radiol 2001; 11:1316-1328.
95. Jakobsen JA. Ultrasound contrast agents: clinical applications. Eur Radiol 2001; 11:1329-1337.
96. Lindner JR. Microbubbles in medical imaging: current applications and future directions. Nat Rev Drug Discov 2004; 3:527-532.
97. Van Roessel J, Wamsteker K, Exalto N. Sonographic investigation of the uterus during artificial uterine cavity distension. J Clin Ultrasound 1987; 15:768-775.
98. Ayida G, Harris P, Kennedy PS, Seif M, Barlow D, Chamberlain P. Hysterosalpingo-contrast sonography (HyCoSy) using Echovist 200 in the outpatient investigation of infertility patients. Br J Radiol 1997; 69:910-913.
99. Strandell A, Bourne T, Bergh C, Granberg S, Asztely M, Thoburn J. The assessment of endometrial pathology and tubal patency: a comparison between the use of ultrasonography and X-ray hysterosalpingography for the investigation of infertility patients. Ultrasound Obstet Gynecol 1999; 14:200-204.
100. Achiron R, Lipitz S, Sivan E, Goldenberg M, Mashiah S. Sonohysterography for ultrasonographic evaluation of tamoxifen-associated cystic thickened endometrium. J Ultrasound Med 1995; 14:685-688.
101. Kazandi M, Aksehirli S, Cirpan T, Akercan F. Transvaginal sonography combined with saline contrast sonohysterography to evaluate the uterine cavity in patients with abnormal uterine bleeding and postmenopausal endometrium more than 5 mm. Eur J Gynaecol Oncol 2003; 24:185-190.
102. Deichert V, van de Sandt M, Lauth G, Daume E. Transvaginal hysterosonography: a new diagnostic procedure for differentiating intrauterine and myometrial findings. Geburtshilfe Frauenheilkd 1988; 48:835-844.
103. Parsons AK, Fleischer AC, Londono JL. Sonohysterography and sonohysterosalpingography: a text atlas of normal and abnormal findings. In: Fleischer AC, Manning FA, Jeanty P, Romero R (eds). Sonography in Obstetrics and Gynecology, Principles and Practice. 6th ed. New York, NY: McGraw-Hill; 2001:1109-1161.
104. Dorn C, Reinsberg J, Willeke C, Wendt A, Van Der Ven H, Schild RL. Three-dimensional power Doppler ultrasound of the subendometrial blood flow under the administration of a contrast agent (Levovist). Arch Gynecol Obstet 2004; 270:94-98.
105. Peterson PG, Keifer WS Jr. Diagnosis of an incompetent cervical os. Trans Pac Coast Obstet Gynecol Soc 1972; 40:43-49.
106. Henrich W, Meckies J, Friedmann W. Demonstration of a recto-vaginal fistula with the ultrasound contrast medium Echovist. Ultrasound Obstet Gynecol 2000; 15:148-149.
107. Reis MM, Soares SR, Cancado ML, Camargos AF. Hysterosalpingo-contrast- sonography (HyCoSy) with SHU 454 (Echovist(r)) for the assessment of tubal patency. Hum Reprod 1998; 13:3049-3056.
108. Richman TS, Viscomi GN, DeCherney A, Polan ML, Alcebo LO. Fallopian tubal patency assessed by ultrasound following fluid injection. Radiology 1984; 152:507-510.
109. Boudghene FP, Bazot M, Robert Y, et al. Assessment of fallopian tube patency by HyCoSy: comparison of a positive contrast agent with saline solution. Ultrasound Obstet Gynecol 2001; 18:525-530.
110. Prefumo F, Serafini G, Martinoli C, Gandolfo N, Gandolfo NG, Derchi LE. The sonographic evaluation of tubal patency with stimulated acoustic emission imaging. Ultrasound Obstet Gynecol 2002; 20:386-389.
111. Holte J, Rasmussen C, Morris H. First clinical experience with sonicated human serum albumin (Albunex) as an intrafallopian ultrasound contrast medium. Ultrasound Obstet Gynecol 1995; 6:62-65.
112. Albayram F, Hamper UM. Ovarian and adnexal torsion: spectrum of sonographic findings with pathologic correlation. J Ultrasound Med 2001; 20:1083-1089.
113. Pena JE, Ufberg D, Looney N, Denis AL. Usefulness of Doppler sonography in the diagnosis of ovarian torsion. Fertil Steril 2000; 73:1047-1050.
114. Coley BD, Frush DP, Babcock DS, et al. Acute testicular torsion: comparison of unenhanced and contrast-enhanced power Doppler ultrasound, color ultrasound and radionuclide imaging. Radiology 1996; 199:441-446.
115. Ahmedin J, Murray T, Samuels A, Ghafoor A, Ward E, Thun MJ. Cancer statistics. CA Cancer J Clin 2003; 53:5-26.
116. de la Rosette JJ, Aarnink RG. New developments in ultrasonography for the detection of prostate cancer. J Endourol 2001; 15:93-104.
117. Fleischer AC, Rogers WH, Kepple DM, Williams LL, Jones HW III. Color Doppler sonography of ovarian masses: a multiparameter analysis. J Ultrasound Med 1993; 12:41-48.
118. Fleischer AC. New developments in the sonographic assessment of ovarian, uterine, and breast vascularity. Semin Ultrasound CT MR 2001; 22:42-49.
119. Suren A, Osmers R, Kulenkampff D, Kuhn W. Visualization of blood flow in small ovarian tumor vessels by transvaginal color Doppler sonography after echo enhancement with injection of Levovist. Gynecol Obstet Invest 1994; 38:210-212.
120. Szymanski M, Szymanski W, Grabiec M, Korenkiewicz J. Evaluation of Levovist in the differential diagnosis of ovarian tumors [in Polish]. Ginekol Pol 1999; 70:444-449.
121. Kupesic S, Kurjak A. Contrast-enhanced, three-dimensional power Doppler sonography for differentiation of adnexal masses. Obstet Gynecol 2000; 96:452-458.
122. Orden MR, Gudmunson S, Kirkinen PP. Contrast-enhanced sonography in the examination of benign and malignant adnexal masses. J Ultrasound Med 2000; 19:783-788.
123. Orden MR, Jurvelin JS, Kirkinen PP. Kinetics of a US contrast agent in benign and malignant adnexal tumors. Radiology 2003; 226:405-410.
124. Marret H, Sauget S, Giraudeau B, et al. Contrast-enhanced sonography helps discrimination of benign from malignant adnexal masses. J Ultrasound Med 2004; 23:1629-1639.
125. Turetschek K, Huber S, Floyd E, et al. MR imaging characterization of microvessels in experimental breast tumors by using a particulate contrast agent with histopathologic correlation. Radiology 2001; 218:562-569.
126. Schirner M, Menrad A, Stephens A, Frenzel T, Hauff P, Licha K. Molecular imaging of tumor angiogenesis. Ann NY Acad Sci 2004; 1014:67-75.
127. Costouros NG, Diehn FE, Libutti SK. Molecular imaging of tumor angiogenesis. J Cell Biochem 2002; 39(suppl):72-78.
128. Feleppa EJ, Alam SK, Deng CX. Emerging ultrasound technologies for early markers of disease. Dis Markers 2002; 18:249-268.
129. Hata K, Miyazaki K. Color Doppler imaging and angiogenesis in ovarian tumors. Med Electron Microsc 2003; 36:127-130.
130. Hibbs K, Skubitz KM, Pambuccian SE, et al. Differential gene expression in ovarian carcinoma: identification of potential biomarkers. Am J Pathol 2004; 165:397-414.
131. Dijkmans PA, Juffermans LJ, Musters RJ, et al. Microbubbles and ultrasound: from diagnosis to therapy. Eur J Echocardiogr 2004; 5:245-256.
132. Unger EC, Porter T, Culp W, Labell R, Matsunaga T, Zutshi R. Therapeutic applications of lipid-coated microbubbles. Adv Drug Deliv Rev 2004; 56:1291-1314.
133. Casado E, Nettelbeck DM, Navarro J, et al. Transcriptional targeting for ovarian cancer gene therapy. Gynecol Oncol 2001; 82:229-237.
134. Lee MJ, Cho SS, You JR, et al. Intraperitoneal gene delivery mediated by a novel cationic liposome in a peritoneal disseminated ovarian cancer model. Gene Ther 2002; 9:859-866.
135. Phillips WT, Medina LA, Klipper R, Goins B. A novel approach for the increased delivery of pharmaceutical agents to peritoneum and associated lymph nodes. J Pharmacol Exp Ther 2002; 303:11-16.
136. Daw E. Amniography and fetography: old diagnostic aides-new uses. Clin Exp Obstet Gynecol 1986; 13:10-11.
137. Mennuti MT, Moranz JG, Schwarz RH, Melman WJ. Amniography for the early detection of neural tube defects. Obstet Gynecol 1977; 49:25-30.
138. Pearce JM, Frisk NM, Rodeck CH. Operative management of abnormalities of amniotic fluid volume. In: Chervenack FA, Isaacson GC, Campbell S (eds). Ultrasound in Obstetrics and Gynecology. Boston, MA: Little Brown & Co; 1993:1357-1360.
139. Schmiedl UP, Komarniski K, Winter TC, et al. Assessment of fetal and placental blood flow in primates using contrast enhanced ultrasonography. J Ultrasound Med 1998; 17:75-80.
140. Simpson NA, Nimrod C, De Vermette R, Leblanc C, Fournier J. Sonographic evaluation of intervillous flow in early pregnancy: use of echo-enhancement agents. Ultrasound Obstet Gynecol 1998; 11:204-208.
141. Grüssner S, Klingmüller V, Bohle R. Increased signal intensity of velocity measurements in duplex sonography by using the contrast agent Levovist: a prospective, randomized study in a fetal sheep model [in German]. ROFO Fortschr Geb Rontgenstr Nuklearmed 2004; 10:91-97.
142. Ragavendra N, Tarantal AF. Intervillous blood flow in the third trimester gravid rhesus monkey (Macaca mulatto): use of a sonographic contrast agent and harmonic imaging. Placenta 2001; 22:200-205.
143. Abramowicz JS, Pillips DB, Jessee LN, Levene H, Parker KJ, Miller RK. Sonographic investigation of flow patterns in the perfused human placenta and their modulation by vasoactive agents with enhanced visualization by the ultrasound contrast agent Albunex. J Clin Ultrasound 1999; 27:513-522.
144. Jauniaux E, Greenwold N, Hempstock J, Burton GJ. Comparison of ultrasonographic and Doppler mapping of the intervillous circulation in normal and abnormal early pregnancies. Fertil Steril 2003; 79:100-106.
145. Orden MR, Gudmundsson S, Helin HL, Kirkinen PP. Intravascular contrast agent in the ultrasonography of ectopic pregnancy. Ultrasound Obstet Gynecol 1999; 14:348-352.
146. Kirkinen P, Helin-Martikainen HL, Vanninen R, Partanen K. Placenta accreta: imaging by gray-scale and contrast-enhanced color Doppler sonography and magnetic resonance imaging. J Clin Ultrasound 1998; 26:90-94.
147. Denbow ML, Welsch AW, Taylor MJ, Hammal DM, Fisk NM. Twin fetuses: intravascular microbubble ultrasound contrast agent administration-early experience. Radiology 2000; 214:724-728.
148. van der Wouw P, Brauns AC, Bailey SE, Powers JE, Wilde AAA. Premature ventricular contractions during triggered imaging with ultrasound contrast. J Am Soc Echocardiogr 2000; 13:288-294.
149. Orden MR, Leinonen M, Kirkinen P. Contrast-enhanced ultrasonography of uteroplacental circulation does not evoke harmful CTG changes or perinatal events. Fetal Diagn Ther 2000; 15:139-145.
150. Robbin ML. Ultrasound contrast agents: a promising future. Radiol Clin North Am 2001; 39:399-414.
151. Barr R. Seeking consensus: contrast ultrasound in radiology. Eur J Radiol 2002; 41:207-216.