Comparing contrast-enhanced ultrasound to immunohistochemical markers of angiogenesis in a human melanoma xenograft model: Preliminary results

Ultrasound in Medicine and Biology

Volumn 28, Issue 4, 2002, Pages 445-451

  Forsberg, Flemming ^a   Dicker, Adam P ^a   Thakur, Mathew L ^a   Rawool, Nandkumar M ^a   Liu, Ji Bin ^a   Shi, William T ^a   Nazarian, Levon N ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Angiogenesis; Melanoma; Murine xenograft model; Ultrasound contrast agent

Indexed keywords

CELLS; DOPPLER EFFECT; IMMUNOLOGY; IMPLANTS (SURGICAL); REGRESSION ANALYSIS; SURGERY; TUMORS;

NEOVASCULARITY;

ULTRASONIC IMAGING;

BASIC FIBROBLAST GROWTH FACTOR; CYCLOOXYGENASE 2; FS 069; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LINE; COMPUTED TOMOGRAPHY SCANNER; CONTRAST ENHANCEMENT; CONTROLLED STUDY; CORRELATION ANALYSIS; DOPPLER FLOWMETRY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LINEAR REGRESSION ANALYSIS; MELANOMA; MELANOMA CELL; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STATISTICAL ANALYSIS; THIGH; ULTRASOUND; XENOGRAFT;

ALBUMINS; ANIMALS; CONTRAST MEDIA; CYCLOOXYGENASE 2; FLUOROCARBONS; ISOENZYMES; MELANOMA, EXPERIMENTAL; MICE; MICE, NUDE; MODELS, ANIMAL; NEOVASCULARIZATION, PATHOLOGIC; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; REGRESSION ANALYSIS; THIGH; TUMOR MARKERS, BIOLOGICAL; ULTRASONOGRAPHY, DOPPLER; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0036277695     PISSN: 03015629     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-5629(02)00482-9     Document Type: Article

References (45)

1. B-mode enhancement using phase-inversion US with air-based microbubble contrast agent: Initial experience in humans
2. Multiple significance tests: The Bonferroni method
3. Quantitative morphometric analysis of the microcirculation in prostate carcinoma
4. Assessment of myocardial perfusion by intermittent harmonic power Doppler using SonoVue, a new ultrasound contrast agent
5. Development of surrogate markers of response for antiangiogenic therapies utilizing non-invasive and invasive assessments of tumor angiogenesis (Abstr.)
6. Breast tumor vascularity identified by contrast enhanced ultrasound and pathology: Initial results
7. Higher harmonics of vibrating gas-filled microspheres. Part one: Simulations
8. Higher harmonics of vibrating gas-filled microspheres. Part two: Measurements
9. Expression of cyclooxygenase 2 in human malignant melanoma
10. Inhibition of basic fibroblast growth factor expression, angiogenesis, and growth of human bladder carcinoma in mice by systemic interferon-alpha administration
11. Quantified power Doppler US of tumor blood flow correlates with microscopic quantification of tumor blood vessels
12. Evaluation of tumor angiogenesis with US: Imaging, Doppler and contrast agents
13. Angiogenic heterogeneity: Regulation of neoplastic angiogenesis by the organ microenvironment
14. Sonographic depiction of tumor vascularity and flow from in vivo models to clinical applications
15. Quantified color Doppler sonography of tumor vascularity in an animal model
16. What is the evidence that tumors are angiogenesis dependent?
17. The logic of anti-angiogenic gene therapy
18. Isolation of a tumor factor responsible for angiogenesis
19. On the feasibility of real-time, in vivo harmonic imaging with proteinaceous microspheres
20. Comparison of fundamental and wideband harmonic contrast imaging of liver tumors
21. Clinical applications of ultrasound contrast agents
22. Does the mechanical index predict destruction rates for contrast microbubbles?
23. Angiogenesis as a diagnostic factor in primary breast cancer: Microvessel quantitation by stereological methods and correlation with color Doppler sonography
24. Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression
25. Pulse inversion Doppler: A new method for detecting nonlinear echoes from microbubble contrast agents
26. Determination of tumor blood flow: A review
27. Microcirculation of cutaneous melanoma in German
28. Role of cyclooxygenases in angiogenesis
29. Augmenting of tumor uptake of anti-melanoma antibody MEM136: Influence of interferon
30. Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors
31. Vascular endothelial growth factor (VEGF) in human breast cancer: Correlation with disease-free survival
32. What's wrong with Bonferroni adjustments
33. Transient myocardial contrast after initial exposure to diagnostic ultrasound pressures with minute doses of intravenously injected microbubbles
34. Factors influencing the neovascularization of experimental tumours
35. Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis
36. Sonographic evaluation of orthotopic bladder tumors in mice treated with TNP-470, an angiogenesis inhibitor
37. Evaluating power Doppler ultrasound as a method for clinical monitoring of tumor antiangiogenic therapy
38. Tumour angiogenesis
39. Tumor vascularization in experimental melanomas: Correlation between unenhanced and contrast enhanced power Doppler imaging and histological grading
40. Blood flow compared in benign melanocytic naevi, malignant melanomas and basal cell carcinomas
41. Cutaneous blood flow measurements for the detection of malignancy in pigmented skin lesions
42. The inverse relationship between microvessel counts and tumor volume in breast cancer
43. Tumor angiogenesis: A new significant and independent prognostic indicator in early-stage breast cancer
44. Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma
45. Invasive carcinoma and fibroadenomas of the breast: Comparison of microvessel distributions - Implications for imaging modalities