APS, an adaptor molecule containing PH and SH2 domains, has a negative regulatory role in B cell proliferation

Biochemical and Biophysical Research Communications

Volumn 330, Issue 3, 2005, Pages 1005-1013

  Iseki, Masanori ^a   Kubo Akashi, Chiyomi ^a   Kwon, Sang Mo ^a   Yamaguchi, Akiko ^a   Takatsu, Kiyoshi ^a   Takaki, Satoshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Adaptor protein; B cell receptor; Cytoskeleton; Signal transduction; Transgenic mice

Indexed keywords

ACTIN; ADAPTOR PROTEIN; B LYMPHOCYTE RECEPTOR; MITOGENIC AGENT; PROTEIN APS; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CELL LINEAGE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CROSS LINKING; CYTOSKELETON; GENE ACTIVATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PERITONEAL CAVITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SPLEEN; TRANSGENE;

EID: 16244423339     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.03.073     Document Type: Article

References (39)

1. A.L. DeFranco The complexity of signaling pathways activated by the BCR Curr. Opin. Immunol. 9 1997 296 308
2. M. Yokouchi, R. Suzuki, M. Masuhara, S. Komiya, A. Inoue, and A. Yoshimura Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor Oncogene 15 1997 7 15
3. M. Iseki, S. Takaki, and K. Takatsu Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins Biochem. Biophys. Res. Commun. 272 2000 45 54
4. S. Takaki, K. Sauer, B.M. Iritani, S. Chien, Y. Ebihara, K. Tsuji, K. Takatsu, and R.M. Perlmutter Control of B cell production by the adaptor protein Lnk: definition of a conserved family of signal-modulating proteins Immunity 13 2000 599 609
5. M.A. Osborne, S. Dalton, and J.P. Kochan The yeast tribrid system: genetic detection of trans-phosphorylated ITAM-SH2-interactions Biotechnology 13 1995 1474 1478
6. S. Takaki, H. Morita, Y. Tezuka, and K. Takatsu Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk J. Exp. Med. 195 2002 151 160
7. S. Takaki, Y. Tezuka, K. Sauer, C. Kubo, S.M. Kwon, E. Armstead, K. Nakao, M. Katsuki, R.M. Perlmutter, and K. Takatsu Impaired lymphopoiesis and altered B cell subpopulations in mice overexpressing Lnk adaptor protein J. Immunol. 170 2003 703 710
8. S. Ohtsuka, S. Takaki, M. Iseki, K. Miyoshi, N. Nakagata, Y. Kataoka, N. Yoshida, K. Takatsu, and A. Yoshimura SH2-B is required for both male and female reproduction Mol. Cell. Biol. 22 2002 3066 3077
9. J. Herrington, M. Diakonova, L. Rui, D.R. Gunter, and C. Carter-Su SH2-B is required for growth hormone-induced actin reorganization J. Biol. Chem. 275 2000 13126 13133
10. M. Diakonova, D.R. Gunter, J. Herrington, and C. Carter-Su SH2-Bβ is a Rac-binding protein that regulates cell motility J. Biol. Chem. 277 2002 10669 10677
11. X. Qian, A. Riccio, Y. Zhang, and D.D. Ginty Identification and characterization of novel substrates of Trk receptors in developing neurons Neuron 21 1998 1017 1029
12. S.A. Moodie, J. Alleman-Sposeto, and T.A. Gustafson Identification of the APS protein as a novel insulin receptor substrate J. Biol. Chem. 274 1999 11186 11193
13. M. Iseki, C. Kubo, S.M. Kwon, A. Yamaguchi, Y. Kataoka, N. Yoshida, K. Takatsu, and S. Takaki Increased numbers of B-1 cells and enhanced responses against TI-2 antigen in mice lacking APS, an adaptor molecule containing PH and SH2 domains Mol. Cell. Biol. 24 2004 2243 2250
14. A. Minami, M. Iseki, K. Kishi, M. Wang, M. Ogura, N. Furukawa, S. Hayashi, M. Yamada, T. Obata, Y. Takeshita, Y. Nakaya, Y. Bando, K. Izumi, S.A. Moodie, F. Kajiura, M. Matsumoto, K. Takatsu, S. Takaki, and Y. Ebina Increased insulin sensitivity and hypoinsulinemia in APS knockout mice Diabetes 52 2003 2657 2665
15. B.M. Iritani, K.A. Forbush, M.A. Farrar, and R.M. Perlmutter Control of B cell development by Ras-mediated activation of Raf EMBO J. 16 1997 7019 7031
16. H. Kaku, K. Horikawa, Y. Obata, I. Kato, H. Okamoto, N. Sakaguchi, S. Gerondakis, and K. Takatsu NF-κB is required for CD38-mediated induction of Cγ1 germline transcripts in murine B lymphocytes Int. Immunol. 14 2002 1055 1064
17. X. He, Y. Li, J. Schembri-King, S. Jakes, and J. Hayashi Identification of actin binding protein, ABP-280, as a binding partner of human Lnk adaptor protein Mol. Immunol. 37 2000 603 612
18. S. Gerondakis, and A. Strasser The role of Rel/NF-κB transcription factors in B lymphocyte survival Semin. Immunol. 15 2003 159 166
19. M. Yokouchi, T. Wakioka, H. Sakamoto, H. Yasukawa, S. Ohtsuka, A. Sasaki, M. Ohtsubo, M. Valius, A. Inoue, S. Komiya, and A. Yoshimura APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis Oncogene 18 1999 759 767
20. T. Wakioka, A. Sasaki, K. Mitsui, M. Yokouchi, A. Inoue, S. Komiya, and A. Yoshimura APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl Leukemia 13 1999 760 767
21. Z. Ahmed, B.J. Smith, and T.S. Pillay The APS adapter protein couples the insulin receptor to the phosphorylation of c-Cbl and facilitates ligand-stimulated ubiquitination of the insulin receptor FEBS Lett. 475 2000 31 34
22. N. Yabana, and M. Shibuya Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity Oncogene 21 2002 7720 7729
23. F. Melchers, E. ten Boekel, T. Seidl, X.C. Kong, T. Yamagami, K. Onishi, T. Shimizu, A.G. Rolink, and J. Andersson Repertoire selection by pre-B-cell receptors and B-cell receptors, and genetic control of B-cell development from immature to mature B cells Immunol. Rev. 175 2000 33 46
24. T. Kurosaki Regulation of B cell fates by BCR signaling components Curr. Opin. Immunol. 14 2002 341 347
25. K. Hayakawa, M. Asano, S.A. Shinton, M. Gui, L.J. Wen, J. Dashoff, and R.R. Hardy Positive selection of anti-thy-1 autoreactive B-1 cells and natural serum autoantibody production independent from bone marrow B cell development J. Exp. Med. 197 2003 87 99
26. X. Qian, and D.D. Ginty SH2-B and APS are multimeric adapters that augment TrkA signaling Mol. Cell. Biol. 21 2001 1613 1620
27. H.W. Sohn, H. Gu, and S.K. Pierce Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk J. Exp. Med. 197 2003 1511 1524
28. N. Rao, A.K. Ghosh, S. Ota, P. Zhou, A.L. Reddi, K. Hakezi, B.K. Druker, J. Wu, and H. Band The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation EMBO J. 20 2001 7085 7095
29. G.M. Doody, S.E. Bell, E. Vigorito, E. Clayton, S. McAdam, R. Tooze, C. Fernandez, I.J. Lee, and M. Turner Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation Nat. Immunol. 2 2001 542 547
30. K. Tedford, L. Nitschke, I. Girkontaite, A. Charlesworth, G. Chan, V. Sakk, M. Barbacid, and K.D. Fischer Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling Nat. Immunol. 2 2001 548 555
31. K. Fujikawa, A.V. Miletic, F.W. Alt, R. Faccio, T. Brown, J. Hoog, J. Fredericks, S. Nishi, S. Mildiner, S.L. Moores, J. Brugge, F.S. Rosen, and W. Swat Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells J. Exp. Med. 198 2003 1595 1608
32. K. Inabe, M. Ishiai, A.M. Scharenberg, N. Freshney, J. Downward, and T. Kurosaki Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation J. Exp. Med. 195 2002 189 200
33. A. Wilcox, K.D. Katsanakis, F. Bheda, and T.S. Pillay Asb6, an Adipocyte-specific Ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex J. Biol. Chem. 279 2004 38881 38888
34. W.S. Alexander, and D.J. Hilton The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response Annu. Rev. Immunol. 22 2004 503 529
35. I. Melamed, G.P. Downey, K. Aktories, and C.M. Roifman Microfilament assembly is required for antigen-receptor-mediated activation of human B lymphocytes J. Immunol. 147 1991 1139 1146
36. I. Melamed, and E.W. Gelfand Microfilament assembly is involved in B-cell apoptosis Cell. Immunol. 194 1999 136 142
37. C. Kubo-Akashi, M. Iseki, S.M. Kwon, H. Takizawa, K. Takatsu, and S. Takaki Roles of a conserved family of adaptor proteins, Lnk, SH2-B, and APS, for mast cell development, growth, and functions: APS-deficiency causes augmented degranulation and reduced actin assembly Biochem. Biophys. Res. Commun. 315 2004 356 362
38. N. Ramesh, I.M. Anton, J.H. Hartwig, and R.S. Geha WIP, a protein associated with Wiskott-Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells Proc. Natl. Acad. Sci. USA 94 1997 14671 14676
39. I.M. Anton, M.A. de la Fuente, T.N. Sims, S. Freeman, N. Ramesh, J.H. Hartwig, M.L. Dustin, and R.S. Geha WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation Immunity 16 2002 193 204