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Volumn 31, Issue 2, 2005, Pages 191-202

Discovery of a perinecrotic 60 kDa MDM2 isoform within glioma spheroids and glioblastoma biopsy material

Author keywords

Glioblastoma; MDM2; Necrosis; p53; Spheroid

Indexed keywords

PROTEIN BAX; PROTEIN MDM2; PROTEIN P53;

EID: 15944399340     PISSN: 03051846     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2990.2004.00627.x     Document Type: Article
Times cited : (4)

References (29)
  • 2
    • 0030746401 scopus 로고    scopus 로고
    • Apoptosis and carcinogenesis
    • Wyllie AH. Apoptosis and carcinogenesis. Eur J Cell Biol 1997; 73: 189-97
    • (1997) Eur J Cell Biol , vol.73 , pp. 189-197
    • Wyllie, A.H.1
  • 3
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner MO. The biochemistry of apoptosis. Nature 2000; 407: 770-6
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 4
    • 0034708458 scopus 로고    scopus 로고
    • Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
    • Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM. Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J Biol Chem 2000; 275: 8945-51
    • (2000) J Biol Chem , vol.275 , pp. 8945-8951
    • Fang, S.1    Jensen, J.P.2    Ludwig, R.L.3    Vousden, K.H.4    Weissman, A.M.5
  • 5
    • 0027196974 scopus 로고
    • Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations
    • Reifenberger G, Liu L, Ichimura K, Schmidt EE, Collins VP. Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res 1993; 53: 2736-9
    • (1993) Cancer Res , vol.53 , pp. 2736-2739
    • Reifenberger, G.1    Liu, L.2    Ichimura, K.3    Schmidt, E.E.4    Collins, V.P.5
  • 7
    • 0029908244 scopus 로고    scopus 로고
    • Preferential expression of Fas/APO1 (CD95) and apoptotic cell death in perinecrotic cells of glioblastoma multiforme
    • Tachibana O, Lampe J, Kleihues P, Ohgaki H. Preferential expression of Fas/APO1 (CD95) and apoptotic cell death in perinecrotic cells of glioblastoma multiforme. Acta Neuropathol 1996; 92: 431-4
    • (1996) Acta Neuropathol , vol.92 , pp. 431-434
    • Tachibana, O.1    Lampe, J.2    Kleihues, P.3    Ohgaki, H.4
  • 9
    • 0034213146 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor 1alpha in brain tumors, association with angiogenesis, invasion, and progression
    • Zagzag D, Zhong H, Scalzitti JM, Laughner E, Simons JW, Semenza GL. Expression of hypoxia-inducible factor 1alpha in brain tumors, association with angiogenesis, invasion, and progression. Cancer 2000; 88: 2606-18
    • (2000) Cancer , vol.88 , pp. 2606-2618
    • Zagzag, D.1    Zhong, H.2    Scalzitti, J.M.3    Laughner, E.4    Simons, J.W.5    Semenza, G.L.6
  • 10
    • 0034524833 scopus 로고    scopus 로고
    • Expression of poly(ADP-ribose) polymerase and distribution of poly(ADP-ribosyl)ation in glioblastoma and in a glioma multicellular tumour spheroid model
    • Wharton SB, McNelis U, Bell HS, Whittle IR. Expression of poly(ADP-ribose) polymerase and distribution of poly(ADP-ribosyl)ation in glioblastoma and in a glioma multicellular tumour spheroid model. Neuropathol Appl Neurobiol 2000; 26: 528-35
    • (2000) Neuropathol Appl Neurobiol , vol.26 , pp. 528-535
    • Wharton, S.B.1    McNelis, U.2    Bell, H.S.3    Whittle, I.R.4
  • 11
    • 0034878927 scopus 로고    scopus 로고
    • The development of necrosis and apoptosis in glioma: Experimental findings using spheroid culture systems
    • Bell HS, Whittle IR, Walker M, Leaver HA, Wharton SB. The development of necrosis and apoptosis in glioma: experimental findings using spheroid culture systems. Neuropathol Appl Neurobiol 2001; 27: 291-304
    • (2001) Neuropathol Appl Neurobiol , vol.27 , pp. 291-304
    • Bell, H.S.1    Whittle, I.R.2    Walker, M.3    Leaver, H.A.4    Wharton, S.B.5
  • 12
    • 0034328531 scopus 로고    scopus 로고
    • Tumor biology and experimental therapeutics
    • Mueller-Klieser W. Tumor biology and experimental therapeutics. Crit Rev Oncol Hematol 2000; 36: 123-39
    • (2000) Crit Rev Oncol Hematol , vol.36 , pp. 123-139
    • Mueller-Klieser, W.1
  • 13
    • 0030883774 scopus 로고    scopus 로고
    • Implantation of C6 astrocytoma spheroid into collagen type I gels: Invasive, proliferatlve, and enzymatic characterisations
    • Tamaki M, McDonald W, Amberger VR, Moore E. Del Maestro RF. Implantation of C6 astrocytoma spheroid into collagen type I gels: invasive, proliferatlve, and enzymatic characterisations. J Neurosurg 1997; 87: 602-9
    • (1997) J Neurosurg , vol.87 , pp. 602-609
    • Tamaki, M.1    McDonald, W.2    Amberger, V.R.3    Moore, E.4    Del Maestro, R.F.5
  • 14
    • 0032977124 scopus 로고    scopus 로고
    • Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines
    • Ishii N, Maier D, Merlo A, Tada M, Sawamura Y. Diserens AC, Van Meir EG. Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines. Brain Pathol 1999; 9: 469-79
    • (1999) Brain Pathol , vol.9 , pp. 469-479
    • Ishii, N.1    Maier, D.2    Merlo, A.3    Tada, M.4    Sawamura, Y.5    Diserens, A.C.6    Van Meir, E.G.7
  • 15
    • 0032931517 scopus 로고    scopus 로고
    • The p53 pathway
    • Prives C, Hall PA. The p53 pathway. J Pathol 1999; 187: 112-26
    • (1999) J Pathol , vol.187 , pp. 112-126
    • Prives, C.1    Hall, P.A.2
  • 16
    • 0034671945 scopus 로고    scopus 로고
    • Oncogenic mutations of the p53 tumor suppressor: The demons of the guardian of the genome
    • Sigal A, Rotter V. Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome. Cancer Res 2000; 60: 6788-93
    • (2000) Cancer Res , vol.60 , pp. 6788-6793
    • Sigal, A.1    Rotter, V.2
  • 18
    • 0033578066 scopus 로고    scopus 로고
    • Mutant p53 proteins stimulate spontaneous and radiation-induced intrachromosomal homologous recombination independently of the alteration of the transactivation activity and of the G1 checkpoint
    • Saintigny Y, Rouillard D, Chaput B, Soussi T, Lopez BS. Mutant p53 proteins stimulate spontaneous and radiation-induced intrachromosomal homologous recombination independently of the alteration of the transactivation activity and of the G1 checkpoint. Oncogene 1999; 18: 3553-63
    • (1999) Oncogene , vol.18 , pp. 3553-3563
    • Saintigny, Y.1    Rouillard, D.2    Chaput, B.3    Soussi, T.4    Lopez, B.S.5
  • 19
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt Y, Maya R, Kazaz A, Oren M. Mdm2 promotes the rapid degradation of p53. Nature 1997; 387: 296-9
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 21
    • 0032520932 scopus 로고    scopus 로고
    • Differential regulation of cyclin-dependent kinase inhibitors in monolayer and spheroid cultures of tumorigenic and nontumorigenic fibroblasts
    • LaRue KE, Bradbury EM, Freyer JP. Differential regulation of cyclin-dependent kinase inhibitors in monolayer and spheroid cultures of tumorigenic and nontumorigenic fibroblasts. Cancer Res 1998; 58: 1305-14
    • (1998) Cancer Res , vol.58 , pp. 1305-1314
    • LaRue, K.E.1    Bradbury, E.M.2    Freyer, J.P.3
  • 22
    • 0032572526 scopus 로고    scopus 로고
    • E-cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27(KIP1)
    • St Croix B, Sheehan C, Rak JW, Florenes VA, Slingerland JM, Kerbel RS. E-Cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27(KIP1). J Cell Biol 1998; 142: 557-71
    • (1998) J Cell Biol , vol.142 , pp. 557-571
    • St. Croix, B.1    Sheehan, C.2    Rak, J.W.3    Florenes, V.A.4    Slingerland, J.M.5    Kerbel, R.S.6
  • 24
    • 0032548105 scopus 로고    scopus 로고
    • A 60 kd MDM2 isoform is produced by caspase cleavage in non-apoptotic tumor cells
    • Pochampally R, Fodera B, Chen L, Shao W, Levine EA, Chen J. A 60 kd MDM2 isoform is produced by caspase cleavage in non-apoptotic tumor cells. Oncogene 1998; 17: 2629-36
    • (1998) Oncogene , vol.17 , pp. 2629-2636
    • Pochampally, R.1    Fodera, B.2    Chen, L.3    Shao, W.4    Levine, E.A.5    Chen, J.6
  • 25
    • 0034711218 scopus 로고    scopus 로고
    • Mdm2 inhibits the apoptotic function of p53 mainly by targeting It for degradation
    • Yap DB, Hsieh JK, Lu X. Mdm2 inhibits the apoptotic function of p53 mainly by targeting It for degradation. J Biol Chem 2000; 275: 37296-302
    • (2000) J Biol Chem , vol.275 , pp. 37296-37302
    • Yap, D.B.1    Hsieh, J.K.2    Lu, X.3
  • 26
    • 0029913730 scopus 로고    scopus 로고
    • Mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein
    • Chen J, Wu X, Lin J, Levine AJ. Mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol Cell Biol 1996; 16: 2445-52
    • (1996) Mol Cell Biol , vol.16 , pp. 2445-2452
    • Chen, J.1    Wu, X.2    Lin, J.3    Levine, A.J.4
  • 28
    • 0031992159 scopus 로고    scopus 로고
    • E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2
    • Kowalik TF, DeGregori J, Leone G, Jakoi L, Nevins JR. E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2. Cell Growth Differ 1998; 9: 113-8
    • (1998) Cell Growth Differ , vol.9 , pp. 113-118
    • Kowalik, T.F.1    DeGregori, J.2    Leone, G.3    Jakoi, L.4    Nevins, J.R.5
  • 29
    • 0034463211 scopus 로고    scopus 로고
    • The MDM2 oncoprotein promotes apoptosis in p53-deficient human medullary thyroid carcinoma cells
    • Dilla T, Velasco JA, Medina DL, Gonzalez-Palacios JF, Santisteban P. The MDM2 oncoprotein promotes apoptosis in p53-deficient human medullary thyroid carcinoma cells. Endocrinology 2000; 141: 420-9
    • (2000) Endocrinology , vol.141 , pp. 420-429
    • Dilla, T.1    Velasco, J.A.2    Medina, D.L.3    Gonzalez-Palacios, J.F.4    Santisteban, P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.