Association of the interleukin-1 receptor antagonist gene with asthma

American Journal of Respiratory and Critical Care Medicine

Volumn 169, Issue 11, 2004, Pages 1217-1223

  Gohlke, Henning ^b   Illig, Thomas ^b   Bahnweg, Margret ^b   Klopp, Norman ^b   André, Elisabeth ^b   Altmüller, Janine ^b   Herbon, Nicole ^b   Werner, Monika ^b   Knapp, Michael ^b   Pescollderungg, Lydia ^b   Boner, Attilio ^b   Malerba, Giovanni ^b   Pignatti, Pier Franco ^b   Wjst, Matthias ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b NONE

Author keywords

Association; Asthma; IL1RN; Single nucleotide polymorphisms

Indexed keywords

CYTOKINE; DNA; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT;

ARTICLE; ASTHMA; CHILD; CONTROLLED STUDY; FAMILY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE SEQUENCE; GENETIC CODE; GENETIC VARIABILITY; GERMANY; HAPLOTYPE; HUMAN; INFLAMMATION; ITALY; MALE; MARKER GENE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 2542483648     PISSN: 00030805     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.200302-281oc     Document Type: Article

References (50)

1. Asher MI, Keil U, Anderson HR, Beasley R, Crane J, Martinez F, Mitchell EA, Pearce N, Sibbald B, Stewart AW, et al. International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods. Eur Respir J 1995;8:483-491.
2. Palmer LJ, Cookson WO. Genomic approaches to understanding asthma. Genome Res 2000;10:1280-1287.
3. Los H, Postmus PE, Boomsma DI. Asthma genetics and intermediate phenotypes: a review from twin studies. Twin Res 2001;4:81-93.
4. European Community Respiratory Health Survey Group. Genes for asthma? An analysis of the European Community Respiratory Health Survey. Am J Respir Crit Care Med 1997;156:1773-1780.
5. Hakonarson H, Wjst M. Current concepts on the genetics of asthma. Curr Opin Pediatr 2001;13:267-277.
6. Wjst M, Fischer G, Immervoll T, Jung M, Saar K, Rueschendorf F, Reis A, Ulbrecht M, Gomolka M, Weiss EH, et al. German Asthma Genetics Group. A genome-wide search for linkage to asthma. Genomics 1999;58:1-8.
7. Immervoll T, Loesgen S, Dutsch G, Gohlke H, Herbon N, Klugbauer S, Dempfle A, Bickeboller H, Becker-Follmann J, Ruschendorf F, et al. Fine mapping and single nucleotide polymorphism association results of candidate genes for asthma and related phenotypes. Hum Mutat 2001;18:327-336.
8. Collaborative Study on the Genetics of Asthma. A genome-wide search for asthma susceptibility loci in ethnically diverse populations. Nat Genet 1997;15:389-392.
9. Bhattacharyya S, Leaves NI, Abecasis GR, Moffatt MF, Danils SE, Musk AW, Lathrop GM, Cookson WO. Linkage of asthma and associated phenotypes to the interleukin 1 cluster on human chromosome 2q13. In: Human Genome Meeting: meeting programme and abstract book, Turin, Italy, March 1998. London: Human Genome Organisation; 1998. p. 5.
10. Xu X, Fang Z, Wang B, Chen C, Guang W, Jin Y, Yang J, Lewitzky S, Aelony A, Parker A, et al. A genomewide search for quantitative-trait loci underlying asthma. Am J Hum Genet 2001;69:1271-1277.
11. Haagerup A, Bjerke T, Schoitz PO, Binderup HG, Dahl R, Kruse TA. Allergic rhinitis: a total genome-scan for susceptibility genes suggests a locus on chromosome 4q24-q27. Eur J Hum Genet 2001;9:945-952.
12. Hizawa N, Freidhoff LR, Chiu YF, Ehrlich E, Luehr CA, Anderson JL, Duffy DL, Dunston GM, Weber JL, Huang SK, et al. Collaborative Study on the Genetics of Asthma. Genetic regulation of Dermatophagoides pteronyssinus-specific IgE responsiveness: a genome-wide multipoint linkage analysis in families recruited through 2 asthmatic sibs. J Allergy Clin Immunol 1998;102:436-442.
13. Mathias RA, Freidhoff LR, Blumenthal MN, Meyers DA, Lester L, King R, Xu JF, Solway J, Barnes KC, Pierce J, et al. Genome-wide linkage analyses of total serum IgE using variance components analysis in asthmatic families. Genet Epidemiol 2001;20:340-355.
14. Ober C, Cox NJ, Abney M, Di Rienzo A, Lander ES, Changyaleket B, Gidley H, Kurtz B, Lee J, Nance M, et al. Collaborative Study on the Genetics of Asthma. Genome-wide search for asthma susceptibility loci in a founder population. Hum Mol Genet 1998;7:1393-1398.
15. Ober C, Tsalenko A, Parry R, Cox NJ. A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. Am J Hum Genet 2000;67:1154-1162.
16. Heinzmann A, Daser A. Mouse models for the genetic dissection of atopy. Int Arch Allergy Immunol 2002;127:170-180.
17. Allen M, Heinzmann A, Noguchi E, Abecasis G, Broxholme J, Ponting CP, Bhattacharyya S, Tinsley J, Zhang Y, Holt R, et al. Positional cloning of a novel gene influencing asthma from Chromosome 2q14. Nat Genet 2003;35:258-263.
18. Nicklin MJ, Barton JL, Nguyen M, FitzGerald MG, Duff GW, Kornman K. A sequence-based map of the nine genes of the human interleukin-1 cluster. Genomics 2002;79:718-725.
19. Dale M, Nicklin MJ. Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. Genomics 1999;57:177-179.
20. Born TL, Thomassen E, Bird TA, Sims JE. Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling. J Biol Chem 1998; 273:29445-29450.
21. Nothwang HG, Strahm B, Denich D, Kubler M, Schwabe J, Gingrich JC, Jauch A, Cox A, Nicklin MJ, Kurnit DM, et al. Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/ PAC contig and a partial transcriptional map in the region of Chromosome 2q13. Genomics 1997;41:370-378.
22. Mao XQ, Kawai M, Yamashita T, Enomoto T, Dake Y, Sasaki S, Kataoka Y, Fukuzumi T, Endo K, Sano H, et al. Imbalance production between interleukin-1beta (IL-1beta) and IL-1 receptor antagonist (IL-1Ra) in bronchial asthma. Biochem Biophys Res Commun 2000;276:607-612.
23. Akira S. The role of IL-18 in innate immunity. Curr Opin Immunol 2000; 12:59-63.
24. Rosenwasser LJ. Biologic activities of IL-1 and its role in human disease. J Allergy Clin Immunol 1998;102:344-350.
25. Auron PE. The interleukin 1 receptor: ligand interactions and signal transduction. Cytokine Growth Factor Rev 1998;9:221-237.
26. Chung KF, Barnes PJ. Cytokines in asthma. Thorax 1999;54:825-857.
27. Hakonarson H, Herrick DJ, Serrano PG, Grunstein MM. Autocrine role of interleukin 1beta in altered responsiveness of atopic asthmatic sensitized airway smooth muscle. J Clin Invest 1997;99:117-124.
28. Herbon N, Werner M, Braig C, Gohlke H, Dutsch G, Illig T, Altmuller J, Hampe J, Lantermann A, Schreiber S, et al. High-resolution SNP scan of chromosome 6p21 in pooled samples from patients with complex diseases. Genomics 2003;81:510-518.
29. Malerba G, Lauciello MC, Scherpbier T, Trabetti E, Galavotti R, Cusin V, Pescollderungg L, Zanoni G, Martinati LC, Boner AL, et al. Linkage analysis of Chromosome 12 markers in Italian families with atopic asthmatic children. Am J Respir Crit Care Med 2000;162:1587-1590.
30. Little DP, Braun A, Darnhofer-Demar B, Frilling A, Li Y, McIver RT Jr, Koster H. Detection of RET proto-oncogene codon 634 mutations using mass spectrometry [comments]. J Mol Med 1997;75:745-750.
31. Little DP, Braun A, Darnhofer-Demar B, Koster H. Identification of apolipoprotein E polymorphisms using temperature cycled primer oligo base extension and mass spectrometry. Eur J Clin Chem Clin Biochem 1997;35:545-548.
32. Buetow KH, Edmonson M, MacDonald R, Clifford R, Yip P, Kelley J, Little DP, Strausberg R, Koester H, Cantor CR, et al. High-throughput development and characterization of a genomewide collection of gene-based single nucleotide polymorphism markers by chip-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Proc Natl Acad Sci USA 2001;98:581-584.
33. Dütsch G, Illig T, Loesgen S, Rohde K, Klopp N, Herbon N, Gohlke H, Altmueller J, Wjst M. STAT6 as an asthma candidate gene: polymorphism-screening, association and haplotype analysis in a Caucasian sib-pair study. Hum Mol Genet 2002;11:613-621.
34. Spielman RS, McGinnis RE, Ewens WJ. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993;52:506-516.
35. Zhao H, Zhang S, Merikangas KR, Trixler M, Wildenauer DB, Sun F, Kidd KK. Transmission/disequilibrium tests using multiple tightly linked markers. Am J Hum Genet 2000;67:936-946.
36. Lewontin RC. On measures of gametic disequilibrium. Genetics 1988;120: 849-852.
37. Becker T, Knapp M. Efficiency of haplotype frequency estimation when nuclear family information is included. Hum Hered 2002;54:45-53.
38. Joki-Erkkila VP, Karjalainen J, Hulkkonen J, Pessi T, Nieminen MM, Aromaa A, Klaukka T, Hurme M. Allergic rhinitis and polymorphisms of the interleukin 1 gene complex. Ann Allergy Asthma Immunol 2003; 91:275-279.
39. Pessi T, Karjalainen J, Hulkkonen J, Nieminen MM, Hurme M. A common IL-1 complex haplotype is associated with an increased risk of atopy. J Med Genet 2003;40:e66A.
40. Karjalainen J, Joki-Erkkila VP, Hulkkonen J, Pessi T, Nieminen MM, Aromaa A, Klaukka T, Hurme M. The IL1A genotype is associated with nasal polyposis in asthmatic adults. Allergy 2003;58:393-396.
41. Joos L, McIntyre L, Ruan J, Connett JE, Anthonisen NR, Weir TD, Pare PD, Sandford AJ. Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers. Thorax 2001;56:863-866.
42. Ishii T, Matsuse T, Teramoto S, Matsui H, Miyao M, Hosoi T, Takahashi H, Fukuchi Y, Ouchi Y. Neither IL-1beta, IL-1 receptor antagonist, nor TNF-alpha polymorphisms are associated with susceptibility to COPD. Respir Med 2000;94:847-851.
43. Dinarello CA. Biologic basis for interleukin-1 in disease. Blood 1996; 87:2095-2147.
44. Braun-Fahrländer C, Riedler J, Herz U, Eder W, Waser M, Grize L, Maisch S, Carr D, Gerlach F, Bufe A, et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 2002;347:869-877.
45. Raby BA, Klimecki WT, Laprise C, Renaud Y, Faith J, Lemire M, Greenwood C, Weiland KM, Lange C, Palmer LJ, et al. Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypes. Am J Respir Crit Care Med 2002;166:1449-1456.
46. Kim KC, McCracken K, Lee BC, Shin CY, Jo MJ, Lee CJ, Ko KH. Airway goblet cell mucin: its structure and regulation of secretion. Eur Respir J 1997;10:2644-2649.
47. Kim YD, Kwon EJ, Park DW, Song SY, Yoon SK, Baek SH. Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase2 in NCI-H292 cells. Mol Pharmacol 2002;62:1112-1118.
48. Arend WP, Guthridge CJ. Biological role of interleukin 1 receptor antagonist isoforms. Ann Rheum Dis 2000;59:i60-i64.
49. Becker KG, Simon RM, Bailey-Wilson JE, Freidlin B, Biddison WE, McFarland HF, Trent JM. Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases. Proc Natl Acad Sci USA 1998;95:9979-9984.
50. Kong A, Gudbjartsson DF, Sainz J, Jonsdottir GM, Gudjonsson SA, Richardsson B, Sigurdardottir S, Barnard J, Hallbeck B, Masson G, et al. A high-resolution recombination map of the human genome. Nat Genet 2002;31:241-247.