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Volumn 7, Issue 1-2, 2005, Pages 69-76

Insoluble α-synuclein in alzheimer's disease without lewy body formation

Author keywords

Synuclein; Alzheimer's disease; Protein solubility; Senileplaques

Indexed keywords

ALPHA SYNUCLEIN; NERVE PROTEIN; SNCA PROTEIN, HUMAN; SYNUCLEIN;

EID: 15844421282     PISSN: 10298428     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03033777     Document Type: Article
Times cited : (11)

References (41)
  • 1
    • 0035847186 scopus 로고    scopus 로고
    • β-Synuclein-positive structures in cases with sporadic Alzheimer's disease: Morphology and its relationship to tau aggregation
    • Arai Y, M Yamazaki, O Mori, H Muramatsu, G Asano and Y Katayama (2001) β-Synuclein-positive structures in cases with sporadic Alzheimer's disease: Morphology and its relationship to tau aggregation. Brain Res. 888, 287-296.
    • (2001) Brain Res. , vol.888 , pp. 287-296
    • Arai, Y.1    Yamazaki, M.2    Mori, O.3    Muramatsu, H.4    Asano, G.5    Katayama, Y.6
  • 2
    • 0033945604 scopus 로고    scopus 로고
    • NACP/α-synuclein and tau constitute two distinctive subsets of filaments in the same neuronal inclusions in brains from a family of parkinsonism and dementia with Lewy bodies: Double-immunolabeling fluorescence and electron microscopic studies
    • Arima K, T Mizutani, MA Alim, H Tonozuka-Uehara, Y Izumiyama, S Hirai and K Ueda (2000) NACP/α-synuclein and tau constitute two distinctive subsets of filaments in the same neuronal inclusions in brains from a family of parkinsonism and dementia with Lewy bodies: double-immunolabeling fluorescence and electron microscopic studies. Acta Neuropathol. 100, 115-121.
    • (2000) Acta Neuropathol. , vol.100 , pp. 115-121
    • Arima, K.1    Mizutani, T.2    Alim, M.A.3    Tonozuka-Uehara, H.4    Izumiyama, Y.5    Hirai, S.6    Ueda, K.7
  • 4
    • 0034751077 scopus 로고    scopus 로고
    • Neurofilament proteins NF-L, NF-M and NF-H in brain of patients with Down syndrome and Alzheimer's disease
    • Bajo M, BC Yoo, N Cairns, M Gratzer and G Lubec (2001) Neurofilament proteins NF-L, NF-M and NF-H in brain of patients with Down syndrome and Alzheimer's disease. Amino Acids 21, 293-301.
    • (2001) Amino Acids , vol.21 , pp. 293-301
    • Bajo, M.1    Yoo, B.C.2    Cairns, N.3    Gratzer, M.4    Lubec, G.5
  • 8
    • 0035110055 scopus 로고    scopus 로고
    • Lysosomal membrane damage in soluble β-mediated cell death in Alzheimer's disease
    • Ditaranto K, TL Tekirian and A J Yang (2001) Lysosomal membrane damage in soluble β-mediated cell death in Alzheimer's disease. Neurobiol. Dis. 8, 19-31.
    • (2001) Neurobiol. Dis. , vol.8 , pp. 19-31
    • Ditaranto, K.1    Tekirian, T.L.2    Yang, A.J.3
  • 9
    • 0033850190 scopus 로고    scopus 로고
    • Review: Formation and properties of amyloid-like fibrils derived from ?-synuclein and related proteins
    • El-Agnaf OMA and GB Irvine (2000) Review: Formation and properties of amyloid-like fibrils derived from ?-synuclein and related proteins. J. Struct. Biol. 130, 300-309.
    • (2000) J. Struct. Biol. , vol.130 , pp. 300-309
    • El-Agnaf, O.M.A.1    Irvine, G.B.2
  • 10
    • 0035409575 scopus 로고    scopus 로고
    • α-Synuclein and neurodegenerative diseases
    • Goedert M (2001) α-Synuclein and neurodegenerative diseases. Nat. Rev. Neurosci. 2, 492-501.
    • (2001) Nat. Rev. Neurosci. , vol.2 , pp. 492-501
    • Goedert, M.1
  • 11
    • 0029938770 scopus 로고    scopus 로고
    • The synaptic protein NACP is abnormally expressed during the progression of Alzheimer's disease
    • Iwai A, E Masliah, MP Sundsmo, R DeTeresa, M Mallory, DP Salmon and T Saitoh (1996) The synaptic protein NACP is abnormally expressed during the progression of Alzheimer's disease. Brain Res. 720, 230-234.
    • (1996) Brain Res. , vol.720 , pp. 230-234
    • Iwai, A.1    Masliah, E.2    Sundsmo, M.P.3    DeTeresa, M.4    Mallory, R.5    Salmon, D.P.6    Saitoh, T.7
  • 12
    • 1442275729 scopus 로고    scopus 로고
    • Clearance of α-synuclein oligomeric intermediates via the lysosomal degradation pathway
    • Lee H-J, F Khoshaghideh, S Patel and S-J Lee (2004) Clearance of α-synuclein oligomeric intermediates via the lysosomal degradation pathway. J. Neurosci. 24, 1888-1896.
    • (2004) J. Neurosci. , vol.24 , pp. 1888-1896
    • Lee, H.-J.1    Khoshaghideh, F.2    Patel, S.3    Lee, S.-J.4
  • 13
    • 0037016741 scopus 로고    scopus 로고
    • Membrane-bound α-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form
    • Lee HJ, C Choi and SJ Lee (2002) Membrane-bound α-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form. J. Biol. Chem. 277, 671-678.
    • (2002) J. Biol. Chem. , vol.277 , pp. 671-678
    • Lee, H.J.1    Choi, C.2    Lee, S.J.3
  • 15
    • 0034653871 scopus 로고    scopus 로고
    • Occurrence of human α-synuclein immunoreactive neurons with neurofibrillary tangle formation in the limbic areas of patients with Alzheimer's disease
    • Marui W, E Iseki, K Ueda and K Kosaka (2000) Occurrence of human α-synuclein immunoreactive neurons with neurofibrillary tangle formation in the limbic areas of patients with Alzheimer's disease. J. Neurol. Sci. 174, 81-84.
    • (2000) J. Neurol. Sci. , vol.174 , pp. 81-84
    • Marui, W.1    Iseki, E.2    Ueda, K.3    Kosaka, K.4
  • 16
    • 0030025635 scopus 로고    scopus 로고
    • Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease
    • Masliah E, A Iwai, M Mallory, K Uéda and T Saitoh (1996) Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease. Am. J. Pathol. 148, 201-210.
    • (1996) Am. J. Pathol. , vol.148 , pp. 201-210
    • Masliah, E.1    Iwai, A.2    Mallory, M.3    Uéda, K.4    Saitoh, T.5
  • 17
    • 0035834076 scopus 로고    scopus 로고
    • β-Amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic model linking Alzheimer's disease and Parkinson's disease
    • Masliah E, E Rockenstein, I Veinbergs, Y Sagara, M Mallory, M Hashimoto and L Mucke (2001) β-Amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic model linking Alzheimer's disease and Parkinson's disease. Proc. Natl. Acad. Sci. USA 98, 12245-12250.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 12245-12250
    • Masliah, E.1    Rockenstein, E.2    Veinbergs, I.3    Sagara, Y.4    Mallory, M.5    Hashimoto, M.6    Mucke, L.7
  • 18
    • 0035884905 scopus 로고    scopus 로고
    • A novel action of Alzheimer's amyloid β-protein (Aβ): Oligomeric Aβ promotes lipid release
    • Michikawa M, J-S Gong, Q-W Fan, N Sawamura and K Yanagisawa (2001) A novel action of Alzheimer's amyloid β-protein (Aβ): Oligomeric Aβ promotes lipid release. J. Neurosci. 15, 7226-7235.
    • (2001) J. Neurosci. , vol.15 , pp. 7226-7235
    • Michikawa, M.1    Gong, J.-S.2    Fan, Q.-W.3    Sawamura, N.4    Yanagisawa, K.5
  • 22
    • 0032472212 scopus 로고    scopus 로고
    • Selfoligomerization of NACP, the precursor protein of the non-amyloid β/A4 protein (Aβ) component of Alzheimer's disease amyloid, observed in the presence of a C-terminal Aβ fragment (residues 25-35)
    • Paik S, J-H Lee, D-H Kim, C-S Chang and Y-S Kim (1998) Selfoligomerization of NACP, the precursor protein of the non-amyloid β/A4 protein (Aβ) component of Alzheimer's disease amyloid, observed in the presence of a C-terminal Aβ fragment (residues 25-35). FEBS Lett. 421, 73-76.
    • (1998) FEBS Lett. , vol.421 , pp. 73-76
    • Paik, S.1    Lee, J.-H.2    Kim, D.-H.3    Chang, C.-S.4    Kim, Y.-S.5
  • 23
    • 0035834655 scopus 로고    scopus 로고
    • Exposure to long chain polysaturated fatty acids trigger rapid multimerization of synucleins
    • Perrin RJ, WS Woods, DF Clayton and JM George (2001) Exposure to long chain polysaturated fatty acids trigger rapid multimerization of synucleins. J. Biol. Chem. 276, 41958-41962.
    • (2001) J. Biol. Chem. , vol.276 , pp. 41958-41962
    • Perrin, R.J.1    Woods, W.S.2    Clayton, D.F.3    George, J.M.4
  • 26
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: Genes, proteins, and therapy
    • Selkoe DJ (2001) Alzheimer's disease: Genes, proteins, and therapy. Physiol. Rev. 81, 741-766.
    • (2001) Physiol. Rev. , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 27
    • 0037456578 scopus 로고    scopus 로고
    • The formation of highly soluble oligomers of α-synuclein is regulated by fatty acids and enhanced in Parkinson's disease
    • Sharon R, I Bar-Josef, MP Frosch, DM Walsh, JA Hamilton and DJ Selkoe (2003) The formation of highly soluble oligomers of α-synuclein is regulated by fatty acids and enhanced in Parkinson's disease. Neuron 37, 583-595.
    • (2003) Neuron , vol.37 , pp. 583-595
    • Sharon, R.1    Bar-Josef, I.2    Frosch, M.P.3    Walsh, D.M.4    Hamilton, J.A.5    Selkoe, D.J.6
  • 28
    • 0035979233 scopus 로고    scopus 로고
    • α-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to fatty acid-binding proteins
    • Sharon R, MS Goldberg, I Bar-Josef, RA Betensky, J Shen and DJ Selkoe (2001) α-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to fatty acid-binding proteins. Proc. Natl. Acad. Sci. USA 98, 9110-9115.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 9110-9115
    • Sharon, R.1    Goldberg, M.S.2    Bar-Josef, I.3    Betensky, R.A.4    Shen, J.5    Selkoe, D.J.6
  • 29
    • 0029888944 scopus 로고    scopus 로고
    • Intraneuronal β-amyloid immunoreactivity in the CNS
    • Sparks DL (1996) Intraneuronal β-amyloid immunoreactivity in the CNS. Neurobiol. Aging 17, 291-299.
    • (1996) Neurobiol. Aging , vol.17 , pp. 291-299
    • Sparks, D.L.1
  • 30
    • 0028177562 scopus 로고
    • Inducation of Alzheimer-like β-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol
    • Sparks DL, SW Scheff, JC Hunsaker, H Liu, T Landers and DR Gross (1994) Inducation of Alzheimer-like β-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol. Exp. Neurol. 126, 88-94.
    • (1994) Exp. Neurol. , vol.126 , pp. 88-94
    • Sparks, D.L.1    Scheff, S.W.2    Hunsaker, J.C.3    Liu, H.4    Landers, T.5    Gross, D.R.6
  • 31
    • 0028911485 scopus 로고
    • Antigen unmasking for immunoelectron microscopy: Labeling is improved by treating with sodium ethoxide or sodium metaperiodate, then heating on retrieval medium
    • Stirling JW and PS Graff (1995) Antigen unmasking for immunoelectron microscopy: Labeling is improved by treating with sodium ethoxide or sodium metaperiodate, then heating on retrieval medium. J. Histochem. Cytochem. 43, 115-123.
    • (1995) J. Histochem. Cytochem. , vol.43 , pp. 115-123
    • Stirling, J.W.1    Graff, P.S.2
  • 32
    • 0033954218 scopus 로고    scopus 로고
    • C-terminal α-synuclein immunoreactivity in structures other than Lewy bodies in neurodegenerative disorders
    • Takeda A, M Hashimoto, M Mallory, M Sundsumo, L Hansen and E Masliah (2000) C-terminal α-synuclein immunoreactivity in structures other than Lewy bodies in neurodegenerative disorders. Acta Neuropathol. 99, 296-304.
    • (2000) Acta Neuropathol. , vol.99 , pp. 296-304
    • Takeda, A.1    Hashimoto, M.2    Mallory, M.3    Sundsumo, M.4    Hansen, L.5    Masliah, E.6
  • 34
    • 0035837274 scopus 로고    scopus 로고
    • β-Amyloid deposits in transgenic mice expressing human β-amyloid precursor protein have the same characteristics as those in Alzheimer's disease
    • Terai K, A Iwai, S Kawabata, Y Tasaki, T Watanabe, K Miyata and T Yamaguchi (2001) β-Amyloid deposits in transgenic mice expressing human β-amyloid precursor protein have the same characteristics as those in Alzheimer's disease. Neuroscience 104, 299-310.
    • (2001) Neuroscience , vol.104 , pp. 299-310
    • Terai, K.1    Iwai, A.2    Kawabata, S.3    Tasaki, Y.4    Watanabe, T.5    Miyata, K.6    Yamaguchi, T.7
  • 35
    • 0030681215 scopus 로고    scopus 로고
    • Consensus recommendations for the postmortem diagnosis of Alzheimer's disease
    • The National Institute on Aging and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease
    • The National Institute on Aging and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease (1997) Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. Neurobiol. Aging 18 Suppl. 4, S1-S2.
    • (1997) Neurobiol. Aging , vol.18 , Issue.SUPPL. 4
  • 38
    • 0037023699 scopus 로고    scopus 로고
    • Biophysical properties of the synucleins and their propensities to fibrillate: Inhibition of α-synuclein assembly by β- and γ-synucleins
    • Uversky VN, J Li, P Souillac, IS Millett, S Doniach, R Jakes, M Goedert and AL Fink (2002b) Biophysical properties of the synucleins and their propensities to fibrillate: Inhibition of α-synuclein assembly by β- and γ-synucleins. J. Biol. Chem. 277, 11970-11978.
    • (2002) J. Biol. Chem. , vol.277 , pp. 11970-11978
    • Uversky, V.N.1    Li, J.2    Souillac, P.3    Millett, I.S.4    Doniach, S.5    Jakes, R.6    Goedert, M.7    Fink, A.L.8
  • 40
    • 0032526652 scopus 로고    scopus 로고
    • Loss of endosomal/lysosomal membrane permeability is an early event in amyloid Aβ1-42 pathogenesis
    • Yang AJ, D Chandswangbhuvana, L Margol and CG Glabe (1998) Loss of endosomal/lysosomal membrane permeability is an early event in amyloid Aβ1-42 pathogenesis. J. Neurosci. Res. 52, 691-698.
    • (1998) J. Neurosci. Res. , vol.52 , pp. 691-698
    • Yang, A.J.1    Chandswangbhuvana, D.2    Margol, L.3    Glabe, C.G.4
  • 41
    • 0035943343 scopus 로고    scopus 로고
    • Cholesterol, a modulator of membrane-associated Aβ fibrillogenesis and neurotoxicity
    • Yip CM, EA Elton, AA Darabie, MR Morrison and J McLaurin (2001) Cholesterol, a modulator of membrane-associated Aβ fibrillogenesis and neurotoxicity. J. Mol. Biol. 311, 723-734.
    • (2001) J. Mol. Biol. , vol.311 , pp. 723-734
    • Yip, C.M.1    Elton, E.A.2    Darabie, A.A.3    Morrison, M.R.4    McLaurin, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.