Accumulation of insoluble α-synuclein in dementia with Lewy bodies

Neurobiology of Disease

Volumn 7, Issue 3, 2000, Pages 192-200

  Campbell, Bruce C V ^a   Li, Qiao Xin ^a   Culvenor, Janetta G ^a   Jäkälä, Pekka ^b   Cappai, Roberto ^a   Beyreuther, Konrad ^c   Masters, Colin L ^a   McLean, Catriona A ^a  

^a FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; SYNAPTOPHYSIN;

ALZHEIMER DISEASE; ARTICLE; BRAIN CORTEX; COGNITIVE DEFECT; CONTROLLED STUDY; DEMENTIA; DISEASE MARKER; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; LEWY BODY; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

EID: 0034210668     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1006/nbdi.2000.0286     Document Type: Article

References (41)

1. Berg L., McKeel D. W. Jr., Miller J. P., Storandt M., Rubin E. H., Morris J. C., Baty J., Coats M., Norton J., Goate A. M., Price J. L., Gearing M., Mirra S. S., Saunders A. M. Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: Relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype. Arch. Neurol. 55:1998;326-335.
2. Bierer L. M., Hof P. R., Purohit D. P., Carlin L., Schmeidler J., Davis K. L., Perl D. P. Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer's disease. Arch. Neurol. 52:1995;81-88.
3. Brown D. F., Risser R. C., Bigio E. H., Tripp P., Stiegler A., Welch E., Eagan K. P., Hladik C. L., White C. L. Neocortical synapse density and Braak stage in the Lewy body variant of Alzheimer disease: A comparison with classic Alzheimer disease and normal aging. J. Neuropathol. Exp. Neurol. 57:1998;955-960.
4. Culvenor J. G., McLean C. A., Cutt S., Campbell B. C., Maher F., P J. k. l., Hartmann T., Beyreuther K., Masters C. L., Li Q. X. Non-Aβ component of Alzheimer's disease amyloid (NAC) revisited: NAC and α-synuclein are not associated with Aβ amyloid. Am. J. Pathol. 155:1999;1173-1181.
5. Davidson W. S., Jonas A., Clayton D. F., George J. M. Stabilization of α-synuclein secondary structure upon binding to synthetic membranes. J. Biol. Chem. 273:1998;9443-9449.
6. El-Agnaf O. M., Curran M. D., Wallace A., Middleton D., Murgatroyd C., Curtis A., Perry R., Jaros E. Mutation screening in exons 3 and 4 of α-synuclein in sporadic Parkinson's and sporadic and familial dementia with Lewy bodies cases. Neuroreport. 9:1998a;3925-3927.
7. El-Agnaf O. M., Jakes R., Curran M. D., Middleton D., Ingenito R., Bianchi E., Pessi A., Neill D., Wallace A. Aggregates from mutant and wild-type α-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β-sheet and amyloid-like filaments. FEBS. Lett. 440:1998b;71-75.
8. Forloni G., Angeretti N., Chiesa R., Monzani E., Salmona M., Bugiani O., Tagliavini F. Neurotoxicity of a prion protein fragment. Nature. 362:1993;543-546.
9. Galvin J. E., Uryu K., Lee V. M., Trojanowski J. Q. Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains α-, β-, and γ-synuclein. Proc. Natl. Acad. Sci. USA. 96:1999;13450-13455.
10. Gearing M., Lynn M., Mirra S. S. Neurofibrillary pathology in Alzheimer disease with Lewy bodies: Two subgroups. Arch. Neurol. 56:1999;203-208.
11. George J. M., Jin H., Woods W. S., Clayton D. F. Characterization of a novel protein regulated during the critical period for song learning in the zebra finch. Neuron. 15:1995;361-372.
12. Hansen L., Salmon D., Galasko D., Masliah E., Katzman R., DeTeresa R., Thal L., Pay M. M., Hofstetter R., Klauber M. The Lewy body variant of Alzheimer's disease: A clinical and pathologic entity. Neurology. 40:1990;1-8.
13. Hansen L. A., Masliah E., Galasko D., Terry R. D. Plaque-only Alzheimer disease is usually the Lewy body variant, and vice versa. J. Neuropathol. Exp. Neurol. 52:1993;648-654.
14. Hansen L. A., Masliah E., Terry R. D., Mirra S. S. A neuropathological subset of Alzheimer's disease with concomitant Lewy body disease and spongiform change. Acta. Neuropathol. (Berlin). 78:1989;194-201.
15. Ince P. G., Perry E. K., Morris C. M. Dementia with Lewy bodies. A distinct non-Alzheimer dementia syndrome? Brain. Pathol. 8:1998;299-324.
16. Iseki E., Li F., Kosaka K. Close relationship between spongiform change and ubiquitin-positive granular structures in diffuse Lewy body disease. J. Neurol. Sci. 146:1997;53-57.
17. Jakes R., Spillantini M. G., Goedert M. Identification of two distinct synucleins from human brain. FEBS Lett. 345:1994;27-32.
18. Krüger R., Kuhn W., Muller T., Woitalla D., Graeber M., Kosel S., Przuntek H., Epplen J. T., Schols L., Riess O. Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nat. Genet. 18:1998;106-108.
19. Kuzuhara S., Mori H., Izumiyama N., Yoshimura M., Ihara Y. Lewy bodies are ubiquitinated. A light and electron microscopic immunocytochemical study. Acta. Neuropathol. (Berlin). 75:1988;345-353.
20. Lansbury P. T. Jr. Evolution of amyloid: What normal protein folding may tell us about fibrillogenesis and disease. Proc. Natl. Acad. Sci. USA. 96:1999;3342-3344.
21. Lennox G., Lowe J., Landon M., Byrne E. J., Mayer R. J., Godwin-Austen R. B. Diffuse Lewy body disease: Correlative neuropathology using anti- ubiquitin immunocytochemistry. J. Neurol. Neurosurg. Psychiatry. 52:1989;1236-1247.
22. Lewy, F. H. 1912, Paralysis agitans, Handbuch der Neurologie, (, M. Lawandowsky, Ed.), Springer-Verlag, Berlin.
23. Li Q. X., Maynard C., Cappai R., McLean C. A., Cherny R. A., Lynch T., Culvenor J. G., Trevaskis J., Tanner J. E., Bailey K. A., Czech C., Bush A. I., Beyreuther K., Masters C. L. Intracellular accumulation of detergent-soluble amyloidogenic Aβ fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice. J. Neurochem. 72:1999;2479-2487.
24. Lippa C. F., Fujiwara H., Mann D. M., Giasson B., Baba M., Schmidt M. L., Nee L. E., O'Connell B., Pollen D. A., St. George-Hyslop P., Ghetti B., Nochlin D., Bird T. D., Cairns N. J., Lee V. M., Iwatsubo T., Trojanowski J. Q. Lewy bodies contain altered α-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes. Am. J. Pathol. 153:1998;1365-1370.
25. Liu X., Brun A. Synaptophysin immunoreactivity is stable 36 h postmortem. Dementia. 6:1995;211-217.
26. McKeith I. G., Galasko D., Kosaka K., Perry E. K., Dickson D. W., Hansen L. A., Salmon D. P., Lowe J., Mirra S. S., Byrne E. J., Lennox G., Quinn N. P., Edwardson J. A., Ince P. G., Bergeron C., Burns A., Miller B. L., Lovestone S., Collerton D., Jansen E. N., Ballard C., de Vos R. A., Wilcock G. K., Jellinger K. A., Perry R. H. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop. Neurology. 47:1996;1113-1124.
27. Mirra S. S., Heyman A., McKeel D., Sumi S. M., Crain B. J., Brownlee L. M., Vogel F. S., Hughes J. P., van Belle G., Berg L. The consortium to establish a registry for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology. 41:1991;479-486.
28. Ostrerova N., Petrucelli L., Farrer M., Mehta N., Choi P., Hardy J., Wolozin B. α-Synuclein shares physical and functional homology with 14-3-3 proteins. J. Neurosci. 19:1999;5782-5791.
29. Pike C. J., Burdick D., Walencewicz A. J., Glabe C. G., Cotman C. W. Neurodegeneration induced by β-amyloid peptides in vitro: The role of peptide assembly state. J. Neurosci. 13:1993;1676-1687.
30. Polymeropoulos M. H., Lavedan C., Leroy E., Ide S. E., Dehejia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., Stenroos E. S., Chandrasekharappa S., Athanassiadou A., Papapetropoulos T., Johnson W. G., Lazzarini A. M., Duvoisin R. C., Di Iorio G., Golbe L. I., Nussbaum R. L. Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science. 276:1997;2045-2047.
31. Samuel W., Alford M., Hofstetter C. R., Hansen L. Dementia with Lewy bodies versus pure Alzheimer disease: Differences in cognition, neuropathology, cholinergic dysfunction, and synapse density. J. Neuropathol. Exp. Neurol. 56:1997;499-508.
32. Samuel W., Galasko D., Masliah E., Hansen L. A. Neocortical lewy body counts correlate with dementia in the Lewy body variant of Alzheimer's disease. J. Neuropathol. Exp. Neurol. 55:1996;44-52.
33. Spillantini M. G., Schmidt M. L., Lee V. M., Trojanowski J. Q., Jakes R., Goedert M. α-synuclein in Lewy bodies. Nature. 388:1997;839-840.
34. Sze C. I., Troncoso J. C., Kawas C., Mouton P., Price D. L., Martin L. J. Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease. J. Neuropathol. Exp. Neurol. 56:1997;933-944.
35. Uéda K., Fukushima H., Masliah E., Xia Y., Iwai A., Yoshimoto M., Otero D. A., Kondo J., Ihara Y., Saitoh T. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc. Natl. Acad. Sci. USA. 90:1993;11282-11286.
36. Uéda K., Saitoh T., Mori H. Tissue-dependent alternative splicing of mRNA for NACP, the precursor of non-Aβ component of Alzheimer's disease amyloid. Biochem. Biophys. Res. Commun. 205:1994;1366-1372.
37. Wakabayashi K., Hansen L. A., Masliah E. Cortical Lewy body-containing neurons are pyramidal cells: Laser confocal imaging of double-immunolabeled sections with anti-ubiquitin and SMI32. Acta. Neuropathol. (Berlin). 89:1995;404-408.
38. Wakabayashi K., Hayashi S., Ishikawa A., Hayashi T., Okuizumi K., Tanaka H., Tsuji S., Takahashi H. Autosomal dominant diffuse Lewy body disease. Acta. Neuropathol. (Berlin). 96:1998;207-210.
39. Wakabayashi K., Honer W. G., Masliah E. Synapse alterations in the hippocampal-entorhinal formation in Alzheimer's disease with and without Lewy body disease. Brain. Res. 667:1994;24-32.
40. Wakabayashi K., Takahashi H., Ohama E., Takeda S., Ikuta F. Lewy bodies in the visceral autonomic nervous system in Parkinson's disease. Adv. Neurol. 60:1993;609-612.
41. Weinreb P. H., Zhen W., Poon A. W., Conway K. A., Lansbury P. T. Jr. NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded. Biochemistry. 35:1996;13709-13715.