C-terminal α-synuclein immunoreactivity in structures other than Lewy bodies in neurodegenerative disorders

Acta Neuropathologica

Volumn 99, Issue 3, 2000, Pages 296-304

  Takeda, Ayako ^a,c   Hashimoto, Makoto ^a   Mallory, Margaret ^a   Sundsumo, Mary ^a   Hansen, Lawrence ^a,b   Masliah, Eliezer ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

Corticobasal degeneration; Non amyloid component; Progressive supranuclear palsy; Proteinase K; synuclein

Indexed keywords

ALPHA SYNUCLEIN; FORMIC ACID; PROTEINASE K;

AGED; ALZHEIMER DISEASE; ARTICLE; ASTROCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICOBASAL DEGENERATION; DEGENERATIVE DISEASE; GLIA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; LEWY BODY; NEUROFIBRILLARY TANGLE; PICK PRESENILE DEMENTIA; PRIORITY JOURNAL; PROGRESSIVE SUPRANUCLEAR PALSY; WESTERN BLOTTING;

EID: 0033954218     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00007441     Document Type: Article

References (30)

1. Baba M, Nakajo S, Tu P-H, Tomita T, Nakaya K, Lee VM-Y, Trojanowski JQ, Iwatsubo T (1998) Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am J Pathol 152:879-884
2. Barry RA, Kent SBH, McKinley MP, Meyer RK, DeArmond SJ, Hood LE, Prusiner SB (1986) Scrapie and cellular prion proteins share polypeptide epitopes. J Infect Dis 153:848-854
3. Clayton DF, George JM (1998) The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease. Trends Neurosci 21:249-254
4. Dickson DW, Ruan D, Crystal H, Mark MH, Davies P, Kress Y, Yen S-H (1991) Hippocampal degeneration differentiates diffuse Lewy body disease (DLBD) from Alzheimer's disease: light and electron microscopic immunocytochemistry of CA2-3 neurites specific to DLBD. Neurology 41:1402-1409
5. Ebeling W, Hennrich N, Klockow M, Metz H, Orth HD, Lang H (1974) Proteinase K from Tritirachium album Limber. Eur J Biochem 47:91-97
6. Ensoli B, Barillari G, Salahuddin SZ, Gallo RC, Wong-Staal F (1990) Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients. Nature 345: 84-86
7. Gai WP, Power JHT, Blumberg PC, Blessing WW (1998) Multiple-system atrophy: a new α-synuclein disease? Lancet 352: 547-548
8. Graham JC, Oppenheimer DR (1969) Orthostatic hypotension and nicotine sensitivity in a case of multiple system atrophy. Neurol Neurosurg Psychiatry 32:28-34
9. Hansen L, Salmon D, Galasko D, Masliah E, Katzman R, DeTeresa R, Thal L, Pay MM, Hofstetter R, Klauber M (1990) The Lewy body variant of Alzheimer's disease: a clinical and pathologic entity. Neurology 40:1-7
10. Hashimoto M, Hsu LJ, Sisk A, Xia Y, Takeda A, Sundsmo M, Masliah E (1998) Human recombinant NACP/α-synuclein is aggregated and fibrillated in vitro: relevance for Lewy body disease. Brain Res 799:301-306
11. Hashimoto M, Hsu LJ, Xia Y, Takeda A, Sundsmo M, Masliah E (1999) Oxidative stress induces amyloid-like aggregate formation of NACP/α-synuclein in vitro. NeuroReport 10:717-721
12. Irizarry MC, Growdon W, Gomez-Isla T, Newell K, George JM, Clayton DF, Hyman BT (1998) Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity. J Neuropathol Exp Neurol 57:334-337
13. Iwai A, Masliah E, Yoshimoto M, De Silva R, Ge N, Kittel A, Saitoh T (1994) The precursor protein of non-Aβ component of Alzheimer's disease amyloid (NACP) is a presynaptic protein of the central nervous system. Neuron 14:467-475
14. Kruger R, Kuhn W, Muller T, Woitalla D, Graeber M, Kosel S, Przuntek H, Epplen JT, Schols L, Reiss O (1998) Ala30Pro mutation in the gene encoding α-synuclein in Parkinsons's disease. Nat Genet 18:106-108
15. Lippa CF, Fujiwara H, Mann DM, Giasson B, Baba M, Schmidt ML, Nee LE, O'Connell B, Pollen DA, St.George-Hyslop P (1998) Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes. Am J Pathol 153:1365-1370
16. Masliah E (1998) The role of synaptic proteins in neurodegenerative disorders. Neurosci News 1:14-20
17. Masliah E, Iwai A, Mallory M, Ueda K, Saitoh T (1996) Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease. Am J Pathol 148:201-210
18. Meltzer JC, Grimm PC, Greenberg AH, Nance DM (1997) Enhanced immunohistochemical detection of autonomic nerve fibers, cytokines and inducible nitric oxide synthase by light and fluorescent microscopy in rat spleen. J Histochem Cytochem 45:599-610
19. Paik SR, Lee JH, Kim DH, Chang CS, Kim J (1997) Aluminum-induced structural alterations of the precursor of the non-A beta component of Alzheimer's disease amyloid. Arch Biochem Biophys 344:325-334
20. Polymeropoulos MH, Lavedant C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papapetropulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Di Iorio G, Golbe LI, Nussbaum RL (1997) Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276: 2045-2047
21. Spillantini MG, Schmidt ML, Lee VM-Y, Trojanowski JQ, Jakes R, Goedert M (1997) α-Synuclein in Lewy bodies. Nature 388:839-840
22. Spillantini MG, Crowther RA, Jakes R, Cairns NJ, Lantos PL, Goedert M (1998) Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementita with Lewy bodies. Neurosci Lett 251:205-208
23. Spillantini MG, Crowther RA, Jakes R, Hasegawa M, Goedert M (1998) α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc Natl Acad Sci USA 95:6469-6473
24. Takedu A, Hashimoto M, Mallory M, Sundsmo M, Hansen L, Sisk A, Masliah E (1998) Abnormal distribution of NACP/α-synuclein in Lewy body disease as revealed by proteinase K and formic acid pretreatment. Lab Invest 78:1169-1177
25. Takeda A, Mallory M, Sundsmo M, Honer W, Hansen L, Masliah E (1998) Abnormal accumulation of NACP/α-synuclein in neurodegenerative disorders. Am J Pathol 152:367-372
26. Tu P-h, Galvin JE, Baba M, Giasson B, Tomita T, Leight S, Nakajo S, Iwatsubo T, Trojanowski JQ, Lee VM-Y (1998) Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α-synuclein. Ann Neurol 44:415-422
27. Ueda K, Fukushima H, Masliah E, Xia Y, Iwai A, Otero D, Kondo J, Ihara Y, Saitoh T (1993) Molecular cloning of a novel component of amyloid in Alzheimer's disease. Proc Natl Acad Sci USA 90:11282-11286
28. Wakabayashi K, Matsumoto K, Takayama K, Yoshimoto M, Takahashi H (1997) NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease. Neurosci Lett 239:45-48
29. Wakabayashi K, Yoshimoto M, Tsuji S, Takahashi H (1998) α-Synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy. Neurosci Lett 249:180-182
30. Wakabayashi K, Hayashi S, Kakita A, Yamada M, Toyoshima Y, Yoshimoto M, Takahashi H (1998) Accumulation of α-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy. Acta Neuropathol 96:445-452