Phenotype-based treatment of dietary obesity: Differential effects of fenofibrate in obesity-prone and obesity-resistant rats

Metabolism: Clinical and Experimental

Volumn 54, Issue 4, 2005, Pages 421-429

  Ji, Hong ^a   Outterbridge, Lisa V ^a   Friedman, Mark I ^a  

^a MONELL CHEMICAL SENSES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A OXIDASE; CARNITINE PALMITOYLTRANSFERASE; FENOFIBRATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ORGANELLE; CELL PROLIFERATION; CONTROLLED STUDY; FATTY ACID OXIDATION; FEEDING; FOOD INTAKE; LIPID DIET; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WEIGHT GAIN;

EID: 15744403599     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2004.10.007     Document Type: Article

References (53)

1. R. Schemmel, O. Mickelsen, and J.L. Gill Dietary obesity in rats: body weight and body fat accretion in seven strains of rats J. Nutr. 100 1970 1041 1048
2. B.E. Levin, J. Triscari, and S. Hogan Resistance to diet-induced obesity: food intake, pancreatic sympathetic tone, and insulin Am. J. Physiol. 252 1987 R471 R478
3. D.B. West, C.N. Boozer, and D.L. Moody Dietary obesity in nine inbred mouse strains Am. J. Physiol. 262 1992 R1025 R1032
4. J.E. Blundell, and J. Cooling High-fat and low-fat (behavioural) phenotypes: biology or environment? Proc. Nutr. Soc. 58 1999 773 777
5. A. Astrup, and A. Raben Obesity: an inherited metabolic deficiency in the control of macronutrient balance? Eur. J. Clin. Nutr. 46 1992 611 620
6. E. Jequier Pathways to obesity Int. J. Obes. Relat. Metab. Disord. 26 Suppl. 2 2002 S12 S17
7. M.I. Friedman Fuel partitioning and food intake Am. J. Clin. Nutr. 67 1998 513S 518S
8. J. Abou Mrad, F. Yakubu, and D. Lin Skeletal muscle composition in dietary obesity-susceptible and dietary obesity-resistant rats Am. J. Physiol. 262 1992 R684 R688
9. E.C. Gayles, M.J. Pagliassotti, and P.A. Prach Contribution of energy intake and tissue enzymatic profile to body weight gain in high-fat-fed rats Am. J. Physiol. 272 1997 R188 R194
10. J.Y. Kim, R.C. Hickner, and R.L. Cortright Lipid oxidation is reduced in obese human skeletal muscle Am. J. Physiol. Endocrinol. Metab. 279 2000 E1039 E1044
11. M.I. Friedman, R.B. Harris, and H. Ji Fatty acid oxidation affects food intake by altering hepatic energy status Am. J. Physiol. 276 1999 R1046 R1053
12. E. Scharrer, and W. Langhans Control of food intake by fatty acid oxidation Am. J. Physiol. 250 1986 R1003 R1006
13. A. Kahler, M. Zimmermann, and W. Langhans Suppression of hepatic fatty acid oxidation and food intake in men Nutrition 15 1999 819 828
14. H. Ji, and M.I. Friedman Fasting plasma triglyceride levels and fat oxidation predict dietary obesity in rats Physiol. Behav. 78 2003 767 772
15. J.K. Reddy, and T. Hashimoto Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic system Annu. Rev. Nutr. 21 2001 193 230
16. B. Staels, J. Dallongeville, and J. Auwerx Mechanism of action of fibrates on lipid and lipoprotein metabolism Circulation 98 1998 2088 2093
17. J. Najib Fenofibrate in the treatment of dyslipidemia: a review of the data as they relate to the new suprabioavailable tablet formulation Clin. Ther. 24 2002 2022 2050
18. G.A. Francis, J.S. Annicotte, and J. Auwerx PPAR-alpha effects on the heart and other vascular tissues Am. J. Physiol. Heart Circ. Physiol. 285 2003 H1 H9
19. P.J. Larsen, P.B. Jensen, and R.V. Sorensen Differential influences of peroxisome proliferator-activated receptors gamma and -alpha on food intake and energy homeostasis Diabetes 52 2003 2249 2259
20. E. Chaput, R. Saladin, and M. Silvestre Fenofibrate and rosiglitazone lower serum triglycerides with opposing effects on body weight Biochem. Biophys. Res. Commun. 271 2000 445 450
21. F.P. Mancini, A. Lanni, and L. Sabatino Fenofibrate prevents and reduces body weight gain and adiposity in diet-induced obese rats FEBS Lett. 491 2001 154 158
22. M. Guerre-Millo, P. Gervois, and E. Raspe Peroxisome proliferator- activated receptor alpha activators improve insulin sensitivity and reduce adiposity J. Biol. Chem. 275 2000 16638 16642
23. H.J. Lee, S.S. Choi, and M.K. Park Fenofibrate lowers abdominal and skeletal adiposity and improves insulin sensitivity in OLETF rats Biochem. Biophys. Res. Commun. 296 2002 293 299
24. B.E. Levin, S. Hogan, and A.C. Sullivan Initiation and perpetuation of obesity and obesity resistance in rats Am. J. Physiol. 256 1989 R766 R771
25. I. Ramirez, and M.I. Friedman Dietary hyperphagia in rats: role of fat, carbohydrate, and energy content Physiol. Behav. 47 1990 1157 1163
26. I. Ramirez Physiological and biochemical measurements in relation to feeding F.M. Toates N.E. Rowland Feeding and drinking 1987 Elsevier Amsterdam 151 165
27. L. Berthou, R. Saladin, and P. Yaqoob Regulation of rat liver apolipoprotein A-I, apolipoprotein A-II and acyl-coenzyme A oxidase gene expression by fibrates and dietary fatty acids Eur. J. Biochem. 232 1995 179 187
28. S.L. Dana, P.A. Hoener, and J.M. Bilakovics Peroxisome proliferator-activated receptor subtype-specific regulation of hepatic and peripheral gene expression in the Zucker diabetic fatty rat Metabolism 50 2001 963 971
29. M. Furuhashi, N. Ura, and H. Murakami Fenofibrate improves insulin sensitivity in connection with intramuscular lipid content, muscle fatty acid-binding protein, and beta-oxidation in skeletal muscle J. Endocrinol. 174 2002 321 329
30. B. Staels, N. Vu-Dac, and V.A. Kosykh Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates J. Clin. Invest. 95 1995 705 712
31. M. Yoon, S. Jeong, and H. Lee Fenofibrate improves lipid metabolism and obesity in ovariectomized LDL receptor-null mice Biochem. Biophys. Res. Commun. 302 2003 29 34
32. Q. Guo, P.R. Wang, and D.P. Milot Regulation of lipid metabolism and gene expression by fenofibrate in hamsters Biochim. Biophys. Acta 1533 2001 220 232
33. P.C. Liu, R. Huber, and M.D. Stow Induction of endogenous genes by peroxisome proliferator activated receptor alpha ligands in a human kidney cell line and in vivo J. Steroid Biochem. Mol. Biol. 85 2003 71 79
34. C. Henninger, P. Clouet, and H. Cao Danh Effects of fenofibrate treatment on fatty acid oxidation in liver mitochondria of obese Zucker rats Biochem. Pharmacol. 36 1987 3231 3236
35. A. Aarsland, and R.K. Berge Peroxisome proliferating sulphur- and oxy-substituted fatty acid analogues are activated to acyl coenzyme A thioesters Biochem. Pharmacol. 41 1991 53 61
36. K. Yamamoto, N. Fukuda, and L. Zhang Altered hepatic metabolism of fatty acids in rats fed a hypolipidaemic drug, fenofibrate Pharmacol. Res. 33 1996 337 342
37. A. Lanni, F. Mancini, and L. Sabatino De novo expression of uncoupling protein 3 is associated to enhanced mitochondrial thioesterase-1 expression and fatty acid metabolism in liver of fenofibrate-treated rats FEBS Lett. 525 2002 7 12
38. M. Yoon, S. Jeong, and C.J. Nicol Fenofibrate regulates obesity and lipid metabolism with sexual dimorphism Exp. Mol. Med. 34 2002 481 488
39. H. Pilegaard, B. Saltin, and P.D. Neufer Effect of short-term fasting and refeeding on transcriptional regulation of metabolic genes in human skeletal muscle Diabetes 52 2003 657 662
40. G. Arias, G. Asins, and F.G. Hegardt The effect of fasting/refeeding and insulin treatment on the expression of the regulatory genes of ketogenesis in intestine and liver of suckling rats Arch. Biochem. Biophys. 340 1997 287 298
41. C.C. Horn, H. Ji, and M.I. Friedman Etomoxir, a fatty acid oxidation inhibitor, increases food intake and reduces hepatic energy status in rats Physiol. Behav. 81 2004 157 162
42. J. Fu, S. Gaetani, and F. Oveisi Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha Nature 425 2003 90 93
43. O. Bosello, and M. Zamboni Visceral obesity and metabolic syndrome Obes. Rev. 1 2000 47 56
44. K. Giesen, L. Plum, and R. Kluge Diet-dependent obesity and hypercholesterolemia in the New Zealand obese mouse: identification of a quantitative trait locus for elevated serum cholesterol on the distal mouse chromosome 5 Biochem. Biophys. Res. Commun. 304 2003 812 817
45. M.I. Harris Epidemiologic studies on the pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM) Clin. Invest. Med. 18 1995 231 239
46. H.E. Lebovitz Type 2 diabetes: an overview Clin. Chem. 45 1999 1339 1345
47. I. Seidman, A.A. Horland, and G.W. Teebor Glycolytic and gluconeogenic enzyme activities in the hereditary obese-hyperglycemic syndrome and in acquired obesity Diabetologia 6 1970 313 316
48. J. Triscari, J.S. Stern, and P.R. Johnson Carbohydrate metabolism in lean and obese Zucker rats Metabolism 28 1979 183 189
49. A.J. Scheen, N. Paquot, and M.R. Letiexhe Glucose metabolism in obese subjects: lessons from OGTT, IVGTT and clamp studies Int. J. Obes. Relat. Metab. Disord. 19 Suppl. 3 1995 S14 S20
50. S. Kersten, B. Desvergne, and W. Wahli Roles of PPARs in health and disease Nature 405 2000 421 424
51. P. De Vos, A.-M. Lefebvre, and S.G. Miller Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma J. Clin. Invest. 98 1996 1004 1009
52. T.M. Larsen, S. Toubro, and A. Astrup PPARgamma agonists in the treatment of type II diabetes: is increased fatness commensurate with long-term efficacy? Int. J. Obes. Relat. Metab. Disord. 27 2003 147 161
53. J.W. Lawrence, Y. Li, and S. Chen Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha. PPAR alpha fails to induce peroxisome proliferation-associated genes in human cells independently of the level of receptor expression J. Biol. Chem. 276 2001 31521 31527