메뉴 건너뛰기




Volumn 33, Issue 6, 1996, Pages 337-342

Altered hepatic metabolism of fatty acids in rats fed a hypolipidaemic drug, fenofibrate

Author keywords

Fatty acid oxidation; Fenofibrate; Perfused rat liver; Triglyceride secretion

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACETOACETIC ACID; ANTILIPEMIC AGENT; FENOFIBRATE; KETONE BODY; OLEIC ACID;

EID: 0030175193     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1996.0046     Document Type: Article
Times cited : (22)

References (37)
  • 1
    • 0025804381 scopus 로고
    • Mechanisms of lipid-lowering agents
    • 1. Sirtori CR, Manzoni C, Lovati. Mechanisms of lipid-lowering agents. Cardiology 1991; 78: 226-35.
    • (1991) Cardiology , vol.78 , pp. 226-235
    • Sirtori, C.R.1    Manzoni, C.2    Lovati3
  • 2
    • 0018726338 scopus 로고
    • Influence of procetofen on lipid metabolism in normocholesterolemic rats
    • 2. Kritchevsky D, Tepper SA, Story JA. Influence of procetofen on lipid metabolism in normocholesterolemic rats. Pharmacol Res Commun 1979; 11: 635-41.
    • (1979) Pharmacol Res Commun , vol.11 , pp. 635-641
    • Kritchevsky, D.1    Tepper, S.A.2    Story, J.A.3
  • 3
    • 0023623394 scopus 로고
    • Comparative toxicity and safety profile of fenofibrate and other fibric acid derivatives
    • 3. Blane GF. Comparative toxicity and safety profile of fenofibrate and other fibric acid derivatives. Am J Med 1987; 83 (Suppl 5B): 26-36.
    • (1987) Am J Med , vol.83 , Issue.SUPPL. 5B , pp. 26-36
    • Blane, G.F.1
  • 4
    • 0023613889 scopus 로고
    • Effect of fibric acid derivatives on blood lipid and lipoprotein levels
    • 4. Hunninghake DB, Peters JR. Effect of fibric acid derivatives on blood lipid and lipoprotein levels. Am J Med 1987; 83 (Suppl 5B): 44-9.
    • (1987) Am J Med , vol.83 , Issue.SUPPL. 5B , pp. 44-49
    • Hunninghake, D.B.1    Peters, J.R.2
  • 5
    • 0025128458 scopus 로고
    • Fenofibrate. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in dyslipidaemia
    • 5. Balfour JA, McTavish DM, Heel RC. Fenofibrate. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in dyslipidaemia. Drugs 1990; 40: 260-90.
    • (1990) Drugs , vol.40 , pp. 260-290
    • Balfour, J.A.1    McTavish, D.M.2    Heel, R.C.3
  • 6
    • 0028905270 scopus 로고
    • Comparison of hypolipidemic action of fenofibrate, bezafibrate, clinofibrate and clofibrate in rats
    • 6. Tsuchiya A, Kasai H, Nagayama T, Saito K. Comparison of hypolipidemic action of fenofibrate, bezafibrate, clinofibrate and clofibrate in rats. Jpn Pharmacol Ther (Suppl) 1995; 23: 175-81.
    • (1995) Jpn Pharmacol Ther (Suppl) , vol.23 , pp. 175-181
    • Tsuchiya, A.1    Kasai, H.2    Nagayama, T.3    Saito, K.4
  • 7
    • 0024519850 scopus 로고
    • The biochemical pharmacology of fenofibrate
    • 7. Caldwell J. The biochemical pharmacology of fenofibrate. Cardiology 1989; 76 (Suppl 1): 33-44.
    • (1989) Cardiology , vol.76 , Issue.SUPPL. 1 , pp. 33-44
    • Caldwell, J.1
  • 8
    • 0023613751 scopus 로고
    • Structure and biochemical effects of fenofibrate
    • 8. Kloer HU. Structure and biochemical effects of fenofibrate. Am J Med 1987; 83 (Suppl 5B): 3-8.
    • (1987) Am J Med , vol.83 , Issue.SUPPL. 5B , pp. 3-8
    • Kloer, H.U.1
  • 9
    • 0024245703 scopus 로고
    • Effects of ciprofibrate and fenofibrate on liver lipids and lipoprotein synthesis in normo-and hyperlipidemic rats
    • 9. Petit D, Bonnefis MT, Rey C, Infante R. Effects of ciprofibrate and fenofibrate on liver lipids and lipoprotein synthesis in normo-and hyperlipidemic rats. Atheroscler 1988; 74: 215-25.
    • (1988) Atheroscler , vol.74 , pp. 215-225
    • Petit, D.1    Bonnefis, M.T.2    Rey, C.3    Infante, R.4
  • 10
    • 0020533327 scopus 로고
    • Effects of clofibrate, bezafibrate, fenofibrate and probucol on plasma lipolytic enzymes in normolipaemic subjects
    • 10. Heller F, Harvengt C. Effects of clofibrate, bezafibrate, fenofibrate and probucol on plasma lipolytic enzymes in normolipaemic subjects. Eur J Clin Pharmacol 1983; 25: 57-63.
    • (1983) Eur J Clin Pharmacol , vol.25 , pp. 57-63
    • Heller, F.1    Harvengt, C.2
  • 11
    • 0024522835 scopus 로고
    • Low-dose of colestipol plus fenofibrate: Effects on plasma lipoproteins, lecithin:cholesterol ayltransferase, and postheparin lipases in familial hypercholesterolemia
    • 11. Weisweiler P. Low-dose of colestipol plus fenofibrate: effects on plasma lipoproteins, lecithin:cholesterol ayltransferase, and postheparin lipases in familial hypercholesterolemia. Metabol 1989; 38: 271-5.
    • (1989) Metabol , vol.38 , pp. 271-275
    • Weisweiler, P.1
  • 13
    • 0029058733 scopus 로고
    • Postprandial lipoprotein clearance in type 2 diabetes: Fenofibrate effects
    • 13. Cavellero E, Piolot A, Jacotot B. Postprandial lipoprotein clearance in type 2 diabetes: Fenofibrate effects. Diab Metabol 1995; 21: 118-20.
    • (1995) Diab Metabol , vol.21 , pp. 118-120
    • Cavellero, E.1    Piolot, A.2    Jacotot, B.3
  • 14
    • 0017805412 scopus 로고
    • Rat liver peroxisomes catalyze the β-oxidation of fatty acids
    • 14. Lazarow PB. Rat liver peroxisomes catalyze the β-oxidation of fatty acids. J Biol Chem 1978; 253: 1522-8.
    • (1978) J Biol Chem , vol.253 , pp. 1522-1528
    • Lazarow, P.B.1
  • 15
    • 0018356140 scopus 로고
    • Mitochondrial and peroxisomal fatty acid oxidation in liver homogenates and isolated hepatocytes from control and clofibrate-treated rats
    • 15. Mannaerts GP, Debeer LJ, Thomas J, De Schepper PJ. Mitochondrial and peroxisomal fatty acid oxidation in liver homogenates and isolated hepatocytes from control and clofibrate-treated rats. J Biol Chem 1979; 254: 4585-95.
    • (1979) J Biol Chem , vol.254 , pp. 4585-4595
    • Mannaerts, G.P.1    Debeer, L.J.2    Thomas, J.3    De Schepper, P.J.4
  • 16
    • 0019979824 scopus 로고
    • Triglyceride lowering effect and induction of liver enzymes in male rats after administration of hypolipidemic drugs
    • 16. Stegmeir K, Schmidt FH, Reinicke A, Fahimi HD. Triglyceride lowering effect and induction of liver enzymes in male rats after administration of hypolipidemic drugs. Ann N Y Acad Sci 1982; 386: 449-52.
    • (1982) Ann N Y Acad Sci , vol.386 , pp. 449-452
    • Stegmeir, K.1    Schmidt, F.H.2    Reinicke, A.3    Fahimi, H.D.4
  • 17
    • 0019957432 scopus 로고
    • Reciprocal responses to clofibrate in ketogenesis and triglyceride and cholesterol secretion in isolated rat liver
    • 17. Ide T, Oku H, Sugano M. Reciprocal responses to clofibrate in ketogenesis and triglyceride and cholesterol secretion in isolated rat liver. Metabol 1982; 31: 1065-72.
    • (1982) Metabol , vol.31 , pp. 1065-1072
    • Ide, T.1    Oku, H.2    Sugano, M.3
  • 18
    • 0023766322 scopus 로고
    • Pharmacological investigation of bezafibrate, a hypolipidemic agent (1). Effects of bezafibrate on normal and experimental hyperlipidemia in rats
    • 18. Kusama H, Nishiyama M, Ikeda S. Pharmacological investigation of bezafibrate, a hypolipidemic agent (1). Effects of bezafibrate on normal and experimental hyperlipidemia in rats. Folia Pharmacol Jpn 1988; 92: 175-80.
    • (1988) Folia Pharmacol Jpn , vol.92 , pp. 175-180
    • Kusama, H.1    Nishiyama, M.2    Ikeda, S.3
  • 19
    • 0023729415 scopus 로고
    • Pharmacological investigation of ezafibrate, a hypolipidemic agent (2). Mechanism of the hypolipidemic action of bezafibrate in rats
    • 19. Kusama H, Nishiyama M, Matsubara Y, Ikeda S. Pharmacological investigation of ezafibrate, a hypolipidemic agent (2). Mechanism of the hypolipidemic action of bezafibrate in rats. Folia Pharmacol Jpn 1988; 92: 181-91.
    • (1988) Folia Pharmacol Jpn , vol.92 , pp. 181-191
    • Kusama, H.1    Nishiyama, M.2    Matsubara, Y.3    Ikeda, S.4
  • 20
    • 0019212577 scopus 로고
    • Comparative ultrastructural study of rat hepatocytes after treatment with the hypolipidaemic agents probucol, clofibrate, and fenofibrate
    • 20. Barnard SD, Molello JA, Caldwell WJ, LeBeau JE. Comparative ultrastructural study of rat hepatocytes after treatment with the hypolipidaemic agents probucol, clofibrate, and fenofibrate. J Toxicol Environ Health 1980; 6: 547-57.
    • (1980) J Toxicol Environ Health , vol.6 , pp. 547-557
    • Barnard, S.D.1    Molello, J.A.2    Caldwell, W.J.3    Lebeau, J.E.4
  • 21
    • 0021678109 scopus 로고
    • Effect of fenofibrate and LF 2151 on hepatic peroxisomes in hamsters
    • 21. Pourbaix S, Heller F, Harvengt C. Effect of fenofibrate and LF 2151 on hepatic peroxisomes in hamsters. Biochem Pharmacol 1984; 33: 3661-6.
    • (1984) Biochem Pharmacol , vol.33 , pp. 3661-3666
    • Pourbaix, S.1    Heller, F.2    Harvengt, C.3
  • 22
    • 0021174043 scopus 로고
    • Effects of benfluorex and fenofibrate treatment on mitochondrial and peroxisomal marker enzymes in rat liver
    • 22. Veldhoven VP, Declercq PE, Debeer LJ, Mannaerts GP. Effects of benfluorex and fenofibrate treatment on mitochondrial and peroxisomal marker enzymes in rat liver. Biochem Pharmacol 1984; 33: 1153-5.
    • (1984) Biochem Pharmacol , vol.33 , pp. 1153-1155
    • Veldhoven, V.P.1    Declercq, P.E.2    Debeer, L.J.3    Mannaerts, G.P.4
  • 23
  • 24
    • 0021170046 scopus 로고
    • Interactions between fatty acid synthesis, oxidation, and esterification in the production of triglyceride-rich lipoproteins by the liver
    • 24. Fukuda N, Ontko JA. Interactions between fatty acid synthesis, oxidation, and esterification in the production of triglyceride-rich lipoproteins by the liver. J Lipid Res 1984; 25: 831-42.
    • (1984) J Lipid Res , vol.25 , pp. 831-842
    • Fukuda, N.1    Ontko, J.A.2
  • 25
    • 0029155472 scopus 로고
    • Differential effects of geometrical isomers of octadecadienoic acids on ketogenesis and lipid secretion in the livers from rats fed a cholesterol-enriched diet
    • 25. Fukuda N, Etoh T, Wada K, Hidaka T, Yamamoto K, Ikeda I, Sugano M. Differential effects of geometrical isomers of octadecadienoic acids on ketogenesis and lipid secretion in the livers from rats fed a cholesterol-enriched diet. Ann Nutr Metabol 1995; 39: 185-92.
    • (1995) Ann Nutr Metabol , vol.39 , pp. 185-192
    • Fukuda, N.1    Etoh, T.2    Wada, K.3    Hidaka, T.4    Yamamoto, K.5    Ikeda, I.6    Sugano, M.7
  • 26
    • 0020445326 scopus 로고
    • Altered hepatic metabolism of free fatty acids underlying hypersecretion of very low density lipoproteins in the genetically obese zucker rat
    • 26. Fukuda N, Azain MJ, Ontko JA. Altered hepatic metabolism of free fatty acids underlying hypersecretion of very low density lipoproteins in the genetically obese Zucker rat. J Biol Chem 1982; 25: 14066-72.
    • (1982) J Biol Chem , vol.25 , pp. 14066-14072
    • Fukuda, N.1    Azain, M.J.2    Ontko, J.A.3
  • 27
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipids from animal tissues
    • 27. Folch J, Lees M, Sloane-Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 1957; 226: 497-509.
    • (1957) J Biol Chem , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane-Stanley, G.H.3
  • 28
    • 0000130569 scopus 로고
    • Multiple range and multiple F tests
    • 28. Duncan DB. Multiple range and multiple F tests. Biometrics 1955; 11: 1-42.
    • (1955) Biometrics , vol.11 , pp. 1-42
    • Duncan, D.B.1
  • 29
    • 0026501622 scopus 로고
    • Modulation of lipoprotein production in Hep G2 cells by fenofibrate and clofibrate
    • 29. Hahn SE, Goldberg DM. Modulation of lipoprotein production in Hep G2 cells by fenofibrate and clofibrate. Biochem Pharmacol 1992; 43: 625-33.
    • (1992) Biochem Pharmacol , vol.43 , pp. 625-633
    • Hahn, S.E.1    Goldberg, D.M.2
  • 30
    • 0029812327 scopus 로고    scopus 로고
    • Increased secretion of triglyceride and cholesterol following inhibition of long-chain fatty acid oxidation in rat liver
    • in press
    • 30. Yamamoto K, Fukuda N, Fukui M, Kai Y, Ikeda S, Sakai T. Increased secretion of triglyceride and cholesterol following inhibition of long-chain fatty acid oxidation in rat liver. Ann Nutr Metabol 1996; in press.
    • (1996) Ann Nutr Metabol
    • Yamamoto, K.1    Fukuda, N.2    Fukui, M.3    Kai, Y.4    Ikeda, S.5    Sakai, T.6
  • 31
    • 0022198148 scopus 로고
    • Decreased hepatic production of very low density lipoproteins following activation of fatty acid oxidation by Ro 22-0654
    • 31. Yamamoto M, Fukuda N, Triscari J, Sullivan AC, Ontko JA. Decreased hepatic production of very low density lipoproteins following activation of fatty acid oxidation by Ro 22-0654. J Lipid Res 1985; 26: 1196-204.
    • (1985) J Lipid Res , vol.26 , pp. 1196-1204
    • Yamamoto, M.1    Fukuda, N.2    Triscari, J.3    Sullivan, A.C.4    Ontko, J.A.5
  • 33
    • 0028068292 scopus 로고
    • Peroxisomal lipid metabolism
    • 33. Reddy JK, Mannaerts GP. Peroxisomal lipid metabolism. Annu Rev Nutr 1994; 14: 343-70.
    • (1994) Annu Rev Nutr , vol.14 , pp. 343-370
    • Reddy, J.K.1    Mannaerts, G.P.2
  • 34
    • 0018662384 scopus 로고
    • The immediate and long term effects of clofibrate on the metabolism of the perfused rat liver
    • 34. Laker ME, Mayes PA. The immediate and long term effects of clofibrate on the metabolism of the perfused rat liver. Biochem Pharmacol 1979; 28: 2813-27.
    • (1979) Biochem Pharmacol , vol.28 , pp. 2813-2827
    • Laker, M.E.1    Mayes, P.A.2
  • 35
    • 0023699839 scopus 로고
    • Effects of fenofibrate on lipoprotein metabolism and fatty acid distribution in Zucker rats
    • 35. Olivier P, Plancke MO, Theret N, Marzin D, Clavey V, Fruchart JC. Effects of fenofibrate on lipoprotein metabolism and fatty acid distribution in Zucker rats. Atheroscler 1988; 74: 15-21.
    • (1988) Atheroscler , vol.74 , pp. 15-21
    • Olivier, P.1    Plancke, M.O.2    Theret, N.3    Marzin, D.4    Clavey, V.5    Fruchart, J.C.6
  • 36
    • 0025333458 scopus 로고
    • Interruption of long-term lipid-lowering treatment with bezafibrate in hypertriglyceridaemic patients. Effects on lipoprotein composition, lipase activities and the plasma lipid fatty acid spectrum
    • 36. Vessby B, Lithell H. Interruption of long-term lipid-lowering treatment with bezafibrate in hypertriglyceridaemic patients. Effects on lipoprotein composition, lipase activities and the plasma lipid fatty acid spectrum. Atheroscler 1990; 82: 137-43.
    • (1990) Atheroscler , vol.82 , pp. 137-143
    • Vessby, B.1    Lithell, H.2
  • 37
    • 0011878619 scopus 로고
    • Mechanisms of action of fenofibrate: New data
    • Paoletti R, Kritchevsky D, Holmeswl, eds. Berlin: Springer
    • 37. Pascal M, Danh HC, Legendre C. Mechanisms of action of fenofibrate: New data. In: Paoletti R, Kritchevsky D, Holmeswl, eds. Drug affecting lipid metabolism. Berlin: Springer, 1987, p. 319-23.
    • (1987) Drug Affecting Lipid Metabolism , pp. 319-323
    • Pascal, M.1    Danh, H.C.2    Legendre, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.