Lysophosphatidic acid (LPA) protects primary chronic lymphocytic leukemia cells from apoptosis through LPA receptor activation of the anti-apoptotic protein AKT/PKB

Journal of Biological Chemistry

Volumn 280, Issue 10, 2005, Pages 9498-9508

  Hu, Xiaojie ^a   Haney, Neil ^a   Kropp, Dianne ^a   Kabore, Albert F ^a   Johnston, James B ^a,b   Gibson, Spencer B ^a,b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; ALCOHOLS; DISEASES; DRUG PRODUCTS; PROTEINS; RNA;

CHRONIC LYMPHOCYTIC LEUKEMIA (CLL); CLL CELLS; LYSOPHOSPHATIDIC ACID (LPA); PROLIFERATION;

CARBOXYLIC ACIDS;

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; DIACYLGLYCEROL PYROPHOSPHATE; ETOPOSIDE; FLUDARABINE; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHATIDIC ACID RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PYROPHOSPHORIC ACID DERIVATIVE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

AGED; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL PROTECTION; CELL SURVIVAL; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; DOWN REGULATION; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; LEUKEMIA CELL; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

APOPTOSIS; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC; LYMPHOCYTES; LYSOPHOSPHOLIPIDS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, LYSOPHOSPHATIDIC ACID; TUMOR CELLS, CULTURED; VIDARABINE;

EID: 15744389876     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M410455200     Document Type: Article

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