Suramin affects coupling of rhodopsin to transducin

Biophysical Journal

Volumn 82, Issue 2, 2002, Pages 793-802

  Lehmann, Nicole ^a   Aradhyam, Gopala Krishna ^b   Fahmy, Karim ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; NUCLEOTIDE; PROTEIN SUBUNIT; RECEPTOR; RHODOPSIN; SURAMIN; TRANSDUCIN; TRYPTOPHAN;

ANIMAL TISSUE; ARTICLE; CATALYST; CATTLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISSOCIATION; DRUG BINDING SITE; DRUG EFFECT; DRUG PROTEIN BINDING; ENERGY TRANSFER; ENZYME ACTIVITY; FLUORESCENCE SPECTROSCOPY; INFRARED SPECTROSCOPY; NONHUMAN; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION;

ANIMALIA; BOS TAURUS; BOVINAE;

EID: 0036156679     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(02)75441-6     Document Type: Article

References (60)

1. GTP hydrolysis by purified a-subunit of transducin and its complex with the cyclic GMP phosphodiesterase inhibitor
2. Inhibition of receptor/G protein coupling by suramin analogues
3. sα
4. On the molecular origins of thermal noise in vertebrate and invertebrate photoreceptors
5. Differential effects of suramin on the coupling of receptors to individual species of pertussis-toxin-sensitive guanine-nucleotide-binding proteins
6. A prospective study of suramin-induced peripheral neuropathy
7. Suramin inhibition of growth factor receptor binding and mitogenicity in AKR-2B cells
8. Phase II study of suramin plus aminoglutethimide in two cohorts of patients with androgen-independent prostate cancer: Simultaneous antiandrogen withdrawal and prior antiandrogen withdrawal
9. Phase II trial of suramin in patients with metastatic renal cell carcinoma
10. Intrinsic biophysical monitors of transducin activation: Fluorescence, UV-visible spectroscopy, light scattering, and evanescent field techniques
11. Binding of transducin and transducin-derived peptides to rhodopsin studied by attenuated total reflection-Fourier transform infrared difference spectroscopy
12. Protonation states of membrane-embedded carboxylic acid groups in rhodopsin and metarhodopsin II: A Fourier-transform infrared spectroscopic study of site-directed mutants
13. Light-dependent transducin activation by an ultraviolet-absorbing rhodopsin mutant
14. A mutant rhodopsin with a protonated Schiff base displays an active-state conformation: A Fourier transform infrared spectroscopy study
15. Theoretical study of the electrostatically driven step of receptor-G-protein recognition
16. Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin
17. Tryptophan W207 in transducin T alpha is the fluorescence sensor of the G protein activation switch and is involved in the effector binding
18. Antiproliferative and angiostatic activity of suramin analogues
19. Suramin analogues as subtype-selective g protein inhibitors
20. Flow of information in the light-triggered cyclic nucleotide cascade of vision
21. Antiangiogenic and antiproliferative activity of suramin analogues
22. Uncovering molecular mechanisms involved in activation of G protein-coupled receptors
23. Functional interaction of transmembrane helices 3 and 6 in rhodopsin: Replacement of phenylalanine 261 by alanine causes reversion of phenotype of a glycine 121 replacement mutant
24. Structure and function of proteins in G-protein-coupled signal transfer
25. Ocular symptoms and signs associated with suramin sodium treatment for metastatic cancer of the prostate
26. The effect of activating ligands on the intrinsic fluorescence of guanine nucleotide-binding regulatory proteins
27. sα-selective G protein antagonists
28. G proteins as drug targets
29. Identification of allosteric antagonists of receptor guanine nucleotide-binding protein interactions
30. Identification of glutamic acid 113 as the Schiff base proton acceptor in the metarhodopsin II photointermediate of rhodopsin
31. G protein-coupled receptors. I. Diversity of receptor-ligand interactions
32. Effects of suramin-related and other clinically therapeutic polyanions on protein kinase C activity
33. Light- and GTP-regulated interaction of GTPase and other proteins with bovine photoreceptor membranes
34. Solution structure of acidic fibroblast growth factor bound to 1,3,6-naphthalenetrisulfonate: A minimal model for the anti-tumoral action of suramins and suradistas
35. Characterization of interactions between transducin alpha/beta gamma-subunits and lipid membranes
36. Mapping the suramin-binding sites of human neutrophil elastase: Investigation by fluorescence resonance energy transfer and molecular modeling
37. Rhodopsin: The structural basis of molecular physiology
38. How do G-proteins stay at the plasma membrane?
39. Suramin in non-small cell lung cancer and advanced breast cancer: Two parallel phase II studies
40. Activation of rhodopsin: New insights from structural and biochemical studies
41. Resonance Raman spectroscopy of rhodopsin in disk membranes
42. Modulation of the GTPase activity of transducin: Kinetic studies of reconstituted systems
43. Crystal structure of rhodopsin: A G protein-coupled receptor
44. Preparation of rod outer segments
45. Influence of the location of tryptophanyl residues in proteins on their photosensitivity
46. A site on rod G protein alpha subunit that mediates effector activation
47. Fourier transform infrared difference spectroscopy of rhodopsin mutants: Light activation of rhodopsin causes hydrogen-bonding change in residue aspartic acid-83 during meta II formation
48. Molecular origin of continuous dark noise in rod photoreceptors
49. Kinetic study on the equilibrium between membrane-bound and free photoreceptor G-protein: Membrane association of G-protein
50. Molecular determinants of the reversible membrane anchorage of the G-protein transducin
51. Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices c and f
52. GTP binding protein: Properties and lack of activation by phosphorylated rhodopsin
53. Application of FTIR spectroscopy to the investigation of dark structures and photoreactions of visual pigments
54. Novel competitive antagonists for P2 purinoceptors
55. Differential uncoupling of A1 adenosine and D2 dopamine receptors by suramin and didemethylated suramin (NF037)
56. sα
57. Lipid modifications of trimeric G proteins
58. Stereochemistry of the guanyl nucleotide binding site of transducin probed by phosphorothioate analogues of GTP and GDP
59. Suramin is an active site-directed, reversible, and tight-binding inhibitor of protein-tyrosine phosphatases
60. Characterization of the mutant visual pigment responsible for congenital night blindness: A biochemical and Fourier-transform infrared spectroscopy study