Synthesis of a novel dimeric bis-benzimidazole with site-selective DNA-binding properties

Tetrahedron Letters

Volumn 43, Issue 40, 2002, Pages 7239-7241

  Sun, Xiao Wen ^a   Neidle, Stephen ^b   Mann, John ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; BIS[3 [4 [2' (4 METHOXYPHENYL) 3H,3'H(5,5') DIBENZIMIDAZOLYL 2 YL]PHENOXY]PROPYL]METHYLAMINE; DNA; OLIGONUCLEOTIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DNA BINDING; DRUG SYNTHESIS; NUCLEOTIDE SEQUENCE; STEREOCHEMISTRY;

EID: 0037201090     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(02)01595-2     Document Type: Article

References (12)

1. Reddy B.S.P., Sondhi S.M., Lown J.W. Pharmacol. Ther. 84:1999;1-111.
2. Neidle S. Nat. Prod. Rep. 18:2001;291-309.
3. Kraut E.H., Masspeis L., Bakerzak S., Grever M. Proc. Am. Soc. Clin. Oncol. 7:1988;62.
4. Neidle S., Mann J., Rayner E.L., Baron A., Opoku-Boahen Y., Simpson I.J., Smith N.J., Fox K.R., Hartley J.A., Kelland L.R. Chem. Commun. 1999;929-930.
5. Mann J., Baron A., Opoku-Boahen Y., Johansson E., Parkinson G., Kelland L.R., Neidle S. J. Med. Chem. 44:2001;138-144.
6. Van den Berg, H. W., School of Oncology, QUB, personal communication.
7. +) 443.2308, found 443.2314.
8. Bencini A., Bianchi A., Borselli A., Ciampolini M., Garcia-Espana E., Dapporto P., Micheloni M., Paoli P., Ramirez J.A., Valtancoli B. Inorg. Chem. 28:1989;4279-4284.
9. Granier C., Guilard R. Tetrahedron. 51:1995;1197-1208.
10. +) 330.1481, found 330.1468.
11. Eaton P.E., Carlson G.R., Lee J.T. J. Org. Chem. 38:1973;4071-4073.
12. +) 976.4299, found 976.4333.