Role of polyamines and NMDA receptors in ethanol dependence and withdrawal

Alcoholism: Clinical and Experimental Research

Volumn 25, Issue 5 SUPPL., 2001, Pages

  Littleton, J M ^a   Lovinger, D ^a   Liljequist, S ^a   Ticku, R ^a   Matsumoto, I ^a   Barron, S ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Acamprosate; Ifenprodil; Neurotoxicity; NMDA; Seizures; Subunits

Indexed keywords

ACAMPROSATE; ALCOHOL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; POLYAMINE; RECEPTOR SUBUNIT; RECOMBINANT RECEPTOR; SPERMINE;

ALCOHOL WITHDRAWAL; ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; GRANULE CELL; HUMAN; JAPAN; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; SYMPOSIUM;

ANIMALIA; RODENTIA;

EID: 0034965698     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2001.tb02387.x     Document Type: Conference Paper

References (35)

1. Mechanism of acamprosate II. Ethanol dependence modifies effects of acamprosate on NMDA receptor binding in membranes from rat cerebral cortex
2. Effects of c-SRC tyrosine kinase on ethanol sensitivity of recombinant NMDA receptors expressed in HEK 293 cells
3. Agmatine reduces some of the effects of "third trimester" alcohol exposure using a rodent model
4. Increased agonist and antagonist sensitivity of NMDA-stimulated calcium flux in cultured neurons following chronic ethanol exposure
5. Release of spermidine from the rat cortex following permanent middle cerebral artery occlusion
6. Chronic ethanol treatment leads to increased ornithine decarboxylase activity: Implications for a role of polyamines in ethanol dependence and withdrawal
7. Gender-selective effects of ethanol dependence on NMDA receptor subunit expression in cerebral cortex hippocampus and hypothalamus
8. Investigation of the involvement of the NMDA receptor macrocomplex in the development of spermine-induced CNS excitation in vivo
9. Polyamine neurotoxicity is antagonized by dizocilpine in cultured chick cortical neurons
10. Interactions between ifenprodil and the NR2B subunit of the NMDA receptor
11. Arginine and ornithine decarboxylation in rodent brain: Coincidental changes during development and after ischemia
12. Cell death and immunohistochemistry of p53, c-Fos and c-Jun after spermine injection into the rat striatum
13. Chronic ethanol treatment produces a selective up-regulation of the NMDA receptor subunit gene expression in mammalian cultured cortical neurons
14. Chronic ethanol treatment up-regulates the NMDA receptor function and binding in mammalian cortical neurons
15. Modulation of channel function by polyamines
16. Oral administration of glycine and polyamine receptor antagonists blocks ethanol withdrawal seizures
17. Polyamine metabolism in epileptic cortex
18. Ethanol inhibition of NMDA neurotoxicity on the polyamine site in cerebellar granule cells
19. Alcohol dependence and modulation of calcium channels
20. The role of polyamines in neurotoxicity induced by alcohol withdrawal in vitro
21. Examination of ethanol spermine and acamprosate actions on native and recombinant NMDA receptors
22. Role of polyamine synthesis in aspects of alcohol withdrawal in vivo
23. Polyamine-enhanced NMDA receptor activity: Effect of ethanol
24. Fyn-kinase as a determinant of ethanol sensitivity: Relation to NMDA receptor function
25. Mechanisms of action of acamprosate I: Characterization of spermidine-sensitive acamprosate binding site (ABS) in rat brain
26. In vivo pharmacological study of spermine-induced neurotoxicity
27. Interaction of acamprosate with ethanol and spermine on NMDA receptors in primary cultured neurons
28. The novel anti-craving drug acamprosate alters the expression of NMDA R1 splice variant mRNAs in the rat brain
29. Polyamine regulation of the NMDA receptor channel
30. Developmental maturation of NMDA receptor channel complex in postnatal rat brain
31. Effects of gestational or neonatal treatment with alpha-dimethylornithine on ornithine decarboxylase and polyamines in developing rat brain and on adult rat neurochemistry
32. Effects of agmatine on ethanol withdrawal syndrome in rats
33. Modulation and block of ion channels: A new biology of polyamines
34. Sensitivity of the NMDA receptor to polyamines is controlled by NR2 subunits
35. Evidence for a selective effect of ethanol on NMDA responses: Ethanol affects a subtype of the ifenprodil-sensitive NMDA receptors