Discriminative stimulus effects of ethanol and 3α-hydroxy-5α-pregnan-20-one in relation to menstrual cycle phase in cynomolgus monkeys (Macaca fascicularis)

Psychopharmacology

Volumn 130, Issue 1, 1997, Pages 59-68

  Grant, Kathleen A ^a   Azarov, Alexey ^a   Shively, Carol A ^b   Purdy, Robert H ^b  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

3 Hydroxy 5 pregnan 20 one; Cynomolgus monkeys; Drug discrimination; Ethanol; Menstrual cycle; Neuroactive steroids; Neurosteroids

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; ALCOHOL; ANXIOLYTIC AGENT; NEUROSTEROID; PROGESTERONE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DISCRIMINATIVE STIMULUS; DRUG MECHANISM; FEMALE; FOLLICULAR PHASE; FOOD; HORMONE BLOOD LEVEL; INSTRUMENTAL CONDITIONING; INTRAGASTRIC DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LUTEAL PHASE; MENSTRUAL CYCLE; MONKEY; NONHUMAN; PRIORITY JOURNAL; REINFORCEMENT;

ANIMALS; DISCRIMINATION (PSYCHOLOGY); DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; FEMALE; MACACA; MENSTRUAL CYCLE; NEUROPROTECTIVE AGENTS; PREGNANOLONE;

EID: 0031018087     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050211     Document Type: Article

References (50)

1. Adams MR, Clarkson TB, Kaplan JR, Koritnik DR (1985) Ovariectomy, social status, and atherosclerosis in cynomolgus monkeys. Arteriosclerosis 5:192-200
2. Ator NA (1990) Drug discrimination and drug stimulus generalization with anxiolytic. Drug Dev Res 20:189-204
3. Ator NA, Grant KA, Purdy RH, Paul SM, Griffiths RR (1993) Drug discrimination analysis of endogenous neuroactive steroids in rats. Eur J Pharmacol 241:237-243
4. Baulieu EE (1981) Steroid hormones in the brain: several mechanisms? In: Fuxe K, Gustafsson JA, Wetterberg L (eds) Steroid hormone regulation of the brain, Stockholm. Wenner-Gren Center International Symposium series, vol. 34. Oxford Press, Oxford, pp 3014
5. Belfar ML, Shader RI (1976) Premenstrual factors as determinants of alcoholism in women. In: Greenblatt M, Schuckit MA (eds) Alcohol problems in women and children. Grune and Stratton, New York, pp 97-102
6. Bolby MR (1993) Pregnenolone sulfate potentiation of N-methyl-D-aspartate receptor channels in hippocampal neurons. Mol Pharmacol 43:813-819
7. Brick J, Nathan PE, Westrick E, Frankenstein W, Shapiro A (1986) The effect of menstrual cycle on blood alcohol levels and behavior. J Stud Alcohol 47:472-477
8. Cole-Harding S, Wilson JR (1987) Ethanol metabolism in men and women. J Stud Alcohol 48:380-387
9. Corpechot C, Young J, Calvel M, Wehrey C, Veltz JN, Touyer G, Mouren M, Prasad VVD, Banner C, Sjovall J, Baulieu EE, Robel P (1993) Neurosteroids: 3a-hydroxy-5a-regnan-20-one and its precursors in the brain, plasma, and steroidogenic glands of male and female rats. Endocrinology 133:1003-1009
10. Crawley JN, Glowa JR, Majewska MD, Paul SM (1986) Anxiolytic activity of an endogenous adrenal steroid. Brain Res 398: 382-385
11. Deutsch SI, Mastropaolo J (1993) Discriminative stimulus properties of midazolam are shared by a GABA-receptor positive steroid. Pharmacol Biochem Behav 46:963-965
12. Devaud LL, Purdy RH, Morrow AL (1995) The neurosteroid, 3a-hydroxy-5a-pregnan-20-one, protects against bicuculline-induced seizures during ethanol withdrawal in rats. Alcohol Clin Exp Res 19:350-355
13. Dukelow WR (1977) Ovulatory cycle characteristics in Macaca fascicularis. J Med Primatol 6:33-42
14. Dyer CA, Bonnet DJ, Curtiss LK (1994) Ovarian theca-interstitial cell neurosteroid production is stimulated by LH and glucocorticoids. Abstract, Endocrine Society Annual Meeting, Anaheim, Calif., #1668
15. A receptor complex. J Pharmacol Exp Ther 265: 1374-1379
16. Finn DA, Gee KW (1994) Estrus cycle and sensitivity to convulsants and the anticonvulsant effects of a neurosteroid. J Pharmacol Exp Ther 271: 164-170
17. Finn DA, Roberts AJ, Crabbe JC (1995) Neuroactive steroid sensitivity in withdrawal seizure-prone and-resistant mice. Alcohol Clin Exp Res 19:410-415
18. Frye CA (1995) The neurosteroid 3a, 5a THP has antiseizure and possible neuroprotective effects in an animal model of epilepsy. Brain Res 696:113-120
19. Fujuwara T, Uchino I, Honjo S, Imaizumi K, Imanichi T (1967) Normal range of the menstrual cycle of cynomolgus monkeys under laboratory conditions. Jpn J Med Sci Biol 20:505-507
20. Grant KA, Azarov A, Bowen CA, Mirkis S, Purdy RH (1996) Ethanol-like discriminative stimulus effects of the neurosteroid 3α-hydroxy-5α-pregnan-20-one in female Macaca fascicularis monkeys. Psychopharmacology 124:340-346
21. Harvey SM, Beckman LJ (1985) Cyclic fluctuation in alcohol consumption among female social drinkers. Alcohol Clin Exp Res 9:465-467
22. 3H]flurnitrazepam binding and gamma-aminobutyric acidA receptor function. Mol Pharmacol 46:977-985
23. Hay WM, Nathan PE, Heermans HW, Frankenstein W (1984) Menstrual cycle, tolerance and blood alcohol level discrimination ability. Addict Behav 9:67-77
24. Holzbauer M, Birmingham MK, DeNicola AF, Oliver JT (1985) In vivo secretion of 3α-hydroxy-5α-pregnan-20-one, a potent anesthetic steroid, by the adrenal gland of the rat. J Steroid Biochem 22:97-102
25. Ichikawa S, Morioka H, Sawada T (1972) Identification of neutral steroids in the ovarian venous plasma of LH stimulated rats. Endocrinology 88:372-383
26. Irwin PR, Lin S-Z, Rogawski MA, Purdy RH, Paul SM (1994) Steroid potentiation and inhibition of N-methyl-D-aspartate receptor-mediated Intracellular Ca++ responses: structure-activity studies. J Pharmacol Exp Ther 271:677-682
27. Jones BM, Jones MK (1976) Women and Alcohol: intoxication, metabolism, and the menstrual cycle. In: Greenblatt M, Shuckit MA (eds) Alcoholism problems in women and children. Grune and Stratton, New York, pp 103-126
28. Kokate TG, Svensson BE, Rogawski MA (1994) Anticonvulsant activity of neurosteroids: correlation with γ-aminobutyric acid-evoked chloride current potentiation J Pharmacol Exp Ther 270: 1223-1229
29. A receptor function: molecular and physiological determinants. In: Biggio G, Costa E (eds) GABAergic synaptic transmission. Raven Press, New York, pp 269-279
30. Mathis C, Paul SM, Crawley JN (1994) The neurosteroid pregnenolone sulfate blocks NMDA antagonist-induced deficits in a passive avoidance memory task. Psychopharmacology 116:201-206
31. A receptor complex in the rat. J Pharmacol Exp Ther 275: 1412-1417
32. A receptor channels. Annu Rev Neurosci 17: 569-603
33. Melchior CL, Ritzmann RF (1994) Dehydroepiandrosterone is an anxiolytic in mice on the plus maze. Pharmacol Biochem Behav 47:437-441
34. Mello NK, Mendelson JH, Lex BW (1990) Alcohol use and premenstrual symptoms in social drinkers. Psychopharmacology 101:448-455
35. Mello NK, Bree MP, Skumpy AST, Mendelson JH (1984) Blood alcohol levels as a function of menstrual cycle phase in female macaque monkeys. Alcohol 1:27-31
36. Paul SM, Purdy RH (1992) Neuroactive steroids. FASEB J 6:2311-2322
37. Podolsky E (1963) Women alcoholics and premenstrual tension. J Am Med Wom Assoc 18:816-818
38. Purdy RH, Moore PH Jr, Rao PN, Hagino N, Yamaguchi T, Schmidt P, Rubinow DR, Morrow AL, Paul SM (1990) Radioimmunoassay of 3α-hydroxy-5α-pregnan-20-one in rat and human plasma. Steroids 55:290-296
39. Purdy RH, Morrow AL, Moore PH, Paul SM (1991) Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain. Proc Natl Acad Sci USA 88:4553-4557
40. A receptor research. Synapse 21: 189-274
41. Rubinow DR, Hoban MC, Grover GN (1988) Changes in plasma hormones across the menstrual cycle in patients with menstrually related mood disorders and in control subjects. Am J Obstet Gynecol 158:5-11
42. Schmidt PJ, Purdy RH, Moore PH Jr, Paul SM, Rubinow DR (1994) Circulating levels of anxiolytic steroids in the luteal phase in women with premenstrual syndrome and in control subjects. J Clin Endocrinol Metab 79:1256-1260
43. Sutker PB, Libet JM, Allain AN, Randall CL (1983) Alcohol use, negative mood states, and menstrual cycle phases. Alcohol Clin Exp Res 7:327-331
44. Sutker PB, Goist KC, King AR (1987a) Acute alcohol intoxication in women: relationship to dose and menstrual cycle phase. Alcohol Clin Exp Res 11:74-79
45. Sutker PB, Goist KC, Allain AN, Bugg F (1987b) Acute alcohol intoxication: sex comparisons on pharmacokinetics and mood measures. Alcohol Clin Exp Res 11:507-512
46. Tate DL, Charette L (1991) Personality, alcohol consumption and menstrual distress in young women. Alcoholism 15:647-652
47. Wu FS, Gibbs TT, Farb DH (1991) Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor. Mol Pharmacol 40:333-336
48. Yamamoto KR (1985) Steroid receptor regulated transcription of specific genes and gene networks. Annu Rev Genet 19:209-252
49. Yen SCC (1991) The human menstrual cycle. In: Yen SCC, Jaffe RB (eds) Reproductive endocrinology: physiology, pathophysiology and clinical management. Saunders, Philadelphia
50. Zimmerberg B, Drucker PC, Weider JM (1995) Differential behavioral effects of the neuroactive steroid allopregnanolone on neonatal rats prenatally exposed to alcohol. Pharmacol Biochem Behav 51:463-468