The discriminative stimulus effects of ethanol are mediated by NMDA and GABA(A) receptors in specific limbic brain regions

Psychopharmacology

Volumn 139, Issue 1-2, 1998, Pages 95-107

  Hodge, Clyde W ^a   Cox, Amy A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Amygdala; Discriminative stimulus; Drug discrimination; Ethanol; Frontal cortex; GABA(A); Hippocampus; Limbic system; MK 801; Muscimol; NMDA; Nucleus accumbens; Rat

Indexed keywords

4 (3 PHOSPHONOPROPYL) 2 PIPERAZINECARBOXYLIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; DIZOCILPINE; MUSCIMOL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; SODIUM CHLORIDE;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DISCRIMINATIVE STIMULUS; DRUG DISCRIMINATION; FRONTAL CORTEX; HIPPOCAMPUS; INTRACEREBRAL DRUG ADMINISTRATION; LIMBIC SYSTEM; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; REGIONAL PERFUSION;

AMYGDALA; ANIMALS; DISCRIMINATION (PSYCHOLOGY); DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; FRONTAL LOBE; GABA AGONISTS; HIPPOCAMPUS; LIMBIC SYSTEM; MALE; MUSCIMOL; N-METHYLASPARTATE; NEUROPROTECTIVE AGENTS; NUCLEUS ACCUMBENS; RATS; RECEPTORS, GABA-A; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0031693278     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050694     Document Type: Article

References (74)

1. Allan A, Harris R (1987) Acute and chronic ethanol treatments alter gaba receptor-operated chloride channels. Pharmacol Biochem Behav 27:665-670
2. Barry H III (1991) Distinctive discriminative effects of ethanol. In: Glennon RA, Jarbe TUC, Frankenheim J (eds) Drug discrimination: applications to drug abuse research. NIDA Monograph 116, US Government Printing Office, Washington, pp 131-144
3. Barry H III, Krimmer EC (1978) Similarities and differences in discriminative stimulus effects of chlordiazepoxide, pentobarbital, ethanol, and other sedatives. In: Colpaert FC, Rosecrans JA (eds) Stimulus properties of drugs: ten years of progress. Elsevier, Amsterdam, pp 31-51
4. Benjamin D, Emmett-Oglesby MW, Lal H (1987) Modulation of the discriminative stimulus produced by pentylenetetrazol by centrally administered drugs. Neuropharmacology 26:1727-1731
5. Butelman ER, Baron SP, Woods JH (1993) Ethanol effects in pigeons trained to discriminate MK-801, PCP or CGS-19755. Behav Pharmacol 4:57-60
6. Carter CJ (1980) Glutamatergic pathways from the medial prefrontal cortex to the anterior striatum, nucleus accumbens, and substantia nigra. Br J Pharmacol 70:50P-51P
7. 3H] GABA. Neuroscience 22:425-439
8. Cooper BR, Viik K, Ferris RM, White HL (1979) Antagonism of the enhanced susceptibility to audiogenic seizures during alcohol withdrawal in the rat by γ-aminobutyric acid (GABA) and "GABA-mimetic" agents. J Pharmacol Exp Ther 209:396-403
9. Cotman CW, Monaghan DT, Ottersen OP, Storm-Mathisen J (1987) Anatomical organization of excitatory amino acid receptors and their pathways. Trends Neurosci 10:273-280
10. A receptors: generalization to other ligand-gated ion channels. J Pharmacol Exp Ther 267:522-537
11. Doble A, Martin IL (1992) Multiple benzodiazepine receptors: no reason for anxiety. Trends Pharmacol Sci 13:76-81
12. France CP, Adams JU, Woods JH (1987) Comparison of naltrexone and quaternary naltrexone after systemic and intracerebroventricular administration in pigeons. Neuropharmacology 26: 541-548
13. Franklin CL, Gruol DL (1987) Acute ethanol alters the firing pattern and glutamate response of cerebellar Purkinje neurons in culture. Brain Res 416:205-218
14. Frye GD, Breese GR (1982) GABAergic modulation of ethanol-induced motor impairment. J Pharmacol Exp Ther 223:750-756
15. Goldstein DB (1978) Alcohol withdrawal reactions in mice: effects of drugs that modify neurotransmission. J Pharmacol Exp Ther 186:1-9
16. 3H]norepinephrine release from rat cortical slices. J Pharmacol Exp Ther 253:1138-1144
17. Grant K (1994) Emerging neurochemical concepts in the actions of ethanol at ligand-gated ion channels. Behav Pharmacol 5:383-404
18. Grant K, Colombo G (1992) Discriminative stimulus effects of ethanol: effect of training dose on the substitution of N-methyl-D-aspartate antagonists. J Pharmacol Exp Ther 264:1241-1247
19. Grant KA, Colombo G (1993) Pharmacological analysis of the mixed discriminative stimulus effects of ethanol. Alcohol Alcohol 2:445-449
20. Grant K, Lovinger D (1995) Cellular and behavioral neurobiology of alcohol: receptor-mediated neuronal processes. Clin Neurosci 3:155-164
21. Grant KA, Kinsely JS, Tuhukoff B, Barrett JE, Balster RL (1991) Ethanol-like discriminative stimulus effects of noncompetitive N-methyl-D-aspartate antagonists. Behav Pharmacol 2:87-95
22. Hiltunen AJ, Jarbe TUC (1986) Discrimination of Ro 11-6896, chlordiazepoxide and ethanol in gerbils: generalization and antagonism tests. Psychopharmacology 89:284-290
23. Hodge C (1994) Comparison of the discriminative stimulus function of ethanol following intracranial and systemic administration: evidence of a central mechanism. Pharmacol Bioehem Behav 47:743-747
24. A receptors in the nucleus accumbens. Alcohol Clin Exp Res 20:1221-1228
25. Hodge C, Samson H, Haraguchi M (1992) Microinjections of dopamine agonists in the nucleus accumbens increase ethanol-reinforced responding. Pharmacol Biochem Behav 43:249-254
26. Hodge C, Chappelle A, Samson H (1995) GABAergic transmission in the nucleus accumbens is involved in the termination of ethanol self-administration in rats. Alcohol Clin Exp Res 19:1486-1493
27. Hodge C, Chappelle A, Samson H (1996) Dopamine receptors in the medial prefrontal cortex influence ethanol and sucrose-reinforced responding. Alcohol Clin Exp Res 20:1631-1638
28. Hoffman PL, Rabe CS, Moses F, Tabakoff B (1989) N-Methyl-D-aspartate receptors and ethanol: inhibition of calcium flux and cyclic GMP production. J Neuroehem 52:1937-1940
29. Holloway F, Gauvin D (1989) Comments on method and theory in drug discrimination: a potpourri of problems, perplexities, and possibilities. Drug Dev Res 16:195-207
30. Järbe TUC, McMillan DE (1983) Interaction of the discriminative stimulus properties of diazepam and ethanol in pigeons. Pharmacol Bioehem Behav 18:73-80
31. Kelley AE, Domesick VB (1982) The distribution of the projection from the hippocampal formation to the nucleus accumbens in the rat: an anterograde- and retrograde-horseradish peroxidase study. Neuroscience 7:2321-2335
32. Kline FS, Young AM (1986) Differential modification of pentobarbital stimulus control by d-amphetamine and ethanol. Pharmacol Bioehem Behav 24:1305-1313
33. Koob G, Weiss F (1992) Neuropharmacology of cocaine and ethanol dependence. In: Galanter M (ed) Recent developments in alcoholism, vol 10: alcohol and cocaine: similarities and differences. Plenum Press. New York, pp 201-233
34. Koob GF, Mendelson WB, Schaffer J, Wall TL, Britton KT, Bloom FE (1989) Picrotoxin receptor ligand blocks anti-punishment effects of alcohol. Alcohol 5:437-443
35. Krynock GM, Rosecrans JA (1979) Morphine as a discriminative stimulus: role of the periaqueductal gray neurons. Res Commun Chem Pathol Pharmacol 23:49-60
36. Kubena RK, Barry H (1969) Generalization by rats of alcohol and atropine stimulus characteristics to other drugs. Psychopharmacology 15:196-206
37. Liebman JM, Bennett DA (1988) Anxiolytic actions of competitive N-methyl-D-aspartate receptor antagonists: a comparison with benzodiazepine modulators and dissociative anesthetics. In: Cavalheiro J, Lehmann J, Turski L (eds) Frontiers in excitatory amino acid research. Liss, New York
38. Liljequist S, Engel JA (1984) The effects of GABA and benzodiazepine receptor antagonists on the anti-conflict actions of diazepam or ethanol. Pharmacol Bioehem Behav 21:521-525
39. Lin A, Freund R, Palmer M (1993) Sensitization of γ-aminobutyric acid-induced depressions of cerebellar Purkinje neurons to the potentiative effects of ethanol by beta adrenergic mechanisms in rat brain. J Pharmacol Exp Ther 265:426-432
40. Lovinger DM, White G, Weight F (1989) Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science 243:1721-1724
41. A-gated chloride channels. J Pharmacol Exp Ther 246:558-564
42. Meredith G, Pennartz, C, Groenewegen H (1993) The cellular framework for chemical signaling in the nucleus accumbens. In: Arhuthnott G, Emson P (eds) Progress in brain research. Elsevier., Oxford, pp 3-24
43. Millie SJ, Ye Q, Wick MJ, Koltchine VV, Krasowski MD, Finn SE, Mascia MP, Valenzuela CF, Hanson KK, Greenblatt EP, Harris RA, Harrison NL (1997) Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors. Nature 389:385-389
44. 3H-L-glutamtate binding sites. Nature 306:176-179
45. Nielsen E, Scheel-Kruger J (1986) Cueing effects of amphetamine and LSD: elicitation by direct microinjection of the drugs into the nucleus accumbens. Eur J Pharmacol 125:85-92
46. O'Donnell P, Grace A (1995) Synaptic interactions among excitatory afferents to nucleus accumbens neurons: hippocampal gating of prefrontal cortical input. J Neurosci 15:3622-3639
47. Olsen RW, Bergman MO, Van Ness PC, Lummis SC, Watkins AE, Napias C, Greenlee DV (1981) γ-Aminobutyric acid receptor binding in mammalian brain: heterogeneity of binding sites. Mol Pharmacol 19:217-227
48. A receptor subtypes: autoradiographic comparison of GABA, benzodiazepine, and convulsant binding sites in the rat central nervous system. J Chem Neuroanat 3:59-76
49. Overton DA (1977) Comparison of ethanol, pentobarbital, and phenobarbital using drug vs. drug discrimination training. Psychopharmacology 53:195-199
50. Patel S, Chapman AG, Graham JL, Meldrum BS, Frey P (1990) Anticonvulsant activity of the NMDA antagonists (D-CPP and CPPene) in a rodent and primate model of reflex epilepsy. Epilepsy Res 7:3-10
51. Paxinos G, Watson C (1997) The rat brain in stereotaxic coordinates, 3rd edn. Academic Press, San Diego
52. A by depressant barbiturates and pregnane steroids. Br J Pharmacol 94:1257-1269
53. Rabe CS, Tabakoff B (1988) High sensitivity of NMDA-stimulated calcium uptake to inhibition by ethanol in primary cultures of cerebellar neurons. Soc Neurosci Abstr 14:479
54. A receptor research. Synapse 21:189-274
55. Samson HH, Haraguchi M, Tolliver GA, Sadeghi KG (1988) Antagonism of ethanol-reinforced behavior by the benzodiazepine inverse agonists Ro 15-4513 and FG 7142: relation to sucrose reinforcement. Pharmacol Biochem Behav 33:601-608
56. Sannerud CA, Ator NA, Griffiths RR (1991) Comparison of the discriminative stimulus effects of midazolam after intracranial and peripheral administration in the rat. Life Sci 49:261-268
57. Scheel-Kruger J, Willner P (1991) The mesolimbic system: principles of operation. In: Willner P, Scheel-Kruger J (eds) The mesolimbic dopamine system: from motivation to action. Wiley, New York, pp 559-598
58. A receptors. Trends Pharmacol Sci 16:162-168
59. Study RE, Barker JL (1981) Diazepam and (-)pentobarbital: fluctuation analysis reveals different mechanisms for potentiation of γ-aminobutyric acid responses in cultured central neurons. Proc Natl Acad Sci USA 78:7180-7184
60. Suzdak PD, Schwartz RD, Skolnick P, Paul SM (1986) Ethanol stimulates γ-aminobutyric aid receptor-mediated chloride transport in rat brain synaptoneurosomes. Proc Natl Acad Sci USA 83:4071-4075
61. Suzdak PD, Schwanz RD, Skolnick P, Paul SM (1988) Alcohols stimulate γ-aminobutyric aid receptor-mediated chloride uptake in brain vesicles: correlation with intoxication potency. Brain Res 444:340-345
62. Taber M, Fibiger H (1995) Electrical stimulation of the prefrontal cortex increases dopamine release in the nucleus accumbens of the rat: modulation by metabotropic glutamate receptors. J Neurosci 15:3896-3906
63. Ticku MK (1990) Alcohol and GABA-benzodiazepine receptor function. Ann Med 22:241-246
64. a. Ann NY Acad Sci 625:136-144
65. Turski L, Schwarz M, Turski WA, Klockgether T, Sontag KH, Collins JF (1985) Muscle relaxant action ot excitatory amino acid antagonists. Neurosci Lett 53:321-326
66. Wallas I, Fonnum F (1979) The effects of surgical and chemical lesions on neurotransmitter candidates in the nucleus accumbens of the rat. Neuroscience 4:209-216
67. Weight FF (1992) Cellular and molecular physiology of alcohol actions in the nervous system. Int Rev Neurobiol 33:289-348
68. Weight FF, Lovinger DM, White G, Peoples RW (1991) Alcohol and anesthetic actions on excitatory amino acid-activated ion channels. Electrophysiology 625:97-107
69. A-mediated synaptic current by ethanol in hippocampal CA1 neurons: possible role of protein kinase C. J Pharmacol Exp Ther 268:1388-1395
70. Williams-Hernby L, Porrino L (1994) Low and moderate doses of ethanol produce distinct patterns of cerebral metabolic changes in rats. Alcohol Clin Exp Res 18:982-988
71. Wood DM, Emmett-Oglesby MW (1989) Mediation in the nucleus accumbens of the discriminative stimulus produced by cocaine. Pharmacol Biochem Behav 33:453-457
72. Wood DM. Retz KC, Emmett-Oglesby MW (1987) Evidence of a central mechanism mediating tolerance to the discriminative stimulus properties of cocaine. Pharmacol Biochem Behav 28:401-406
73. Woodward JJ, Gonzales RA (1990) Ethanol inhibition of N-methyl-D-aspartate-stimulated endogenous dopamine release from rat striatal slices. J Neurochem 54:712-715
74. York JL (1978) A comparison of the discriminative stimulus effects of ethanol, barbital, and phenobarbital in rats. Psychopharmacology 60:19-23