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Volumn 136, Issue 1, 2003, Pages 85-94

Sex differences in the pharmacokinetics of pioglitazone in rats

Author keywords

Active metabolites; Adipose tissue; Concentration; Peroxisome proliferator activated receptor (PPAR ); Pharmacokinetics; Pioglitazone; Rats; Sex difference

Indexed keywords

DRUG METABOLITE; PIOGLITAZONE;

EID: 1542714421     PISSN: 15320456     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1532-0456(03)00194-7     Document Type: Article
Times cited : (51)

References (32)
  • 1
    • 17544396164 scopus 로고    scopus 로고
    • Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation
    • Adams M., Montague C.T., Prins J.B., Holder J.C., Smith S.A., Sanders L., et al. Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation. J. Clin. Invest. 100:1997;3149-3153.
    • (1997) J. Clin. Invest. , vol.100 , pp. 3149-3153
    • Adams, M.1    Montague, C.T.2    Prins, J.B.3    Holder, J.C.4    Smith, S.A.5    Sanders, L.6
  • 2
    • 0033851886 scopus 로고    scopus 로고
    • Efficacy of troglitazone on body fat distribution in type 2 diabetes
    • Akazawa S., Sun F., Ito M., Kawasaki E., Eguchi K. Efficacy of troglitazone on body fat distribution in type 2 diabetes. Diabetes Care. 23:2000;1067-1071.
    • (2000) Diabetes Care , vol.23 , pp. 1067-1071
    • Akazawa, S.1    Sun, F.2    Ito, M.3    Kawasaki, E.4    Eguchi, K.5
  • 3
    • 0034748953 scopus 로고    scopus 로고
    • The effects of androgens and estrogens on preadipocyte proliferation in human adipose tissue: Influence of gender and sidte
    • Anderson L.A. The effects of androgens and estrogens on preadipocyte proliferation in human adipose tissue: influence of gender and sidte. J. Clin. Endocrinol. Metab. 86:2001;5045-5051.
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 5045-5051
    • Anderson, L.A.1
  • 4
    • 0032818309 scopus 로고    scopus 로고
    • Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone
    • Baldwin S.J., Clarke S.E., Chenery R.J. Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone. Br. J. Clin. Pharmacol. 48:1999;424-432.
    • (1999) Br. J. Clin. Pharmacol. , vol.48 , pp. 424-432
    • Baldwin, S.J.1    Clarke, S.E.2    Chenery, R.J.3
  • 5
    • 0033911580 scopus 로고    scopus 로고
    • Absorption, disposition, and metabolism of rosiglitazone, a potent thiazolidinedione insulin sensitizer, in humans
    • Cox P.J., Ryan D.A., Hollis F.J., Harris A.M., Miller A.K., Vousden M., et al. Absorption, disposition, and metabolism of rosiglitazone, a potent thiazolidinedione insulin sensitizer, in humans. Drug Metab. Dispos. 28:2000;772-780.
    • (2000) Drug Metab. Dispos. , vol.28 , pp. 772-780
    • Cox, P.J.1    Ryan, D.A.2    Hollis, F.J.3    Harris, A.M.4    Miller, A.K.5    Vousden, M.6
  • 6
    • 0031798630 scopus 로고    scopus 로고
    • Androgen receptors in human preadipocytes and adipocytes: Regional specificities and regulation by sex steroids
    • Dieudonne M.N., Pecquery R., Boumediene A., Leneveu M.C., Giudicelli Y. Androgen receptors in human preadipocytes and adipocytes: regional specificities and regulation by sex steroids. Am. J. Physiol. 274:1998;C1645-1652.
    • (1998) Am. J. Physiol. , vol.274 , pp. 1645-1652
    • Dieudonne, M.N.1    Pecquery, R.2    Boumediene, A.3    Leneveu, M.C.4    Giudicelli, Y.5
  • 7
    • 0034465232 scopus 로고    scopus 로고
    • Opposite effects of androgens and estrogens on adipogenesis in rat preadipocytes: Evidence for sex and site-related specificities and possible involvement of insulin-like growth factor 1 receptor and peroxisome proliferator-activated receptor gamma2
    • Dieudonne M.N., Pecquery R., Leneveu M.C., Giudicelli Y. Opposite effects of androgens and estrogens on adipogenesis in rat preadipocytes: evidence for sex and site-related specificities and possible involvement of insulin-like growth factor 1 receptor and peroxisome proliferator-activated receptor gamma2. Endocrinology. 141:2000;649-656.
    • (2000) Endocrinology , vol.141 , pp. 649-656
    • Dieudonne, M.N.1    Pecquery, R.2    Leneveu, M.C.3    Giudicelli, Y.4
  • 8
    • 0034810107 scopus 로고    scopus 로고
    • Pharmacokinetics and clinical efficacy of pioglitazone
    • Hanefeld M. Pharmacokinetics and clinical efficacy of pioglitazone. Int. J. Clin. Pract. (Suppl.):2001;19-25.
    • (2001) Int. J. Clin. Pract. , Issue.SUPPL. , pp. 19-25
    • Hanefeld, M.1
  • 9
    • 0031754460 scopus 로고    scopus 로고
    • The effect of pioglitazone on glucose metabolism and insulin uptake in the perfused liver and hindquarter of high-fructose-fed rats
    • Ikeda T., Fujiyama K. The effect of pioglitazone on glucose metabolism and insulin uptake in the perfused liver and hindquarter of high-fructose-fed rats. Metabolism. 47:1998;1152-1155.
    • (1998) Metabolism , vol.47 , pp. 1152-1155
    • Ikeda, T.1    Fujiyama, K.2
  • 10
    • 0036891121 scopus 로고    scopus 로고
    • Sex-dependent pharmacokinetics of S(-)-hydroxyhexamide, a pharmacologically active metabolite of acetohexamide, in rats
    • Imamura Y., Kaneko M., Takada H., Otagiri M., Shimada H., Akita H. Sex-dependent pharmacokinetics of S(-)-hydroxyhexamide, a pharmacologically active metabolite of acetohexamide, in rats. Comp. Biochem. Physiol. C. 133:2002;587-592.
    • (2002) Comp. Biochem. Physiol. C , vol.133 , pp. 587-592
    • Imamura, Y.1    Kaneko, M.2    Takada, H.3    Otagiri, M.4    Shimada, H.5    Akita, H.6
  • 11
    • 0026716863 scopus 로고
    • Sex-specific cytochrome P450 as a cause of sex- and species-related differences in drug toxicity
    • Kato R., Yamazoe Y. Sex-specific cytochrome P450 as a cause of sex- and species-related differences in drug toxicity. Toxicol. Lett. 64-65:1992;661-667.
    • (1992) Toxicol. Lett. , vol.6465 , pp. 661-667
    • Kato, R.1    Yamazoe, Y.2
  • 13
    • 0031052587 scopus 로고    scopus 로고
    • Studies on the metabolism of the new antidiabetic agent pioglitazone. Identification of metabolites in rats and dogs
    • Kiyota Y., Kondo T., Maeshiba Y., Hashimoto A., Yamashita K., Yoshimura Y., et al. Studies on the metabolism of the new antidiabetic agent pioglitazone. Identification of metabolites in rats and dogs. Arzneim.-Forsch./Drug Res. 47:1997;22-28.
    • (1997) Arzneim.-Forsch./Drug Res. , vol.47 , pp. 22-28
    • Kiyota, Y.1    Kondo, T.2    Maeshiba, Y.3    Hashimoto, A.4    Yamashita, K.5    Yoshimura, Y.6
  • 14
    • 0027980611 scopus 로고
    • Disposition and metabolism of the hypoglycemic agent pioglitazone in rats
    • Krieter P.A., Colletti A.E., Doss G.A., Miller R.R. Disposition and metabolism of the hypoglycemic agent pioglitazone in rats. Drug Metab. Dispos. 22:1994;625-630.
    • (1994) Drug Metab. Dispos. , vol.22 , pp. 625-630
    • Krieter, P.A.1    Colletti, A.E.2    Doss, G.A.3    Miller, R.R.4
  • 15
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)
    • Lehmann J.M., Moore L.B., Smith-Oliver T.A., Wilkison W.O., Willson T.M., Kliewer S.A. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J. Biol. Chem. 270:1995;12953-12956.
    • (1995) J. Biol. Chem. , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1    Moore, L.B.2    Smith-Oliver, T.A.3    Wilkison, W.O.4    Willson, T.M.5    Kliewer, S.A.6
  • 16
    • 0033615353 scopus 로고    scopus 로고
    • PPARgamma: An essential regulator of adipogenesis and modulator of fat cell function
    • Lowell B.B. PPARgamma: an essential regulator of adipogenesis and modulator of fat cell function. Cell. 99:1999;239-242.
    • (1999) Cell , vol.99 , pp. 239-242
    • Lowell, B.B.1
  • 19
    • 0033744396 scopus 로고    scopus 로고
    • Rosiglitazone in the treatment of type 2 diabetes mellitus: A critical review
    • Discussion 1149-1150
    • Malinowski J.M., Bolesta S. Rosiglitazone in the treatment of type 2 diabetes mellitus: a critical review. Clin. Ther. 22:2000;1151-1168. Discussion 1149-1150.
    • (2000) Clin. Ther. , vol.22 , pp. 1151-1168
    • Malinowski, J.M.1    Bolesta, S.2
  • 20
    • 0034833667 scopus 로고    scopus 로고
    • Improved glycemic control and enhanced insulin sensitivity in type 2 diabetic subjects treated with pioglitazone
    • Miyazaki Y., Mahankali A., Matsuda M., Glass L., Mahankali S., Ferrannini E., et al. Improved glycemic control and enhanced insulin sensitivity in type 2 diabetic subjects treated with pioglitazone. Diabetes Care. 24:2001;710-719.
    • (2001) Diabetes Care , vol.24 , pp. 710-719
    • Miyazaki, Y.1    Mahankali, A.2    Matsuda, M.3    Glass, L.4    Mahankali, S.5    Ferrannini, E.6
  • 21
    • 0032969421 scopus 로고    scopus 로고
    • Effect of troglitazone on body fat distribution in type 2 diabetic patients
    • Mori Y., Murakawa Y., Okada K., Horikoshi H., Yokoyama J., Tajima N., et al. Effect of troglitazone on body fat distribution in type 2 diabetic patients. Diabetes Care. 22:1999;908-912.
    • (1999) Diabetes Care , vol.22 , pp. 908-912
    • Mori, Y.1    Murakawa, Y.2    Okada, K.3    Horikoshi, H.4    Yokoyama, J.5    Tajima, N.6
  • 22
    • 0031948975 scopus 로고    scopus 로고
    • Sex-dependent metabolism of xenobiotics
    • Mugford C.A., Kedderis G.L. Sex-dependent metabolism of xenobiotics. Drug Metab. Rev. 30:1998;441-498.
    • (1998) Drug Metab. Rev. , vol.30 , pp. 441-498
    • Mugford, C.A.1    Kedderis, G.L.2
  • 23
    • 0031750246 scopus 로고    scopus 로고
    • Pioglitazone time-dependently reduces tumour necrosis factor-alpha level in muscle and improves metabolic abnormalities in Wistar fatty rats
    • Murase K., Odaka H., Suzuki M., Tayuki N., Ikeda H. Pioglitazone time-dependently reduces tumour necrosis factor-alpha level in muscle and improves metabolic abnormalities in Wistar fatty rats. Diabetologia. 41:1998;257-264.
    • (1998) Diabetologia , vol.41 , pp. 257-264
    • Murase, K.1    Odaka, H.2    Suzuki, M.3    Tayuki, N.4    Ikeda, H.5
  • 24
    • 0032520921 scopus 로고    scopus 로고
    • Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats
    • Okuno A., Tamemoto H., Tobe K., Ueki K., Mori Y., Iwamoto K., et al. Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. J. Clin. Invest. 101:1998;1354-1361.
    • (1998) J. Clin. Invest. , vol.101 , pp. 1354-1361
    • Okuno, A.1    Tamemoto, H.2    Tobe, K.3    Ueki, K.4    Mori, Y.5    Iwamoto, K.6
  • 25
    • 0029612201 scopus 로고
    • Studies on antidiabetic agents. XII. Synthesis and activity of the metabolites of (+/-)-5(-)[p(-)[2-(5-ethyl-2-pyridyl)ethoxy]benzyl]-2,4- thiazolidinedione (pioglitazone)
    • Sohda T., Ikeda H., Meguro K. Studies on antidiabetic agents. XII. Synthesis and activity of the metabolites of (+/-)-5(-)[p(-)[2-(5-ethyl-2- pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione (pioglitazone). Chem. Pharm. Bull. 43:1995;2168-2172.
    • (1995) Chem. Pharm. Bull. , vol.43 , pp. 2168-2172
    • Sohda, T.1    Ikeda, H.2    Meguro, K.3
  • 26
    • 0030297919 scopus 로고    scopus 로고
    • Adipogenesis and obesity: Rounding out the big picture
    • Spiegelman B.M., Flier J.S. Adipogenesis and obesity: rounding out the big picture. Cell. 87:1996;377-389.
    • (1996) Cell , vol.87 , pp. 377-389
    • Spiegelman, B.M.1    Flier, J.S.2
  • 27
    • 0030459837 scopus 로고    scopus 로고
    • Synthesis and biological activity of metabolites of the antidiabetic, antihyperglycemic agent pioglitazone
    • Tanis S.P., Parker T.T., Colca J.R., Fisher R.M., Kletzein R.F. Synthesis and biological activity of metabolites of the antidiabetic, antihyperglycemic agent pioglitazone. J. Med. Chem. 39:1996;5053-5063.
    • (1996) J. Med. Chem. , vol.39 , pp. 5053-5063
    • Tanis, S.P.1    Parker, T.T.2    Colca, J.R.3    Fisher, R.M.4    Kletzein, R.F.5
  • 29
    • 0029670236 scopus 로고    scopus 로고
    • High-performance liquid chromatographic determination of pioglitazone and its metabolites in human serum and urine
    • Yamashita K., Murakami H., Okuda T., Motohashi M. High-performance liquid chromatographic determination of pioglitazone and its metabolites in human serum and urine. J. Chromatogr. B Biomed. Appl. 677:1996;141-146.
    • (1996) J. Chromatogr. B Biomed. Appl. , vol.677 , pp. 141-146
    • Yamashita, K.1    Murakami, H.2    Okuda, T.3    Motohashi, M.4
  • 30
    • 0035798713 scopus 로고    scopus 로고
    • The mechanisms by which both heterozygous peroxisome proliferator- activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance
    • Yamauchi T., Kamon J., Waki H., Murakami K., Motojima K., Komeda K., et al. The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance. J. Biol. Chem. 276:2001;41245-41254.
    • (2001) J. Biol. Chem. , vol.276 , pp. 41245-41254
    • Yamauchi, T.1    Kamon, J.2    Waki, H.3    Murakami, K.4    Motojima, K.5    Komeda, K.6
  • 31
    • 0036481709 scopus 로고    scopus 로고
    • Synthetic peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patients
    • Yang W.S., Jeng C.Y., Wu T.J., Tanaka S., Funahashi T., Matsuzawa Y., et al. Synthetic peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patients. Diabetes Care. 25:2002;376-380.
    • (2002) Diabetes Care , vol.25 , pp. 376-380
    • Yang, W.S.1    Jeng, C.Y.2    Wu, T.J.3    Tanaka, S.4    Funahashi, T.5    Matsuzawa, Y.6
  • 32
    • 0037362638 scopus 로고    scopus 로고
    • PPARalpha/gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegaly
    • Ye J.M., Iglesias M.A., Watson D.G., Ellis B., Wood L., Jensen P.B., et al. PPARalpha/gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegaly. Am. J. Physiol. 284:2003;E531-540.
    • (2003) Am. J. Physiol. , vol.284 , pp. 531-540
    • Ye, J.M.1    Iglesias, M.A.2    Watson, D.G.3    Ellis, B.4    Wood, L.5    Jensen, P.B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.