Troglitazone reduces plasma levels of tumour necrosis factor-α in obese patients with type 2 diabetes

Diabetes, Obesity and Metabolism

Volumn 2, Issue 3, 2000, Pages 189-191

  Katsuki, Akira ^a   Sumida, Y ^a   Murata, K ^b   Furuta, M ^a   Araki Sasaki, R ^a   Tsuchihashi, K ^a   Hori, Y ^a   Yano, Y ^a   Gabazza, E C ^a   Adachi, Y ^a  

^a MIE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b ISE RED CROSS HOSPITAL   (Japan)

Author keywords

Obesity; Troglitazone; Tumour necrosis factor ; Type 2 diabetes

Indexed keywords

C PEPTIDE; GLIBENCLAMIDE; GLUCOSE; HEMOGLOBIN A1C; INSULIN; ORAL ANTIDIABETIC AGENT; TROGLITAZONE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DIET THERAPY; DOSE RESPONSE; DRUG EFFECT; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; HEMOSTASIS; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PANCREAS ISLET BETA CELL;

EID: 0034522659     PISSN: 14628902     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1463-1326.2000.00072.x     Document Type: Article

References (12)

1. TNF-α-induced insulin resistance in vivo and its prevention by troglitazone
2. Thiazolidinediones block tumor necrosis factor-α-induced inhibition of insulin signaling
3. Serum levels of tumor necrosis factor-α (TNF-α) are increased in obese patients with noninsulin-dependent diabetes mellitus
4. Circulating tumor necrosis factor α is elevated in male but not in female patients with type II diabetes mellitus
5. Circulating tumor necrosis factor-α concentrations in a native Canadian population with high rates of type 2 diabetes mellitus
6. Tumor necrosis factor-α in sera of obese patients: Fall with weight loss
7. Homeostasis model assessment: Insulin resistance and β-cell function from fasting glucose and insulin concentrations in man
8. Effect of troglitazone on body fat distributionin type 2 diabetic patients
9. Troglitazone reduces plasma leptin concentration but increases hunger in NIDDM patients
10. Tumor necrosis factor-α contribute to obesity-related hyperleptinemia by regulating leptin release from adipocyte
11. Advancing age and insulin resistance: Role of plasma tumor necrosis factor-α
12. Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats