Mitochondrial ROS generation following acetylcholine-induced EGF receptor transactivation requires metalloproteinase cleavage of proHB-EGF

Journal of Molecular and Cellular Cardiology

Volumn 36, Issue 3, 2004, Pages 435-443

  Krieg, Thomas ^a   Cui, Lin ^a   Qin, Qining ^a   Cohen, Michael V ^a   Downey, James M ^a  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

Author keywords

Acetylcholine; Cardioprotection; Epidermal growth factor; Metalloproteinase; Preconditioning

Indexed keywords

ACETYLCHOLINE; DELTA OPIATE RECEPTOR AGONIST; ENKEPHALIN[2 DEXTRO ALANINE 5 DEXTRO LEUCINE]; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; G PROTEIN COUPLED RECEPTOR; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; METALLOPROTEINASE; METALLOPROTEINASE INHIBITOR; NEUTRALIZING ANTIBODY; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; ENZYME ACTIVITY; FLUORESCENCE ANALYSIS; HEART INFARCTION SIZE; HEART MITOCHONDRION; HEART MUSCLE CELL; HEART PROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEINASE INHIBITION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACETYLCHOLINE; ANIMALS; CELLS, CULTURED; ISCHEMIC PRECONDITIONING, MYOCARDIAL; METALLOPROTEASES; MITOCHONDRIA, HEART; MYOCARDIAL INFARCTION; MYOCARDIUM; MYOCYTES, CARDIAC; PHOSPHORYLATION; PROTEINASE INHIBITORY PROTEINS, SECRETORY; PROTEINS; RABBITS; REACTIVE OXYGEN SPECIES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, CELL SURFACE; RECEPTORS, MUSCARINIC; SERINE PROTEINASE INHIBITORS; TRANS-ACTIVATION (GENETICS);

ORYCTOLAGUS CUNICULUS;

EID: 1542298924     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2003.12.013     Document Type: Article

References (32)

1. Murry C.E., Jennings R.B., Reimer K.A. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 74:1986;1124-1136.
2. Yao Z., Gross G.J. Acetylcholine mimics ischemic preconditioning via a glibenclamide-sensitive mechanism in dogs. Am J Physiol. 264:1993;H2221-H2225.
3. Schulz R., Cohen M.V., Behrends M., Downey J.M., Heusch G. Signal transduction of ischemic preconditioning. Cardiovasc Res. 52:2001;181-198.
4. ATP channels. Circ Res. 89:2001;273-278.
5. ATP channel opening. J Mol Cell Cardiol. 35:2003;653-660.
6. Krieg T., Landsberger M., Alexeyev M.F., Felix S.B., Cohen M.V., Downey J.M. Activation of Akt is essential for acetylcholine to trigger generation of oxygen free radicals. Cardiovasc Res. 58:2003;196-202.
7. Yao Z., Tong J., Tan X., Li C., Shao Z., Kim W.C., et al. Role of reactive oxygen species in acetylcholine-induced preconditioning in cardiomyocytes. Am J Physiol. 277:1999;H2504-H2509.
8. Tong H., Chen W., Steenbergen C., Murphy E. Ischemic preconditioning activates phosphatidylinositol-3-kinase upstream of protein kinase C. Circ Res. 87:2000;309-315.
9. Qin Q., Downey J.M., Cohen M.V. Acetylcholine but not adenosine triggers preconditioning through PI3-kinase and a tyrosine kinase. Am J Physiol. 284:2003;H727-H734.
10. Krieg T., Qin Q., McIntosh E.C., Cohen M.V., Downey J.M. ACh and adenosine activate PI3-kinase in rabbit hearts through transactivation of receptor tyrosine kinases. Am J Physiol. 283:2002;H2322-H2330.
11. Daub H., Weiss F.U., Wallasch C., Ullrich A. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature. 379:1996;557-560.
12. Luttrell L.M., Della Rocca G.J., van Biesen T., Luttrell D.K., Lefkowitz R.J. Gβγ subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation. J Biol Chem. 272:1997;4637-4644.
13. Prenzel N., Zwick E., Daub H., Leserer M., Abraham R., Wallasch C., et al. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature. 402:1999;884-888.
14. Armstrong S., Downey J.M., Ganote C.E. Preconditioning of isolated rabbit cardiomyocytes: induction by metabolic stress and blockade by the adenosine antagonist SPT and calphostin C, a protein kinase C inhibitor. Cardiovasc Res. 28:1994;72-77.
15. Piper H.M., Probst I., Schwartz P., Hütter F.J., Spieckermann P.G. Culturing of calcium stable adult cardiac myocytes. J Mol Cell Cardiol. 14:1982;397-412.
16. Mitcheson J.S., Hancox J.C., Levi A.J. Cultured adult cardiac myocytes: future applications, culture methods, morphological and electrophysiological properties. Cardiovasc Res. 39:1998;280-300.
17. i proteins, phosphatidylinositol 3-kinase and tyrosine kinase. Cardiovasc Res. 55:2002;544-552.
18. Krenz M., Oldenburg O., Wimpee H., Cohen M.V., Garlid K.D., Critz S.D., et al. Opening of ATP-sensitive potassium channels causes generation of free radicals in vascular smooth muscle cells. Basic Res Cardiol. 97:2002;365-373.
19. Mitamura T., Higashiyama S., Taniguchi N., Klagsbrun M., Mekada E. Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity. J Biol Chem. 270:1995;1015-1019.
20. Daub H., Wallasch C., Lankenau A., Herrlich A., Ullrich A. Signal characteristics of G protein-transactivated EGF receptor. EMBO J. 16:1997;7032-7044.
21. + channels: possible mechanism of cardioprotection. Circ Res. 81:1997;1072-1082.
22. Liu Y., Sato T., O'Rourke B., Marban E. Mitochondrial ATP-dependent potassium channels: novel effectors of cardioprotection? Circulation. 97:1998;2463-2469.
23. Mockridge J.W., Marber M.S., Heads R.J. Activation of Akt during simulated ischemia/reperfusion in cardiac myocytes. Biochem Biophys Res Commun. 270:2000;947-952.
24. Suzuki M., Raab G., Moses M.A., Fernandez C.A., Klagsbrun M. Matrix metalloproteinase-3 releases active heparin-binding EGF-like growth factor by cleavage at a specific juxtamembrane site. J Biol Chem. 272:1997;31730-31737.
25. Raab G., Klagsbrun M. Heparin-binding EGF-like growth factor. Biochim Biophys Acta. 1333:1997;F179-F199.
26. Naglich J.G., Metherall J.E., Russell D.W., Eidels L. Expression cloning of a diphtheria toxin receptor: identity with a heparin-binding EGF-like growth factor precursor. Cell. 69:1992;1051-1061.
27. Izumi Y., Hirata M., Hasuwa H., Iwamoto R., Umata T., Miyado K., et al. A metalloprotease-disintegrin, MDC9/meltrin-γ/ADAM9 and PKCδ are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. EMBO J. 17:1998;7260-7272.
28. Weskamp G., Cai H., Brodie T.A., Higashyama S., Manova K., Ludwig T., et al. Mice lacking the metalloprotease-disintegrin MDC9 (ADAM9) have no evident major abnormalities during development or adult life. Mol Cell Biol. 22:2002;1537-1544.
29. Yan Y., Shirakabe K., Werb Z. The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors. J Cell Biol. 158:2002;221-226.
30. Asakura M., Kitakaze M., Takashima S., Liao Y., Ishikura F., Yoshinaka T., et al. Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy. Nat Med. 8:2002;35-40.
31. Ichikawa Y., Miura M., Miki T., Nakano A., Nishino Y., Nakamura Y., et al. Metalloprotease-disintegrin is involved in tyrosine kinase-mediated signaling in ischemic preconditioning. Circulation. 106:2002;II-266. [Abstract].
32. Filardo E.J., Quinn J.A., Bland K.I., Frackelton A.R. Jr. Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via transactivation of the epidermal growth factor receptor through release of HB-EGF. Mol Endocrinol. 14:2000;1649-1660.