Activation of Akt is essential for acetylcholine to trigger generation of oxygen free radicals

Cardiovascular Research

Volumn 58, Issue 1, 2003, Pages 196-202

  Krieg, Thomas ^a   Landsberger, Martin ^b   Alexeyev, Mikhail F ^c   Felix, Stephan B ^b   Cohen, Michael V ^a,c   Downey, James M ^a  

^a UNIVERSITY OF SOUTH ALABAMA   (United States)

^b UNIVERSITY OF GREIFSWALD   (Germany)

^c UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

Author keywords

Acetylcholine; Free radicals; K ATP channel; Protein phosphorylation; Signal transduction; Smooth muscle

Indexed keywords

ACETYLCHOLINE; CHOLINERGIC RECEPTOR; DIAZOXIDE; FLUORESCENT DYE; GREEN FLUORESCENT PROTEIN; OXYGEN RADICAL; POTASSIUM CHANNEL; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; VALINOMYCIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EXPERIMENTAL MODEL; FLUORESCENCE; GENETIC TRANSFECTION; INCUBATION TIME; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

ACETYLCHOLINE; ANIMALS; CELL LINE; DIAZOXIDE; ENZYME ACTIVATION; IONOPHORES; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA, MUSCLE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; REACTIVE OXYGEN SPECIES; TRANSFECTION; VALINOMYCIN;

EID: 0344405752     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(02)00861-1     Document Type: Article

References (28)

1. Schulz R., Cohen M.V., Behrends M., Downey J.M., Heusch G. Signal transduction of ischemic preconditioning. Cardiovasc Res. 52:2001;181-198.
2. ATP channels. Circ Res. 89:2001;273-278.
3. + channel in mediating the effects of acetylcholine to mimic preconditioning in dogs. Circ Res. 73:1993;1193-1201.
4. Krenz M., Oldenburg O., Wimpee H., et al. Opening of ATP-sensitive potassium channels causes generation of free radicals in vascular smooth muscle cells. Basic Res Cardiol. 97:2002;365-373.
5. i proteins, phosphatidylinositol 3-kinase and tyrosine kinase. Cardiovasc Res. 55:2002;544-552.
6. Krieg T., Qin Q., McIntosh E.C., Cohen M.V., Downey J.M. ACh and adenosine activate PI3-kinase in rabbit hearts through transactivation of receptor tyrosine kinases. Am J Physiol. 283:(6):2002;H2322-2330.
7. Stokoe D., Stephens L.R., Copeland T., et al. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science. 277:1997;567-570.
8. Coffer P.J., Jin J., Woodgett J.R. Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J. 335:1998;1-13.
9. Stephens L., Anderson K., Stokoe D., et al. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science. 279:1998;710-714.
10. Luttrell L.M., Della Rocca G.J., van Biesen T., Luttrell D.K., Lefkowitz R.J. Gβγ subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation. J Biol Chem. 272:1997;4637-4644.
11. Tsai W., Morielli A.D., Peralta E.G. The m1 muscarinic acetylcholine receptor transactivates the EGF receptor to modulate ion channel activity. EMBO J. 16:1997;4597-4605.
12. Okano J.-i., Gaslightwala I., Birnbaum M.J., Rustgi A.K., Nakagawa H. Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation. J Biol Chem. 275:2000;30934-30942.
13. Tong H., Chen W., Steenbergen C., Murphy E. Ischemic preconditioning activates phosphatidylinositol-3-kinase upstream of protein kinase C. Circ Res. 87:2000;309-315.
14. Qin Q., Downey J.M., Cohen M.V. Acetylcholine but not adenosine triggers preconditioning through PI3-kinase and a tyrosine kinase. Am J Physiol. 284:2003;H727-H734.
15. Wang Q., Somwar R., Bilan P.J., et al. Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts. Mol Cell Biol. 19:1999;4008-4018.
16. Mocanu M.M., Bell R.M., Yellon D.M. PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning. J Mol Cell Cardiol. 34:2002;661-668.
17. ATP channels triggers the preconditioned state by generating free radicals. Circ Res. 87:2000;460-466.
18. ATP channel opening protects a human atrial-derived cell line by a mechanism involving free radical generation. Cardiovasc Res. 51:2001;691-700.
19. Yao Z., Tong J., Tan X., et al. Role of reactive oxygen species in acetylcholine-induced preconditioning in cardiomyocytes. Am J Physiol. 277:1999;H2504-H2509.
20. Forbes R.A., Steenbergen C., Murphy E. Diazoxide-induced cardioprotection requires signaling through a redox-sensitive mechanism. Circ Res. 88:2001;802-809.
21. Murry C.E., Jennings R.B., Reimer K.A. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 74:1986;1124-1136.
22. Yao Z., Gross G.J. Acetylcholine mimics ischemic preconditioning via a glibenclamide-sensitive mechanism in dogs. Am J Physiol. 264:1993;H2221-H2225.
23. Chen L., Hahn H., Wu G., et al. Opposing cardioprotective actions and parallel hypertrophic effects of δPKC and εPKC. Proc Natl Acad Sci. 98:2001;11114-11119.
24. Downward J. Mechanisms and consequences of activation of protein kinase B/Akt. Curr Opin Cell Biol. 10:1998;262-267.
25. Matsui T., Li L., del Monte F., et al. Adenoviral gene transfer of activated phosphatidylinositol 3′-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro. Circulation. 100:1999;2373-2379.
26. Matsui T., Tao J., del Monte F., et al. Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo. Circulation. 104:2001;330-335.
27. Fujio Y., Nguyen T., Wencker D., Kitsis R.N., Walsh K. Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation. 101:2000;660-667.
28. ATP channel opening. Circulation. 106:2002;II-230. [Abstract].