Opening of ATP-sensitive potassium channels causes generation of free radicals in vascular smooth muscle cells

Basic Research in Cardiology

Volumn 97, Issue 5, 2002, Pages 365-373

  Krenz, Maike ^a,b   Oldenburg, Olaf ^a,b   Wimpee, Holly ^a,b   Cohen, Michael V ^a,b   Garlid, Keith D ^b,d   Critz, Stuart D ^b,c   Downey, James M ^a,b   Benoit, Joseph N ^a,b  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

^b Deparment of Medicine   (United States)

^c Department of Cell Biology and Neuroscience ^*  (United States)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

A7r5 cells; Diazoxide; K ATP channel; Myxothiazol; Reactive oxygen species; Valinomycin; Vascular smooth muscle

Indexed keywords

2,4 DINITROPHENOL; 5 HYDROXYDECANOIC ACID; ADENOSINE TRIPHOSPHATE; AMPHOTERICIN B DEOXYCHOLATE; CHELERYTHRINE; CLAMIKALANT; DIAZOXIDE; FLUORESCENT DYE; FREE RADICAL; IONOPHORE; MYXOTHIAZOL; PINACIDIL; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL STIMULATING AGENT; POTASSIUM ION; PROTEIN KINASE C INHIBITOR; REACTIVE OXYGEN METABOLITE; TIOPRONIN; TIRON; VALINOMYCIN;

ANIMAL CELL; AORTA; ARTICLE; BIOLOGICAL MODEL; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENCY; ELECTRON TRANSPORT; FLUORESCENCE; HEART INFARCTION PREVENTION; HEART MITOCHONDRION; HEART MUSCLE; INHIBITION KINETICS; NONHUMAN; POTASSIUM TRANSPORT; RAT; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CELLS, CULTURED; DIAZOXIDE; FREE RADICALS; ION CHANNEL GATING; MITOCHONDRIA; MUSCLE, SMOOTH, VASCULAR; PINACIDIL; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN KINASE C; REACTIVE OXYGEN SPECIES; VASODILATOR AGENTS;

EID: 0036735699     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003950200045     Document Type: Article

References (44)

1. Theodore Cooper Memorial Lecture: Hypertension and the pathogenesis of atherosclerosis. Oxidative stress and the mediation of arterial inflammatory response: A new perspective
2. Oxygen radicals released during ischemic preconditioning contribute to cardioprotection in the rabbit myocardium
3. ATP channels and actin cytoskeleton
4. Identification and properties of a novel intracellular (mitochondrial) ATP-sensitive potassium channel in brain
5. S-T segment voltage during sequential coronary occlusions is an unreliable marker of preconditioning
6. ATP channel opening protects a human atrial-derived cell line by a mechanism involving free radical generation
7. ATP channels
8. + channels and protects against simulated ischemia in rabbit myocytes
9. Chloride channel inhibition blocks the protection of ischemic preconditioning and hypo-osmotic stress in rabbit ventricular myocardium
10. Diazoxide-induced cardioprotection requires signaling through a redox-sensitive mechanism
11. 1b-adrenoceptor function in small mesenteric arteries
12. Effects of hypoxia/reoxygenation on aortic vasoconstrictor responsiveness
13. Mitochondrial volume control
14. ATP channel as a receptor for potassium channel openers
15. +-channels: Possible mechanism of cardioprotection
16. NAD(P)H oxidase: Role in cardiovascular biology and disease
17. Probes for reactive oxygen species, including nitric oxide
18. No confirmation for a causal role of volume-regulated chloride channels in ischemic preconditioning in rabbits
19. 2+ overload in rat cardiac mitochondrial
20. + channel in the mitochondrial inner membrane
21. Oxidant signaling in vascular cell growth, death, and survival: A review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling
22. ATP channel by glyburide and 5-hydroxydecanoate
23. + channel of heart mitochondria
24. Mitochondrial ATP-dependent potassium channels: Novel effectors of cardioprotection?
25. Oxygen-derived free radicals in postischemic tissue injury
26. Physiological roles and properties of potassium channels in arterial smooth muscle
27. + channels in cardiac muscle
28. + channels reduces hydroxyl radicals in the rat myocardium
29. ATP channels triggers the preconditioned state by generating free radicals
30. + channel from rat liver and beef heart mitochondria
31. ATP channels in ischemic cardioprotection
32. + current by isoprenaline, carbachol, and phorbol ester in cultured (and fresh) rat aortic vascular smooth muscle cells
33. Interactions of chloromethyltetramethylrosamine (Mitotracker Orange™) with isolated mitochondria and intact cells
34. Membrane-linked systems preventing superoxide formation
35. Cell transformation by the superoxide-generating oxidase Mox1
36. Oxygen radicals can induce preconditioning in rabbit hearts
37. Superoxide production by the mitochondrial respiratory chain
38. Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells
39. + channel in aortic smooth muscle cells (A7r5 line and primary culture)
40. + channel for cardiac protection against ischemic injury is dependent on protein kinase C activity
41. ATP channels by diazoxide
42. Increased NADH-oxidase-mediated superoxide production in the early stages of atherosclerosis: Evidence for involvement of the renin-angiotensin system
43. Role of reactive oxygen species in acetylcholine-induced preconditioning in cardiomyocytes
44. Hypoxia-reoxygenation impairs endothelium-dependent relaxation in isolated rat aorta