DARPP-32 knockout mice exhibit impaired reversal learning in a discriminated operant task

Brain Research

Volumn 867, Issue 1-2, 2000, Pages 122-130

  Heyser, Charles J ^a   Fienberg, Allen A ^b   Greengard, Paul ^b   Gold, Lisa H ^c  

^a FRANKLIN AND MARSHALL COLLEGE   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

DARPP 32; Dopamine transmission; Knockout mice; Operant conditioning; Reversal learning

Indexed keywords

PHOSPHOPROTEIN; PHOSPHOPROTEIN DARPP 32; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DISCRIMINATION LEARNING; KNOCKOUT MOUSE; MALE; MOUSE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; REINFORCEMENT;

ANIMALS; CONDITIONING, OPERANT; DISCRIMINATION LEARNING; DOPAMINE; DOPAMINE AND CAMP-REGULATED PHOSPHOPROTEIN 32; FEMALE; MALE; MEMORY; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; PHOSPHOPROTEINS; REVERSAL LEARNING; SYNAPTIC TRANSMISSION;

EID: 0034625471     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02272-1     Document Type: Article

References (65)

1. Albin R.L., Young A.B., Penney J.B. The functional anatomy of basal ganglia disorders. Trends Neurosci. 12:1989;366-375.
2. Anisman H., Corradini A., Tombaugh T.N., Zacharko R.M. Avoidance performance, cue and response-choice discrimination after neuroleptic treatment. Pharmacol. Biochem. Behav. 17:1982;1245-1249.
3. Beninger R.J. A comparison of the effects of pimozide and nonreinforcement on discriminated operant responding in rats. Pharmacol. Biochem. Behav. 16:1982;667-669.
4. Berger T.W., Orr W.B. Hippocamectomy selectively disrupts discrimination reversal conditioning of the rabbit nictitating membrane response. Behav. Brain Res. 8:1983;49-68.
5. Bignami G. Effects of neuroleptics, ethanol, hypnotic-sedatives, tranqulizers, narcotics, and minor stimulants in aversive paradigms. Anisman H., Bignami G. Psychopharmacology of Aversively Motivated Behavior. 1978;Plenum, New York.
6. Bowers W., Hamilton M., Zacharko R.M., Anisman H. Differential effects of pimozide on response-rate and choice accuracy in a self-stimulation paradigm in mice. Pharmacol. Biochem. Behav. 22:1985;521-526.
7. Brene S., Hall H., Lindefors N., Karlsson P., Halldin C., Sedvall G. Distribution of messenger RNAs for D1 dopamine receptors and DARPP-32 in striatum and cerebral cortex of the cynomolgus monkey: relationship to D1 dopamine receptors. Neuroscience. 67:1995;37-48.
8. Brown R.G., Marsden C.D. Dual task performance and processing resources in normal subjects and patients with Parkinson's disease. Brain. 114:1991;215-231.
9. Cousins M.S., Sokolowski J.D., Salamone J.D. Different effects of nucleus accumbens and ventrolateral striatal dopamine depletions on instrumental response selection in the rat. Pharmacol. Biochem. Behav. 46:1993;943-951.
10. Dickinson A. Contemporary Animal Learning Theory. 1980;Cambridge Univ. Press, New York.
11. Elmer G.I., George F.R. Genetic differences in the operant rate-depressant effects of ethanol between four inbred mouse strains. Behav. Pharmacol. 6:1995;794-800.
12. Faustman W.O., Fowler S.C. Use of operant response duration to distinguish the effects of haloperidol from nonreward. Pharmacol. Biochem. Behav. 15:1981;327-329.
13. Fibiger H.C., Carter D.A., Phillips A.G. Decreased intracranial self-stimulation after neuroleptics or 6-hydroxydopamine: evidence for mediation by motor deficits rather than by reduced reward. Psychopharmacology. 47:1976;21-27.
14. Fienberg A.A., Hiroi N., Mermelstein P., Song W.-J., Snyder G.L., Nishi A., Cheramy A., O'Callaghan J.P., Miller D.B., Cole D.G., Corbett R., Haile C.N., Cooper D.C., Onn S.P., Grace A.A., Ouimet C.C., White F.J., Hyman S.E., Surmeier J.A., Girault J.A., Nestler E.J., Greengard P. DARPP-32: regulator of the efficacy of dopaminergic neurotransmission. Science. 281:1998;838-842.
15. Glowa J.R. Some effects of D-amphetamine, caffeine, nicotine and cocaine on schedule-controlled responding in the mouse. Neuropharmacology. 25:1986;1127-1135.
16. Halpain S., Girault J-A., Greengard P. Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices. Nature. 343:1990;369-372.
17. Hemmings H.C. Jr., Nairn A.C., Greengard P. DARPP-32, a dopamine- and adenosine 3′:5′-monophosphate-regulated neuronal phosphoprotein. II. Comparison of the kinetics of phosphorylation of DARPP-32 and phosphatase inhibitor 1. J. Biol. Chem. 259:1984;14491-14497.
18. Hemmings H.C. Jr., Greengard P., Tung H.Y., Cohen P. DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1. Nature. 310:1984;503-505.
19. Heyser C.J., McDonald J.S., Beauchamp V., Koob G.F., Gold L.H. The effects of cocaine on operant responding for food in several strains of mice. Psychopharmacology. 132:1997;202-208.
20. Horstink M.W., Berger H.J., van Spaendonck K.P., van den Bercken J.H., Cools A.R. Bimanual simultaneous motor performance and impaired ability to shift attention in Parkinson's disease. J. Neurol. Neurosurg. Psychiatry. 53:1990;685-690.
21. Hsiao S., Chen B.H. Complex response competition and dopamine blocking: choosing of high cost sucrose solution versus low cost water in rats. Chin. J. Physiol. 38:1995;99-109.
22. Kalivas P.W., Stewart J. Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity. Brain Res. Rev. 16:1991;223-244.
23. Kirk R.E. Experimental Design: Procedures For the Behavioral Sciencees. 2nd Edition :1982;Brooks/Cole, Belmont, CA.
24. Kiyatkin E.A., Gratton A. Electrochemical monitoring of extracellular dopamine in nucleus accumbens of rats lever-pressing for food. Brain Res. 652:1994;225-234.
25. Koob G.F. Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends Pharmacol. Sci. 13:1992;177-184.
26. Koob G.F., Le Moal M. Drug abuse: hedonic homeostatic dysregulation. Science. 278:1997;52-58.
27. Koob G.F., Riley S.J., Smith S.C., Robbins T.W. Effects of 6-hydroxydopamine lesions of the nucleus accumbens septi and olfactory tubercle on feeding, locomotor activity, and amphetamine anorexia in the rat. J. Comp. Physiol. Psychol. 92:1978;917-9127.
28. Lalonde R., Vikis-Freibergs V. The effects of chlorpromazine and lithium on appetitive discrimination learning in the rat. Psychopharmacology. 76:1982;218-221.
29. Ljungberg T. Blockade by neuroleptics of water intake and operant responding for water in the rat: anhedonia, motor deficit, or both? Pharmacol. Biochem. Behav. 27:1978;341-350.
30. Ljungberg T., Apicella P., Schultz W. Responses of monkey dopamine neurons during learning of behavioral reactions. J. Neurophysiol. 67:1992;145-163.
31. Malapani C., Pillon B., Dubois B., Agid Y. Impaired simultaneous cognitive task performance in Parkinson's disease: a dopamine-related dysfunction. Neurology. 44:1994;319-326.
32. Mirenowicz J., Schultz W. Preferential activation of midbrain dopamine neurons by appetitive rather than aversive stimuli. Nature. 379:1996;449-451.
33. Montague P.R., Dayan P., Sejnowski T.J. A framework for mesencephalic dopamine systems based on predictive Hebbian learning. J. Neurosci. 16:1996;1936-1947.
34. Nishi A., Snyder G.L., Greengard P. Bidirectional regulation of DARPP-32 phosphorylation by dopamine. J. Neurosci. 17:1997;8147-8155.
35. Nishino N., Kitamura N., Hashimoto T., Tanaka C. Transmembrane signalling systems in the brain of patients with Parkinson's disease. Rev. Neurosci. 4:1993;213-222.
36. Oades R.D. The role of noradrenaline in tuning and dopamine in switching between signals in the CNS. Neurosci. Biobehav. Rev. 9:1985;261-282.
37. Ouimet C.C., Greengard P. Distribution of DARPP-32 in the basal ganglia: an electron microscope study. J. Neurocytol. 19:1990;39-52.
38. Ouimet C.C., Miller P.E., Hemmings H.C. Jr., Walaas S.I., Greengard P. DARPP-32, a dopamine and adenosine 3′:5′-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. III. Immunocytochemical localization. J. Neurosci. 4:1984;111-124.
39. r=32 000 ) mRNA in mouse brain. J. Comp. Neurol. 318:1992;304-315.
40. Picker M. Effects of clozapine on fixed-consecutive-number responding in rats: a comparison to other neuroleptic drugs. Pharmacol. Biochem. Behav. 10:1988;603-612.
41. Rescorla R.A., Wagner A.R. A theory of pavlovian conditioning: variations in the effectiveness of reinforcement and nonreinforcement. Black A.H., Prokasy W.F. Classical Conditioning. II. Current Research and Theory. 1972;64-99 Appleton Century Crofts, New York.
42. Robbins T.W., Giardini V., Jones G.H., Reading P., Sahakian B.J. Effects of dopmaine depletion from the caudate-putamen and nucleus accumbens septi on the acquisition and performance of a conditional discrimination task. Behav. Brain Res. 38:1990;243-261.
43. Robbins T.W., Koob G.F. Selective disruption of displacement behaviour by lesions of the mesolimbic dopamine system. Nature. 285:1980;409-412.
44. Rolls E.T., Rolls B.J., Kelly P.H., Shaw S.G., Wood R.J., Dale R. The relative attenuation of self-stimulation, eating and drinking produced by dopamine-receptor blockade. Psychopharmacologia. 38:1974;219-230.
45. Romo R., Schultz W. Dopamine neurons of the monkey midbrain: contingencies of responses to active touch during self-initiated arm movements. J. Neurophysiol. 63:1990;592-606.
46. Salamone J.D. Complex motor and sensorimotor functions of striatal and accumbens dopamine: involvement in instrumental behavior processes. Psychopharmacology. 107:1992;160-174.
47. Salamone J.D. The involvement of nucleus accumbens dopamine in appetitive and aversive motivation. Behav. Brain Res. 61:1994;117-131.
48. Salamone J.D., Cousins M.S., Snyder B.J. Behavioral functions of nucleus accumbens dopamine: empirical and conceptual problems with the anhedonia hypothesis. Neurosci. Biobehav. Rev. 21:1997;341-359.
49. Salamone J.D., Steinpreis R.E., McCullough L.D., Smith P., Grebel D., Mahan K. Haloperidol and nucleus accumbens dopamine depletion suppress lever pressing for food but increase free food consumption in a novel food choice procedure. Psychopharmacology. 104:1991;515-521.
50. Schultz W. Responses of midbrain dopamine neurons to behavioral trigger stimuli in the monkey. J. Neurophysiol. 56:1986;1439-1461.
51. Schultz W., Appicella P., Ljungberg T. Responses of monkey dopamine neurons to reward and conditioned stimuli during successive steps of learning a delayed response task. J. Neurosci. 13:1993;900-913.
52. Schultz W., Dayan P., Montague R.R. A neural substrate of prediction and reward. Science. 275:1997;1593-1599.
53. Schultz W., Romo R. Dopamine neurons of the monkey midbrain: contingencies of response to stimuli eliciting immediate behavioral reactions. J. Neurophysiol. 63:1990;607-624.
54. Shenolikar S., Nairn A.C. Protein phosphatases: recent progress. Adv. Second Messenger Phosphoprotein Res. 23:1991;1-121.
55. Smart J.L. Trial-and-error behaviour of inbred and F1 hybrid mice. Anim. Behav. 18:1970;445-453.
56. Telner J.I., Vikis-Freibergs V., Lepore F. Effects of low and moderate doses of chlorpromazine on discrimination learning in the rat. Psychopharmacology. 47:1976;205-208.
57. Tombaugh T.N., Szostak C., Mills P. Failure of pimozide to disrupt the acquisition of light-dark and spatial discrimination problems. Psychopharmacology. 79:1983;161-168.
58. Tremblay L., Hollerman J.R., Schultz W. Modifications of reward expectation-related neuronal activity during learning in primate striatum. J. Neurophysiol. 80:1998;964-977.
59. Walaas S.I., Aswad D.W., Greengard P. A dopamine- and cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. Nature. 301:1983;69-71.
60. Walaas S.I., Nairn A.C., Greengard P. Regional distribution of calcium- and adenosine 3′:5′-monophasphate-regulated protein phosphorylating systems in mammalian brain. II. Soluble systems. J. Neurosci. 3:1983;302-311.
61. Weiner I. Neural substates of latent inhibition: the switching model. Psychol. Bull. 108:1990;442-461.
62. Wenger G.R., Dews P.B. The effects of phencyclidine, ketamine, D-amphetamine and pentobarbital on schedule-controlled behavior in the mouse. J. Pharmacol. Exp. Ther. 196:1976;616-624.
63. Williams G.V., Goldman-Rakic P.S. Modulation of memory fields by dopamine D1 receptors in prefrontal cortex. Nature. 376:1995;572-575.
64. Wise R.A. The anhedonia hypothesis: Mark III. Behav. Brain Sci. 8:1985;178-186.
65. Wise R.A., Spindler J., deWit H., Gerberg G.J. Neuroleptic-induced 'anhedonia' in rats: pimozide blocks reward quality of food. Science. 201:1978;262-264.