Vascular endothelial growth factor overproduced by tumour cells acts predominantly as a potent angiogenic factor contributing to malignant progression

International Journal of Experimental Pathology

Volumn 80, Issue 5, 1999, Pages 271-281

  Aonuma, Masashi ^a   Saeki, Yoshiyuki ^a   Akimoto, Toshihiko ^a   Nakayama, Yutaka ^a   Hattori, Chiharu ^a   Yoshitake, Yoshino ^b   Nishikawa, Katsuzo ^b   Shibuya, Masabumi ^c   Tanaka, Noriko G ^a  

^a DAIICHI SANKYO CO   (Japan)

^b KANAZAWA MEDICAL UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Angiogenesis; bFGF; Malignancy; Tumorigenicity; VEGF

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; ESTROGEN; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CARCINOGENICITY; CONTROLLED STUDY; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; MOUSE; PRIORITY JOURNAL; SOLID TUMOR; TUMOR CELL CULTURE;

ANIMALS; DISEASE PROGRESSION; DNA, COMPLEMENTARY; ENDOTHELIAL GROWTH FACTORS; FEMALE; HUMANS; LYMPHOKINES; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR STEM CELLS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0032705610     PISSN: 09599673     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2613.1999.00122.x     Document Type: Article

References (32)

1. ABRAHAM J.A., MERGIA A., WHANG J.L., ET AL. (1986) Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor. Science 233, 545-548.
2. AONUMA M., IWAHANA M., NAKAYAMA Y., ET AL. (1998) Tumorigenicity depends on angiogenic potential of tumor cells: dominant role of vascular endothelial growth factor and/or fibroblast growth factors produced by tumor cells. Angiogenesis 2, 57-66.
3. BOSARI S., LEE A.K., DELELLIS R.A., WILEY B.D., HEATLEY G.J. & SILVERMAN M.L. (1992) Microvessel quantitation and prognosis in invasive breast carcinoma. Hum. Pathol. 23, 755-761.
4. BROWN L., BERSE B., JACKMAN R., ET AL. (1993) Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinoma. Am. J. Pathol. 143, 1255-1262.
5. BROWN L., BERSE B., JACKMAN R., ET AL. & SCHNITT S. (1995) Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer. Hum. Pathol. 26, 86-91.
6. CHOMCZYNSKI P. & SACCHI N. (1987) Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
7. CLAFFEY K.P., BROWN L.F., ET AL. (1996) Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis. Cancer Res. 56, 172-181.
8. COLTRINI D., GUALANDRIS A., NELLI E.E., ET AL. (1995) Growth advantage and vascularization induced by basic fibroblast growth factor overexpression in endometrial HEC-1-B cells: an export-dependent mechanism of action. Cancer Res. 55, 4729-4738.
9. FERRARA N., WINER J., BURTON T., ET AL. (1993) Expression of vascular endothelial growth factor does not promote transformation but confers a growth advantage in vivo to Chinese hamster ovary cells. J. Clin. Invest. 91, 160-170.
10. FOLKMAN J. (1995) Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med. 1, 27-31.
11. FOLKMAN J. & SHING Y. (1992) Angiogenesis. J. Biol. Chem. 267, 10931-10934.
12. GOTO F., GOTO K., WEINDEL K. & FOLKMAN J. (1993) Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord formation of bovine capillary endothelial cells within collagen gels. Lab. Invest. 69, 508-517.
13. HEIMANN R., FERGUSON D., POWERS C., RECANT W.M., WEICHSELBAUM R.R. & HELLMAN S. (1996) Angiogenesis as a predictor of long-term survival for patients with node-negative breast cancer. J. Natl. Cancer Inst. 88, 1764-1769.
14. KIM K.J., LI B., WINER J., ARMANINI M., GILLETT N., PHILLIPS H.S. & FERRARA N. (1993) Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 362, 841-844.
15. KONDO S., ASANO M. & SUZUKI H. (1993) Significance of vascular endothelial growth factor/vascular permeability factor for solid tumor growth, and its inhibition by the antibody. Biochem. Biophys. Res. Commun. 194, 1234-1241.
16. LEUNG D.W., CACHIANES G., KUANG W.J., GOEDDEL D.V. & Ferrara N. (1989) Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 248, 1306-1309.
17. MILLAUER B., SHAWVER L.K., PLATE K.H., RISAU W. & ULLRICH A. (1994) Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature 367, 576-579.
18. MITSUI I., KUMAZAWA E., HIROTA Y., ET AL. (1995) A new water-soluble camptothecin derivative, DX-8951f, exhibit potent antitumor activity against human tumors in vitro and in vivo. Jpn. J. Cancer Res. 86, 776-782.
19. MOORE G.E. & KOIKE A. (1964) Growth of human tumor cells in vitro and in vivo. Cancer 17, 11-20.
20. NANUS D., SCHMITZ-DRAGER B., MOTZER R., ET AL. (1993) Expression of basic fibroblast growth factor in primary human renal tumors: correlation with poor survival. J. Natl. Cancer Inst. 85, 1597-1599.
21. NAOMOTO Y., KONDO H., TANAKA N. & ORITA K. (1987) Novel experimental models of human cancer metastasis in nude mice: lung metastasis, intraabdominal carcinomatosis with ascites, and liver metastasis. J. Cancer Res. Clin. Oncol. 113, 544-549.
22. NAWATA H., BRONZERT D. & LIPPMAN M.E. (1981) Isolation and characterization of a tamoxifen-resistant cell line derived from MCF-7 human breast cancer cells. J. Biol. Chem. 256, 5016-5021.
23. OHTA Y., ENDO Y., TANAKA M., ET AL. (1996) Significance of vascular endothelial growth factor messenger RNA expression in primary lung cancer. Clin. Cancer Res. 2, 1411-1416.
24. PEPPER M.S., FERRARA N., ORCI L. & MONTESANO R. (1992) Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro. Biochem. Biophys. Res. Commun. 189, 824-831.
25. PLATE K.H., BREIER G., WEICH H.A. & RISAU W. (1992) Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 359, 845-848.
26. SAWANO A., TAKAHASHI T., YAMAGUCHI S., AONUMA M. & SHIBUYA M. (1996) Flt-1 but not KDR/Flk-1 tyrosine kinase is a receptor for placenta growth factor, which is related to vascular endothelial growth factor. Cell Growth Differentiation 7, 213-221.
27. SENGER D.R., PERRUZZI C.A., FEDER J. & DVORAK H.F. (1986) A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines. Cancer Res. 46, 5629-5632.
28. SHIBUYA M. (1995) Role of Veg F-flt receptor system in normal and tumor angiogenesis. Adv. Cancer Res. 67, 281-316.
29. TAKAHASHI Y., KITADAI Y., BUCANA C.D., CLEARY K.R. & ELLIS L.M. (1995) Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res. 55, 3964-3968.
30. TANAKA N.G., SAKAMOTO N., INOUE K., ET AL. (1989) Antitumor effects of an antiangiogenic polysaccharide from an Arthrobacter species with or without a steroid. Cancer Res. 49, 6727-6730.
31. YAMANAKA Y., FRIESS H., BUCHLER M., ET AL. (1993) Overexpression of acidic and basic fibroblast growth factors in human pancreatic cancer correlates with advanced tumor stage. Cancer Res. 53, 5289-5296.
32. ZHANG H.T., CRAFT P., SCOTT P.A., ET AL. (1995) Enhancement of tumor growth and vascular density by transfection of vascular endothelial cell growth factor into MCF-7 human breast carcinoma cells. J. Natl. Cancer Inst. 87, 213-219.