-
1
-
-
44949280863
-
Combinatorial immunoglobulin libraries on the surface of phage (Phabs): Rapid selection of antigen specific Fabs
-
BARBAS CF III, LERNER RA: Combinatorial immunoglobulin libraries on the surface of phage (Phabs): rapid selection of antigen specific Fabs. Methods (1991) 2:119-124.
-
(1991)
Methods
, vol.2
, pp. 119-124
-
-
Barbas III, C.F.1
Lerner, R.A.2
-
2
-
-
0025740577
-
Multi-subunit proteins on the surface of filamentous phage: Methodologies for displaying antibody (Fab) heavy and light chains
-
HOOGENBOOM HR, GRIFFITHS AD, JOHNSON KS, CHISWELL DJ, HUDSON P, WINTER G: Multi-subunit proteins on the surface of filamentous phage: methodologies for displaying antibody (Fab) heavy and light chains. Nucleic Acids Res. (1991) 19:4133-4137.
-
(1991)
Nucleic Acids Res.
, vol.19
, pp. 4133-4137
-
-
Hoogenboom, H.R.1
Griffiths, A.D.2
Johnson, K.S.3
Chiswell, D.J.4
Hudson, P.5
Winter, G.6
-
3
-
-
0033511863
-
Antibody engineering via genetic engineering of the mouse: XenoMouse strains are a vehicle for the facile generation of therapeutic human monoclonal antibodies
-
GREEN LL: Antibody engineering via genetic engineering of the mouse: XenoMouse strains are a vehicle for the facile generation of therapeutic human monoclonal antibodies. J. Immunol. Meth. (1999) 231:11-23.
-
(1999)
J. Immunol. Meth.
, vol.231
, pp. 11-23
-
-
Green, L.L.1
-
4
-
-
0842303168
-
Antibodies and gene therapy: Teaching old 'magic bullets' new tricks
-
SANZ L, BLANCO B, ALVAREZ-VALLINA L: Antibodies and gene therapy: teaching old 'magic bullets' new tricks. Trends Immunol. (2004) 25:85-91.
-
(2004)
Trends Immunol.
, vol.25
, pp. 85-91
-
-
Sanz, L.1
Blanco, B.2
Alvarez-Vallina, L.3
-
5
-
-
15244359484
-
-
CENTERS FOR DISEASE CONTROL AND PREVENTION: National Vital Statistics Report (2003) 52:1-114.
-
(2003)
National Vital Statistics Report
, vol.52
, pp. 1-114
-
-
-
6
-
-
0037132703
-
Role of body surface area in dosing of investigational anticancer agents in adults, 1991-2001
-
BAKER SD, VERWEIJ J, ROWINSKY EK et al.: Role of body surface area in dosing of investigational anticancer agents in adults, 1991-2001. J. Natl. Cancer Inst. (2002) 94(24):1883-1888.
-
(2002)
J. Natl. Cancer Inst.
, vol.94
, Issue.24
, pp. 1883-1888
-
-
Baker, S.D.1
Verweij, J.2
Rowinsky, E.K.3
-
9
-
-
0036022516
-
Uncorking the biomanufacturing bottleneck
-
DOVE A: Uncorking the biomanufacturing bottleneck. Nat. Biotechnol. (2002) 20:777-779.
-
(2002)
Nat. Biotechnol.
, vol.20
, pp. 777-779
-
-
Dove, A.1
-
10
-
-
2442640723
-
Characterization of humanized antibodies secreted by Apsergillus niger
-
WARD M, LIN C, VICTORIA DC et al.: Characterization of humanized antibodies secreted by Apsergillus niger. Appl. Environ. Microbiol. (2004) 70:2567-2576.
-
(2004)
Appl. Environ. Microbiol.
, vol.70
, pp. 2567-2576
-
-
Ward, M.1
Lin, C.2
Victoria, D.C.3
-
11
-
-
0024959945
-
Production of antibodies in transgenic plants
-
HIATT A, CAFFERKY R, BOWDISH K: Production of antibodies in transgenic plants. Nature (1988) 342:76-78. First example of antibody expression and assembly in higher plants via nuclear gene expression. However, such antibodies are glycosylated in a plant-specific fashion.
-
(1988)
Nature
, vol.342
, pp. 76-78
-
-
Hiatt, A.1
Cafferky, R.2
Bowdish, K.3
-
12
-
-
0028031827
-
Assembly of monoclonal antibodies with IgG1 and IgA heavy chain domains in transgenic tobacco plants
-
MA JK, LEHNER T, STABILA P, FUX CI, HIATT A: Assembly of monoclonal antibodies with IgG1 and IgA heavy chain domains in transgenic tobacco plants. Eur. J. Immunol. (1994) 24:131-138.
-
(1994)
Eur. J. Immunol.
, vol.24
, pp. 131-138
-
-
Ma, J.K.1
Lehner, T.2
Stabila, P.3
Fux, C.I.4
Hiatt, A.5
-
13
-
-
0029035201
-
Generation and assembly of secretory antibodies in plants
-
MA JK, HIATTA, HEIN M et al.: Generation and assembly of secretory antibodies in plants. Science (1995) 268:716-719.
-
(1995)
Science
, vol.268
, pp. 716-719
-
-
Ma, J.K.1
Hiatta Hein, M.2
-
14
-
-
0031835622
-
Characterization of a recombinant plant monoclonal secretory antibody and preventive immunotherapy in humans
-
MA JK, HIKMAT BY, WYCOFF K et al.: Characterization of a recombinant plant monoclonal secretory antibody and preventive immunotherapy in humans. Nat. Med. (1998) 4:601-606.
-
(1998)
Nat. Med.
, vol.4
, pp. 601-606
-
-
Ma, J.K.1
Hikmat, B.Y.2
Wycoff, K.3
-
15
-
-
0035032249
-
When transgenes wander, should we worry?
-
ELLSTRAND NC: When transgenes wander, should we worry? Plant Physiol. (2001) 125:1543-1545. Very thoughtful discussion on the implications of genetically modified organisms on food crops, as well as substantial supportive data.
-
(2001)
Plant Physiol.
, vol.125
, pp. 1543-1545
-
-
Ellstrand, N.C.1
-
16
-
-
0035969540
-
Transgenic DNA introgressed into traditional maite landraces in Oaxaca, Mexico
-
QUIST D, CHAPELA I: Transgenic DNA introgressed into traditional maite landraces in Oaxaca, Mexico. Nature (2001) 414:541-543.
-
(2001)
Nature
, vol.414
, pp. 541-543
-
-
Quist, D.1
Chapela, I.2
-
18
-
-
0034493524
-
Pollen flow between herbicide-resistant Brassica napus is the cause of multiple resistant B. napus volunteers
-
HALL L, TOPINKA K, HUFFMAN J, DAVIS L, GOOD A: Pollen flow between herbicide-resistant Brassica napus is the cause of multiple resistant B. napus volunteers. Weed Sci. (2000) 48:493-503.
-
(2000)
Weed Sci.
, vol.48
, pp. 493-503
-
-
Hall, L.1
Topinka, K.2
Huffman, J.3
Davis, L.4
Good, A.5
-
20
-
-
0038691863
-
Clinical and laboratory investigation of allergy to genetically modified foods
-
BERNSTEIN JA, BERNSTEIN IL, BUCCHINI L et al.: Clinical and laboratory investigation of allergy to genetically modified foods. Environ. Health Perspect. (2003) 111:1114-1121.
-
(2003)
Environ. Health Perspect.
, vol.111
, pp. 1114-1121
-
-
Bernstein, J.A.1
Bernstein, I.L.2
Bucchini, L.3
-
21
-
-
0034016818
-
High-yield production of a human therapeutic protein in tobacco chloroplasts
-
STAUB JM, GARCIA B, GRAVES J et al.: High-yield production of a human therapeutic protein in tobacco chloroplasts. Nat. Biotechnol. (2000) 18:333-338.
-
(2000)
Nat. Biotechnol.
, vol.18
, pp. 333-338
-
-
Staub, J.M.1
Garcia, B.2
Graves, J.3
-
22
-
-
0033514914
-
Overexpression of the Bacillus thuringiensis (Bt) Cry2Aa2 protein in chloroplasts confers resistance to plants against susceptible and Bt-resistant insects
-
KOTA M, DANIELL H, VARMA S, GARCZYNSKI SF, GOULD F, MOAR WJ: Overexpression of the Bacillus thuringiensis (Bt) Cry2Aa2 protein in chloroplasts confers resistance to plants against susceptible and Bt-resistant insects Proc. Natl. Acad. Sci. USA (1999) 96:1840-1845.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 1840-1845
-
-
Kota, M.1
Daniell, H.2
Varma, S.3
Garczynski, S.F.4
Gould, F.5
Moar, W.J.6
-
23
-
-
0032861138
-
Stable chloroplast transformation in potato: Use of green fluorescent prorein as a plastid marker
-
SIDOROV VA, KASTEN D, PANG SZ, HAJDUKIEWICZ PT, STAUB JM, NEHRA NS: Stable chloroplast transformation in potato: use of green fluorescent prorein as a plastid marker. Plant J. (1999) 19:209-216.
-
(1999)
Plant J.
, vol.19
, pp. 209-216
-
-
Sidorov, V.A.1
Kasten, D.2
Pang, S.Z.3
Hajdukiewicz, P.T.4
Staub, J.M.5
Nehra, N.S.6
-
24
-
-
0034868497
-
Stable genetic transformation of tomato plastids and expression of a foreign protein in fruit
-
RUF S, HERRMANN M, BERGER I, CARRER I, BOCK R: Stable genetic transformation of tomato plastids and expression of a foreign protein in fruit. Nat. Biotechnol. (2001) 19:870-875.
-
(2001)
Nat. Biotechnol.
, vol.19
, pp. 870-875
-
-
Ruf, S.1
Herrmann, M.2
Berger, I.3
Carrer, I.4
Bock, R.5
-
25
-
-
0033859426
-
Genetic engineering of the chloroplast
-
HEIFETZ PB: Genetic engineering of the chloroplast. Biochimie (2000) 82:655-666. Extensive overview of the landscape of recombinant proteins expressed to date in plastids, primarily chloroplasts, in higher plants.
-
(2000)
Biochimie
, vol.82
, pp. 655-666
-
-
Heifetz, P.B.1
-
26
-
-
0036017875
-
Development of a GFP reporter gene for Chlamydomonas reinhardtii chloroplast
-
FRANKLIN SE, NGO B, EFFUET E, MAYFIELD SP: Development of a GFP reporter gene for Chlamydomonas reinhardtii chloroplast. Plant J. (2002) 30:733-744. Demonstrated that codon optimisation had a profound effect on recombinant protein accumulation.
-
(2002)
Plant J.
, vol.30
, pp. 733-744
-
-
Franklin, S.E.1
Ngo, B.2
Effuet, E.3
Mayfield, S.P.4
-
27
-
-
0037457888
-
Expression and assembly of a fully active antibody in algae
-
MAYFIELD SP, FRANKLIN SE, LERNER RA: Expression and assembly of a fully active antibody in algae. Proc. Natl. Acad. Sci. USA (2003) 100:438-442. The first demonstration that an antibody could be expressed in the chloroplast of any species, and that it assembled into a functional antigen-binding protein.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 438-442
-
-
Mayfield, S.P.1
Franklin, S.E.2
Lerner, R.A.3
-
28
-
-
1042290212
-
Development of a luciferase reporter gene, luxCt, for Chlamydomonas reinhardtii chloroplast
-
MAYFIELD SP, SCHULTZ J: Development of a luciferase reporter gene, luxCt, for Chlamydomonas reinhardtii chloroplast. Plant J. (2004) 37:449-458.
-
(2004)
Plant J.
, vol.37
, pp. 449-458
-
-
Mayfield, S.P.1
Schultz, J.2
-
29
-
-
1542321146
-
Prospects for molecular farming in the green alga Chlamydomonas reinhardtii
-
FRANKLIN SE, MAYFIELD SP: Prospects for molecular farming in the green alga Chlamydomonas reinhardtii. Curr. Opin. Plant Biol. (2004) 7:159-165.
-
(2004)
Curr. Opin. Plant Biol.
, vol.7
, pp. 159-165
-
-
Franklin, S.E.1
Mayfield, S.P.2
-
30
-
-
0003783284
-
-
Harris EH (Ed.), Academic Press, Inc., New York, NY, USA
-
HARRIS EH: The Chlamydomonas Sourcebook: A Comprehensive Guide to Biology and Laboratory Use. Harris EH (Ed.), Academic Press, Inc., New York, NY, USA (1989).
-
(1989)
The Chlamydomonas Sourcebook: A Comprehensive Guide to Biology and Laboratory Use
-
-
Harris, E.H.1
-
31
-
-
0031036071
-
A eubacterial gene conferring spectinomycin resistance on Chlamydomonas reinhardtii: Integration into the nuclear genome and gene expression
-
CERUTTI H, JOHNSON AM, GILHAM NW, BOYNTON NE: A eubacterial gene conferring spectinomycin resistance on Chlamydomonas reinhardtii: integration into the nuclear genome and gene expression. Genetics (1997) 145:97-110.
-
(1997)
Genetics
, vol.145
, pp. 97-110
-
-
Cerutti, H.1
Johnson, A.M.2
Gilham, N.W.3
Boynton, N.E.4
-
32
-
-
0031153996
-
Epigenetic silencing of a foreign gene in nuclear transformants of Chlamydomonas
-
CERUTTI H, JOHNSON AM, GILHAM NW, BOYNTON NE: Epigenetic silencing of a foreign gene in nuclear transformants of Chlamydomonas. Plant Cell (1997) 9:925-945.
-
(1997)
Plant Cell
, vol.9
, pp. 925-945
-
-
Cerutti, H.1
Johnson, A.M.2
Gilham, N.W.3
Boynton, N.E.4
-
33
-
-
0024283282
-
Chloroplast transformation in Chlamydomonas with high velocity microprojectiles
-
BOYNTON JE, GILLHAM NW, HARRIS EH et al.: Chloroplast transformation in Chlamydomonas with high velocity microprojectiles. Science (1988) 240:1534-1538.
-
(1988)
Science
, vol.240
, pp. 1534-1538
-
-
Boynton, J.E.1
Gillham, N.W.2
Harris, E.H.3
-
34
-
-
0025637832
-
Transformation of chloroplast ribosomal RNA in Chlamydomonas: Molecular and genetic characterization of integration events
-
NEWMAN SM, BOYNTON JE, GILLHAM NW, RANDOLPH-ANDERSON BL, JOHNSON AM, HARRIS EH: Transformation of chloroplast ribosomal RNA in Chlamydomonas: molecular and genetic characterization of integration events. Genetics (1990) 126:875-888.
-
(1990)
Genetics
, vol.126
, pp. 875-888
-
-
Newman, S.M.1
Boynton, J.E.2
Gillham, N.W.3
Randolph-Anderson, B.L.4
Johnson, A.M.5
Harris, E.H.6
-
35
-
-
0003539882
-
-
Rochaix JD, Merchant S, Goldschmidt-Clermont M (Eds), Kluwer Academic Publishers, New York, NY, USA
-
ROCHAIX JD, MERCHANT S, GOLDSCHMIDT-CLERMONT M: The Molecular Biology of Chloroplasts and Mitochondria in Chlamydomonas. Rochaix JD, Merchant S, Goldschmidt-Clermont M (Eds), Kluwer Academic Publishers, New York, NY, USA (2000).
-
(2000)
The Molecular Biology of Chloroplasts and Mitochondria in Chlamydomonas
-
-
Rochaix, J.D.1
Merchant, S.2
Goldschmidt-Clermont, M.3
-
36
-
-
0025766849
-
Transgenic expression of aminoglycoside adenine transferase in the chloroplast: A selectable marker for site-directed transformation of Chlamydomonas
-
GOLDSCHMIDT-CLERMONT M: Transgenic expression of aminoglycoside adenine transferase in the chloroplast: a selectable marker for site-directed transformation of Chlamydomonas. Nucleic Acids Res. (1991) 19:4083-4089.
-
(1991)
Nucleic Acids Res.
, vol.19
, pp. 4083-4089
-
-
Goldschmidt-Clermont, M.1
-
37
-
-
12244272391
-
Enhancement of therapeutic protein in vivo activities through glycoengineering
-
ELLIOTT S, LORENZINI T, ASHER S et al.: Enhancement of therapeutic protein in vivo activities through glycoengineering. Nat. Biotechnol. (2003) 21:414-421.
-
(2003)
Nat. Biotechnol.
, vol.21
, pp. 414-421
-
-
Elliott, S.1
Lorenzini, T.2
Asher, S.3
-
38
-
-
18344372376
-
Expression of full-length immunoglobulins in Escherichia coli: Rapid and efficient production of aglycosylated antibodies
-
SIMMONS L, REILLY D, KLIMOWSKI L et al.: Expression of full-length immunoglobulins in Escherichia coli: rapid and efficient production of aglycosylated antibodies. J. Immunol. Meth. (2003) 263:133-147.
-
(2003)
J. Immunol. Meth.
, vol.263
, pp. 133-147
-
-
Simmons, L.1
Reilly, D.2
Klimowski, L.3
-
39
-
-
0024438061
-
Studies of aglycosylated chimeric mouse-human IgG. Role of carbohydrate in the structure and effector functions mediated by the human IgG constant region
-
TAO MH, MORRISON SL: Studies of aglycosylated chimeric mouse-human IgG. Role of carbohydrate in the structure and effector functions mediated by the human IgG constant region. J. Immunol. (1989) 143:2595-2601.
-
(1989)
J. Immunol.
, vol.143
, pp. 2595-2601
-
-
Tao, M.H.1
Morrison, S.L.2
-
40
-
-
0025763066
-
Aglycosylated chimeric mouse/human IgG1 antibody retains some effector function
-
DORAI H, MUELLER BM, REISFELD RA, GILLIES SD: Aglycosylated chimeric mouse/human IgG1 antibody retains some effector function. Hybridoma (1991) 10:211-217.
-
(1991)
Hybridoma
, vol.10
, pp. 211-217
-
-
Dorai, H.1
Mueller, B.M.2
Reisfeld, R.A.3
Gillies, S.D.4
-
41
-
-
0026710786
-
Comparative biological properties of a recombinant chimeric anti-carcinoma mAb and a recombinant aglycosylated variant
-
HAND P, CALVO B, MILENIC D et al.: Comparative biological properties of a recombinant chimeric anti-carcinoma mAb and a recombinant aglycosylated variant. Cancer Immunol. Immunother. (1992) 35:165-174.
-
(1992)
Cancer Immunol. Immunother.
, vol.35
, pp. 165-174
-
-
Hand, P.1
Calvo, B.2
Milenic, D.3
-
42
-
-
0034886490
-
Characterization of human FSH isoforms reveals a nonglycosylated B-subunit in addition to the conventional glycosylated B-subunit
-
WALTON W, NGUYEN VT, BUTNEV V, SINGH V, MOORE WT, BOUSFIELD GR: Characterization of human FSH isoforms reveals a nonglycosylated B-subunit in addition to the conventional glycosylated B-subunit. J. Clin. Endocrinol. (2001) 86:3675-3685.
-
(2001)
J. Clin. Endocrinol.
, vol.86
, pp. 3675-3685
-
-
Walton, W.1
Nguyen, V.T.2
Butnev, V.3
Singh, V.4
Moore, W.T.5
Bousfield, G.R.6
-
43
-
-
0026475392
-
Immunoradiometric analysis of circulating human glycosylated and nonglycosylated prolactin forms: Spontaneous and stimulated secretions
-
BRUE T, CARUSO E, MORANGE I et al.: Immunoradiometric analysis of circulating human glycosylated and nonglycosylated prolactin forms: spontaneous and stimulated secretions. J. Clin. Endocrinol. Metab. (1992) 75:1338-1344.
-
(1992)
J. Clin. Endocrinol. Metab.
, vol.75
, pp. 1338-1344
-
-
Brue, T.1
Caruso, E.2
Morange, I.3
-
44
-
-
0028789353
-
Studies on the microheterogeneity and in vitro activity of glycosylated and nonglycosylated recombinant human prolactin separated using a novel purification process
-
PRICE AE, LOGVINENKO KB, HIGGINS EA, COLE ES, RICHARDS SM: Studies on the microheterogeneity and in vitro activity of glycosylated and nonglycosylated recombinant human prolactin separated using a novel purification process. Endocrinology (1995) 136:4827-4833.
-
(1995)
Endocrinology
, vol.136
, pp. 4827-4833
-
-
Price, A.E.1
Logvinenko, K.B.2
Higgins, E.A.3
Cole, E.S.4
Richards, S.M.5
-
45
-
-
0034455719
-
Deficiency of total and nonglycosylated amylin in plasma characterizes subjects with impaired glucose tolerance and type 2 diabetes
-
MAKIMATTILA S, FINEMAN MS, YKI-JARVINEN H: Deficiency of total and nonglycosylated amylin in plasma characterizes subjects with impaired glucose tolerance and type 2 diabetes. J. Clin. Endocrinol. Metab. (2000) 85:2822-2827.
-
(2000)
J. Clin. Endocrinol. Metab.
, vol.85
, pp. 2822-2827
-
-
Makimattila, S.1
Fineman, M.S.2
Yki-Jarvinen, H.3
-
46
-
-
0033572786
-
Phase I study of an engineered aglycosylated humanized CD3 antibody in renal transplant rejection
-
FRIEND PJ, HALE G, CHATENOUD L et al.: Phase I study of an engineered aglycosylated humanized CD3 antibody in renal transplant rejection. Transplantation (1999) 68:1632-1637.
-
(1999)
Transplantation
, vol.68
, pp. 1632-1637
-
-
Friend, P.J.1
Hale, G.2
Chatenoud, L.3
-
47
-
-
0037313086
-
CD3-specific antibody-induced active tolerance: From bench to bedside
-
CHATENOUD L: CD3-specific antibody-induced active tolerance: from bench to bedside. Nat. Rev. Immunol. (2003) 3:123-132.
-
(2003)
Nat. Rev. Immunol.
, vol.3
, pp. 123-132
-
-
Chatenoud, L.1
-
48
-
-
0030266995
-
Post-transcriptional regulation of chloroplast gene expression in Chlamydomonas
-
ROCHAIX JD: Post-transcriptional regulation of chloroplast gene expression in Chlamydomonas. Plant Mol. Biol. (1996) 32:327-341.
-
(1996)
Plant Mol. Biol.
, vol.32
, pp. 327-341
-
-
Rochaix, J.D.1
-
49
-
-
0036324267
-
Searching limiting steps in the expression of chloroplast encoded proteins: Relations between gene copy number, transcription, transcript abundance and translation rate in the chloroplast of Chlamydomonas reinhardtii
-
EBERHARD S, DRAPIER D, WOLLMAN FA: Searching limiting steps in the expression of chloroplast encoded proteins: relations between gene copy number, transcription, transcript abundance and translation rate in the chloroplast of Chlamydomonas reinhardtii. Plant J. (2002) 31:149-160. Clear demonstration that translation is the key modulator of chloroplast gene expression in C. reinhardtii. A critical point for deciding how to impact therapeutic protein production in this organism.
-
(2002)
Plant J.
, vol.31
, pp. 149-160
-
-
Eberhard, S.1
Drapier, D.2
Wollman, F.A.3
-
50
-
-
0032837715
-
In vivo analysis of plastid psbA, rbcL and rpl32 UTR elements by chloroplast transformation: Tobacco plastid gene expression is controlled by modulation of transcript levels and translation efficiency
-
EIBL C, ZOU Z, BECK A, KIM M, MULLET J, KOOP HU: In vivo analysis of plastid psbA, rbcL and rpl32 UTR elements by chloroplast transformation: tobacco plastid gene expression is controlled by modulation of transcript levels and translation efficiency. Plant J. (1999) 19:333-345.
-
(1999)
Plant J.
, vol.19
, pp. 333-345
-
-
Eibl, C.1
Zou, Z.2
Beck, A.3
Kim, M.4
Mullet, J.5
Koop, H.U.6
|