메뉴 건너뛰기




Volumn 92, Issue 6, 2005, Pages 1285-1294

Heterodimerization of opioid receptor-like 1 and μ-opioid receptors impairs the potency of μ receptor agonist

Author keywords

opioid receptor; DAMGO; Nociceptin; Opioid receptor like 1 receptor; Receptor heterodimerization

Indexed keywords

MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; OPIATE RECEPTOR;

EID: 15244346473     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2004.02921.x     Document Type: Article
Times cited : (69)

References (39)
  • 1
    • 0034618268 scopus 로고    scopus 로고
    • AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration
    • AbdAlla S., Lother H. and Quitterer U. (2000) AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration. Nature 407, 94-98.
    • (2000) Nature , vol.407 , pp. 94-98
    • AbdAlla, S.1    Lother, H.2    Quitterer, U.3
  • 3
    • 0042467972 scopus 로고    scopus 로고
    • Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptor with examples from striatopallidal GABA neurons
    • Agnati L., Ferre S., Lluis C., Franco R. and Fuxe K. (2003) Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptor with examples from striatopallidal GABA neurons. Pharmacol. Rev. 55, 509-550.
    • (2003) Pharmacol. Rev. , vol.55 , pp. 509-550
    • Agnati, L.1    Ferre, S.2    Lluis, C.3    Franco, R.4    Fuxe, K.5
  • 4
    • 0036174608 scopus 로고    scopus 로고
    • Dimerization: An emerging concept for G protein-coupled receptor ontogeny and function
    • Angers S., Salahpour A. and Bouvier M. (2002) Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function. Ann. Rev. Pharmacol. Toxicol. 42, 409-435,.
    • (2002) Ann. Rev. Pharmacol. Toxicol. , vol.42 , pp. 409-435
    • Angers, S.1    Salahpour, A.2    Bouvier, M.3
  • 6
    • 0031694279 scopus 로고    scopus 로고
    • Pharmacological characterization of the nociceptin receptor mediating hyperalgesia in the mouse tail withdrawal assay
    • Calo G., Rizzi A., Marzola G., Guerrini R., Salvadori S., Beani L., Regoli D. and Bianchi C. (1998) Pharmacological characterization of the nociceptin receptor mediating hyperalgesia in the mouse tail withdrawal assay. Br. J. Pharmacol. 125, 373-378.
    • (1998) Br. J. Pharmacol. , vol.125 , pp. 373-378
    • Calo, G.1    Rizzi, A.2    Marzola, G.3    Guerrini, R.4    Salvadori, S.5    Beani, L.6    Regoli, D.7    Bianchi, C.8
  • 7
    • 0034101842 scopus 로고    scopus 로고
    • 2 receptor, a new selective nociceptin receptor antagonist
    • 2 receptor, a new selective nociceptin receptor antagonist. Br. J. Pharmacol. 129, 1183-1193.
    • (2000) Br. J. Pharmacol. , vol.129 , pp. 1183-1193
    • Calo, G.1    Guerrini, R.2    Bigoni, R.3
  • 9
    • 0027202213 scopus 로고
    • Molecular cloning and functional expression of a μ opioid receptor from rat brain
    • Chen Y., Mestek A., Liu J., Hurley J. A. and Yu L. (1993) Molecular cloning and functional expression of a μ opioid receptor from rat brain. Mol. Pharmacol. 44, 8-12.
    • (1993) Mol. Pharmacol. , vol.44 , pp. 8-12
    • Chen, Y.1    Mestek, A.2    Liu, J.3    Hurley, J.A.4    Yu, L.5
  • 10
    • 0242460494 scopus 로고    scopus 로고
    • Metabotropic glutamate 1α and adenosine A1 receptors assemble into functionally interacting complexes
    • Ciruela F., Escriche M., Burgueno J. et al. (2001) Metabotropic glutamate 1α and adenosine A1 receptors assemble into functionally interacting complexes. J. Biol. Chem. 276, 18 345-18 351.
    • (2001) J. Biol. Chem. , vol.276 , pp. 18345-18351
    • Ciruela, F.1    Escriche, M.2    Burgueno, J.3
  • 11
    • 0037727707 scopus 로고    scopus 로고
    • Regulation of heptaspanning-membrane-receptor function by dimerization and clustering
    • Franco R., Canals M., Marcellino D. et al. (2003) Regulation of heptaspanning-membrane-receptor function by dimerization and clustering. Trends Biohem. Sci. 28, 238-243.
    • (2003) Trends Biohem. Sci. , vol.28 , pp. 238-243
    • Franco, R.1    Canals, M.2    Marcellino, D.3
  • 12
    • 0034714335 scopus 로고    scopus 로고
    • Oligomerization of μ and δ-opioid receptors: Generation of novel functional properties
    • George S. R., Fan T., Xie Z., Tse R., Tam V., Varghese G. and O'Dowd B. F. (2000) Oligomerization of μ and δ-opioid receptors: Generation of novel functional properties. J. Biol. Chem. 275, 26128-26135.
    • (2000) J. Biol. Chem. , vol.275 , pp. 26128-26135
    • George, S.R.1    Fan, T.2    Xie, Z.3    Tse, R.4    Tam, V.5    Varghese, G.6    O'Dowd, B.F.7
  • 14
    • 0034668742 scopus 로고    scopus 로고
    • Heterodimerization of μ and δ opioid receptors: A role in opiate synergy
    • Gomes I., Jordan B. A., Gupta A., Trapaidze N., Nagy V. and Devi L. A. (2000) Heterodimerization of μ and δ opioid receptors: a role in opiate synergy. J. Neurosci. 20, RC110(1-5).
    • (2000) J. Neurosci. , vol.20 , Issue.1-5
    • Gomes, I.1    Jordan, B.A.2    Gupta, A.3    Trapaidze, N.4    Nagy, V.5    Devi, L.A.6
  • 15
    • 0029804988 scopus 로고    scopus 로고
    • Orphanin FQ acts as a supraspinal, but not a spinal, anti-opioid peptide
    • Grisel J. E., Mogil J. S., Belknap J. K. and Grandy D. K. (1996) Orphanin FQ acts as a supraspinal, but not a spinal, anti-opioid peptide. Neuroreport 7, 2125-2129.
    • (1996) Neuroreport , vol.7 , pp. 2125-2129
    • Grisel, J.E.1    Mogil, J.S.2    Belknap, J.K.3    Grandy, D.K.4
  • 16
    • 0031815227 scopus 로고    scopus 로고
    • Nociceptin (ORL-1) and μ-opioid receptors mediate mitogen-activated protein kinase activation in CHO cells through a Gi-coupled signaling pathway: Evidence for distinct mechanisms of agonist-mediated desensitization
    • Hawes B. E., Fried S., Yao X. R., Weig B. and Graziano M. P. (1998) Nociceptin (ORL-1) and μ-opioid receptors mediate mitogen-activated protein kinase activation in CHO cells through a Gi-coupled signaling pathway: evidence for distinct mechanisms of agonist-mediated desensitization. J. Neurochem. 71, 1024-1033.
    • (1998) J. Neurochem. , vol.71 , pp. 1024-1033
    • Hawes, B.E.1    Fried, S.2    Yao, X.R.3    Weig, B.4    Graziano, M.P.5
  • 17
    • 0031415767 scopus 로고    scopus 로고
    • Circuitry underlying antiopioid actions of orphanin FQ in the rostral ventromedial medulla
    • Heinricher M. M., McGaraughty S. and Grandy D. K. (1997) Circuitry underlying antiopioid actions of orphanin FQ in the rostral ventromedial medulla. J. Neurophysiol. 78, 3351-3358.
    • (1997) J. Neurophysiol. , vol.78 , pp. 3351-3358
    • Heinricher, M.M.1    McGaraughty, S.2    Grandy, D.K.3
  • 18
    • 0034726619 scopus 로고    scopus 로고
    • Distribution of nociceptin/orphanin FQ precursor protein and receptor in brain and spinal cord: A study using in sit hybridization and X-gal histochemistry in receptor-eficient mice
    • Houtani T., Nishi M., Takeshima H., Sato K., Sakuma S., Kakimoto S., Ueyama T., Noda T. and Sugimoto T. (2000) Distribution of nociceptin/orphanin FQ precursor protein and receptor in brain and spinal cord: a study using in sit hybridization and X-gal histochemistry in receptor-eficient mice. J. Comp. Neurol. 424, 489-508.
    • (2000) J. Comp. Neurol. , vol.424 , pp. 489-508
    • Houtani, T.1    Nishi, M.2    Takeshima, H.3    Sato, K.4    Sakuma, S.5    Kakimoto, S.U.6    Eyama, T.7    Noda, T.8    Sugimoto, T.9
  • 21
    • 0028894449 scopus 로고
    • Molecular cloning of a novel G protein-coupled receptor related to the opiate receptor family
    • Lachowicz J. E., Shen Y., Monsma F. J. Jr and Sibley D. R. (1995) Molecular cloning of a novel G protein-coupled receptor related to the opiate receptor family. J. Neurochem. 64, 34-40.
    • (1995) J. Neurochem. , vol.64 , pp. 34-40
    • Lachowicz, J.E.1    Shen, Y.2    Monsma Jr., F.J.3    Sibley, D.R.4
  • 22
    • 0035048317 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 2 mediates μ-opioid receptor desensitization in GABAergic neurons of the nucleus raphe magnus
    • Li A. H. and Wang H. L. (2001) G protein-coupled receptor kinase 2 mediates μ-opioid receptor desensitization in GABAergic neurons of the nucleus raphe magnus. J. Neurochem. 77, 435-444.
    • (2001) J. Neurochem. , vol.77 , pp. 435-444
    • Li, A.H.1    Wang, H.L.2
  • 23
    • 0036073214 scopus 로고    scopus 로고
    • Orphanin FQ/nociceptin-mediated desensitization of opioid receptor-like 1 receptor and μ opioid receptors involves protein kinase C: A molecular mechanism for heterologous cross-talk
    • Mandyam C. D., Thakker D. R., Christensen J. L. and Standifer K. M. (2002) Orphanin FQ/nociceptin-mediated desensitization of opioid receptor-like 1 receptor and μ opioid receptors involves protein kinase C: a molecular mechanism for heterologous cross-talk. J. Pharmacol. Exp. Ther. 302, 502-509.
    • (2002) J. Pharmacol. Exp. Ther. , vol.302 , pp. 502-509
    • Mandyam, C.D.1    Thakker, D.R.2    Christensen, J.L.3    Standifer, K.M.4
  • 24
    • 0028887626 scopus 로고
    • Opioid-receptor mRNA expression in the rat CNS: Anatomical and functional implications
    • Mansour A., Fox A. C., Akil H. and Waston S. J. (1995) Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications. Trends Neurosci. 18, 22-29.
    • (1995) Trends Neurosci. , vol.18 , pp. 22-29
    • Mansour, A.1    Fox, A.C.2    Akil, H.3    Waston, S.J.4
  • 25
    • 0036277865 scopus 로고    scopus 로고
    • Descending control of pain
    • Millan M. J. (2002) Descending control of pain. Prog. Neurobiol. 66, 355-474.
    • (2002) Prog. Neurobiol. , vol.66 , pp. 355-474
    • Millan, M.J.1
  • 26
    • 0034850298 scopus 로고    scopus 로고
    • The molecular and behavioral pharmacology of the orphanin FQ/nociceptin peptide and receptor family
    • Mogil J. S. and Pasternak G. W. (2001) The molecular and behavioral pharmacology of the orphanin FQ/nociceptin peptide and receptor family. Pharmacol. Rev. 53, 381-415.
    • (2001) Pharmacol. Rev. , vol.53 , pp. 381-415
    • Mogil, J.S.1    Pasternak, G.W.2
  • 27
    • 0030598929 scopus 로고    scopus 로고
    • Functional antagonism of μ-, δ- and κ-opioid antinociception by orphanin FQ
    • Mogil J. S., Grisel J. E., Zhangs G., Belknap J. K. and Grandy D. K. (1996) Functional antagonism of μ-, δ- and κ-opioid antinociception by orphanin FQ. Neurosci. Lett. 214, 131-134.
    • (1996) Neurosci. Lett. , vol.214 , pp. 131-134
    • Mogil, J.S.1    Grisel, J.E.2    Zhangs, G.3    Belknap, J.K.4    Grandy, D.K.5
  • 28
    • 0030694216 scopus 로고    scopus 로고
    • Antinociception mediated by the periaqueductal grey is attenuated by orphanin FQ
    • Morgan M. M., Grisel J. E., Robbins C. S. and Grandy D. K. (1997) Antinociception mediated by the periaqueductal grey is attenuated by orphanin FQ. Neuroreport 8, 3431-3434.
    • (1997) Neuroreport , vol.8 , pp. 3431-3434
    • Morgan, M.M.1    Grisel, J.E.2    Robbins, C.S.3    Grandy, D.K.4
  • 29
    • 0036387204 scopus 로고    scopus 로고
    • Dimerization of morphine and orphanin FQ /nociceptin receptors: Generation of a novel opioid receptor subtype
    • Pan Y. X., Bolan E. and Pasternak G. W. (2002) Dimerization of morphine and orphanin FQ /nociceptin receptors: generation of a novel opioid receptor subtype. Biochem. Biophy. Res. Commun. 297, 659-663.
    • (2002) Biochem. Biophy. Res. Commun. , vol.297 , pp. 659-663
    • Pan, Y.X.1    Bolan, E.2    Pasternak, G.W.3
  • 30
    • 0033698211 scopus 로고    scopus 로고
    • A cellular mechanism for the bidirectional pain-modulating actions of orphanin FQ/nociceptin
    • Pan Z. Z., Hirakawa N. and Fields H. L. (2000) A cellular mechanism for the bidirectional pain-modulating actions of orphanin FQ/nociceptin. Neuron 26, 515-522.
    • (2000) Neuron , vol.26 , pp. 515-522
    • Pan, Z.Z.1    Hirakawa, N.2    Fields, H.L.3
  • 31
    • 0037205489 scopus 로고    scopus 로고
    • Heterodimerization of somatostatin and opioid receptors cross-modulate phosphorylation, internalization, and desensitization
    • Pfeiffer M., Koch T., Schroder H., Laugsch M., Hollt V. and Schulz S. (2002) Heterodimerization of somatostatin and opioid receptors cross-modulate phosphorylation, internalization, and desensitization. J. Biol. Chem. 277, 19 762-19 772.
    • (2002) J. Biol. Chem. , vol.277 , pp. 19762-19772
    • Pfeiffer, M.1    Koch, T.2    Schroder, H.3    Laugsch, M.4    Hollt, V.5    Schulz, S.6
  • 32
    • 0345803929 scopus 로고    scopus 로고
    • Heterodimerization of substance P and μ-opioid receptors regulates receptor trafficking and resensitization
    • Pfeiffer M., Koch T., Schroder H., Laugsch M., Hollt V. and Schulz S. (2003) Heterodimerization of substance P and μ-opioid receptors regulates receptor trafficking and resensitization. J. Biol. Chem. 278, 51 630-51 637.
    • (2003) J. Biol. Chem. , vol.278 , pp. 51630-51637
    • Pfeiffer, M.1    Koch, T.2    Schroder, H.3    Laugsch, M.4    Hollt, V.5    Schulz, S.6
  • 33
    • 0034616021 scopus 로고    scopus 로고
    • Receptors for dopamine and somatostatin: Formation of hetero-oligomers with enhanced functional activity
    • Rocheville M., Lange D. C., Kumar U., Patel S. C., Patel R. C. and Patel Y. C. (2000) Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity. Science 288, 154-157.
    • (2000) Science , vol.288 , pp. 154-157
    • Rocheville, M.1    Lange, D.C.2    Kumar, U.3    Patel, S.C.4    Patel, R.C.5    Patel, Y.C.6
  • 34
    • 0030614373 scopus 로고    scopus 로고
    • Actions of the ORL1 receptor ligand nociceptin on membrane properties of rat periaqueductal gray neurons in vitro
    • Vaughan C. W., Ingram S. L. and Christie M. J. (1997) Actions of the ORL1 receptor ligand nociceptin on membrane properties of rat periaqueductal gray neurons in vitro. J. Neurosci. 17, 996-1003.
    • (1997) J. Neurosci. , vol.17 , pp. 996-1003
    • Vaughan, C.W.1    Ingram, S.L.2    Christie, M.J.3
  • 35
    • 0033048623 scopus 로고    scopus 로고
    • A conserved arginine in the distal third intracellular loop of the μ-opioid receptor is required for G protein activation
    • Wang H. L. (1999) A conserved arginine in the distal third intracellular loop of the μ-opioid receptor is required for G protein activation. J. Neurochem. 72, 1307-1314.
    • (1999) J. Neurochem. , vol.72 , pp. 1307-1314
    • Wang, H.L.1
  • 36
    • 0033978672 scopus 로고    scopus 로고
    • A cluster of Ser/Thr residues at the C-terminus of μ-opioid receptor is required for G protein-coupled receptor kinase 2-mediated desensitization
    • Wang H. L. (2000) A cluster of Ser/Thr residues at the C-terminus of μ-opioid receptor is required for G protein-coupled receptor kinase 2-mediated desensitization. Neuropharmacology 39, 353-363.
    • (2000) Neuropharmacology , vol.39 , pp. 353-363
    • Wang, H.L.1
  • 37
    • 0037099297 scopus 로고    scopus 로고
    • Identification of two C-terminal amino acids, Ser355 and Thr357, required for short-term homologous desensitization of μ-opioid receptors
    • Wang H. L., Chang W. T., Hsu C. Y., Huang P. C., Chow Y. W. and Li A. (2002) Identification of two C-terminal amino acids, Ser355 and Thr357, required for short-term homologous desensitization of μ-opioid receptors. Biochem. Pharmacol. 64, 257-266.
    • (2002) Biochem. Pharmacol. , vol.64 , pp. 257-266
    • Wang, H.L.1    Chang, W.T.2    Hsu, C.Y.3    Huang, P.C.4    Chow, Y.W.5    Li, A.6
  • 38
    • 0033600513 scopus 로고    scopus 로고
    • Effects of orphanin. FQ on endomorphin-1 induced analgesia
    • Wang Y. Q., Zhu C. B., Wu G. C., Cao X. D., Wang Y. and Cui D. F. (1999) Effects of orphanin. FQ on endomorphin-1 induced analgesia. Brain Res. 835, 241-246.
    • (1999) Brain Res. , vol.835 , pp. 241-246
    • Wang, Y.Q.1    Zhu, C.B.2    Wu, G.C.3    Cao, X.D.4    Wang, Y.5    Cui, D.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.