Surface molecules essential for positive selection are retained but interfered in thymic epithelial cells after monolayer culture

Cellular Immunology

Volumn 211, Issue 1, 2001, Pages 71-79

  Sato, Takehito ^a   Sato, Chiharu ^a   Suzuki, Daisuke ^a   Yoshida, Yuki ^a   Nunomura, Satoshi ^a   Matsumura, Takuya ^a   Hozumi, Katsuto ^a   Habu, Sonoko ^a  

^a TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cellular differentiation; Cellular proliferation; Stromal cells; T lymphocytes; Thymus

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; EPITHELIUM CELL; MONOLAYER CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; THYMOCYTE;

MUS MUSCULUS;

EID: 0035838269     PISSN: 00088749     EISSN: None     Source Type: Journal    
DOI: 10.1006/cimm.2001.1823     Document Type: Article

References (41)

1. Molecular basis for developmental changes in interleukin-2 gene inducibility
2. The final maturation of at least some single-positive CD4(hi) thymocytes does not require T cell receptor-major histocompatibility complex contact
3. The majority of post selection CD4+ single-positive thymocytes requires the thymus to produce long-lived, functional T cells
4. The development of functionally responsive T cells
5. T-cell differentiation is influenced by thymic microenvironments
6. Cellular interactions in thymocyte development
7. Development in the thymus: It takes two to tango
8. The thymic microenvironment
9. Positive selection of thymocytes: The long and winding road
10. The role of the thymus during T-lymphocyte development in vitro
11. Positive selection of TcR alpha beta thymocytes: Is cortical thymic epithelium an obligatory participant in the presentation of major histocompatibility complex protein?
12. Studies on T cell maturation on defined thymic stromal cell populations in vitro
13. Fetal thymic organ cultures
14. Discrimination between maintenance- and differentiation-inducing signals during initial and intermediate stages of positive selection
15. Naive T cells can mediate delayed-type hypersensitivity response in T cell receptor transgenic mice
16. Evidence for down-regulation of highly expressed TCR by CD4 and CD45 on non-selected CD4+CD8+ thymocytes
17. CD45 can act as a negative regulator for the transition from early to late CD4+CD8+ thymocytes
18. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
19. CD69 expression during selection and maturation of CD4+8+ thymocytes
20. CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection
21. CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity
22. Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities
23. Antagonist peptide selects thymocyte expressing a class II major histocompatibility complex-restricted T cell receptor into the CD8 lineage
24. Activation of the extracellular signal-related kinase/mitogen-activated protein kinase pathway discriminates CD4 versus CD8 lineage commitment in the thymus
25. Thymic epithelial cells provide unique signals for positive selection of CD4+CD8+ thymocytes in vitro
26. Identification of a developmentally regulated phase of post selection expansion driven by thymic epithelium
27. CD69 expression discriminates MHC-dependent and-independent stages of thymocyte positive selection
28. Thymic selection and cell division
29. MHC class II molecules are required for initiation of positive selection but not during terminal differentiation of human CD4 single positive thymocytes
30. In vitro positive selection and anergy induction of class II-restricted TCR transgenic thymocytes by a cortical thymic epithelial cell line
31. In vitro positive selection of alpha beta TCR transgenic thymocytes by a conditionally immortalized cortical epithelial clone
32. Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28
33. CD28-B7 interactions function to co-stimulate clonal deletion of doule-positive thymocytes
34. An essential role for gp39, the ligand for CD40, in thymic selection
35. IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression
36. Requirement of a second signal from antigen presenting cells in the clonal deletion of immature T cells
37. In vitro models of T cell development
38. An essential role for the IL-7 receptor during intrathymic expansion of the positively selected neonatal T cell repertoire
39. Helper T cell differentiation is controlled by the cell cycle
40. Instruction for cytokine expression in T helper lymphocytes in relation to proliferation and cell cycle progression
41. Molecular basis for functional maturation of thymocytes: Increase in c-fos translation with positive selection