Evidence for 5-HT2B and 5-HT7 receptor-mediated relaxation in pulmonary arteries of weaned pigs

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 371, Issue 1, 2005, Pages 89-98

  Jahnichen S ^a   Glusa, E ^b   Pertz, H H ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

5 HT2B receptors; 5 HT7 receptors; 5 Hydroxytryptamine; Pulmonary arteries; Relaxation; SB 269970; Weaned pigs

Indexed keywords

1 [5 (2 THIENYLMETHOXY) 3 INDOLYL] 2 PROPANAMINE; 1,2,3,5 TETRAHYDRO 5 METHYL 1 (3 PYRIDYLCARBAMOYL)PYRROLO[2,3 F]INDOLE; 3 [2 [2 (4 METHYL 1 PIPERIDINYL)ETHYL] 1 PYRROLIDINESULFONYL]PHENOL; 5 CARBAMOYLTRYPTAMINE; 5 METHOXYTRYPTAMINE; 6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; CLOZAPINE; CYCLIC AMP; FROVATRIPTAN; MESULERGINE; METHYSERGIDE; METITEPINE; N(G) NITROARGININE METHYL ESTER; PIMOZIDE; PROSTAGLANDIN F2 ALPHA; SEROTONIN; SEROTONIN 2B RECEPTOR; SEROTONIN 2B RECEPTOR ANTAGONIST; SEROTONIN 2C ANTAGONIST; SEROTONIN 7 RECEPTOR; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SPIPERONE; UNCLASSIFIED DRUG; SEROTONIN RECEPTOR;

ANIMAL TISSUE; ARTERY CONSTRICTION; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG RESPONSE; DRUG SELECTIVITY; IN VITRO STUDY; NONHUMAN; PULMONARY ARTERY; SWINE; WEANING; ALGORITHM; ANIMAL; DOSE RESPONSE; DRUG EFFECT; MUSCLE RELAXATION; PHYSIOLOGY; RADIOASSAY; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE;

ALGORITHMS; ANIMALS; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; PULMONARY ARTERY; RADIOLIGAND ASSAY; RECEPTOR, SEROTONIN, 5-HT2B; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SWINE;

EID: 15044346046     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-004-1006-6     Document Type: Article

References (48)

1. Arunlakshana O, Schild HO (1959) Some quantitative uses of drug antagonists. Br J Pharmacol 14:48-58
2. 2B receptors. Behav Brain Res 73:149-152
3. 7 receptor and its comparison with the structure of other species. Mol Cell Biochem 238:81-88
4. 2C receptor antagonist. J Med Chem 40:3494-3496
5. 1B/1D agonist frovatriptan. Headache 42 [Suppl 2]:S47-S53
6. 7 receptor ligand, blocks serotonin-induced relaxation in canine coronary artery. J Pharmacol Exp Ther 277:1560-1566
7. 7 receptor: orphan found. Trends Pharmacol Sci 18:104-107
8. 2B receptors of endothelium-dependent relaxation in rat jugular vein. Br J Pharmacol 114:400-404
9. 2B receptor antagonist with improved affinity, selectivity, and oral activity. J Med Chem 38:2524-2530
10. Furchgott RF (1972) The classification of adrenoceptors (adrenergic receptors). An evaluation from the standpoint of receptor theory. In: Blaschko H, Muscholl E (eds) Catecholamines, handbook of experimental pharmacology, vol 33. Springer, Berlin Heidelberg New York, pp 283-335
11. 2B receptors. Br J Pharmacol 130:692-698
12. 1C-like receptors. Naunyn-Schmiedebergs Arch Pharmacol 347:471-477
13. Glusa E, Roos A (1996) Endothelial 5-HT receptors mediate relaxation of porcine pulmonary arteries in response to ergotamine and dihydroergotamine. Br J Pharmacol 119:330-334
14. Grayson KL, Gupta P (1995) Preliminary characterization of an endothelial 5-HT receptor which mediates relaxation in a preparation of dog isolated vena cava. Br J Pharmacol 106:703-709
15. 1D subtype. Br J Pharmacol 106:703-709
16. Hagan JJ, Price GW, Jeffrey P, Deeks NJ, Stean T, Piper D, Smth MI, Upton N, Medhurst AD, Middlemiss DN, Riley GJ, Lovell PJ, Bromidge SM, Thomas DR (2000) Characterization of SB-269970-A, a selective 5-HT(7) receptor antagonist. Br J Pharmacol 130:539-548
17. Hoyer D, Boddeke HWGM (1993) Partial agonists, full agonists, antagonists: dilemmas of definition. Trends Pharmacol Sci 14:270-275
18. Hoyer D, Martin GR (1996) Classification and nomenclature of 5-HT receptors: a comment on current issues. Behav Brain Res 73:263-268
19. Hoyer D, Hannon JP, Martin GR (2002) Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol Biochem Behav 71:533-554
20. 7 receptor-mediated relaxation of the oviduct in nonpregnant proestrus pigs. Eur J Pharmacol 461:207-218
21. 7 receptors mediate relaxation of porcine pial veins. Am J Physiol Heart Circ Physiol 278:H907-H912
22. 7 receptors mediate direct vascular relaxation in piglet pulmonary artery. Naunyn-Schmiedebergs Arch Pharmacol 369:R27
23. 7b). Br J Pharmacol 122:126-132
24. Jenkinson DH, Barnard EA, Hoyer D, Humphrey PPA, Leff P, Shankley NP (1995) International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. IX. Recommendations on terms and symbols in quantitative pharmacology. Pharmacol Rev 47:255-266
25. 7 receptors in inhibition of porcine myometrical contractility by 5-hydroxytryptamine. Br J Pharmacol 123:173-182
26. Kitazawa T, Yamada Y, Iwano H, Yokota H, Yuasa A, Taneike T (2000) Smooth muscle layer-dependent distribution of 5-hydroxytryptamine receptor in the porcine myometrium. Br J Pharmacol 130:79-89
27. 6 serotonin receptor. J Neurochem 66:47-56
28. 7 receptor splice variants: a comparative characterization of their pharmacology, function and distribution. Naunyn-Schmiedebergs Arch Pharmacol 363:620-632
29. 1-histamine receptor affinity predicts short term weight gain for typical and atypical antipsychotic drugs. Neuropsychopharmacology 28:519-526
30. 7 receptors mediating direct relaxation in Cynomolgus monkey isolated jugular vein. Br J Pharmacol 117:926-930
31. 7 antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phenol (SB-269970). J Med Chem 43:342-345
32. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275
33. Martin GR (1994) Vascular receptors for 5-hydroxytryptamine: distribution, function and classification. Pharmacol Ther 62:283-324
34. 7 receptors? Br J Pharmacol 114:383P
35. Morecroft I, MacLean MR (1998) 5-Hydroxytryptamine receptors mediating vasoconstriction and vasodilation in perinatal and adult rabbit small pulmonary arteries. Br J Pharmacol 125:69-78
36. 1B receptor. Br J Pharmacol 128:730-734
37. 1B/1D-receptor ligand frovatriptan in human isolated basilar and coronary arteries. J Cardiovasc Pharmacol 32:220-224
38. 5A serotonin receptor. FEBS Lett 355:242-246
39. Roth BL, Craigo SC, Choudhary MS, Uluer A, Monsma FJ Jr, Shen Y, Meltzer HY, Sibley DR (1994) Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther 268:1403-1410
40. 2B receptors: an early step in the generation of migraine headache? Eur J Neurosci 8:959-967
41. 1D receptor subtype. J Pharmacol Exp Ther 252:387-394
42. Schoeffter P, Ullmer C, Bobirnac I, Gabbiani G, Lübbert H (1996) Functional, endogenously expressed 5-hydroxytryptamine 5-ht7 receptors in human vascular smooth muscle cells. Br J Pharmacol 117:993-994
43. 7 receptor subtype. Br J Pharmacol 118:1421-1428
44. 7 receptor mediating smooth muscle relaxation in canine cerebral arteries. Br J Pharmacol 127:609-616
45. Ullmer C, Schmuck K, Kalkman HO, Lübbert H (1995) Expression of serotonin receptor mRNAs in blood vessels. FEBS Lett 370:215-221
46. 2B) receptor. Naunyn-Schmiedebergs Arch Pharmacol 357:17-24
47. 7 receptors. Neurotransmissions 15:3-15
48. Wiklund N, Persson M, Gustaffson L, Moncada S, Hedqvist P (1990) Modulatory role of endogenous nitric oxide in pulmonary circulation in vivo. Eur J Pharmacol 185:123-124