The relaxant 5-HT receptor in the dog coronary artery smooth muscle: Pharmacological resemblance to the cloned 5-ht7 receptor subtype

British Journal of Pharmacology

Volumn 118, Issue 6, 1996, Pages 1421-1428

  Terrón, José A ^a  

^a INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

5 ht7 receptor; 5 hydroxytryptamine; Antipsychotic drugs; Canine coronary artery; Relaxation; Vascular smooth muscle

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 5 CARBAMOYLTRYPTAMINE; 5 METHOXYTRYPTAMINE; CLOZAPINE; LISURIDE; MESULERGINE; METERGOLINE; METITEPINE; MIANSERIN; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; NEUROLEPTIC AGENT; PARTIAL AGONIST; PIMOZIDE; PROSTAGLANDIN F2 ALPHA; RECEPTOR SUBTYPE; RISPERIDONE; SEROTONIN; SEROTONIN 1 RECEPTOR; SEROTONIN 2 RECEPTOR; SEROTONIN 3 RECEPTOR; SEROTONIN 4 RECEPTOR; SEROTONIN RECEPTOR; SPIPERONE; SUMATRIPTAN;

ANIMAL TISSUE; ARTERY MUSCLE; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; CORONARY ARTERY; DOG; FEMALE; MALE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR BLOCKING; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 0029948901     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15555.x     Document Type: Article

References (30)

1. 7) positively linked to adenylate cyclase. J. Biol. Chem., 268, 23422-23426.
2. 2 receptors: Implications for drug mechanisms of action. Life Sci., 39, 2571-2586.
3. 2-serotonergic blockade. J. Pharmacol. Exp. Ther., 237, 548-552.
4. COHEN, R.A., SHEPHERD, J.T. & VANHOUTTE, P.M. (1983). Prejunctional and posjunctional actions of endogenous norepinephrine at the sympathetic neuroeffector junction in canine coronary arteries. Circ. Res., 52, 16-25.
5. 1D-like receptor. Life Sci., 54, 1671-1680.
6. CUSHING, D.J. & COHEN, M.L. (1992a). Serotonin-induced relaxation in canine coronary artery smooth muscle. J. Pharmacol. Exp. Ther., 263, 123-129.
7. CUSHING, D.J. & COHEN, M.L. (1992b). Comparison of the serotonin receptors that mediate smooth muscle contraction in the canine coronary artery. J. Pharmacol. Exp. Ther., 261, 856-862.
8. HOUSTON, D.S. & VANHOUTTE, P.M. (1988). Comparison of serotonergic receptor subtypes on the smooth muscle and endothelium of the canine coronary artery. J. Pharmacol. Exp. Ther., 244, 1-10.
9. HOYER, D., CLARKE, D.E., FOZARD, J.R., HARTIG, P.R., MARTIN, G.R., MYLECHARANE, E.J., SAXENA, P.R. & HUMPHREY, P.P.A. (1994). International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev., 46, 157-203.
10. 1c receptor-mediated stimulation of inositol phosphate production in pig choroid plexus. A pharmacological characterization. Naunyn-Schmied. Arch. Pharmacol., 339, 252-258.
11. LEYSEN, J.E. (1985). Serotonin binding sites. In Serotonin and the Cardiovascular System, ed. Vanhoutte, P.M. pp. 43-62. New York: Raven Press.
12. LEYSEN, J.E., GOMMEREN, W.., EENS, A., DE CHAFFOY DE COURCELLES, D., STOOF, J.C. & JANNSSEN, P.A.J. (1988). Biochemical profile of risperidone, a new antipsychotic. J. Pharmacol. Exp. Ther., 247, 661-670.
13. 7) implicated in the regulation of mammalian circadian rhythms. Neuron, 11, 449-458.
14. MARTIN, G.R. (1994). Vascular receptors for 5-hydroxytryptamine: distribution, function and classification. Pharmacol. Ther., 62, 283-324.
15. 7 receptor? Br. J. Pharmacol., 114, 383P.
16. i values. J. Pharmacol. Exp. Ther., 251, 238-246.
17. MONSMA, F.J., SHEN, Y., WARD, R..P., HAMBLIN, M.W. & SIBLEY, D.R. (1993). Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol. Pharmacol., 43, 320-327.
18. PLASSAT, J.L., AMLAIKY, N. & HEN, R. (1993). Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase. Mol. Pharmacol., 44, 229-236.
19. 1C receptors. J. Pharmacol. Exp. Ther., 260, 1361-1365.
20. ROTH, B.L., CRAIGO, S.C, CHOUDHARY, M.S., ULUER, A., MONSMA, F.J., SHEN, Y., MELTZER, H.Y. & SIBLEY, D.R. (1994). Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J. Pharmacol. Exp. Ther., 268, 1403-1410.
21. 1c mRNA and receptor levels. Dev Brain Res., 58, 51-58.
22. 7) activating cAMP formation. Proc. Natl. Acad. Sci. U.S.A., 90, 8547-8551.
23. 7 serotonin receptor subtype. J. Biol. Chem., 268, 18200-18204.
24. 1D receptor antagonist. Br. J. Pharmacol., 110, 9P.
25. STEEL, R.,G.D. & TORRIE, J.H. (1980). Principles and Procedures of Statistics, a Biomedical Approach, 2nd edn, Tokyo: McGraw-Hill Kogakusha, Ltd.
26. 2 and receptor differentiation: A statistical analysis of competitive antagonism. Life Sci., 25, 637-654.
27. 1-like receptor mediating contraction in the canine coronary artery. Eur. J. Pharmacol., 300, 109-112.
28. TERRÒN, J.A. (1996b). Typical and atypical antipsychotic drugs are potent antagonists of the relaxant 5-HT receptor in the canine coronary artery smooth muscle. Proceedings of the 1996 Meeting of the Western Pharmacology Society, Lake Tahoe, California, January 27-February 1, 1996 (Abstract; No. 49).
29. 7 receptors in guinea-pig brain. Br. J. Pharmacol., 115, 107-116.
30. TODA, N. & OKAMURA, T. (1990). Comparison of the response to 5-carboxamidotryptamine and serotonin in isolated human, monkey and dog coronary arteries. J. Pharmacol. Exp. Ther., 253, 676-682.