6-chloro-5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]- indoline (SB-242084): The first selective and brain penetrant 5-HT(2C) receptor antagonist

Journal of Medicinal Chemistry

Volumn 40, Issue 22, 1997, Pages 3494-3496

  Bromidge, S M ^a   Duckworth, M ^a   Forbes, I T ^a   Ham, P ^a   King, F D ^a   Thewlis, K M ^a   Blaney, F E ^a   Naylor, C B ^a   Blackburn, T P ^a   Kennett, G A ^a   Wood, M D ^a   Clarke, S E ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; SEROTONIN 1C RECEPTOR; SEROTONIN ANTAGONIST; UNCLASSIFIED DRUG;

ARTICLE; BLOOD BRAIN BARRIER; DRUG CONFORMATION; DRUG PENETRATION; DRUG RECEPTOR BINDING; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

AMINOPYRIDINES; ANIMALS; BLOOD-BRAIN BARRIER; CELL LINE; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; HUMANS; INDOLES; MOLECULAR STRUCTURE; RATS; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS;

EID: 0030669049     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970424c     Document Type: Article

References (16)